UniProtKB - Q8NHQ1 (CEP70_HUMAN)
Protein
Centrosomal protein of 70 kDa
Gene
CEP70
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
GO - Molecular functioni
- gamma-tubulin binding Source: InterPro
- identical protein binding Source: IntAct
GO - Biological processi
- ciliary basal body-plasma membrane docking Source: Reactome
- G2/M transition of mitotic cell cycle Source: Reactome
- regulation of G2/M transition of mitotic cell cycle Source: Reactome
- regulation of microtubule cytoskeleton organization Source: InterPro
Enzyme and pathway databases
| PathwayCommonsi | Q8NHQ1 |
| Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-8854518, AURKA Activation by TPX2 |
Names & Taxonomyi
| Protein namesi | Recommended name: Centrosomal protein of 70 kDaShort name: Cep70 Alternative name(s): p10-binding protein |
| Gene namesi | Name:CEP70 Synonyms:BITE |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | HostDB:ENSG00000114107.8 |
| HGNCi | HGNC:29972, CEP70 |
| MIMi | 614310, gene |
| neXtProti | NX_Q8NHQ1 |
Subcellular locationi
Cytoskeleton
- centrosome 2 Publications
Note: Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.
Cytoskeleton
- centrosome Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
| DisGeNETi | 80321 |
| OpenTargetsi | ENSG00000114107 |
| PharmGKBi | PA128394729 |
Miscellaneous databases
| Pharosi | Q8NHQ1, Tbio |
Polymorphism and mutation databases
| BioMutai | CEP70 |
| DMDMi | 84028943 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000089497 | 1 – 597 | Centrosomal protein of 70 kDaAdd BLAST | 597 |
Proteomic databases
| EPDi | Q8NHQ1 |
| MassIVEi | Q8NHQ1 |
| PaxDbi | Q8NHQ1 |
| PeptideAtlasi | Q8NHQ1 |
| PRIDEi | Q8NHQ1 |
| ProteomicsDBi | 73734 [Q8NHQ1-1] 73735 [Q8NHQ1-2] 73736 [Q8NHQ1-3] 73737 [Q8NHQ1-4] 73738 [Q8NHQ1-5] |
PTM databases
| iPTMneti | Q8NHQ1 |
| PhosphoSitePlusi | Q8NHQ1 |
Expressioni
Gene expression databases
| Bgeei | ENSG00000114107, Expressed in calcaneal tendon and 218 other tissues |
| ExpressionAtlasi | Q8NHQ1, baseline and differential |
| Genevisiblei | Q8NHQ1, HS |
Organism-specific databases
| HPAi | ENSG00000114107, Low tissue specificity |
Interactioni
Subunit structurei
Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
1 PublicationBinary interactionsi
Q8NHQ1
GO - Molecular functioni
- gamma-tubulin binding Source: InterPro
- identical protein binding Source: IntAct
Protein-protein interaction databases
| BioGRIDi | 123234, 271 interactors |
| IntActi | Q8NHQ1, 268 interactors |
| MINTi | Q8NHQ1 |
| STRINGi | 9606.ENSP00000264982 |
Miscellaneous databases
| RNActi | Q8NHQ1, protein |
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Repeati | 483 – 516 | TPRAdd BLAST | 34 |
Coiled coil
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Coiled coili | 75 – 179 | Sequence analysisAdd BLAST | 105 | |
| Coiled coili | 254 – 326 | Sequence analysisAdd BLAST | 73 |
Domaini
The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.
Keywords - Domaini
Coiled coil, TPR repeatPhylogenomic databases
| eggNOGi | ENOG502QS45, Eukaryota |
| GeneTreei | ENSGT00390000009029 |
| HOGENOMi | CLU_1351558_0_0_1 |
| InParanoidi | Q8NHQ1 |
| KOi | K16802 |
| OMAi | FLCLIDY |
| OrthoDBi | 1217382at2759 |
| PhylomeDBi | Q8NHQ1 |
| TreeFami | TF330986 |
Family and domain databases
| InterProi | View protein in InterPro IPR037692, CEP70 IPR013026, TPR-contain_dom IPR019734, TPR_repeat |
| PANTHERi | PTHR14594, PTHR14594, 3 hits |
| PROSITEi | View protein in PROSITE PS50005, TPR, 1 hit PS50293, TPR_REGION, 1 hit |
Sequences (5+)i
Sequence statusi: Complete.
This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NHQ1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT
60 70 80 90 100
DLKDLIIFDK QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL
110 120 130 140 150
EQSRAANQEQ RANDLEQIME SVKSKIGELE DESLSRACHQ QNKIKDLQKE
160 170 180 190 200
QKTLQVKCQH YKKKRTEQEE TIASLQMEVC RLKKEEEDRI VTQNRVFAYL
210 220 230 240 250
CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS EEENDYRNLD
260 270 280 290 300
ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK
310 320 330 340 350
QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ
360 370 380 390 400
VLCSINSIIH NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA
410 420 430 440 450
DQLTSLKDLY KSLKTLSAEL VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE
460 470 480 490 500
VENKEKDSNM PHFQTLQAIV SHFQKLFDVP SLNGVYPRMN EVYTRLGEMN
510 520 530 540 550
NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV MQVLGPEDLQ
560 570 580 590
SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket| C9J710 | C9J710_HUMAN | Centrosomal protein of 70 kDa | CEP70 | 259 | Annotation score: | ||
| B7Z2D2 | B7Z2D2_HUMAN | Centrosomal protein of 70 kDa | CEP70 | 445 | Annotation score: | ||
| C9J966 | C9J966_HUMAN | Centrosomal protein of 70 kDa | CEP70 | 293 | Annotation score: | ||
| C9JZ04 | C9JZ04_HUMAN | Centrosomal protein of 70 kDa | CEP70 | 116 | Annotation score: | ||
| H7C4Y6 | H7C4Y6_HUMAN | Centrosomal protein of 70 kDa | CEP70 | 71 | Annotation score: | ||
| C9J0F4 | C9J0F4_HUMAN | Centrosomal protein of 70 kDa | CEP70 | 23 | Annotation score: |
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sequence conflicti | 52 | Missing in BAB14403 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 293 | Q → L in BAH12924 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 371 | Q → R in BAB14403 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 385 | Q → R in BAH13584 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 393 | V → A in BAH13584 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 471 | S → P in AAG35616 (Ref. 1) Curated | 1 | |
| Sequence conflicti | 471 | S → P in AAG35791 (Ref. 1) Curated | 1 | |
| Sequence conflicti | 478 | D → G in AAG35616 (Ref. 1) Curated | 1 | |
| Sequence conflicti | 478 | D → G in AAG35791 (Ref. 1) Curated | 1 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_021177 | 135 | S → N3 PublicationsCorresponds to variant dbSNP:rs1673607Ensembl. | 1 | |
| Natural variantiVAR_061590 | 537 | N → S. Corresponds to variant dbSNP:rs35340237Ensembl. | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_042140 | 1 – 18 | Missing in isoform 4 and isoform 5. CuratedAdd BLAST | 18 | |
| Alternative sequenceiVSP_042141 | 22 – 23 | Missing in isoform 5. Curated | 2 | |
| Alternative sequenceiVSP_012745 | 213 – 597 | Missing in isoform 3. CuratedAdd BLAST | 385 | |
| Alternative sequenceiVSP_012746 | 551 – 554 | SIIY → RYLF in isoform 2. 1 Publication | 4 | |
| Alternative sequenceiVSP_012747 | 555 – 597 | Missing in isoform 2. 1 PublicationAdd BLAST | 43 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF202146 mRNA Translation: AAG35616.1 AF289495 mRNA Translation: AAG35791.1 AK023098 mRNA Translation: BAB14403.1 AK299003 mRNA Translation: BAH12924.1 AK301913 mRNA Translation: BAH13584.1 AC020890 Genomic DNA No translation available. AC072045 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79062.1 CH471052 Genomic DNA Translation: EAW79063.1 BC016050 mRNA Translation: AAH16050.1 BC030598 mRNA Translation: AAH30598.1 |
| CCDSi | CCDS3102.1 [Q8NHQ1-1] CCDS75022.1 [Q8NHQ1-4] CCDS75023.1 [Q8NHQ1-2] CCDS82842.1 [Q8NHQ1-3] |
| RefSeqi | NP_001275893.1, NM_001288964.1 [Q8NHQ1-4] NP_001275894.1, NM_001288965.1 [Q8NHQ1-5] NP_001275895.1, NM_001288966.1 [Q8NHQ1-2] NP_001275896.1, NM_001288967.1 NP_001307527.1, NM_001320598.1 [Q8NHQ1-1] NP_001307529.1, NM_001320600.1 [Q8NHQ1-3] NP_077817.2, NM_024491.3 [Q8NHQ1-1] XP_016862764.1, XM_017007275.1 [Q8NHQ1-1] |
Genome annotation databases
| Ensembli | ENST00000264982; ENSP00000264982; ENSG00000114107 [Q8NHQ1-1] ENST00000464035; ENSP00000419743; ENSG00000114107 [Q8NHQ1-3] ENST00000474781; ENSP00000419833; ENSG00000114107 [Q8NHQ1-4] ENST00000481834; ENSP00000417465; ENSG00000114107 [Q8NHQ1-2] ENST00000484888; ENSP00000419231; ENSG00000114107 [Q8NHQ1-1] |
| GeneIDi | 80321 |
| KEGGi | hsa:80321 |
| UCSCi | uc003esl.5, human [Q8NHQ1-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF202146 mRNA Translation: AAG35616.1 AF289495 mRNA Translation: AAG35791.1 AK023098 mRNA Translation: BAB14403.1 AK299003 mRNA Translation: BAH12924.1 AK301913 mRNA Translation: BAH13584.1 AC020890 Genomic DNA No translation available. AC072045 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79062.1 CH471052 Genomic DNA Translation: EAW79063.1 BC016050 mRNA Translation: AAH16050.1 BC030598 mRNA Translation: AAH30598.1 |
| CCDSi | CCDS3102.1 [Q8NHQ1-1] CCDS75022.1 [Q8NHQ1-4] CCDS75023.1 [Q8NHQ1-2] CCDS82842.1 [Q8NHQ1-3] |
| RefSeqi | NP_001275893.1, NM_001288964.1 [Q8NHQ1-4] NP_001275894.1, NM_001288965.1 [Q8NHQ1-5] NP_001275895.1, NM_001288966.1 [Q8NHQ1-2] NP_001275896.1, NM_001288967.1 NP_001307527.1, NM_001320598.1 [Q8NHQ1-1] NP_001307529.1, NM_001320600.1 [Q8NHQ1-3] NP_077817.2, NM_024491.3 [Q8NHQ1-1] XP_016862764.1, XM_017007275.1 [Q8NHQ1-1] |
3D structure databases
| SMRi | Q8NHQ1 |
| ModBasei | Search... |
Protein-protein interaction databases
| BioGRIDi | 123234, 271 interactors |
| IntActi | Q8NHQ1, 268 interactors |
| MINTi | Q8NHQ1 |
| STRINGi | 9606.ENSP00000264982 |
PTM databases
| iPTMneti | Q8NHQ1 |
| PhosphoSitePlusi | Q8NHQ1 |
Polymorphism and mutation databases
| BioMutai | CEP70 |
| DMDMi | 84028943 |
Proteomic databases
| EPDi | Q8NHQ1 |
| MassIVEi | Q8NHQ1 |
| PaxDbi | Q8NHQ1 |
| PeptideAtlasi | Q8NHQ1 |
| PRIDEi | Q8NHQ1 |
| ProteomicsDBi | 73734 [Q8NHQ1-1] 73735 [Q8NHQ1-2] 73736 [Q8NHQ1-3] 73737 [Q8NHQ1-4] 73738 [Q8NHQ1-5] |
Protocols and materials databases
| Antibodypediai | 46706, 200 antibodies |
| DNASUi | 80321 |
Genome annotation databases
| Ensembli | ENST00000264982; ENSP00000264982; ENSG00000114107 [Q8NHQ1-1] ENST00000464035; ENSP00000419743; ENSG00000114107 [Q8NHQ1-3] ENST00000474781; ENSP00000419833; ENSG00000114107 [Q8NHQ1-4] ENST00000481834; ENSP00000417465; ENSG00000114107 [Q8NHQ1-2] ENST00000484888; ENSP00000419231; ENSG00000114107 [Q8NHQ1-1] |
| GeneIDi | 80321 |
| KEGGi | hsa:80321 |
| UCSCi | uc003esl.5, human [Q8NHQ1-1] |
Organism-specific databases
| CTDi | 80321 |
| DisGeNETi | 80321 |
| EuPathDBi | HostDB:ENSG00000114107.8 |
| GeneCardsi | CEP70 |
| HGNCi | HGNC:29972, CEP70 |
| HPAi | ENSG00000114107, Low tissue specificity |
| MIMi | 614310, gene |
| neXtProti | NX_Q8NHQ1 |
| OpenTargetsi | ENSG00000114107 |
| PharmGKBi | PA128394729 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | ENOG502QS45, Eukaryota |
| GeneTreei | ENSGT00390000009029 |
| HOGENOMi | CLU_1351558_0_0_1 |
| InParanoidi | Q8NHQ1 |
| KOi | K16802 |
| OMAi | FLCLIDY |
| OrthoDBi | 1217382at2759 |
| PhylomeDBi | Q8NHQ1 |
| TreeFami | TF330986 |
Enzyme and pathway databases
| PathwayCommonsi | Q8NHQ1 |
| Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-8854518, AURKA Activation by TPX2 |
Miscellaneous databases
| BioGRID-ORCSi | 80321, 18 hits in 852 CRISPR screens |
| ChiTaRSi | CEP70, human |
| GeneWikii | CEP70 |
| GenomeRNAii | 80321 |
| Pharosi | Q8NHQ1, Tbio |
| PROi | PR:Q8NHQ1 |
| RNActi | Q8NHQ1, protein |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000114107, Expressed in calcaneal tendon and 218 other tissues |
| ExpressionAtlasi | Q8NHQ1, baseline and differential |
| Genevisiblei | Q8NHQ1, HS |
Family and domain databases
| InterProi | View protein in InterPro IPR037692, CEP70 IPR013026, TPR-contain_dom IPR019734, TPR_repeat |
| PANTHERi | PTHR14594, PTHR14594, 3 hits |
| PROSITEi | View protein in PROSITE PS50005, TPR, 1 hit PS50293, TPR_REGION, 1 hit |
| ProtoNeti | Search... |
| MobiDBi | Search... |
Entry informationi
| Entry namei | CEP70_HUMAN | |
| Accessioni | Q8NHQ1Primary (citable) accession number: Q8NHQ1 Secondary accession number(s): B7Z5I8 Q9H940 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
| Last sequence update: | February 1, 2005 | |
| Last modified: | October 7, 2020 | |
| This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Main funding by:
National Institutes of Health
The European Molecular Biology Laboratory
State Secretariat for Education, Research and InnovationSERI
The European Molecular Biology LaboratoryState Secretariat for Education, Research and InnovationSERIWe'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Do not show this banner again