UniProtKB - Q8NHP6 (MSPD2_HUMAN)
Protein
Motile sperm domain-containing protein 2
Gene
MOSPD2
Organism
Homo sapiens (Human)
Status
Functioni
Endoplasmic reticulum-anchored receptor which modulates interorganelle contacts by interacting with other organelle-bound proteins via their FFAT motif (PubMed:29858488). Might have a more important role in endoplasmic reticulum and endosomes contacts (PubMed:29858488). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892).2 Publications
GO - Biological processi
- chemotaxis Source: UniProtKB-KW
- neutrophil degranulation Source: Reactome
- positive regulation of monocyte chemotaxis Source: UniProtKB
- positive regulation of neutrophil chemotaxis Source: UniProtKB
Keywordsi
Biological process | Chemotaxis |
Enzyme and pathway databases
PathwayCommonsi | Q8NHP6 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Motile sperm domain-containing protein 2 |
Gene namesi | Name:MOSPD2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000130150.11 |
HGNCi | HGNC:28381, MOSPD2 |
neXtProti | NX_Q8NHP6 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Single-pass type IV membrane protein 1 Publication
Note: Localization to contact sites involving the endoplasmic reticulum and several organelles is regulated by interaction with proteins containing FFAT motif.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- endoplasmic reticulum-endosome membrane contact site Source: UniProtKB
- membrane Source: UniProtKB
- organelle membrane contact site Source: UniProtKB
- specific granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 496 | CytoplasmicCuratedAdd BLAST | 496 | |
Transmembranei | 497 – 518 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 404 | R → D: Prevents binding to the FFAT motif of target proteins STARD3, STARD3NL, RMDN3, OSBPL1A and CERT1 and impairs recruitment to interorganelle membrane contacts; when associated with D-406. 1 Publication | 1 | |
Mutagenesisi | 406 | L → D: Prevents binding to the FFAT motif of target proteins STARD3, STARD3NL, RMDN3, OSBPL1A and CERT1 and impairs recruitment to interorganelle membrane contacts; when associated with D-404. 1 Publication | 1 | |
Mutagenesisi | 493 – 518 | Missing : Loss of localization to endoplasmic reticulum membrane. 1 PublicationAdd BLAST | 26 |
Organism-specific databases
DisGeNETi | 158747 |
OpenTargetsi | ENSG00000130150 |
PharmGKBi | PA134898878 |
Miscellaneous databases
Pharosi | Q8NHP6, Tbio |
Polymorphism and mutation databases
BioMutai | MOSPD2 |
DMDMi | 67461057 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213463 | 1 – 518 | Motile sperm domain-containing protein 2Add BLAST | 518 |
Proteomic databases
EPDi | Q8NHP6 |
jPOSTi | Q8NHP6 |
MassIVEi | Q8NHP6 |
MaxQBi | Q8NHP6 |
PaxDbi | Q8NHP6 |
PeptideAtlasi | Q8NHP6 |
PRIDEi | Q8NHP6 |
ProteomicsDBi | 73729 [Q8NHP6-1] 73730 [Q8NHP6-2] |
PTM databases
iPTMneti | Q8NHP6 |
PhosphoSitePlusi | Q8NHP6 |
Expressioni
Tissue specificityi
Highly expressed in CD14+ monocytes, and at lower levels in neutrophils. Does not show significant expression in B-cells or T-cells.1 Publication
Gene expression databases
Bgeei | ENSG00000130150, Expressed in corpus callosum and 229 other tissues |
ExpressionAtlasi | Q8NHP6, baseline and differential |
Genevisiblei | Q8NHP6, HS |
Organism-specific databases
HPAi | ENSG00000130150, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via MSP domain) with STARD3 (via FFAT motif), STARD3NL (via FFAT motif), RMDN3 (via FFAT motif), OSBPL1A (via FFAT motif) and CERT1 (via FFAT motif).
1 PublicationBinary interactionsi
Q8NHP6
With | #Exp. | IntAct |
---|---|---|
BTN1A1 [Q13410] | 3 | EBI-2812848,EBI-2372803 |
Protein-protein interaction databases
BioGRIDi | 127702, 35 interactors |
IntActi | Q8NHP6, 23 interactors |
STRINGi | 9606.ENSP00000369860 |
Miscellaneous databases
RNActi | Q8NHP6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 82 – 239 | CRAL-TRIOPROSITE-ProRule annotationAdd BLAST | 158 | |
Domaini | 327 – 445 | MSP1 PublicationAdd BLAST | 119 |
Domaini
The MSP domain is required for binding to the FFAT motif of target proteins.1 Publication
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1470, Eukaryota |
GeneTreei | ENSGT00390000016713 |
HOGENOMi | CLU_028924_1_0_1 |
InParanoidi | Q8NHP6 |
OMAi | WLEHYAK |
OrthoDBi | 457524at2759 |
PhylomeDBi | Q8NHP6 |
TreeFami | TF351054 |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR036273, CRAL/TRIO_N_dom_sf IPR013783, Ig-like_fold IPR000535, MSP_dom IPR008962, PapD-like_sf |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit PF00635, Motile_Sperm, 1 hit |
SMARTi | View protein in SMART SM00516, SEC14, 1 hit |
SUPFAMi | SSF46938, SSF46938, 1 hit SSF49354, SSF49354, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit PS50202, MSP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NHP6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAENHAQNKA KLISETRRRF EAEYVTDKSD KYDARDVERL QQDDNWVESY
60 70 80 90 100
LSWRHNIVDE TLKMLDESFQ WRKEISVNDL NESSIPRWLL EIGVIYLHGY
110 120 130 140 150
DKEGNKLFWI RVKYHVKDQK TILDKKKLIA FWLERYAKRE NGKPVTVMFD
160 170 180 190 200
LSETGINSID MDFVRFIINC FKVYYPKYLS KIVIFDMPWL MNAAFKIVKT
210 220 230 240 250
WLGPEAVSLL KFTSKNEVQD YVSVEYLPPH MGGTDPFKYS YPPLVDDDFQ
260 270 280 290 300
TPLCENGPIT SEDETSSKED IESDGKETLE TISNEEQTPL LKKINPTEST
310 320 330 340 350
SKAEENEKVD SKVKAFKKPL SVFKGPLLHI SPAEELYFGS TESGEKKTLI
360 370 380 390 400
VLTNVTKNIV AFKVRTTAPE KYRVKPSNSS CDPGASVDIV VSPHGGLTVS
410 420 430 440 450
AQDRFLIMAA EMEQSSGTGP AELTQFWKEV PRNKVMEHRL RCHTVESSKP
460 470 480 490 500
NTLTLKDNAF NMSDKTSEDI CLQLSRLLES NRKLEDQVQR CIWFQQLLLS
510
LTMLLLAFVT SFFYLLYS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketR4GMN1 | R4GMN1_HUMAN | Motile sperm domain-containing prot... | MOSPD2 | 486 | Annotation score: | ||
R4GMW5 | R4GMW5_HUMAN | Motile sperm domain-containing prot... | MOSPD2 | 157 | Annotation score: | ||
R4GNB6 | R4GNB6_HUMAN | Motile sperm domain containing 2, i... | MOSPD2 hCG_15755 | 39 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034109 | 240 | S → N. Corresponds to variant dbSNP:rs35164803Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014046 | 1 – 63 | Missing in isoform 2. 1 PublicationAdd BLAST | 63 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093075 mRNA Translation: BAC04043.1 BC030641 mRNA Translation: AAH30641.1 AL834345 mRNA Translation: CAD39011.1 |
CCDSi | CCDS14162.1 [Q8NHP6-1] |
RefSeqi | NP_001170946.1, NM_001177475.1 [Q8NHP6-2] NP_689794.1, NM_152581.3 [Q8NHP6-1] |
Genome annotation databases
Ensembli | ENST00000380492; ENSP00000369860; ENSG00000130150 [Q8NHP6-1] |
GeneIDi | 158747 |
KEGGi | hsa:158747 |
UCSCi | uc004cwi.4, human [Q8NHP6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093075 mRNA Translation: BAC04043.1 BC030641 mRNA Translation: AAH30641.1 AL834345 mRNA Translation: CAD39011.1 |
CCDSi | CCDS14162.1 [Q8NHP6-1] |
RefSeqi | NP_001170946.1, NM_001177475.1 [Q8NHP6-2] NP_689794.1, NM_152581.3 [Q8NHP6-1] |
3D structure databases
SMRi | Q8NHP6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127702, 35 interactors |
IntActi | Q8NHP6, 23 interactors |
STRINGi | 9606.ENSP00000369860 |
PTM databases
iPTMneti | Q8NHP6 |
PhosphoSitePlusi | Q8NHP6 |
Polymorphism and mutation databases
BioMutai | MOSPD2 |
DMDMi | 67461057 |
Proteomic databases
EPDi | Q8NHP6 |
jPOSTi | Q8NHP6 |
MassIVEi | Q8NHP6 |
MaxQBi | Q8NHP6 |
PaxDbi | Q8NHP6 |
PeptideAtlasi | Q8NHP6 |
PRIDEi | Q8NHP6 |
ProteomicsDBi | 73729 [Q8NHP6-1] 73730 [Q8NHP6-2] |
Protocols and materials databases
Antibodypediai | 516, 78 antibodies |
DNASUi | 158747 |
Genome annotation databases
Ensembli | ENST00000380492; ENSP00000369860; ENSG00000130150 [Q8NHP6-1] |
GeneIDi | 158747 |
KEGGi | hsa:158747 |
UCSCi | uc004cwi.4, human [Q8NHP6-1] |
Organism-specific databases
CTDi | 158747 |
DisGeNETi | 158747 |
EuPathDBi | HostDB:ENSG00000130150.11 |
GeneCardsi | MOSPD2 |
HGNCi | HGNC:28381, MOSPD2 |
HPAi | ENSG00000130150, Low tissue specificity |
neXtProti | NX_Q8NHP6 |
OpenTargetsi | ENSG00000130150 |
PharmGKBi | PA134898878 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1470, Eukaryota |
GeneTreei | ENSGT00390000016713 |
HOGENOMi | CLU_028924_1_0_1 |
InParanoidi | Q8NHP6 |
OMAi | WLEHYAK |
OrthoDBi | 457524at2759 |
PhylomeDBi | Q8NHP6 |
TreeFami | TF351054 |
Enzyme and pathway databases
PathwayCommonsi | Q8NHP6 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 158747, 2 hits in 468 CRISPR screens |
ChiTaRSi | MOSPD2, human |
GenomeRNAii | 158747 |
Pharosi | Q8NHP6, Tbio |
PROi | PR:Q8NHP6 |
RNActi | Q8NHP6, protein |
Gene expression databases
Bgeei | ENSG00000130150, Expressed in corpus callosum and 229 other tissues |
ExpressionAtlasi | Q8NHP6, baseline and differential |
Genevisiblei | Q8NHP6, HS |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf IPR036273, CRAL/TRIO_N_dom_sf IPR013783, Ig-like_fold IPR000535, MSP_dom IPR008962, PapD-like_sf |
Pfami | View protein in Pfam PF00650, CRAL_TRIO, 1 hit PF00635, Motile_Sperm, 1 hit |
SMARTi | View protein in SMART SM00516, SEC14, 1 hit |
SUPFAMi | SSF46938, SSF46938, 1 hit SSF49354, SSF49354, 1 hit SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit PS50202, MSP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MSPD2_HUMAN | |
Accessioni | Q8NHP6Primary (citable) accession number: Q8NHP6 Secondary accession number(s): Q8N3H2, Q8NA83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations