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Protein

Centrosomal protein of 70 kDa

Gene

CEP70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • gamma-tubulin binding Source: InterPro
  • identical protein binding Source: IntAct

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 70 kDa
Short name:
Cep70
Alternative name(s):
p10-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP70
Synonyms:BITE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000114107.8

Human Gene Nomenclature Database

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HGNCi
HGNC:29972 CEP70

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614310 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NHQ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80321

Open Targets

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OpenTargetsi
ENSG00000114107

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394729

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CEP70

Domain mapping of disease mutations (DMDM)

More...
DMDMi
84028943

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894971 – 597Centrosomal protein of 70 kDaAdd BLAST597

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NHQ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NHQ1

PeptideAtlas

More...
PeptideAtlasi
Q8NHQ1

PRoteomics IDEntifications database

More...
PRIDEi
Q8NHQ1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73734
73735 [Q8NHQ1-2]
73736 [Q8NHQ1-3]
73737 [Q8NHQ1-4]
73738 [Q8NHQ1-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NHQ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NHQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000114107 Expressed in 207 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_CEP70

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NHQ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NHQ1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036941
HPA036942

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-739624,EBI-739624
ABT1Q9ULW35EBI-739624,EBI-2602396
AKAP17AQ020405EBI-739624,EBI-1042725
AKAP17AQ02040-33EBI-739624,EBI-10222656
ARHGEF3Q9NR815EBI-739624,EBI-10312733
ATP5POP480475EBI-739624,EBI-355815
BARD1A0AVN23EBI-739624,EBI-9977322
BARD1Q997283EBI-739624,EBI-473181
BEX2Q9BXY85EBI-739624,EBI-745073
BRMS1Q9HCU93EBI-739624,EBI-714781
BYSLQ138957EBI-739624,EBI-358049
C8orf33Q9H7E94EBI-739624,EBI-715389
CARD9Q9H2573EBI-739624,EBI-751319
CDC73Q6P1J99EBI-739624,EBI-930143
CDCA7LQ96GN55EBI-739624,EBI-5278764
CEP57L1Q8IYX83EBI-739624,EBI-1104570
CEP57L1Q8IYX8-23EBI-739624,EBI-10181988
CEP70Q8NHQ1-33EBI-739624,EBI-11526150
CFAP53Q96M913EBI-739624,EBI-742422
CLPBQ9H0783EBI-739624,EBI-2107221
COILP384323EBI-739624,EBI-945751
DDX41Q9UJV93EBI-739624,EBI-1046350
DDX6P261965EBI-739624,EBI-351257
DIEXFQ68CQ45EBI-739624,EBI-747711
ELOAQ142413EBI-739624,EBI-742350
EMDP504026EBI-739624,EBI-489887
EMP1P548493EBI-739624,EBI-4319440
ENKD1Q9H0I24EBI-739624,EBI-744099
ERCC3P194473EBI-739624,EBI-1183307
FAM124AQ86V423EBI-739624,EBI-744506
FAM133AQ8N9E05EBI-739624,EBI-10268158
FAM13CQ8NE313EBI-739624,EBI-751248
FAM161AQ3B8205EBI-739624,EBI-719941
FAM214BQ7L5A33EBI-739624,EBI-745689
GATAD2BQ8WXI93EBI-739624,EBI-923440
GCC1Q96CN95EBI-739624,EBI-746252
GPATCH2LQ9NWQ43EBI-739624,EBI-5666657
GPATCH4Q5T3I05EBI-739624,EBI-2372076
GPX7Q96SL43EBI-739624,EBI-749411
HAUS1Q96CS23EBI-739624,EBI-2514791
HAUS1Q96CS2-23EBI-739624,EBI-11742270
HMGB4Q6NSH13EBI-739624,EBI-10250889
HMGB4Q8WW325EBI-739624,EBI-10277297
HSPD1P108096EBI-739624,EBI-352528
IKQ131233EBI-739624,EBI-713456
KANK2Q63ZY35EBI-739624,EBI-2556193
KANSL1Q7Z3B34EBI-739624,EBI-740244
KDM1AO603412EBI-739624,EBI-710124
KRT31Q153233EBI-739624,EBI-948001
LAMTOR5A0A0C4DGV45EBI-739624,EBI-10173304
LENG1Q96BZ85EBI-739624,EBI-726510
LENG8Q96PV63EBI-739624,EBI-739546
LIN37Q96GY33EBI-739624,EBI-748884
METTL17Q9H7H06EBI-739624,EBI-749353
METTL17Q9H7H0-23EBI-739624,EBI-11098807
MFAP1P550815EBI-739624,EBI-1048159
MMTAG2Q9BU764EBI-739624,EBI-742459
NIPSNAP3AQ9UFN03EBI-739624,EBI-716291
NKAPD1Q6ZUT15EBI-739624,EBI-3920396
NKAPD1Q6ZUT1-23EBI-739624,EBI-10180231
NOL12Q9UGY13EBI-739624,EBI-716098
NOP2P460873EBI-739624,EBI-356811
NRIP1P485523EBI-739624,EBI-746484
NUSAP1Q9BXS63EBI-739624,EBI-2555618
PIBF1A0A087WUI63EBI-739624,EBI-11749468
PIMREGQ9BSJ66EBI-739624,EBI-2568609
PPIGQ134273EBI-739624,EBI-396072
PPP1R16BQ96T493EBI-739624,EBI-10293968
PRKRIP1Q9H8753EBI-739624,EBI-744488
PRPF31Q8WWY38EBI-739624,EBI-1567797
PSMA1P257865EBI-739624,EBI-359352
RBM10P981755EBI-739624,EBI-721525
RNF6A0A0S2Z4G93EBI-739624,EBI-16428950
RPL13P263733EBI-739624,EBI-356849
RPL13Q6NZ553EBI-739624,EBI-10252046
SETD5Q9C0A6-23EBI-739624,EBI-10303449
SFR1Q86XK33EBI-739624,EBI-1104535
SH2D4AQ9H788-23EBI-739624,EBI-10308083
SLU7O953913EBI-739624,EBI-750559
SMARCE1Q969G35EBI-739624,EBI-455078
SNRPD2P623163EBI-739624,EBI-297993
SSX3Q999093EBI-739624,EBI-10295431
STK25O005063EBI-739624,EBI-618295
SUV39H1O434633EBI-739624,EBI-349968
SYT17Q9BSW73EBI-739624,EBI-745392
SYTL4Q96C243EBI-739624,EBI-747142
SYTL5Q8TDW53EBI-739624,EBI-2939487
TAF1DQ9H5J84EBI-739624,EBI-716128
TEAD4A0A0S2Z4E53EBI-739624,EBI-16432288
TEAD4A0A0S2Z4F23EBI-739624,EBI-16429215
TEAD4D3DUQ63EBI-739624,EBI-10176734
TRIM29Q141344EBI-739624,EBI-702370
TRIM42Q8IWZ53EBI-739624,EBI-5235829
TSFMP438973EBI-739624,EBI-1049298
TSGA10IPQ3SY005EBI-739624,EBI-10241197
TSHZ3Q63HK53EBI-739624,EBI-9053916
TTC25Q96NG33EBI-739624,EBI-1046387
TTLL10Q6ZVT03EBI-739624,EBI-7844656
TXLNBQ8N3L35EBI-739624,EBI-6116822
UTP11Q9Y3A23EBI-739624,EBI-2876697
YJU2Q9BW855EBI-739624,EBI-10300345
ZBTB16Q055163EBI-739624,EBI-711925
ZBTB24O431675EBI-739624,EBI-744471
ZBTB49Q6ZSB93EBI-739624,EBI-2859943
ZCCHC10Q8TBK63EBI-739624,EBI-597063
ZFC3H1G3V1X13EBI-739624,EBI-6448783
ZGPATA0A0S2Z6H03EBI-739624,EBI-16428984
ZGPATQ8N5A53EBI-739624,EBI-3439227
ZGPATQ8N5A5-28EBI-739624,EBI-10183064
ZNF136P527375EBI-739624,EBI-749129
ZNF148Q9UQR13EBI-739624,EBI-2688184
ZNF169Q149293EBI-739624,EBI-10234472
ZNF227Q86WZ65EBI-739624,EBI-2799529
ZNF239Q166005EBI-739624,EBI-8787052
ZNF266Q145845EBI-739624,EBI-7115319
ZNF302Q9NR113EBI-739624,EBI-3916142
ZNF329Q86UD45EBI-739624,EBI-7233259
ZNF366Q8N8955EBI-739624,EBI-2813661
ZNF408Q9H9D48EBI-739624,EBI-347633
ZNF410Q86VK43EBI-739624,EBI-720304
ZNF417Q8TAU35EBI-739624,EBI-740727
ZNF439Q8NDP43EBI-739624,EBI-747580
ZNF490Q9ULM25EBI-739624,EBI-1105370
ZNF555Q8NEP93EBI-739624,EBI-10270752
ZNF572Q7Z3I76EBI-739624,EBI-10172590
ZNF578Q3MI943EBI-739624,EBI-10241108
ZNF587Q96SQ55EBI-739624,EBI-6427977
ZNF688A0A0S2Z5X43EBI-739624,EBI-16429014
ZSCAN12O433093EBI-739624,EBI-1210440

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123234, 166 interactors

Protein interaction database and analysis system

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IntActi
Q8NHQ1, 252 interactors

Molecular INTeraction database

More...
MINTi
Q8NHQ1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264982

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NHQ1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NHQ1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati483 – 516TPRAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili75 – 179Sequence analysisAdd BLAST105
Coiled coili254 – 326Sequence analysisAdd BLAST73

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.

Keywords - Domaini

Coiled coil, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFWI Eukaryota
ENOG4111V7R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009029

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290163

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050899

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NHQ1

KEGG Orthology (KO)

More...
KOi
K16802

Identification of Orthologs from Complete Genome Data

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OMAi
IYPRMNE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G08G2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NHQ1

TreeFam database of animal gene trees

More...
TreeFami
TF330986

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037692 CEP70
IPR013026 TPR-contain_dom
IPR019734 TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR14594 PTHR14594, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NHQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPVAPKPQD SSQPSDRLMT EKQQEEAEWE SINVLLMMHG LKPLSLVKRT
60 70 80 90 100
DLKDLIIFDK QSSQRMRQNL KLLVEETSCQ QNMIQELIET NQQLRNELQL
110 120 130 140 150
EQSRAANQEQ RANDLEQIME SVKSKIGELE DESLSRACHQ QNKIKDLQKE
160 170 180 190 200
QKTLQVKCQH YKKKRTEQEE TIASLQMEVC RLKKEEEDRI VTQNRVFAYL
210 220 230 240 250
CKRVPHTVLD RQLLCLIDYY ESKIRKIHTQ RQYKEDESQS EEENDYRNLD
260 270 280 290 300
ASPTYKGLLM SLQNQLKESK SKIDALSSEK LNLQKDLETR PTQHELRLYK
310 320 330 340 350
QQVKKLEKAL KKNVKLQELI NHKKAEDTEK KDEPSKYNQQ QALIDQRYFQ
360 370 380 390 400
VLCSINSIIH NPRAPVIIYK QTKGGVQNFN KDLVQDCGFE HLVPVIEMWA
410 420 430 440 450
DQLTSLKDLY KSLKTLSAEL VPWLNLKKQD ENEGIKVEDL LFIVDTMLEE
460 470 480 490 500
VENKEKDSNM PHFQTLQAIV SHFQKLFDVP SLNGVYPRMN EVYTRLGEMN
510 520 530 540 550
NAVRNLQELL ELDSSSSLCV LVSTVGKLCR LINEDVNEQV MQVLGPEDLQ
560 570 580 590
SIIYKLEEHE EFFPAFQAFT NDLLEILEID DLDAIVPAVK KLKVLSY
Length:597
Mass (Da):69,752
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i345EEEB9B1F0D6C7
GO
Isoform 2 (identifier: Q8NHQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-554: SIIY → RYLF
     555-597: Missing.

Show »
Length:554
Mass (Da):64,880
Checksum:i995E0945339F20CA
GO
Isoform 3 (identifier: Q8NHQ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-597: Missing.

Show »
Length:212
Mass (Da):25,034
Checksum:i5E1C436C297C8CF3
GO
Isoform 4 (identifier: Q8NHQ1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Note: No experimental confirmation available.
Show »
Length:579
Mass (Da):67,770
Checksum:iAE654471BDE652DF
GO
Isoform 5 (identifier: Q8NHQ1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     22-23: Missing.

Note: No experimental confirmation available.
Show »
Length:577
Mass (Da):67,513
Checksum:iF4A66BB90BB75EAE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z2D2B7Z2D2_HUMAN
cDNA FLJ60498, highly similar to Ce...
CEP70
445Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J966C9J966_HUMAN
Centrosomal protein of 70 kDa
CEP70
293Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J710C9J710_HUMAN
Centrosomal protein of 70 kDa
CEP70
259Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ04C9JZ04_HUMAN
Centrosomal protein of 70 kDa
CEP70
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4Y6H7C4Y6_HUMAN
Centrosomal protein of 70 kDa
CEP70
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0F4C9J0F4_HUMAN
Centrosomal protein of 70 kDa
CEP70
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52Missing in BAB14403 (PubMed:14702039).Curated1
Sequence conflicti293Q → L in BAH12924 (PubMed:14702039).Curated1
Sequence conflicti371Q → R in BAB14403 (PubMed:14702039).Curated1
Sequence conflicti385Q → R in BAH13584 (PubMed:14702039).Curated1
Sequence conflicti393V → A in BAH13584 (PubMed:14702039).Curated1
Sequence conflicti471S → P in AAG35616 (Ref. 1) Curated1
Sequence conflicti471S → P in AAG35791 (Ref. 1) Curated1
Sequence conflicti478D → G in AAG35616 (Ref. 1) Curated1
Sequence conflicti478D → G in AAG35791 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021177135S → N3 PublicationsCorresponds to variant dbSNP:rs1673607Ensembl.1
Natural variantiVAR_061590537N → S. Corresponds to variant dbSNP:rs35340237Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0421401 – 18Missing in isoform 4 and isoform 5. CuratedAdd BLAST18
Alternative sequenceiVSP_04214122 – 23Missing in isoform 5. Curated2
Alternative sequenceiVSP_012745213 – 597Missing in isoform 3. CuratedAdd BLAST385
Alternative sequenceiVSP_012746551 – 554SIIY → RYLF in isoform 2. 1 Publication4
Alternative sequenceiVSP_012747555 – 597Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF202146 mRNA Translation: AAG35616.1
AF289495 mRNA Translation: AAG35791.1
AK023098 mRNA Translation: BAB14403.1
AK299003 mRNA Translation: BAH12924.1
AK301913 mRNA Translation: BAH13584.1
AC020890 Genomic DNA No translation available.
AC072045 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79062.1
CH471052 Genomic DNA Translation: EAW79063.1
BC016050 mRNA Translation: AAH16050.1
BC030598 mRNA Translation: AAH30598.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3102.1 [Q8NHQ1-1]
CCDS75022.1 [Q8NHQ1-4]
CCDS75023.1 [Q8NHQ1-2]
CCDS82842.1 [Q8NHQ1-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001275893.1, NM_001288964.1 [Q8NHQ1-4]
NP_001275894.1, NM_001288965.1 [Q8NHQ1-5]
NP_001275895.1, NM_001288966.1 [Q8NHQ1-2]
NP_001275896.1, NM_001288967.1
NP_001307527.1, NM_001320598.1 [Q8NHQ1-1]
NP_001307529.1, NM_001320600.1 [Q8NHQ1-3]
NP_077817.2, NM_024491.3 [Q8NHQ1-1]
XP_016862764.1, XM_017007275.1 [Q8NHQ1-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.531962

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264982; ENSP00000264982; ENSG00000114107 [Q8NHQ1-1]
ENST00000464035; ENSP00000419743; ENSG00000114107 [Q8NHQ1-3]
ENST00000474781; ENSP00000419833; ENSG00000114107 [Q8NHQ1-4]
ENST00000481834; ENSP00000417465; ENSG00000114107 [Q8NHQ1-2]
ENST00000484888; ENSP00000419231; ENSG00000114107 [Q8NHQ1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80321

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80321

UCSC genome browser

More...
UCSCi
uc003esl.5 human [Q8NHQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202146 mRNA Translation: AAG35616.1
AF289495 mRNA Translation: AAG35791.1
AK023098 mRNA Translation: BAB14403.1
AK299003 mRNA Translation: BAH12924.1
AK301913 mRNA Translation: BAH13584.1
AC020890 Genomic DNA No translation available.
AC072045 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79062.1
CH471052 Genomic DNA Translation: EAW79063.1
BC016050 mRNA Translation: AAH16050.1
BC030598 mRNA Translation: AAH30598.1
CCDSiCCDS3102.1 [Q8NHQ1-1]
CCDS75022.1 [Q8NHQ1-4]
CCDS75023.1 [Q8NHQ1-2]
CCDS82842.1 [Q8NHQ1-3]
RefSeqiNP_001275893.1, NM_001288964.1 [Q8NHQ1-4]
NP_001275894.1, NM_001288965.1 [Q8NHQ1-5]
NP_001275895.1, NM_001288966.1 [Q8NHQ1-2]
NP_001275896.1, NM_001288967.1
NP_001307527.1, NM_001320598.1 [Q8NHQ1-1]
NP_001307529.1, NM_001320600.1 [Q8NHQ1-3]
NP_077817.2, NM_024491.3 [Q8NHQ1-1]
XP_016862764.1, XM_017007275.1 [Q8NHQ1-1]
UniGeneiHs.531962

3D structure databases

ProteinModelPortaliQ8NHQ1
SMRiQ8NHQ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123234, 166 interactors
IntActiQ8NHQ1, 252 interactors
MINTiQ8NHQ1
STRINGi9606.ENSP00000264982

PTM databases

iPTMnetiQ8NHQ1
PhosphoSitePlusiQ8NHQ1

Polymorphism and mutation databases

BioMutaiCEP70
DMDMi84028943

Proteomic databases

EPDiQ8NHQ1
PaxDbiQ8NHQ1
PeptideAtlasiQ8NHQ1
PRIDEiQ8NHQ1
ProteomicsDBi73734
73735 [Q8NHQ1-2]
73736 [Q8NHQ1-3]
73737 [Q8NHQ1-4]
73738 [Q8NHQ1-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80321
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264982; ENSP00000264982; ENSG00000114107 [Q8NHQ1-1]
ENST00000464035; ENSP00000419743; ENSG00000114107 [Q8NHQ1-3]
ENST00000474781; ENSP00000419833; ENSG00000114107 [Q8NHQ1-4]
ENST00000481834; ENSP00000417465; ENSG00000114107 [Q8NHQ1-2]
ENST00000484888; ENSP00000419231; ENSG00000114107 [Q8NHQ1-1]
GeneIDi80321
KEGGihsa:80321
UCSCiuc003esl.5 human [Q8NHQ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80321
DisGeNETi80321
EuPathDBiHostDB:ENSG00000114107.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CEP70

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0018484
HGNCiHGNC:29972 CEP70
HPAiHPA036941
HPA036942
MIMi614310 gene
neXtProtiNX_Q8NHQ1
OpenTargetsiENSG00000114107
PharmGKBiPA128394729

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFWI Eukaryota
ENOG4111V7R LUCA
GeneTreeiENSGT00390000009029
HOGENOMiHOG000290163
HOVERGENiHBG050899
InParanoidiQ8NHQ1
KOiK16802
OMAiIYPRMNE
OrthoDBiEOG091G08G2
PhylomeDBiQ8NHQ1
TreeFamiTF330986

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CEP70 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CEP70

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80321

Protein Ontology

More...
PROi
PR:Q8NHQ1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114107 Expressed in 207 organ(s), highest expression level in testis
CleanExiHS_CEP70
ExpressionAtlasiQ8NHQ1 baseline and differential
GenevisibleiQ8NHQ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR037692 CEP70
IPR013026 TPR-contain_dom
IPR019734 TPR_repeat
PANTHERiPTHR14594 PTHR14594, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEP70_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NHQ1
Secondary accession number(s): B7Z5I8
, B7Z7E8, D3DNE9, F5GZX8, Q96B31, Q9H2C3, Q9H2Z1, Q9H940
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: December 5, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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