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UniProtKB - Q8NHS1 (CLDN2_HUMAN)
Protein
Claudin domain-containing protein 2
Gene
CLDND2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Claudin domain-containing protein 2 |
Gene namesi | Name:CLDND2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28511, CLDND2 |
neXtProti | NX_Q8NHS1 |
VEuPathDBi | HostDB:ENSG00000160318 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 59 – 79 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 96 – 116 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 134 – 154 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000160318 |
PharmGKBi | PA144596447 |
Miscellaneous databases
Pharosi | Q8NHS1, Tdark |
Genetic variation databases
BioMutai | CLDND2 |
DMDMi | 74760361 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271020 | 1 – 167 | Claudin domain-containing protein 2Add BLAST | 167 |
Proteomic databases
PaxDbi | Q8NHS1 |
PeptideAtlasi | Q8NHS1 |
PRIDEi | Q8NHS1 |
PTM databases
PhosphoSitePlusi | Q8NHS1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000160318, Expressed in left testis and 120 other tissues |
ExpressionAtlasi | Q8NHS1, baseline and differential |
Genevisiblei | Q8NHS1, HS |
Organism-specific databases
HPAi | ENSG00000160318, Tissue enhanced (testis) |
Interactioni
Binary interactionsi
Q8NHS1
Protein-protein interaction databases
BioGRIDi | 125932, 28 interactors |
IntActi | Q8NHS1, 25 interactors |
STRINGi | 9606.ENSP00000291715 |
Miscellaneous databases
RNActi | Q8NHS1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the PMP-22/EMP/MP20 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SPH8, Eukaryota |
GeneTreei | ENSGT01040000240490 |
HOGENOMi | CLU_136294_0_0_1 |
InParanoidi | Q8NHS1 |
OMAi | RILCQEG |
OrthoDBi | 1579117at2759 |
PhylomeDBi | Q8NHS1 |
TreeFami | TF330587 |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR004032, PMP22_EMP_MP20 |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PROSITEi | View protein in PROSITE PS01221, PMP22_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8NHS1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVKRSLQSG GILLSLVANV LMVLSTATNY WTRQQEGHSG LWQECNHGIC
60 70 80 90 100
SSIPCQTTLA VTVACMVLAV GVGVVGMVMG LRIRCDEGES LRGQTTSAFL
110 120 130 140 150
FLGGLLLLTA LIGYTVKNAW KNNVFFSWSY FSGWLALPFS ILAGFCFLLA
160
DMIMQSTDAI SGFPVCL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R1J6 | M0R1J6_HUMAN | Claudin domain-containing protein 2 | CLDND2 | 109 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC029518 mRNA Translation: AAH29518.1 |
CCDSi | CCDS12829.1 |
RefSeqi | NP_689566.1, NM_152353.2 |
Genome annotation databases
Ensembli | ENST00000291715; ENSP00000291715; ENSG00000160318 ENST00000601435; ENSP00000472077; ENSG00000160318 |
GeneIDi | 125875 |
KEGGi | hsa:125875 |
MANE-Selecti | ENST00000291715.5; ENSP00000291715.1; NM_152353.3; NP_689566.1 |
UCSCi | uc002pwi.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC029518 mRNA Translation: AAH29518.1 |
CCDSi | CCDS12829.1 |
RefSeqi | NP_689566.1, NM_152353.2 |
3D structure databases
SMRi | Q8NHS1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125932, 28 interactors |
IntActi | Q8NHS1, 25 interactors |
STRINGi | 9606.ENSP00000291715 |
PTM databases
PhosphoSitePlusi | Q8NHS1 |
Genetic variation databases
BioMutai | CLDND2 |
DMDMi | 74760361 |
Proteomic databases
PaxDbi | Q8NHS1 |
PeptideAtlasi | Q8NHS1 |
PRIDEi | Q8NHS1 |
Protocols and materials databases
Antibodypediai | 32471, 50 antibodies from 13 providers |
DNASUi | 125875 |
Genome annotation databases
Ensembli | ENST00000291715; ENSP00000291715; ENSG00000160318 ENST00000601435; ENSP00000472077; ENSG00000160318 |
GeneIDi | 125875 |
KEGGi | hsa:125875 |
MANE-Selecti | ENST00000291715.5; ENSP00000291715.1; NM_152353.3; NP_689566.1 |
UCSCi | uc002pwi.1, human |
Organism-specific databases
CTDi | 125875 |
GeneCardsi | CLDND2 |
HGNCi | HGNC:28511, CLDND2 |
HPAi | ENSG00000160318, Tissue enhanced (testis) |
neXtProti | NX_Q8NHS1 |
OpenTargetsi | ENSG00000160318 |
PharmGKBi | PA144596447 |
VEuPathDBi | HostDB:ENSG00000160318 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SPH8, Eukaryota |
GeneTreei | ENSGT01040000240490 |
HOGENOMi | CLU_136294_0_0_1 |
InParanoidi | Q8NHS1 |
OMAi | RILCQEG |
OrthoDBi | 1579117at2759 |
PhylomeDBi | Q8NHS1 |
TreeFami | TF330587 |
Enzyme and pathway databases
PathwayCommonsi | Q8NHS1 |
SignaLinki | Q8NHS1 |
Miscellaneous databases
BioGRID-ORCSi | 125875, 13 hits in 1038 CRISPR screens |
GenomeRNAii | 125875 |
Pharosi | Q8NHS1, Tdark |
PROi | PR:Q8NHS1 |
RNActi | Q8NHS1, protein |
Gene expression databases
Bgeei | ENSG00000160318, Expressed in left testis and 120 other tissues |
ExpressionAtlasi | Q8NHS1, baseline and differential |
Genevisiblei | Q8NHS1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004031, PMP22/EMP/MP20/Claudin IPR004032, PMP22_EMP_MP20 |
Pfami | View protein in Pfam PF00822, PMP22_Claudin, 1 hit |
PROSITEi | View protein in PROSITE PS01221, PMP22_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CLDN2_HUMAN | |
Accessioni | Q8NHS1Primary (citable) accession number: Q8NHS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families