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Entry version 156 (12 Aug 2020)
Sequence version 2 (01 Feb 2005)
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Protein

Centrosomal protein of 70 kDa

Gene

CEP70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q8NHQ1

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-8854518, AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 70 kDa
Short name:
Cep70
Alternative name(s):
p10-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP70
Synonyms:BITE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000114107.8

Human Gene Nomenclature Database

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HGNCi
HGNC:29972, CEP70

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614310, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8NHQ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
80321

Open Targets

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OpenTargetsi
ENSG00000114107

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA128394729

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q8NHQ1, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CEP70

Domain mapping of disease mutations (DMDM)

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DMDMi
84028943

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894971 – 597Centrosomal protein of 70 kDaAdd BLAST597

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NHQ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8NHQ1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NHQ1

PeptideAtlas

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PeptideAtlasi
Q8NHQ1

PRoteomics IDEntifications database

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PRIDEi
Q8NHQ1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
73734 [Q8NHQ1-1]
73735 [Q8NHQ1-2]
73736 [Q8NHQ1-3]
73737 [Q8NHQ1-4]
73738 [Q8NHQ1-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NHQ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NHQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000114107, Expressed in calcaneal tendon and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NHQ1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NHQ1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000114107, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8NHQ1
With#Exp.IntAct
ABT1 [Q9ULW3]6EBI-739624,EBI-2602396
AGBL2 - isoform 3 [Q5U5Z8-3]3EBI-739624,EBI-12226473
AKAP17A [Q02040]7EBI-739624,EBI-1042725
AKAP17A - isoform 3 [Q02040-3]3EBI-739624,EBI-10222656
ARHGEF3 [Q9NR81]7EBI-739624,EBI-10312733
ARMCX1 [Q9P291]3EBI-739624,EBI-2843626
ATP5PO [P48047]6EBI-739624,EBI-355815
BARD1 [A0AVN2]3EBI-739624,EBI-9977322
BARD1 [Q99728]3EBI-739624,EBI-473181
BAZ2B [A0A0A0MR97]3EBI-739624,EBI-11985607
BEX2 [Q9BXY8]6EBI-739624,EBI-745073
BRD1 [O95696]3EBI-739624,EBI-714754
BRMS1 [Q9HCU9]4EBI-739624,EBI-714781
BRMS1L [Q5PSV4]3EBI-739624,EBI-5666615
BRPF1 - isoform 2 [P55201-2]3EBI-739624,EBI-12065306
BYSL [Q13895]8EBI-739624,EBI-358049
C8orf33 [Q9H7E9]5EBI-739624,EBI-715389
CARD9 [Q9H257]3EBI-739624,EBI-751319
CAVIN3 [Q969G5]3EBI-739624,EBI-3893101
CBX8 [Q9HC52]3EBI-739624,EBI-712912
CDC37 [Q16543]3EBI-739624,EBI-295634
CDC73 [Q6P1J9]10EBI-739624,EBI-930143
CDCA7L [Q96GN5]7EBI-739624,EBI-5278764
CEP57L1 [Q8IYX8]3EBI-739624,EBI-1104570
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-739624,EBI-10181988
itself4EBI-739624,EBI-739624
CEP70 - isoform 3 [Q8NHQ1-3]3EBI-739624,EBI-11526150
CFAP53 [Q96M91]3EBI-739624,EBI-742422
CLPB [Q9H078]3EBI-739624,EBI-2107221
COIL [P38432]3EBI-739624,EBI-945751
CWF19L2 [Q2TBE0]3EBI-739624,EBI-5453285
DAXX [Q9UER7]3EBI-739624,EBI-77321
DDX41 [Q9UJV9]3EBI-739624,EBI-1046350
DDX6 [P26196]6EBI-739624,EBI-351257
DIEXF [Q68CQ4]8EBI-739624,EBI-747711
DNTTIP2 [Q5QJE6]3EBI-739624,EBI-5666736
DVL3 [Q92997]3EBI-739624,EBI-739789
EAF1 [Q96JC9]3EBI-739624,EBI-769261
EBNA1BP2 [Q99848]3EBI-739624,EBI-1048111
EIF3D [O15371]3EBI-739624,EBI-353818
ELOA [Q14241]3EBI-739624,EBI-742350
EMD [P50402]6EBI-739624,EBI-489887
EMP1 [P54849]3EBI-739624,EBI-4319440
ENKD1 [Q9H0I2]4EBI-739624,EBI-744099
ERCC3 [P19447]3EBI-739624,EBI-1183307
FAM124A [Q86V42]3EBI-739624,EBI-744506
FAM133A [Q8N9E0]6EBI-739624,EBI-10268158
FAM13C [Q8NE31]3EBI-739624,EBI-751248
FAM161A [Q3B820]6EBI-739624,EBI-719941
FAM161B [Q96MY7]3EBI-739624,EBI-7225287
FAM214B [Q7L5A3]5EBI-739624,EBI-745689
FAM90A1 [Q86YD7]3EBI-739624,EBI-6658203
GADD45GIP1 [Q8TAE8]3EBI-739624,EBI-372506
GAS8 [O95995]3EBI-739624,EBI-1052570
GATAD2B [Q8WXI9]3EBI-739624,EBI-923440
GCC1 [Q96CN9]6EBI-739624,EBI-746252
GEM [P55040]3EBI-739624,EBI-744104
GLYCTK [Q8IVS8]3EBI-739624,EBI-748515
GPATCH2L [Q9NWQ4]3EBI-739624,EBI-5666657
GPATCH4 [Q5T3I0]6EBI-739624,EBI-2372076
GPX7 [Q96SL4]3EBI-739624,EBI-749411
HAUS1 [Q96CS2]3EBI-739624,EBI-2514791
HAUS1 - isoform 2 [Q96CS2-2]3EBI-739624,EBI-11742270
hCG_2042749 [A0A024R4Z4]3EBI-739624,EBI-14231181
HDAC4 - isoform 2 [P56524-2]3EBI-739624,EBI-11953488
HIC2 [Q96JB3]3EBI-739624,EBI-726282
HMGB4 [Q6NSH1]3EBI-739624,EBI-10250889
HMGB4 [Q8WW32]6EBI-739624,EBI-10277297
HOXB5 [P09067]3EBI-739624,EBI-3893317
HOXC8 [P31273]3EBI-739624,EBI-1752118
HSPD1 [P10809]6EBI-739624,EBI-352528
IK [Q13123]3EBI-739624,EBI-713456
INO80B [Q9C086]3EBI-739624,EBI-715611
INPP5J [Q15735]3EBI-739624,EBI-10236940
IPCEF1 [Q8WWN9]3EBI-739624,EBI-4401965
IQUB [Q8NA54]3EBI-739624,EBI-10220600
ITPKB [P27987]3EBI-739624,EBI-751388
KANK2 [Q63ZY3]6EBI-739624,EBI-2556193
KANSL1 [Q7Z3B3]4EBI-739624,EBI-740244
KAT14 [Q9H8E8]3EBI-739624,EBI-750907
KAT5 [Q92993]3EBI-739624,EBI-399080
KDM1A [O60341]2EBI-739624,EBI-710124
KRI1 [A0A494C108]3EBI-739624,EBI-12342761
KRT31 [Q15323]3EBI-739624,EBI-948001
LAMTOR5 [A0A0C4DGV4]6EBI-739624,EBI-10173304
LCOR - isoform 2 [Q96JN0-2]3EBI-739624,EBI-10961483
LENG1 [Q96BZ8]7EBI-739624,EBI-726510
LENG8 [Q96PV6]3EBI-739624,EBI-739546
LIN37 [Q96GY3]3EBI-739624,EBI-748884
LNX1 [Q8TBB1]3EBI-739624,EBI-739832
MAB21L2 [Q9Y586]3EBI-739624,EBI-6659161
MAGOH [P61326]3EBI-739624,EBI-299134
MBD3 - isoform 2 [O95983-2]3EBI-739624,EBI-11978579
MCRS1 [Q96EZ8]3EBI-739624,EBI-348259
METTL17 [Q9H7H0]7EBI-739624,EBI-749353
METTL17 - isoform 2 [Q9H7H0-2]3EBI-739624,EBI-11098807
MFAP1 [P55081]6EBI-739624,EBI-1048159
MGC50722 [Q8IVT4]3EBI-739624,EBI-14086479
MKRN3 [Q13064]3EBI-739624,EBI-2340269
MMTAG2 [Q9BU76]5EBI-739624,EBI-742459
NEBL [O76041]3EBI-739624,EBI-2880203
NIPSNAP3A [Q9UFN0]3EBI-739624,EBI-716291
NKAPD1 [Q6ZUT1]6EBI-739624,EBI-3920396
NKAPD1 - isoform 2 [Q6ZUT1-2]3EBI-739624,EBI-10180231
NOL12 [Q9UGY1]4EBI-739624,EBI-716098
NOP2 [P46087]3EBI-739624,EBI-356811
NOP53 [Q9NZM5]3EBI-739624,EBI-720156
NOXA1 - isoform 2 [Q86UR1-2]3EBI-739624,EBI-12025760
NRIP1 [P48552]3EBI-739624,EBI-746484
NUSAP1 [Q9BXS6]3EBI-739624,EBI-2555618
PIBF1 [A0A087WUI6]3EBI-739624,EBI-11749468
PIMREG [Q9BSJ6]6EBI-739624,EBI-2568609
PKN1 [Q16512]3EBI-739624,EBI-602382
PPIG [Q13427]3EBI-739624,EBI-396072
PPP1R16B [Q96T49]3EBI-739624,EBI-10293968
PPP1R18 [Q6NYC8]3EBI-739624,EBI-2557469
PRKRIP1 [Q9H875]3EBI-739624,EBI-744488
PRPF18 [Q99633]3EBI-739624,EBI-2798416
PRPF3 [O43395]3EBI-739624,EBI-744322
PRPF31 [Q8WWY3]9EBI-739624,EBI-1567797
PSMA1 [P25786]6EBI-739624,EBI-359352
PSORS1C2 [Q9UIG4]3EBI-739624,EBI-11974061
RASSF10 [A6NK89]3EBI-739624,EBI-6912267
RBM10 [P98175]6EBI-739624,EBI-721525
RHPN1 [Q8TCX5]3EBI-739624,EBI-746325
RNF169 [Q8NCN4]3EBI-739624,EBI-6380946
RNF6 [A0A0S2Z4G9]3EBI-739624,EBI-16428950
RPL13 [P26373]3EBI-739624,EBI-356849
RPL13 [Q6NZ55]3EBI-739624,EBI-10252046
SCNM1 [Q9BWG6]3EBI-739624,EBI-748391
SEC14L1 [Q92503]3EBI-739624,EBI-2855587
SETD5 - isoform 2 [Q9C0A6-2]3EBI-739624,EBI-10303449
SFR1 [Q86XK3]3EBI-739624,EBI-1104535
SH2D4A [Q9H788]3EBI-739624,EBI-747035
SH2D4A - isoform 2 [Q9H788-2]3EBI-739624,EBI-10308083
SLU7 [O95391]3EBI-739624,EBI-750559
SMARCE1 [Q969G3]6EBI-739624,EBI-455078
SNRPD2 [P62316]3EBI-739624,EBI-297993
SNW1 [Q13573]3EBI-739624,EBI-632715
SOD2 [P04179]3EBI-739624,EBI-716989
SPANXN3 [Q5MJ09]3EBI-739624,EBI-12037215
SRCAP - isoform 3 [Q6ZRS2-3]3EBI-739624,EBI-12029182
SSX3 [Q99909]3EBI-739624,EBI-10295431
STK25 [O00506]3EBI-739624,EBI-618295
SUV39H1 [O43463]3EBI-739624,EBI-349968
SYT17 [Q9BSW7]3EBI-739624,EBI-745392
SYTL4 [Q96C24]4EBI-739624,EBI-747142
SYTL5 [Q8TDW5]4EBI-739624,EBI-2939487
SYTL5 - isoform 2 [Q8TDW5-2]3EBI-739624,EBI-12243980
TAF1D [Q9H5J8]4EBI-739624,EBI-716128
TBC1D22B [Q9NU19]3EBI-739624,EBI-8787464
TBC1D30 - isoform 2 [Q9Y2I9-2]3EBI-739624,EBI-17455779
TCAF1 - isoform 2 [Q9Y4C2-2]3EBI-739624,EBI-11974855
TCEANC - isoform 2 [Q8N8B7-2]3EBI-739624,EBI-11955057
TEAD4 [A0A0S2Z4E5]3EBI-739624,EBI-16432288
TEAD4 [A0A0S2Z4F2]3EBI-739624,EBI-16429215
TEAD4 [D3DUQ6]3EBI-739624,EBI-10176734
TLK2 [Q86UE8]3EBI-739624,EBI-1047967
TRAF3IP3 [Q9Y228]3EBI-739624,EBI-765817
TRIM29 [Q14134]5EBI-739624,EBI-702370
TRIM3 [O75382]3EBI-739624,EBI-2129889
TRIM42 [Q8IWZ5]3EBI-739624,EBI-5235829
TSFM [P43897]4EBI-739624,EBI-1049298
TSGA10IP [Q3SY00]7EBI-739624,EBI-10241197
TSHZ3 [Q63HK5]3EBI-739624,EBI-9053916
TTC25 [Q96NG3]3EBI-739624,EBI-1046387
TTLL10 [Q6ZVT0]3EBI-739624,EBI-7844656
TTLL10 - isoform 3 [Q6ZVT0-3]3EBI-739624,EBI-11979997
TXLNB [Q8N3L3]8EBI-739624,EBI-6116822
TXN2 [Q99757]3EBI-739624,EBI-2932492
USP2 [O75604]3EBI-739624,EBI-743272
UTP11 [Q9Y3A2]3EBI-739624,EBI-2876697
UTP14C [Q5TAP6]3EBI-739624,EBI-11737646
UTP3 [Q9NQZ2]3EBI-739624,EBI-714067
VXN [Q8TAG6]3EBI-739624,EBI-12071548
WDYHV1 [Q96HA8]3EBI-739624,EBI-741158
YJU2 [Q9BW85]6EBI-739624,EBI-10300345
ZBTB16 [Q05516]4EBI-739624,EBI-711925
ZBTB24 [O43167]6EBI-739624,EBI-744471
ZBTB4 [Q9P1Z0]3EBI-739624,EBI-2564133
ZBTB47 [Q9UFB7]3EBI-739624,EBI-7781767
ZBTB48 [P10074]3EBI-739624,EBI-744864
ZBTB49 [Q6ZSB9]5EBI-739624,EBI-2859943
ZCCHC10 [Q8TBK6]4EBI-739624,EBI-597063
ZFC3H1 [G3V1X1]3EBI-739624,EBI-6448783
ZFHX3 - isoform B [Q15911-2]3EBI-739624,EBI-10237226
ZFP1 [Q6P2D0]3EBI-739624,EBI-2555749
ZGPAT [A0A0S2Z6H0]3EBI-739624,EBI-16428984
ZGPAT [Q8N5A5]4EBI-739624,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]9EBI-739624,EBI-10183064
ZNF136 [P52737]5EBI-739624,EBI-749129
ZNF140 [P52738]3EBI-739624,EBI-12069140
ZNF148 [Q9UQR1]3EBI-739624,EBI-2688184
ZNF165 [P49910]3EBI-739624,EBI-741694
ZNF169 [Q14929]3EBI-739624,EBI-10234472
ZNF17 [P17021]3EBI-739624,EBI-1105334
ZNF20 [P17024]3EBI-739624,EBI-717634
ZNF202 [O95125]3EBI-739624,EBI-751960
ZNF227 [Q86WZ6]7EBI-739624,EBI-2799529
ZNF239 [Q16600]6EBI-739624,EBI-8787052
ZNF264 [O43296]4EBI-739624,EBI-4395808
ZNF266 [Q14584]6EBI-739624,EBI-7115319
ZNF302 [Q9NR11]4EBI-739624,EBI-3916142
ZNF329 [Q86UD4]7EBI-739624,EBI-7233259
ZNF35 [P13682]3EBI-739624,EBI-11041653
ZNF366 [Q8N895]8EBI-739624,EBI-2813661
ZNF408 [Q9H9D4]9EBI-739624,EBI-347633
ZNF410 [Q86VK4]3EBI-739624,EBI-720304
ZNF417 [Q8TAU3]6EBI-739624,EBI-740727
ZNF433 [Q8N7K0]3EBI-739624,EBI-10267553
ZNF439 [Q8NDP4]3EBI-739624,EBI-747580
ZNF490 [Q9ULM2]7EBI-739624,EBI-1105370
ZNF491 [Q8N8L2]3EBI-739624,EBI-12019860
ZNF555 [Q8NEP9]3EBI-739624,EBI-10270752
ZNF572 [Q7Z3I7]6EBI-739624,EBI-10172590
ZNF574 - isoform 2 [Q6ZN55-2]3EBI-739624,EBI-17189720
ZNF578 [Q3MI94]3EBI-739624,EBI-10241108
ZNF578 [Q96N58]3EBI-739624,EBI-11955189
ZNF587 [Q96SQ5]6EBI-739624,EBI-6427977
ZNF599 [Q96NL3]3EBI-739624,EBI-8653994
ZNF648 [Q5T619]3EBI-739624,EBI-11985915
ZNF669 [Q96BR6]3EBI-739624,EBI-12006574
ZNF688 [A0A0S2Z5X4]3EBI-739624,EBI-16429014
ZNF696 [Q9H7X3]3EBI-739624,EBI-11090299
ZNF775 [Q96BV0]3EBI-739624,EBI-7149881
ZNF777 [Q9ULD5]3EBI-739624,EBI-11975599
ZNF785 [A8K8V0]3EBI-739624,EBI-3925400
ZNF835 [Q9Y2P0]3EBI-739624,EBI-5667516
ZNF860 [A6NHJ4]3EBI-739624,EBI-17263060
ZSCAN12 [O43309]3EBI-739624,EBI-1210440
ZSCAN21 [Q9Y5A6]3EBI-739624,EBI-10281938
ZSCAN23 [Q3MJ62]3EBI-739624,EBI-5667532

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123234, 173 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NHQ1, 268 interactors

Molecular INTeraction database

More...
MINTi
Q8NHQ1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264982

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NHQ1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NHQ1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati483 – 516TPRAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili75 – 179Sequence analysisAdd BLAST105
Coiled coili254 – 326Sequence analysisAdd BLAST73

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.

Keywords - Domaini

Coiled coil, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QS45, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009029

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1351558_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NHQ1

KEGG Orthology (KO)

More...
KOi
K16802

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLCLIDY

Database of Orthologous Groups

More...
OrthoDBi
1217382at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NHQ1

TreeFam database of animal gene trees

More...
TreeFami
TF330986

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037692, CEP70
IPR013026, TPR-contain_dom
IPR019734, TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR14594, PTHR14594, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 1 hit
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NHQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT
60 70 80 90 100
DLKDLIIFDK QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL
110 120 130 140 150
EQSRAANQEQ RANDLEQIME SVKSKIGELE DESLSRACHQ QNKIKDLQKE
160 170 180 190 200
QKTLQVKCQH YKKKRTEQEE TIASLQMEVC RLKKEEEDRI VTQNRVFAYL
210 220 230 240 250
CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS EEENDYRNLD
260 270 280 290 300
ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK
310 320 330 340 350
QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ
360 370 380 390 400
VLCSINSIIH NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA
410 420 430 440 450
DQLTSLKDLY KSLKTLSAEL VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE
460 470 480 490 500
VENKEKDSNM PHFQTLQAIV SHFQKLFDVP SLNGVYPRMN EVYTRLGEMN
510 520 530 540 550
NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV MQVLGPEDLQ
560 570 580 590
SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY
Length:597
Mass (Da):69,752
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i345EEEB9B1F0D6C7
GO
Isoform 2 (identifier: Q8NHQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-554: SIIY → RYLF
     555-597: Missing.

Show »
Length:554
Mass (Da):64,880
Checksum:i995E0945339F20CA
GO
Isoform 3 (identifier: Q8NHQ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-597: Missing.

Show »
Length:212
Mass (Da):25,034
Checksum:i5E1C436C297C8CF3
GO
Isoform 4 (identifier: Q8NHQ1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:579
Mass (Da):67,770
Checksum:iAE654471BDE652DF
GO
Isoform 5 (identifier: Q8NHQ1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     22-23: Missing.

Show »
Length:577
Mass (Da):67,513
Checksum:iF4A66BB90BB75EAE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J710C9J710_HUMAN
Centrosomal protein of 70 kDa
CEP70
259Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z2D2B7Z2D2_HUMAN
Centrosomal protein of 70 kDa
CEP70
445Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J966C9J966_HUMAN
Centrosomal protein of 70 kDa
CEP70
293Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ04C9JZ04_HUMAN
Centrosomal protein of 70 kDa
CEP70
116Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4Y6H7C4Y6_HUMAN
Centrosomal protein of 70 kDa
CEP70
71Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0F4C9J0F4_HUMAN
Centrosomal protein of 70 kDa
CEP70
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52Missing in BAB14403 (PubMed:14702039).Curated1
Sequence conflicti293Q → L in BAH12924 (PubMed:14702039).Curated1
Sequence conflicti371Q → R in BAB14403 (PubMed:14702039).Curated1
Sequence conflicti385Q → R in BAH13584 (PubMed:14702039).Curated1
Sequence conflicti393V → A in BAH13584 (PubMed:14702039).Curated1
Sequence conflicti471S → P in AAG35616 (Ref. 1) Curated1
Sequence conflicti471S → P in AAG35791 (Ref. 1) Curated1
Sequence conflicti478D → G in AAG35616 (Ref. 1) Curated1
Sequence conflicti478D → G in AAG35791 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021177135S → N3 PublicationsCorresponds to variant dbSNP:rs1673607Ensembl.1
Natural variantiVAR_061590537N → S. Corresponds to variant dbSNP:rs35340237Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0421401 – 18Missing in isoform 4 and isoform 5. CuratedAdd BLAST18
Alternative sequenceiVSP_04214122 – 23Missing in isoform 5. Curated2
Alternative sequenceiVSP_012745213 – 597Missing in isoform 3. CuratedAdd BLAST385
Alternative sequenceiVSP_012746551 – 554SIIY → RYLF in isoform 2. 1 Publication4
Alternative sequenceiVSP_012747555 – 597Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF202146 mRNA Translation: AAG35616.1
AF289495 mRNA Translation: AAG35791.1
AK023098 mRNA Translation: BAB14403.1
AK299003 mRNA Translation: BAH12924.1
AK301913 mRNA Translation: BAH13584.1
AC020890 Genomic DNA No translation available.
AC072045 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79062.1
CH471052 Genomic DNA Translation: EAW79063.1
BC016050 mRNA Translation: AAH16050.1
BC030598 mRNA Translation: AAH30598.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3102.1 [Q8NHQ1-1]
CCDS75022.1 [Q8NHQ1-4]
CCDS75023.1 [Q8NHQ1-2]
CCDS82842.1 [Q8NHQ1-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001275893.1, NM_001288964.1 [Q8NHQ1-4]
NP_001275894.1, NM_001288965.1 [Q8NHQ1-5]
NP_001275895.1, NM_001288966.1 [Q8NHQ1-2]
NP_001275896.1, NM_001288967.1
NP_001307527.1, NM_001320598.1 [Q8NHQ1-1]
NP_001307529.1, NM_001320600.1 [Q8NHQ1-3]
NP_077817.2, NM_024491.3 [Q8NHQ1-1]
XP_016862764.1, XM_017007275.1 [Q8NHQ1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264982; ENSP00000264982; ENSG00000114107 [Q8NHQ1-1]
ENST00000464035; ENSP00000419743; ENSG00000114107 [Q8NHQ1-3]
ENST00000474781; ENSP00000419833; ENSG00000114107 [Q8NHQ1-4]
ENST00000481834; ENSP00000417465; ENSG00000114107 [Q8NHQ1-2]
ENST00000484888; ENSP00000419231; ENSG00000114107 [Q8NHQ1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80321

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80321

UCSC genome browser

More...
UCSCi
uc003esl.5, human [Q8NHQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202146 mRNA Translation: AAG35616.1
AF289495 mRNA Translation: AAG35791.1
AK023098 mRNA Translation: BAB14403.1
AK299003 mRNA Translation: BAH12924.1
AK301913 mRNA Translation: BAH13584.1
AC020890 Genomic DNA No translation available.
AC072045 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79062.1
CH471052 Genomic DNA Translation: EAW79063.1
BC016050 mRNA Translation: AAH16050.1
BC030598 mRNA Translation: AAH30598.1
CCDSiCCDS3102.1 [Q8NHQ1-1]
CCDS75022.1 [Q8NHQ1-4]
CCDS75023.1 [Q8NHQ1-2]
CCDS82842.1 [Q8NHQ1-3]
RefSeqiNP_001275893.1, NM_001288964.1 [Q8NHQ1-4]
NP_001275894.1, NM_001288965.1 [Q8NHQ1-5]
NP_001275895.1, NM_001288966.1 [Q8NHQ1-2]
NP_001275896.1, NM_001288967.1
NP_001307527.1, NM_001320598.1 [Q8NHQ1-1]
NP_001307529.1, NM_001320600.1 [Q8NHQ1-3]
NP_077817.2, NM_024491.3 [Q8NHQ1-1]
XP_016862764.1, XM_017007275.1 [Q8NHQ1-1]

3D structure databases

SMRiQ8NHQ1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123234, 173 interactors
IntActiQ8NHQ1, 268 interactors
MINTiQ8NHQ1
STRINGi9606.ENSP00000264982

PTM databases

iPTMnetiQ8NHQ1
PhosphoSitePlusiQ8NHQ1

Polymorphism and mutation databases

BioMutaiCEP70
DMDMi84028943

Proteomic databases

EPDiQ8NHQ1
MassIVEiQ8NHQ1
PaxDbiQ8NHQ1
PeptideAtlasiQ8NHQ1
PRIDEiQ8NHQ1
ProteomicsDBi73734 [Q8NHQ1-1]
73735 [Q8NHQ1-2]
73736 [Q8NHQ1-3]
73737 [Q8NHQ1-4]
73738 [Q8NHQ1-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
46706, 200 antibodies

The DNASU plasmid repository

More...
DNASUi
80321

Genome annotation databases

EnsembliENST00000264982; ENSP00000264982; ENSG00000114107 [Q8NHQ1-1]
ENST00000464035; ENSP00000419743; ENSG00000114107 [Q8NHQ1-3]
ENST00000474781; ENSP00000419833; ENSG00000114107 [Q8NHQ1-4]
ENST00000481834; ENSP00000417465; ENSG00000114107 [Q8NHQ1-2]
ENST00000484888; ENSP00000419231; ENSG00000114107 [Q8NHQ1-1]
GeneIDi80321
KEGGihsa:80321
UCSCiuc003esl.5, human [Q8NHQ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80321
DisGeNETi80321
EuPathDBiHostDB:ENSG00000114107.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CEP70
HGNCiHGNC:29972, CEP70
HPAiENSG00000114107, Low tissue specificity
MIMi614310, gene
neXtProtiNX_Q8NHQ1
OpenTargetsiENSG00000114107
PharmGKBiPA128394729

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QS45, Eukaryota
GeneTreeiENSGT00390000009029
HOGENOMiCLU_1351558_0_0_1
InParanoidiQ8NHQ1
KOiK16802
OMAiFLCLIDY
OrthoDBi1217382at2759
PhylomeDBiQ8NHQ1
TreeFamiTF330986

Enzyme and pathway databases

PathwayCommonsiQ8NHQ1
ReactomeiR-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-8854518, AURKA Activation by TPX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
80321, 18 hits in 852 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CEP70, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CEP70

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80321
PharosiQ8NHQ1, Tbio

Protein Ontology

More...
PROi
PR:Q8NHQ1
RNActiQ8NHQ1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000114107, Expressed in calcaneal tendon and 218 other tissues
ExpressionAtlasiQ8NHQ1, baseline and differential
GenevisibleiQ8NHQ1, HS

Family and domain databases

InterProiView protein in InterPro
IPR037692, CEP70
IPR013026, TPR-contain_dom
IPR019734, TPR_repeat
PANTHERiPTHR14594, PTHR14594, 3 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 1 hit
PS50293, TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEP70_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NHQ1
Secondary accession number(s): B7Z5I8
, B7Z7E8, D3DNE9, F5GZX8, Q96B31, Q9H2C3, Q9H2Z1, Q9H940
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: August 12, 2020
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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