UniProtKB - Q8NHQ8 (RASF8_HUMAN)

BLAST

>sp|Q8NHQ8|RASF8_HUMAN Ras association domain-containing protein 8 OS=Homo sapiens OX=9606 GN=RASSF8 PE=1 SV=2
MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIEKWRDTERHLAPHENPI
ISLNKWGQYASDVQLILRRTGPSLSERPTSDSVARIPERTLYRQSLPPLAKLRPQIDKSI
KRREPKRKSLTFTGGAKGLMDIFGKGKETEFKQKVLNNCKTTADELKKLIRLQTEKLQSI
EKQLESNEIEIRFWEQKYNSNLEEEIVRLEQKIKRNDVEIEEEEFWENELQIEQENEKQL
KDQLQEIRQKITECENKLKDYLAQIRTMESGLEAEKLQREVQEAQVNEEEVKGKIGKVKG
EIDIQGQQSLRLENGIKAVERSLGQATKRLQDKEQELEQLTKELRQVNLQQFIQQTGTKV
TVLPAEPIEIEASHADIEREAPFQSGSLKRPGSSRQLPSNLRILQNPISSGFNPEGIYV

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History
Entry version 140 (12 Sep 2018)
Sequence version 2 (21 Jun 2005)
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Protein

Ras association domain-containing protein 8

Gene

RASSF8

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Biological processⁱ

adherens junction maintenance Source: InterPro
signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras association domain-containing protein 8 Alternative name(s): Carcinoma-associated protein HOJ-1
Gene namesⁱ	Name:RASSF8 Synonyms:C12orf2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123094.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13232 RASSF8
MIMⁱ	608231 gene
neXtProtⁱ	NX_Q8NHQ8

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving RASSF8 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with FBLN1.1 Publication

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11228
MIMⁱ	608180 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000123094
PharmGKBⁱ	PA25502

Polymorphism and mutation databases

BioMutaⁱ	RASSF8
DMDMⁱ	68068057

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000089840	1 – 419	Ras association domain-containing protein 8Add BLAST		419

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	105	PhosphoserineCombined sources	1
Modified residueⁱ	129	PhosphoserineCombined sources	1
Modified residueⁱ	131	PhosphothreonineCombined sources	1
Modified residueⁱ	387	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8NHQ8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NHQ8
PaxDbⁱ	Q8NHQ8
PeptideAtlas More...PeptideAtlasⁱ	Q8NHQ8
PRIDEⁱ	Q8NHQ8
ProteomicsDBⁱ	73739 73740 [Q8NHQ8-2]

PTM databases

iPTMnetⁱ	Q8NHQ8
PhosphoSitePlusⁱ	Q8NHQ8

Expressionⁱ

Tissue specificityⁱ

Widely expressed as a 6.2 kb transcript. A 2.2 kb alternatively spliced transcript is expressed exclusively in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000123094 Expressed in 198 organ(s), highest expression level in testis
CleanExⁱ	HS_RASSF8
ExpressionAtlasⁱ	Q8NHQ8 baseline and differential
Genevisibleⁱ	Q8NHQ8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038163 HPA038164

HPAⁱ

HPA038163
HPA038164

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	116395, 51 interactors
IntActⁱ	Q8NHQ8, 35 interactors
Molecular INTeraction database More...MINTⁱ	Q8NHQ8
STRINGⁱ	9606.ENSP00000282884

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 7	Combined sources	3
Beta strandⁱ	10 – 12	Combined sources	3
Beta strandⁱ	15 – 17	Combined sources	3
Beta strandⁱ	19 – 21	Combined sources	3
Helixⁱ	23 – 34	Combined sources	12
Beta strandⁱ	38 – 46	Combined sources	9
Beta strandⁱ	49 – 52	Combined sources	4
Beta strandⁱ	55 – 57	Combined sources	3
Helixⁱ	59 – 64	Combined sources	6
Helixⁱ	67 – 69	Combined sources	3
Beta strandⁱ	74 – 81	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8NHQ8
SMRⁱ	Q8NHQ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8NHQ8

EvolutionaryTraceⁱ

Q8NHQ8

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 82	Ras-associatingPROSITE-ProRule annotationAdd BLAST		82

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	181 – 290	Glu-richAdd BLAST		110

Phylogenomic databases

eggNOGⁱ	KOG1574 Eukaryota ENOG410XPWB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063648
HOGENOMⁱ	HOG000013031
HOVERGENⁱ	HBG050971
InParanoidⁱ	Q8NHQ8
KEGG Orthology (KO) More...KOⁱ	K09855
OMAⁱ	AQIQTME
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RF3
PhylomeDBⁱ	Q8NHQ8
TreeFamⁱ	TF318385

Family and domain databases

InterProⁱ	View protein in InterPro IPR033593 N-RASSF IPR000159 RA_dom IPR033632 RASSF8 IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR15286 PTHR15286, 1 hit PTHR15286:SF9 PTHR15286:SF9, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00788 RA, 1 hit
SMARTⁱ	View protein in SMART SM00314 RA, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50200 RA, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8NHQ8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELKVWVDGV QRIVCGVTEV TTCQEVVIAL AQAIGRTGRY TLIEKWRDTE 
        60         70         80         90        100
RHLAPHENPI ISLNKWGQYA SDVQLILRRT GPSLSERPTS DSVARIPERT 
       110        120        130        140        150
LYRQSLPPLA KLRPQIDKSI KRREPKRKSL TFTGGAKGLM DIFGKGKETE 
       160        170        180        190        200
FKQKVLNNCK TTADELKKLI RLQTEKLQSI EKQLESNEIE IRFWEQKYNS 
       210        220        230        240        250
NLEEEIVRLE QKIKRNDVEI EEEEFWENEL QIEQENEKQL KDQLQEIRQK 
       260        270        280        290        300
ITECENKLKD YLAQIRTMES GLEAEKLQRE VQEAQVNEEE VKGKIGKVKG 
       310        320        330        340        350
EIDIQGQQSL RLENGIKAVE RSLGQATKRL QDKEQELEQL TKELRQVNLQ 
       360        370        380        390        400
QFIQQTGTKV TVLPAEPIEI EASHADIERE APFQSGSLKR PGSSRQLPSN 
       410 
LRILQNPISS GFNPEGIYV

Length:419

Mass (Da):48,327

Last modified:June 21, 2005 - v2

Checksum:ⁱ409223F6BE1C204A

Isoform 2 (identifier: Q8NHQ8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
380-419: EAPFQSGSLKRPGSSRQLPSNLRILQNPISSGFNPEGIYV → GIIILSDKQECKD

« Hide

        10         20         30         40         50
MELKVWVDGV QRIVCGVTEV TTCQEVVIAL AQAIGRTGRY TLIEKWRDTE 
        60         70         80         90        100
RHLAPHENPI ISLNKWGQYA SDVQLILRRT GPSLSERPTS DSVARIPERT 
       110        120        130        140        150
LYRQSLPPLA KLRPQIDKSI KRREPKRKSL TFTGGAKGLM DIFGKGKETE 
       160        170        180        190        200
FKQKVLNNCK TTADELKKLI RLQTEKLQSI EKQLESNEIE IRFWEQKYNS 
       210        220        230        240        250
NLEEEIVRLE QKIKRNDVEI EEEEFWENEL QIEQENEKQL KDQLQEIRQK 
       260        270        280        290        300
ITECENKLKD YLAQIRTMES GLEAEKLQRE VQEAQVNEEE VKGKIGKVKG 
       310        320        330        340        350
EIDIQGQQSL RLENGIKAVE RSLGQATKRL QDKEQELEQL TKELRQVNLQ 
       360        370        380        390 
QFIQQTGTKV TVLPAEPIEI EASHADIERG IIILSDKQEC KD

Show »

Length:392

Mass (Da):45,446

Checksum:ⁱADA799FFB41733AE

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H7J1	F5H7J1_HUMAN	Ras association domain-containing p... Ras association domain-containing protein 8	RASSF8	219	Annotation score:
F5H0S5	F5H0S5_HUMAN	Ras association domain-containing p... Ras association domain-containing protein 8	RASSF8	208	Annotation score:
Q6IB99	Q6IB99_HUMAN	C12orf2 protein C12orf2 protein (Ras association domain-containing protein 8)	RASSF8 C12orf2	109	Annotation score:
H0YG85	H0YG85_HUMAN	Ras association domain-containing p... Ras association domain-containing protein 8	RASSF8	208	Annotation score:
F5H8B9	F5H8B9_HUMAN	Ras association domain-containing p... Ras association domain-containing protein 8	RASSF8	91	Annotation score:
F5GYP8	F5GYP8_HUMAN	Ras association domain-containing p... Ras association domain-containing protein 8	RASSF8	122	Annotation score:
F5H8C5	F5H8C5_HUMAN	Ras association domain-containing p... Ras association domain-containing protein 8	RASSF8	159	Annotation score:
F5H343	F5H343_HUMAN	Ras association domain-containing p... Ras association domain-containing protein 8	RASSF8	29	Annotation score:

Sequence cautionⁱ

The sequence AAC95425 differs from that shown. Reason: Frameshift at position 108.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	15	C → Y in BAC98838 (Ref. 1) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_014248	380 – 419	EAPFQ…EGIYV → GIIILSDKQECKD in isoform 2. 1 PublicationAdd BLAST		40

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB093206 mRNA Translation: BAC98838.1 AY665468 mRNA Translation: AAV54603.1 AK290055 mRNA Translation: BAF82744.1 CH471094 Genomic DNA Translation: EAW96523.1 BC030021 mRNA Translation: AAH30021.1 U82396 mRNA Translation: AAC95425.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53765.1 [Q8NHQ8-1] CCDS8705.1 [Q8NHQ8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001158218.1, NM_001164746.1 [Q8NHQ8-1] NP_001158219.1, NM_001164747.1 [Q8NHQ8-1] NP_001158220.1, NM_001164748.1 [Q8NHQ8-1] NP_009142.2, NM_007211.4 [Q8NHQ8-2] XP_006719090.1, XM_006719027.2 [Q8NHQ8-1] XP_006719091.1, XM_006719028.1 [Q8NHQ8-1] XP_016874235.1, XM_017018746.1 [Q8NHQ8-1]
UniGeneⁱ	Hs.696433

Genome annotation databases

Ensemblⁱ	ENST00000282884; ENSP00000282884; ENSG00000123094 [Q8NHQ8-1] ENST00000381352; ENSP00000370756; ENSG00000123094 [Q8NHQ8-2] ENST00000405154; ENSP00000384491; ENSG00000123094 [Q8NHQ8-1] ENST00000541490; ENSP00000443096; ENSG00000123094 [Q8NHQ8-1] ENST00000542865; ENSP00000439839; ENSG00000123094 [Q8NHQ8-1] ENST00000615708; ENSP00000481417; ENSG00000123094 [Q8NHQ8-2]
GeneIDⁱ	11228
KEGGⁱ	hsa:11228
UCSC genome browser More...UCSCⁱ	uc001rgx.4 human [Q8NHQ8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Protein	Similar proteins		Species	Score	Length	Source
Q8NHQ8	Ras association (RalGDS/AF-6) domain family 8, isoform CRA_b		HUMAN		419	UniRef100_Q8NHQ8
RASSF8 isoform 3		PANTR		419
Carcinoma-associated protein HOJ-1		MACMU		419
Ras association domain family member 8		RHIBE		419
Ras association domain family member 8		MACNE		419
+17
Q8NHQ8-2	RASSF8 isoform 1		PANTR		392	UniRef100_A0A2J8QR11
Uncharacterized protein		COLAP		392
Uncharacterized protein		RHIRO		392
Uncharacterized protein		PAPAN		392
Uncharacterized protein		RHIBE		392

Protein	Similar proteins		Species	Score	Length	Source
Q8NHQ8	Ras association domain-containing protein 8		MOUSE		419	UniRef90_Q8NHQ8
Ras association (RalGDS/AF-6) domain family 8, isoform CRA_b		HUMAN		419
RASSF8 isoform 3		PANTR		419
Carcinoma-associated protein HOJ-1		MACMU		419
Ras association domain family member 8		RHIBE		419
+149

Protein	Similar proteins		Species	Score	Length	Source
Q8NHQ8	Ras association domain-containing protein 8		MOUSE		419	UniRef50_Q8NHQ8
Ras association (RalGDS/AF-6) domain family 8, isoform CRA_b		HUMAN		419
RASSF8 isoform 3		PANTR		419
Carcinoma-associated protein HOJ-1		MACMU		419
Ras association domain family member 8		RHIBE		419
+298

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB093206 mRNA Translation: BAC98838.1 AY665468 mRNA Translation: AAV54603.1 AK290055 mRNA Translation: BAF82744.1 CH471094 Genomic DNA Translation: EAW96523.1 BC030021 mRNA Translation: AAH30021.1 U82396 mRNA Translation: AAC95425.1 Frameshift.
CCDSⁱ	CCDS53765.1 [Q8NHQ8-1] CCDS8705.1 [Q8NHQ8-2]
RefSeqⁱ	NP_001158218.1, NM_001164746.1 [Q8NHQ8-1] NP_001158219.1, NM_001164747.1 [Q8NHQ8-1] NP_001158220.1, NM_001164748.1 [Q8NHQ8-1] NP_009142.2, NM_007211.4 [Q8NHQ8-2] XP_006719090.1, XM_006719027.2 [Q8NHQ8-1] XP_006719091.1, XM_006719028.1 [Q8NHQ8-1] XP_016874235.1, XM_017018746.1 [Q8NHQ8-1]
UniGeneⁱ	Hs.696433

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CS4	NMR	-	A	1-82	[»]
ProteinModelPortalⁱ	Q8NHQ8
SMRⁱ	Q8NHQ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116395, 51 interactors
IntActⁱ	Q8NHQ8, 35 interactors
MINTⁱ	Q8NHQ8
STRINGⁱ	9606.ENSP00000282884

PTM databases

iPTMnetⁱ	Q8NHQ8
PhosphoSitePlusⁱ	Q8NHQ8

Polymorphism and mutation databases

BioMutaⁱ	RASSF8
DMDMⁱ	68068057

Proteomic databases

EPDⁱ	Q8NHQ8
MaxQBⁱ	Q8NHQ8
PaxDbⁱ	Q8NHQ8
PeptideAtlasⁱ	Q8NHQ8
PRIDEⁱ	Q8NHQ8
ProteomicsDBⁱ	73739 73740 [Q8NHQ8-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11228
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000282884; ENSP00000282884; ENSG00000123094 [Q8NHQ8-1] ENST00000381352; ENSP00000370756; ENSG00000123094 [Q8NHQ8-2] ENST00000405154; ENSP00000384491; ENSG00000123094 [Q8NHQ8-1] ENST00000541490; ENSP00000443096; ENSG00000123094 [Q8NHQ8-1] ENST00000542865; ENSP00000439839; ENSG00000123094 [Q8NHQ8-1] ENST00000615708; ENSP00000481417; ENSG00000123094 [Q8NHQ8-2]
GeneIDⁱ	11228
KEGGⁱ	hsa:11228
UCSCⁱ	uc001rgx.4 human [Q8NHQ8-1]

Organism-specific databases

CTDⁱ	11228
DisGeNETⁱ	11228
EuPathDBⁱ	HostDB:ENSG00000123094.15
GeneCardsⁱ	RASSF8
HGNCⁱ	HGNC:13232 RASSF8
HPAⁱ	HPA038163 HPA038164
MIMⁱ	608180 phenotype 608231 gene
neXtProtⁱ	NX_Q8NHQ8
OpenTargetsⁱ	ENSG00000123094
PharmGKBⁱ	PA25502
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1574 Eukaryota ENOG410XPWB LUCA
GeneTreeⁱ	ENSGT00530000063648
HOGENOMⁱ	HOG000013031
HOVERGENⁱ	HBG050971
InParanoidⁱ	Q8NHQ8
KOⁱ	K09855
OMAⁱ	AQIQTME
OrthoDBⁱ	EOG091G0RF3
PhylomeDBⁱ	Q8NHQ8
TreeFamⁱ	TF318385

Miscellaneous databases

ChiTaRSⁱ	RASSF8 human
EvolutionaryTraceⁱ	Q8NHQ8
GeneWikiⁱ	RASSF8
GenomeRNAiⁱ	11228
Protein Ontology More...PROⁱ	PR:Q8NHQ8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123094 Expressed in 198 organ(s), highest expression level in testis
CleanExⁱ	HS_RASSF8
ExpressionAtlasⁱ	Q8NHQ8 baseline and differential
Genevisibleⁱ	Q8NHQ8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033593 N-RASSF IPR000159 RA_dom IPR033632 RASSF8 IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR15286 PTHR15286, 1 hit PTHR15286:SF9 PTHR15286:SF9, 1 hit
Pfamⁱ	View protein in Pfam PF00788 RA, 1 hit
SMARTⁱ	View protein in SMART SM00314 RA, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50200 RA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RASF8_HUMAN
Accessionⁱ	Q8NHQ8Primary (citable) accession number: Q8NHQ8 Secondary accession number(s): A8K1Z0 , O95647, Q5SCI2, Q76KB6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
	Last sequence update:	June 21, 2005
	Last modified:	September 12, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q8NHQ8 (RASF8_HUMAN)

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Ras association domain-containing protein 8

RASSF8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ