UniProtKB - Q8NHM5 (KDM2B_HUMAN)
Lysine-specific demethylase 2B
KDM2B
Functioni
Catalytic activityi
- 2 2-oxoglutarate + N6,N6-dimethyl-L-lysyl36-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl36-[histone H3] + 2 succinate2 PublicationsEC:1.14.11.272 Publications
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 239 | SubstrateBy similarity | 1 | |
Metal bindingi | 242 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 244 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Binding sitei | 259 | SubstrateBy similarity | 1 | |
Metal bindingi | 314 | Iron; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 613 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 616 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 619 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 624 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 627 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 630 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 646 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 651 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 662 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 665 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 688 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 691 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 696 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 699 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 719 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 722 | ZincCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 606 – 652 | CXXC-typePROSITE-ProRule annotation1 PublicationAdd BLAST | 47 | |
Zinc fingeri | 659 – 725 | PHD-typePROSITE-ProRule annotation1 PublicationAdd BLAST | 67 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- histone demethylase activity Source: BHF-UCL
- histone demethylase activity (H3-K36 specific) Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- rRNA binding Source: UniProtKB-KW
- unmethylated CpG binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- embryonic camera-type eye morphogenesis Source: BHF-UCL
- forebrain development Source: BHF-UCL
- fourth ventricle development Source: BHF-UCL
- hindbrain development Source: BHF-UCL
- histone H2A monoubiquitination Source: UniProtKB
- histone H3-K36 demethylation Source: UniProtKB
- initiation of neural tube closure Source: BHF-UCL
- lateral ventricle development Source: BHF-UCL
- midbrain development Source: BHF-UCL
- midbrain-hindbrain boundary morphogenesis Source: BHF-UCL
- negative regulation of neural precursor cell proliferation Source: BHF-UCL
- negative regulation of neuron apoptotic process Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of cell growth Source: Ensembl
- positive regulation of stem cell population maintenance Source: Ensembl
- spermatogenesis Source: BHF-UCL
- third ventricle development Source: BHF-UCL
Keywordsi
Molecular function | Chromatin regulator, Dioxygenase, DNA-binding, Oxidoreductase, Repressor, RNA-binding, rRNA-binding |
Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | Iron, Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | MetaCyc:HS01631-MONOMER |
PathwayCommonsi | Q8NHM5 |
Reactomei | R-HSA-3214842, HDMs demethylate histones |
SignaLinki | Q8NHM5 |
SIGNORi | Q8NHM5 |
Names & Taxonomyi
Protein namesi | Recommended name: Lysine-specific demethylase 2B (EC:1.14.11.272 Publications)Alternative name(s): CXXC-type zinc finger protein 2 F-box and leucine-rich repeat protein 10 F-box protein FBL10 F-box/LRR-repeat protein 10 JmjC domain-containing histone demethylation protein 1B Jumonji domain-containing EMSY-interactor methyltransferase motif protein Short name: Protein JEMMA Protein-containing CXXC domain 2 [Histone-H3]-lysine-36 demethylase 1B |
Gene namesi | Name:KDM2B Synonyms:CXXC2, FBL10, FBXL10, JHDM1B, NDY11 Publication, PCCX2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000089094.16 |
HGNCi | HGNC:13610, KDM2B |
MIMi | 609078, gene |
neXtProti | NX_Q8NHM5 |
Subcellular locationi
Nucleus
Other locations
- Chromosome 1 Publication
Nucleus
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- chromosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1064 | V → W: Increased interaction with UBB. 1 Publication | 1 | |
Mutagenesisi | 1069 | V → A: Decreased ininteraction with UBB. 1 Publication | 1 | |
Mutagenesisi | 1072 | A → Y: Increased interaction with UBB. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 84678 |
OpenTargetsi | ENSG00000089094 |
PharmGKBi | PA164721242 |
Miscellaneous databases
Pharosi | Q8NHM5, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3779760 |
Polymorphism and mutation databases
BioMutai | KDM2B |
DMDMi | 51316032 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119853 | 1 – 1336 | Lysine-specific demethylase 2BAdd BLAST | 1336 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 57 | PhosphoserineCombined sources | 1 | |
Modified residuei | 474 | PhosphoserineCombined sources | 1 | |
Modified residuei | 477 | PhosphoserineCombined sources | 1 | |
Modified residuei | 493 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 497 | PhosphoserineCombined sources | 1 | |
Cross-linki | 857 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 890 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 951 | PhosphoserineCombined sources | 1 | |
Modified residuei | 975 | PhosphoserineCombined sources | 1 | |
Modified residuei | 979 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1018 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1031 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8NHM5 |
jPOSTi | Q8NHM5 |
MassIVEi | Q8NHM5 |
MaxQBi | Q8NHM5 |
PaxDbi | Q8NHM5 |
PeptideAtlasi | Q8NHM5 |
PRIDEi | Q8NHM5 |
ProteomicsDBi | 61239 73723 [Q8NHM5-1] 73724 [Q8NHM5-2] 73725 [Q8NHM5-3] 73726 [Q8NHM5-4] |
PTM databases
iPTMneti | Q8NHM5 |
PhosphoSitePlusi | Q8NHM5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000089094, Expressed in female gonad and 212 other tissues |
ExpressionAtlasi | Q8NHM5, baseline and differential |
Genevisiblei | Q8NHM5, HS |
Organism-specific databases
HPAi | ENSG00000089094, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SKP1, forming heterodimers (PubMed:27568929). The heterodimeric KDM2B-SKP1 complex interacts with the PCGF1-BCORL1 heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (PubMed:27568929). Directly interacts with CUL1. The SKP1-KDM2B complex interacts with UBB (PubMed:30033217).
Curated2 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 124197, 41 interactors |
CORUMi | Q8NHM5 |
IntActi | Q8NHM5, 14 interactors |
MINTi | Q8NHM5 |
STRINGi | 9606.ENSP00000366271 |
Chemistry databases
BindingDBi | Q8NHM5 |
Miscellaneous databases
RNActi | Q8NHM5, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8NHM5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 178 – 346 | JmjCPROSITE-ProRule annotationAdd BLAST | 169 | |
Domaini | 1059 – 1105 | F-boxAdd BLAST | 47 | |
Repeati | 1093 – 1120 | LRR 1Add BLAST | 28 | |
Repeati | 1133 – 1154 | LRR 2Add BLAST | 22 | |
Repeati | 1156 – 1182 | LRR 3Add BLAST | 27 | |
Repeati | 1222 – 1247 | LRR 4Add BLAST | 26 | |
Repeati | 1248 – 1277 | LRR 5Add BLAST | 30 | |
Repeati | 1278 – 1302 | LRR 6Add BLAST | 25 | |
Repeati | 1303 – 1336 | LRR 7Add BLAST | 34 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 943 – 971 | Sequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 409 – 430 | Glu-richAdd BLAST | 22 | |
Compositional biasi | 1014 – 1056 | Pro-richAdd BLAST | 43 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 606 – 652 | CXXC-typePROSITE-ProRule annotation1 PublicationAdd BLAST | 47 | |
Zinc fingeri | 659 – 725 | PHD-typePROSITE-ProRule annotation1 PublicationAdd BLAST | 67 |
Keywords - Domaini
Coiled coil, Leucine-rich repeat, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1633, Eukaryota KOG1947, Eukaryota |
GeneTreei | ENSGT00940000154717 |
HOGENOMi | CLU_003540_0_1_1 |
InParanoidi | Q8NHM5 |
OMAi | NYDYKPR |
OrthoDBi | 324938at2759 |
PhylomeDBi | Q8NHM5 |
TreeFami | TF106480 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR041667, Cupin_8 IPR001810, F-box_dom IPR041070, JHD IPR003347, JmjC_dom IPR006553, Leu-rich_rpt_Cys-con_subtyp IPR032675, LRR_dom_sf IPR002857, Znf_CXXC IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF13621, Cupin_8, 1 hit PF00646, F-box, 1 hit PF17811, JHD, 1 hit PF16866, PHD_4, 1 hit PF02008, zf-CXXC, 1 hit |
SMARTi | View protein in SMART SM00558, JmjC, 1 hit SM00367, LRR_CC, 6 hits SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51184, JMJC, 1 hit PS51058, ZF_CXXC, 1 hit PS50016, ZF_PHD_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY
60 70 80 90 100
DENEDLSDVE EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE
110 120 130 140 150
ALRVPLIFRE KDGLGIKMPD PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE
160 170 180 190 200
MSMSQFVRYY ETPEAQRDKL YNVISLEFSH TKLEHLVKRP TVVDLVDWVD
210 220 230 240 250
NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD FHIDFGGTSV
260 270 280 290 300
WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL
310 320 330 340 350
KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV
360 370 380 390 400
QPKFRYPFYY EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID
410 420 430 440 450
GFSSDSWLEM EEEACDQQPQ EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP
460 470 480 490 500
SEDQEALGKK PKAPALRFLK RTLSNESEES VKSTTLAVDY PKTPTGSPAT
510 520 530 540 550
EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED PQALLEGVKN
560 570 580 590 600
VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN
610 620 630 640 650
RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ
660 670 680 690 700
CIAPVLPHTA VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL
710 720 730 740 750
KIKESEGVVN DELPNCWECP KCNHAGKTGK QKRGPGFKYA SNLPGSLLKE
760 770 780 790 800
QKMNRDNKEG QEPAKRRSEC EEAPRRRSDE HSKKVPPDGL LRRKSDDVHL
810 820 830 840 850
RKKRKYEKPQ ELSGRKRASS LQTSPGSSSH LSPRPPLGSS LSPWWRSSLT
860 870 880 890 900
YFQQQLKPGK EDKLFRKKRR SWKNAEDRMA LANKPLRRFK QEPEDELPEA
910 920 930 940 950
PPKTRESDHS RSSSPTAGPS TEGAEGPEEK KKVKMRRKRR LPNKELSREL
960 970 980 990 1000
SKELNHEIQR TENSLANENQ QPIKSEPESE GEEPKRPPGI CERPHRFSKG
1010 1020 1030 1040 1050
LNGTPRELRH QLGPSLRSPP RVISRPPPSV SPPKCIQMER HVIRPPPISP
1060 1070 1080 1090 1100
PPDSLPLDDG AAHVMHREVW MAVFSYLSHQ DLCVCMRVCR TWNRWCCDKR
1110 1120 1130 1140 1150
LWTRIDLNHC KSITPLMLSG IIRRQPVSLD LSWTNISKKQ LSWLINRLPG
1160 1170 1180 1190 1200
LRDLVLSGCS WIAVSALCSS SCPLLRTLDV QWVEGLKDAQ MRDLLSPPTD
1210 1220 1230 1240 1250
NRPGQMDNRS KLRNIVELRL AGLDITDASL RLIIRHMPLL SKLHLSYCNH
1260 1270 1280 1290 1300
VTDQSINLLT AVGTTTRDSL TEINLSDCNK VTDQCLSFFK RCGNICHIDL
1310 1320 1330
RYCKQVTKEG CEQFIAEMSV SVQFGQVEEK LLQKLS
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6SRV7 | F6SRV7_HUMAN | [Histone H3]-dimethyl-L-lysine(36) ... | KDM2B | 706 | Annotation score: | ||
F8WBN2 | F8WBN2_HUMAN | Lysine-specific demethylase 2B | KDM2B | 510 | Annotation score: | ||
A0A0C4DGG3 | A0A0C4DGG3_HUMAN | Lysine-specific demethylase 2B | KDM2B | 704 | Annotation score: | ||
S4R3G4 | S4R3G4_HUMAN | Lysine-specific demethylase 2B | KDM2B | 507 | Annotation score: | ||
F5H4A7 | F5H4A7_HUMAN | Lysine-specific demethylase 2B | KDM2B | 171 | Annotation score: | ||
F5H6N6 | F5H6N6_HUMAN | Lysine-specific demethylase 2B | KDM2B | 154 | Annotation score: | ||
F5H4X4 | F5H4X4_HUMAN | Lysine-specific demethylase 2B | KDM2B | 125 | Annotation score: | ||
F5H0A1 | F5H0A1_HUMAN | Lysine-specific demethylase 2B | KDM2B | 104 | Annotation score: | ||
F5GXC2 | F5GXC2_HUMAN | Lysine-specific demethylase 2B | KDM2B | 180 | Annotation score: | ||
F5GXW2 | F5GXW2_HUMAN | Lysine-specific demethylase 2B | KDM2B | 123 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 864 | L → F in BAC11159 (Ref. 6) Curated | 1 | |
Sequence conflicti | 1226 | T → R in BAC11159 (Ref. 6) Curated | 1 | |
Sequence conflicti | 1295 | I → T in BAC11159 (Ref. 6) Curated | 1 | |
Sequence conflicti | 1334 | K → R in BAC11159 (Ref. 6) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057394 | 1 – 117 | Missing in isoform 5. 1 PublicationAdd BLAST | 117 | |
Alternative sequenceiVSP_043146 | 1 – 42 | MAGPQ…ESATQ → MEAEKDSGRRL in isoform 4. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_057395 | 654 – 676 | PVLPH…DTVEE → TAIRSLISACPSSNAVETSV ILT in isoform 5. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_057396 | 677 – 1336 | Missing in isoform 5. 1 PublicationAdd BLAST | 660 | |
Alternative sequenceiVSP_011340 | 730 | K → KAYK in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_043147 | 818 – 855 | Missing in isoform 4. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_017475 | 856 – 868 | LKPGK…LFRKK → Q in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_017476 | 1204 | G → GPG in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_011341 | 1277 – 1336 | DCNKV…LQKLS → ASLLGRVFGLQFWGICEPQA RKNAGWA in isoform 2. 1 PublicationAdd BLAST | 60 | |
Alternative sequenceiVSP_043148 | 1320 – 1336 | VSVQF…LQKLS → SFQGRSCSTTRLGDE in isoform 4. 1 PublicationAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ459424 mRNA Translation: CAD30700.1 AK027440 mRNA Translation: BAB55112.1 Different initiation. AK027692 mRNA Translation: BAB55301.1 Different initiation. AK074718 mRNA Translation: BAC11159.1 Different initiation. AK127328 mRNA Translation: BAG54483.1 AC048337 Genomic DNA No translation available. AC073650 Genomic DNA No translation available. AC145422 Genomic DNA No translation available. KC877509 Genomic DNA No translation available. BC008735 mRNA Translation: AAH08735.2 Different initiation. BC115379 mRNA Translation: AAI15380.1 AL133572 mRNA Translation: CAB63721.2 AB031230 mRNA Translation: BAA97672.1 |
CCDSi | CCDS41849.1 [Q8NHM5-4] CCDS41850.1 [Q8NHM5-1] |
PIRi | T43477 |
RefSeqi | NP_001005366.1, NM_001005366.1 [Q8NHM5-4] NP_115979.3, NM_032590.4 [Q8NHM5-1] |
Genome annotation databases
Ensembli | ENST00000377069; ENSP00000366269; ENSG00000089094 [Q8NHM5-4] ENST00000377071; ENSP00000366271; ENSG00000089094 [Q8NHM5-1] ENST00000611216; ENSP00000480847; ENSG00000089094 [Q8NHM5-5] |
GeneIDi | 84678 |
KEGGi | hsa:84678 |
UCSCi | uc058uhm.1, human [Q8NHM5-1] uc058uhn.1, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ459424 mRNA Translation: CAD30700.1 AK027440 mRNA Translation: BAB55112.1 Different initiation. AK027692 mRNA Translation: BAB55301.1 Different initiation. AK074718 mRNA Translation: BAC11159.1 Different initiation. AK127328 mRNA Translation: BAG54483.1 AC048337 Genomic DNA No translation available. AC073650 Genomic DNA No translation available. AC145422 Genomic DNA No translation available. KC877509 Genomic DNA No translation available. BC008735 mRNA Translation: AAH08735.2 Different initiation. BC115379 mRNA Translation: AAI15380.1 AL133572 mRNA Translation: CAB63721.2 AB031230 mRNA Translation: BAA97672.1 |
CCDSi | CCDS41849.1 [Q8NHM5-4] CCDS41850.1 [Q8NHM5-1] |
PIRi | T43477 |
RefSeqi | NP_001005366.1, NM_001005366.1 [Q8NHM5-4] NP_115979.3, NM_032590.4 [Q8NHM5-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4O64 | X-ray | 2.13 | A/B/C | 607-723 | [»] | |
5JH5 | X-ray | 2.55 | A | 1059-1336 | [»] | |
6BVA | X-ray | 2.66 | E/F | 1060-1104 | [»] | |
SMRi | Q8NHM5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124197, 41 interactors |
CORUMi | Q8NHM5 |
IntActi | Q8NHM5, 14 interactors |
MINTi | Q8NHM5 |
STRINGi | 9606.ENSP00000366271 |
Chemistry databases
BindingDBi | Q8NHM5 |
ChEMBLi | CHEMBL3779760 |
PTM databases
iPTMneti | Q8NHM5 |
PhosphoSitePlusi | Q8NHM5 |
Polymorphism and mutation databases
BioMutai | KDM2B |
DMDMi | 51316032 |
Proteomic databases
EPDi | Q8NHM5 |
jPOSTi | Q8NHM5 |
MassIVEi | Q8NHM5 |
MaxQBi | Q8NHM5 |
PaxDbi | Q8NHM5 |
PeptideAtlasi | Q8NHM5 |
PRIDEi | Q8NHM5 |
ProteomicsDBi | 61239 73723 [Q8NHM5-1] 73724 [Q8NHM5-2] 73725 [Q8NHM5-3] 73726 [Q8NHM5-4] |
Protocols and materials databases
Antibodypediai | 31579, 308 antibodies |
Genome annotation databases
Ensembli | ENST00000377069; ENSP00000366269; ENSG00000089094 [Q8NHM5-4] ENST00000377071; ENSP00000366271; ENSG00000089094 [Q8NHM5-1] ENST00000611216; ENSP00000480847; ENSG00000089094 [Q8NHM5-5] |
GeneIDi | 84678 |
KEGGi | hsa:84678 |
UCSCi | uc058uhm.1, human [Q8NHM5-1] uc058uhn.1, human |
Organism-specific databases
CTDi | 84678 |
DisGeNETi | 84678 |
EuPathDBi | HostDB:ENSG00000089094.16 |
GeneCardsi | KDM2B |
HGNCi | HGNC:13610, KDM2B |
HPAi | ENSG00000089094, Low tissue specificity |
MIMi | 609078, gene |
neXtProti | NX_Q8NHM5 |
OpenTargetsi | ENSG00000089094 |
PharmGKBi | PA164721242 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1633, Eukaryota KOG1947, Eukaryota |
GeneTreei | ENSGT00940000154717 |
HOGENOMi | CLU_003540_0_1_1 |
InParanoidi | Q8NHM5 |
OMAi | NYDYKPR |
OrthoDBi | 324938at2759 |
PhylomeDBi | Q8NHM5 |
TreeFami | TF106480 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS01631-MONOMER |
PathwayCommonsi | Q8NHM5 |
Reactomei | R-HSA-3214842, HDMs demethylate histones |
SignaLinki | Q8NHM5 |
SIGNORi | Q8NHM5 |
Miscellaneous databases
BioGRID-ORCSi | 84678, 14 hits in 849 CRISPR screens |
ChiTaRSi | KDM2B, human |
GenomeRNAii | 84678 |
Pharosi | Q8NHM5, Tchem |
PROi | PR:Q8NHM5 |
RNActi | Q8NHM5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000089094, Expressed in female gonad and 212 other tissues |
ExpressionAtlasi | Q8NHM5, baseline and differential |
Genevisiblei | Q8NHM5, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR041667, Cupin_8 IPR001810, F-box_dom IPR041070, JHD IPR003347, JmjC_dom IPR006553, Leu-rich_rpt_Cys-con_subtyp IPR032675, LRR_dom_sf IPR002857, Znf_CXXC IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF13621, Cupin_8, 1 hit PF00646, F-box, 1 hit PF17811, JHD, 1 hit PF16866, PHD_4, 1 hit PF02008, zf-CXXC, 1 hit |
SMARTi | View protein in SMART SM00558, JmjC, 1 hit SM00367, LRR_CC, 6 hits SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51184, JMJC, 1 hit PS51058, ZF_CXXC, 1 hit PS50016, ZF_PHD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KDM2B_HUMAN | |
Accessioni | Q8NHM5Primary (citable) accession number: Q8NHM5 Secondary accession number(s): A8MRS1 Q9UF75 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM