KDM2B

Functionⁱ

Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.2 Publications

Catalytic activityⁱ

Protein N₆,N₆-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O₂ = protein L-lysine + 2 succinate + 2 formaldehyde + 2 CO₂.1 Publication

Cofactorⁱ

Fe²⁺By similarityNote: Binds 1 Fe²⁺ ion per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	239	SubstrateBy similarity	1
Metal bindingⁱ	242	Iron; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	244	Iron; catalyticPROSITE-ProRule annotation	1
Binding siteⁱ	259	SubstrateBy similarity	1
Metal bindingⁱ	314	Iron; catalyticPROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	606 – 652	CXXC-typePROSITE-ProRule annotationAdd BLAST		47
Zinc fingerⁱ	659 – 725	PHD-typePROSITE-ProRule annotationAdd BLAST		67

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10799292
histone demethylase activity
Source: BHF-UCL
Traceable author statementⁱ
- 21220025
histone demethylase activity (H3-K36 specific) Source: UniProtKB-EC
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
rRNA binding Source: UniProtKB-KW
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

embryonic camera-type eye morphogenesis Source: BHF-UCL
forebrain development Source: BHF-UCL
fourth ventricle development Source: BHF-UCL
hindbrain development Source: BHF-UCL
histone H2A monoubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 16943429
initiation of neural tube closure Source: BHF-UCL
lateral ventricle development Source: BHF-UCL
midbrain development Source: BHF-UCL
midbrain-hindbrain boundary morphogenesis Source: BHF-UCL
negative regulation of neural precursor cell proliferation Source: BHF-UCL
negative regulation of neuron apoptotic process Source: BHF-UCL
negative regulation of transcription by RNA polymerase II Source: BHF-UCL
positive regulation of cell growth Source: Ensembl
positive regulation of stem cell population maintenance Source: Ensembl
spermatogenesis Source: BHF-UCL
third ventricle development Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, Dioxygenase, Oxidoreductase, Repressor, RNA-binding, rRNA-binding
Biological process	Transcription, Transcription regulation, Ubl conjugation pathway
Ligand	Iron, Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214842 HDMs demethylate histones
SignaLinkⁱ	Q8NHM5
SIGNORⁱ	Q8NHM5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lysine-specific demethylase 2B (EC:1.14.11.271 Publication) Alternative name(s): CXXC-type zinc finger protein 2 F-box and leucine-rich repeat protein 10 F-box protein FBL10 F-box/LRR-repeat protein 10 JmjC domain-containing histone demethylation protein 1B Jumonji domain-containing EMSY-interactor methyltransferase motif protein Short name: Protein JEMMA Protein-containing CXXC domain 2 [Histone-H3]-lysine-36 demethylase 1B
Gene namesⁱ	Name:KDM2B Synonyms:CXXC2, FBL10, FBXL10, JHDM1B, PCCX2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000089094.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13610 KDM2B
MIMⁱ	609078 gene
neXtProtⁱ	NX_Q8NHM5

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84678
Open Targets More...OpenTargetsⁱ	ENSG00000089094
PharmGKBⁱ	PA164721242

Chemistry databases

ChEMBLⁱ	CHEMBL3779760

ChEMBLⁱ

CHEMBL3779760

Polymorphism and mutation databases

BioMutaⁱ	KDM2B
DMDMⁱ	51316032

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000119853	1 – 1336	Lysine-specific demethylase 2BAdd BLAST		1336

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	57	PhosphoserineCombined sources	1
Modified residueⁱ	474	PhosphoserineCombined sources	1
Modified residueⁱ	477	PhosphoserineCombined sources	1
Modified residueⁱ	493	PhosphothreonineCombined sources	1
Modified residueⁱ	497	PhosphoserineCombined sources	1
Cross-linkⁱ	857	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	890	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	951	PhosphoserineCombined sources	1
Modified residueⁱ	975	PhosphoserineCombined sources	1
Modified residueⁱ	979	PhosphoserineCombined sources	1
Modified residueⁱ	1018	PhosphoserineCombined sources	1
Modified residueⁱ	1031	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8NHM5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NHM5
PaxDbⁱ	Q8NHM5
PeptideAtlas More...PeptideAtlasⁱ	Q8NHM5
PRIDEⁱ	Q8NHM5
ProteomicsDBⁱ	73723 73724 [Q8NHM5-2] 73725 [Q8NHM5-3] 73726 [Q8NHM5-4]

PTM databases

iPTMnetⁱ	Q8NHM5
PhosphoSitePlusⁱ	Q8NHM5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000089094 Expressed in 196 organ(s), highest expression level in female gonad
CleanExⁱ	HS_FBXL10
ExpressionAtlasⁱ	Q8NHM5 baseline and differential
Genevisibleⁱ	Q8NHM5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA071257

HPAⁱ

HPA071257

Interactionⁱ

Subunit structureⁱ

Directly interacts with SKP1 and CUL1.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BCOR	Q6W2J9	4	EBI-3955564,EBI-950027
SKP1	P63208	2	EBI-3955564,EBI-307486

Protein-protein interaction databases

BioGridⁱ	124197, 26 interactors
CORUMⁱ	Q8NHM5
IntActⁱ	Q8NHM5, 12 interactors
STRINGⁱ	9606.ENSP00000366271

Chemistry databases

BindingDBⁱ

Q8NHM5

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	617 – 620	Combined sources	4
Helixⁱ	628 – 632	Combined sources	5
Helixⁱ	634 – 636	Combined sources	3
Helixⁱ	647 – 649	Combined sources	3
Turnⁱ	663 – 665	Combined sources	3
Helixⁱ	671 – 673	Combined sources	3
Helixⁱ	677 – 682	Combined sources	6
Beta strandⁱ	686 – 688	Combined sources	3
Turnⁱ	689 – 691	Combined sources	3
Helixⁱ	697 – 699	Combined sources	3
Beta strandⁱ	711 – 713	Combined sources	3
Beta strandⁱ	716 – 718	Combined sources	3
Turnⁱ	720 – 722	Combined sources	3
Helixⁱ	1067 – 1074	Combined sources	8
Helixⁱ	1079 – 1086	Combined sources	8
Helixⁱ	1092 – 1095	Combined sources	4
Helixⁱ	1099 – 1102	Combined sources	4
Beta strandⁱ	1103 – 1106	Combined sources	4
Helixⁱ	1115 – 1124	Combined sources	10
Beta strandⁱ	1127 – 1130	Combined sources	4
Helixⁱ	1138 – 1147	Combined sources	10
Beta strandⁱ	1153 – 1155	Combined sources	3
Helixⁱ	1161 – 1164	Combined sources	4
Helixⁱ	1165 – 1168	Combined sources	4
Beta strandⁱ	1169 – 1171	Combined sources	3
Beta strandⁱ	1176 – 1179	Combined sources	4
Helixⁱ	1188 – 1195	Combined sources	8
Turnⁱ	1211 – 1214	Combined sources	4
Beta strandⁱ	1217 – 1219	Combined sources	3
Helixⁱ	1227 – 1236	Combined sources	10
Beta strandⁱ	1242 – 1244	Combined sources	3
Helixⁱ	1253 – 1259	Combined sources	7
Helixⁱ	1265 – 1269	Combined sources	5
Beta strandⁱ	1272 – 1274	Combined sources	3
Helixⁱ	1284 – 1289	Combined sources	6
Beta strandⁱ	1297 – 1299	Combined sources	3
Helixⁱ	1308 – 1318	Combined sources	11
Turnⁱ	1319 – 1321	Combined sources	3
Beta strandⁱ	1331 – 1334	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8NHM5
SMRⁱ	Q8NHM5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	178 – 346	JmjCPROSITE-ProRule annotationAdd BLAST	169
Domainⁱ	1059 – 1105	F-boxAdd BLAST	47
Repeatⁱ	1093 – 1120	LRR 1Add BLAST	28
Repeatⁱ	1133 – 1154	LRR 2Add BLAST	22
Repeatⁱ	1156 – 1182	LRR 3Add BLAST	27
Repeatⁱ	1222 – 1247	LRR 4Add BLAST	26
Repeatⁱ	1248 – 1277	LRR 5Add BLAST	30
Repeatⁱ	1278 – 1302	LRR 6Add BLAST	25
Repeatⁱ	1303 – 1336	LRR 7Add BLAST	34

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	943 – 971	Sequence analysisAdd BLAST		29

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	409 – 430	Glu-richAdd BLAST		22
Compositional biasⁱ	1014 – 1056	Pro-richAdd BLAST		43

Domainⁱ

The JmjC domain mediates demethylation activity (By similarity). It is also required for repression of ribosomal RNA genes.By similarity

Sequence similaritiesⁱ

Belongs to the JHDM1 histone demethylase family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	606 – 652	CXXC-typePROSITE-ProRule annotationAdd BLAST		47
Zinc fingerⁱ	659 – 725	PHD-typePROSITE-ProRule annotationAdd BLAST		67

Keywords - Domainⁱ

Coiled coil, Leucine-rich repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1633 Eukaryota KOG1947 Eukaryota ENOG410XQXU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074396
HOGENOMⁱ	HOG000007396
HOVERGENⁱ	HBG051671
InParanoidⁱ	Q8NHM5
KEGG Orthology (KO) More...KOⁱ	K10276
OMAⁱ	NYDYKPR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00M1
PhylomeDBⁱ	Q8NHM5
TreeFamⁱ	TF106480

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001810 F-box_dom IPR003347 JmjC_dom IPR006553 Leu-rich_rpt_Cys-con_subtyp IPR032675 LRR_dom_sf IPR002857 Znf_CXXC IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00646 F-box, 1 hit PF16866 PHD_4, 1 hit PF02008 zf-CXXC, 1 hit
SMARTⁱ	View protein in SMART SM00558 JmjC, 1 hit SM00367 LRR_CC, 6 hits SM00249 PHD, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS51184 JMJC, 1 hit PS51058 ZF_CXXC, 1 hit PS50016 ZF_PHD_2, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8NHM5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY 
        60         70         80         90        100
DENEDLSDVE EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE 
       110        120        130        140        150
ALRVPLIFRE KDGLGIKMPD PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE 
       160        170        180        190        200
MSMSQFVRYY ETPEAQRDKL YNVISLEFSH TKLEHLVKRP TVVDLVDWVD 
       210        220        230        240        250
NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD FHIDFGGTSV 
       260        270        280        290        300
WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL 
       310        320        330        340        350
KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV 
       360        370        380        390        400
QPKFRYPFYY EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID 
       410        420        430        440        450
GFSSDSWLEM EEEACDQQPQ EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP 
       460        470        480        490        500
SEDQEALGKK PKAPALRFLK RTLSNESEES VKSTTLAVDY PKTPTGSPAT 
       510        520        530        540        550
EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED PQALLEGVKN 
       560        570        580        590        600
VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN 
       610        620        630        640        650
RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ 
       660        670        680        690        700
CIAPVLPHTA VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL 
       710        720        730        740        750
KIKESEGVVN DELPNCWECP KCNHAGKTGK QKRGPGFKYA SNLPGSLLKE 
       760        770        780        790        800
QKMNRDNKEG QEPAKRRSEC EEAPRRRSDE HSKKVPPDGL LRRKSDDVHL 
       810        820        830        840        850
RKKRKYEKPQ ELSGRKRASS LQTSPGSSSH LSPRPPLGSS LSPWWRSSLT 
       860        870        880        890        900
YFQQQLKPGK EDKLFRKKRR SWKNAEDRMA LANKPLRRFK QEPEDELPEA 
       910        920        930        940        950
PPKTRESDHS RSSSPTAGPS TEGAEGPEEK KKVKMRRKRR LPNKELSREL 
       960        970        980        990       1000
SKELNHEIQR TENSLANENQ QPIKSEPESE GEEPKRPPGI CERPHRFSKG 
      1010       1020       1030       1040       1050
LNGTPRELRH QLGPSLRSPP RVISRPPPSV SPPKCIQMER HVIRPPPISP 
      1060       1070       1080       1090       1100
PPDSLPLDDG AAHVMHREVW MAVFSYLSHQ DLCVCMRVCR TWNRWCCDKR 
      1110       1120       1130       1140       1150
LWTRIDLNHC KSITPLMLSG IIRRQPVSLD LSWTNISKKQ LSWLINRLPG 
      1160       1170       1180       1190       1200
LRDLVLSGCS WIAVSALCSS SCPLLRTLDV QWVEGLKDAQ MRDLLSPPTD 
      1210       1220       1230       1240       1250
NRPGQMDNRS KLRNIVELRL AGLDITDASL RLIIRHMPLL SKLHLSYCNH 
      1260       1270       1280       1290       1300
VTDQSINLLT AVGTTTRDSL TEINLSDCNK VTDQCLSFFK RCGNICHIDL 
      1310       1320       1330 
RYCKQVTKEG CEQFIAEMSV SVQFGQVEEK LLQKLS

Length:1,336

Mass (Da):152,615

Last modified:October 1, 2002 - v1

Checksum:ⁱ3A1A17B8EA9EA953

GO

Isoform 2 (identifier: Q8NHM5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
730-730: K → KAYK
1277-1336: DCNKVTDQCL...VEEKLLQKLS → ASLLGRVFGLQFWGICEPQARKNAGWA

« Hide

        10         20         30         40         50
MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY 
        60         70         80         90        100
DENEDLSDVE EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE 
       110        120        130        140        150
ALRVPLIFRE KDGLGIKMPD PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE 
       160        170        180        190        200
MSMSQFVRYY ETPEAQRDKL YNVISLEFSH TKLEHLVKRP TVVDLVDWVD 
       210        220        230        240        250
NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD FHIDFGGTSV 
       260        270        280        290        300
WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL 
       310        320        330        340        350
KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV 
       360        370        380        390        400
QPKFRYPFYY EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID 
       410        420        430        440        450
GFSSDSWLEM EEEACDQQPQ EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP 
       460        470        480        490        500
SEDQEALGKK PKAPALRFLK RTLSNESEES VKSTTLAVDY PKTPTGSPAT 
       510        520        530        540        550
EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED PQALLEGVKN 
       560        570        580        590        600
VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN 
       610        620        630        640        650
RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ 
       660        670        680        690        700
CIAPVLPHTA VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL 
       710        720        730        740        750
KIKESEGVVN DELPNCWECP KCNHAGKTGK AYKQKRGPGF KYASNLPGSL 
       760        770        780        790        800
LKEQKMNRDN KEGQEPAKRR SECEEAPRRR SDEHSKKVPP DGLLRRKSDD 
       810        820        830        840        850
VHLRKKRKYE KPQELSGRKR ASSLQTSPGS SSHLSPRPPL GSSLSPWWRS 
       860        870        880        890        900
SLTYFQQQLK PGKEDKLFRK KRRSWKNAED RMALANKPLR RFKQEPEDEL 
       910        920        930        940        950
PEAPPKTRES DHSRSSSPTA GPSTEGAEGP EEKKKVKMRR KRRLPNKELS 
       960        970        980        990       1000
RELSKELNHE IQRTENSLAN ENQQPIKSEP ESEGEEPKRP PGICERPHRF 
      1010       1020       1030       1040       1050
SKGLNGTPRE LRHQLGPSLR SPPRVISRPP PSVSPPKCIQ MERHVIRPPP 
      1060       1070       1080       1090       1100
ISPPPDSLPL DDGAAHVMHR EVWMAVFSYL SHQDLCVCMR VCRTWNRWCC 
      1110       1120       1130       1140       1150
DKRLWTRIDL NHCKSITPLM LSGIIRRQPV SLDLSWTNIS KKQLSWLINR 
      1160       1170       1180       1190       1200
LPGLRDLVLS GCSWIAVSAL CSSSCPLLRT LDVQWVEGLK DAQMRDLLSP 
      1210       1220       1230       1240       1250
PTDNRPGQMD NRSKLRNIVE LRLAGLDITD ASLRLIIRHM PLLSKLHLSY 
      1260       1270       1280       1290       1300
CNHVTDQSIN LLTAVGTTTR DSLTEINLSA SLLGRVFGLQ FWGICEPQAR 

KNAGWA

Show »

Length:1,306

Mass (Da):149,034

Checksum:ⁱ3329D5375AD25930

GO

Isoform 3 (identifier: Q8NHM5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
856-868: LKPGKEDKLFRKK → Q
1204-1204: G → GPG

« Hide

        10         20         30         40         50
MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY 
        60         70         80         90        100
DENEDLSDVE EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE 
       110        120        130        140        150
ALRVPLIFRE KDGLGIKMPD PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE 
       160        170        180        190        200
MSMSQFVRYY ETPEAQRDKL YNVISLEFSH TKLEHLVKRP TVVDLVDWVD 
       210        220        230        240        250
NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD FHIDFGGTSV 
       260        270        280        290        300
WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL 
       310        320        330        340        350
KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV 
       360        370        380        390        400
QPKFRYPFYY EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID 
       410        420        430        440        450
GFSSDSWLEM EEEACDQQPQ EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP 
       460        470        480        490        500
SEDQEALGKK PKAPALRFLK RTLSNESEES VKSTTLAVDY PKTPTGSPAT 
       510        520        530        540        550
EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED PQALLEGVKN 
       560        570        580        590        600
VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN 
       610        620        630        640        650
RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ 
       660        670        680        690        700
CIAPVLPHTA VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL 
       710        720        730        740        750
KIKESEGVVN DELPNCWECP KCNHAGKTGK QKRGPGFKYA SNLPGSLLKE 
       760        770        780        790        800
QKMNRDNKEG QEPAKRRSEC EEAPRRRSDE HSKKVPPDGL LRRKSDDVHL 
       810        820        830        840        850
RKKRKYEKPQ ELSGRKRASS LQTSPGSSSH LSPRPPLGSS LSPWWRSSLT 
       860        870        880        890        900
YFQQQQRRSW KNAEDRMALA NKPLRRFKQE PEDELPEAPP KTRESDHSRS 
       910        920        930        940        950
SSPTAGPSTE GAEGPEEKKK VKMRRKRRLP NKELSRELSK ELNHEIQRTE 
       960        970        980        990       1000
NSLANENQQP IKSEPESEGE EPKRPPGICE RPHRFSKGLN GTPRELRHQL 
      1010       1020       1030       1040       1050
GPSLRSPPRV ISRPPPSVSP PKCIQMERHV IRPPPISPPP DSLPLDDGAA 
      1060       1070       1080       1090       1100
HVMHREVWMA VFSYLSHQDL CVCMRVCRTW NRWCCDKRLW TRIDLNHCKS 
      1110       1120       1130       1140       1150
ITPLMLSGII RRQPVSLDLS WTNISKKQLS WLINRLPGLR DLVLSGCSWI 
      1160       1170       1180       1190       1200
AVSALCSSSC PLLRTLDVQW VEGLKDAQMR DLLSPPTDNR PGPGQMDNRS 
      1210       1220       1230       1240       1250
KLRNIVELRL AGLDITDASL RLIIRHMPLL SKLHLSYCNH VTDQSINLLT 
      1260       1270       1280       1290       1300
AVGTTTRDSL TEINLSDCNK VTDQCLSFFK RCGNICHIDL RYCKQVTKEG 
      1310       1320 
CEQFIAEMSV SVQFGQVEEK LLQKLS

Note: No experimental confirmation available.

Show »

Length:1,326

Mass (Da):151,328

Checksum:ⁱBCBDAE3F675E017C

GO

Isoform 4 (identifier: Q8NHM5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQ → MEAEKDSGRRL
     818-855: Missing.
     1320-1336: VSVQFGQVEEKLLQKLS → SFQGRSCSTTRLGDE

« Hide

        10         20         30         40         50
MEAEKDSGRR LRPIDRQRYD ENEDLSDVEE IVSVRGFSLE EKLRSQLYQG 
        60         70         80         90        100
DFVHAMEGKD FNYEYVQREA LRVPLIFREK DGLGIKMPDP DFTVRDVKLL 
       110        120        130        140        150
VGSRRLVDVM DVNTQKGTEM SMSQFVRYYE TPEAQRDKLY NVISLEFSHT 
       160        170        180        190        200
KLEHLVKRPT VVDLVDWVDN MWPQHLKEKQ TEATNAIAEM KYPKVKKYCL 
       210        220        230        240        250
MSVKGCFTDF HIDFGGTSVW YHVFRGGKIF WLIPPTLHNL ALYEEWVLSG 
       260        270        280        290        300
KQSDIFLGDR VERCQRIELK QGYTFFIPSG WIHAVYTPVD SLVFGGNILH 
       310        320        330        340        350
SFNVPMQLRI YEIEDRTRVQ PKFRYPFYYE MCWYVLERYV YCVTQRSHLT 
       360        370        380        390        400
QEYQRESMLI DAPRKPSIDG FSSDSWLEME EEACDQQPQE EEEKDEEGEG 
       410        420        430        440        450
RDRAPKPPTD GSTSPTSTPS EDQEALGKKP KAPALRFLKR TLSNESEESV 
       460        470        480        490        500
KSTTLAVDYP KTPTGSPATE VSAKWTHLTE FELKGLKALV EKLESLPENK 
       510        520        530        540        550
KCVPEGIEDP QALLEGVKNV LKEHADDDPS LAITGVPVVT WPKKTPKNRA 
       560        570        580        590        600
VGRPKGKLGP ASAVKLAANR TTAGARRRRT RCRKCEACLR TECGECHFCK 
       610        620        630        640        650
DMKKFGGPGR MKQSCIMRQC IAPVLPHTAV CLVCGEAGKE DTVEEEEGKF 
       660        670        680        690        700
NLMLMECSIC NEIIHPGCLK IKESEGVVND ELPNCWECPK CNHAGKTGKQ 
       710        720        730        740        750
KRGPGFKYAS NLPGSLLKEQ KMNRDNKEGQ EPAKRRSECE EAPRRRSDEH 
       760        770        780        790        800
SKKVPPDGLL RRKSDDVHLR KKRKYEKPQE LSGRKRLKPG KEDKLFRKKR 
       810        820        830        840        850
RSWKNAEDRM ALANKPLRRF KQEPEDELPE APPKTRESDH SRSSSPTAGP 
       860        870        880        890        900
STEGAEGPEE KKKVKMRRKR RLPNKELSRE LSKELNHEIQ RTENSLANEN 
       910        920        930        940        950
QQPIKSEPES EGEEPKRPPG ICERPHRFSK GLNGTPRELR HQLGPSLRSP 
       960        970        980        990       1000
PRVISRPPPS VSPPKCIQME RHVIRPPPIS PPPDSLPLDD GAAHVMHREV 
      1010       1020       1030       1040       1050
WMAVFSYLSH QDLCVCMRVC RTWNRWCCDK RLWTRIDLNH CKSITPLMLS 
      1060       1070       1080       1090       1100
GIIRRQPVSL DLSWTNISKK QLSWLINRLP GLRDLVLSGC SWIAVSALCS 
      1110       1120       1130       1140       1150
SSCPLLRTLD VQWVEGLKDA QMRDLLSPPT DNRPGQMDNR SKLRNIVELR 
      1160       1170       1180       1190       1200
LAGLDITDAS LRLIIRHMPL LSKLHLSYCN HVTDQSINLL TAVGTTTRDS 
      1210       1220       1230       1240       1250
LTEINLSDCN KVTDQCLSFF KRCGNICHID LRYCKQVTKE GCEQFIAEMS 
      1260 
SFQGRSCSTT RLGDE

Note: No experimental confirmation available.

Show »

Length:1,265

Mass (Da):144,769

Checksum:ⁱ69C8C16EFDE3541C

GO

Isoform 5 (identifier: Q8NHM5-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.
     654-676: PVLPHTAVCLVCGEAGKEDTVEE → TAIRSLISACPSSNAVETSVILT
     677-1336: Missing.

« Hide

        10         20         30         40         50
MPDPDFTVRD VKLLVGSRRL VDVMDVNTQK GTEMSMSQFV RYYETPEAQR 
        60         70         80         90        100
DKLYNVISLE FSHTKLEHLV KRPTVVDLVD WVDNMWPQHL KEKQTEATNA 
       110        120        130        140        150
IAEMKYPKVK KYCLMSVKGC FTDFHIDFGG TSVWYHVFRG GKIFWLIPPT 
       160        170        180        190        200
LHNLALYEEW VLSGKQSDIF LGDRVERCQR IELKQGYTFF IPSGWIHAVY 
       210        220        230        240        250
TPVDSLVFGG NILHSFNVPM QLRIYEIEDR TRVQPKFRYP FYYEMCWYVL 
       260        270        280        290        300
ERYVYCVTQR SHLTQEYQRE SMLIDAPRKP SIDGFSSDSW LEMEEEACDQ 
       310        320        330        340        350
QPQEEEEKDE EGEGRDRAPK PPTDGSTSPT STPSEDQEAL GKKPKAPALR 
       360        370        380        390        400
FLKRTLSNES EESVKSTTLA VDYPKTPTGS PATEVSAKWT HLTEFELKGL 
       410        420        430        440        450
KALVEKLESL PENKKCVPEG IEDPQALLEG VKNVLKEHAD DDPSLAITGV 
       460        470        480        490        500
PVVTWPKKTP KNRAVGRPKG KLGPASAVKL AANRTTAGAR RRRTRCRKCE 
       510        520        530        540        550
ACLRTECGEC HFCKDMKKFG GPGRMKQSCI MRQCIATAIR SLISACPSSN 

AVETSVILT

Note: No experimental confirmation available.

Show »

Length:559

Mass (Da):63,630

Checksum:ⁱ8D324402C781480D

GO

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	F6SRV7	F6SRV7_HUMAN	Lysine-specific demethylase 2B Lysine-specific demethylase 2B	KDM2B	706	Annotation score:
	A0A0C4DGG3	A0A0C4DGG3_HUMAN	Lysine-specific demethylase 2B Lysine-specific demethylase 2B	KDM2B	704	Annotation score:
	F5H6N6	F5H6N6_HUMAN	Lysine-specific demethylase 2B Lysine-specific demethylase 2B	KDM2B	154	Annotation score:
	F5GXW2	F5GXW2_HUMAN	Lysine-specific demethylase 2B Lysine-specific demethylase 2B	KDM2B	123	Annotation score:
	F5H4A7	F5H4A7_HUMAN	Lysine-specific demethylase 2B Lysine-specific demethylase 2B	KDM2B	171	Annotation score:
	F8WBN2	F8WBN2_HUMAN	Lysine-specific demethylase 2B Lysine-specific demethylase 2B	KDM2B	510	Annotation score:
	F5GXC2	F5GXC2_HUMAN	Lysine-specific demethylase 2B Lysine-specific demethylase 2B	KDM2B	180	Annotation score:
	F5H7T7	F5H7T7_HUMAN	Lysine-specific demethylase 2B Lysine-specific demethylase 2B	KDM2B	97	Annotation score:
	F5H4X4	F5H4X4_HUMAN	Lysine-specific demethylase 2B Lysine-specific demethylase 2B	KDM2B	125	Annotation score:
	S4R3G4	S4R3G4_HUMAN	Lysine-specific demethylase 2B Lysine-specific demethylase 2B	KDM2B	507	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAH08735 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB55112 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB55301 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAC11159 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	864	L → F in BAC11159 (Ref. 6) Curated	1
Sequence conflictⁱ	1226	T → R in BAC11159 (Ref. 6) Curated	1
Sequence conflictⁱ	1295	I → T in BAC11159 (Ref. 6) Curated	1
Sequence conflictⁱ	1334	K → R in BAC11159 (Ref. 6) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_057394	1 – 117	Missing in isoform 5. 1 PublicationAdd BLAST	117
Alternative sequenceⁱVSP_043146	1 – 42	MAGPQ…ESATQ → MEAEKDSGRRL in isoform 4. 1 PublicationAdd BLAST	42
Alternative sequenceⁱVSP_057395	654 – 676	PVLPH…DTVEE → TAIRSLISACPSSNAVETSV ILT in isoform 5. 1 PublicationAdd BLAST	23
Alternative sequenceⁱVSP_057396	677 – 1336	Missing in isoform 5. 1 PublicationAdd BLAST	660
Alternative sequenceⁱVSP_011340	730	K → KAYK in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_043147	818 – 855	Missing in isoform 4. 1 PublicationAdd BLAST	38
Alternative sequenceⁱVSP_017475	856 – 868	LKPGK…LFRKK → Q in isoform 3. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_017476	1204	G → GPG in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_011341	1277 – 1336	DCNKV…LQKLS → ASLLGRVFGLQFWGICEPQA RKNAGWA in isoform 2. 1 PublicationAdd BLAST	60
Alternative sequenceⁱVSP_043148	1320 – 1336	VSVQF…LQKLS → SFQGRSCSTTRLGDE in isoform 4. 1 PublicationAdd BLAST	17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ459424 mRNA Translation: CAD30700.1 AK027440 mRNA Translation: BAB55112.1 Different initiation. AK027692 mRNA Translation: BAB55301.1 Different initiation. AK074718 mRNA Translation: BAC11159.1 Different initiation. AK127328 mRNA Translation: BAG54483.1 AC048337 Genomic DNA No translation available. AC073650 Genomic DNA No translation available. AC145422 Genomic DNA No translation available. KC877509 Genomic DNA No translation available. BC008735 mRNA Translation: AAH08735.2 Different initiation. BC115379 mRNA Translation: AAI15380.1 AL133572 mRNA Translation: CAB63721.2 AB031230 mRNA Translation: BAA97672.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41849.1 [Q8NHM5-4] CCDS41850.1 [Q8NHM5-1]
PIRⁱ	T43477
NCBI Reference Sequences More...RefSeqⁱ	NP_001005366.1, NM_001005366.1 [Q8NHM5-4] NP_115979.3, NM_032590.4 [Q8NHM5-1]
UniGeneⁱ	Hs.524800

Genome annotation databases

Ensemblⁱ	ENST00000377069; ENSP00000366269; ENSG00000089094 [Q8NHM5-4] ENST00000377071; ENSP00000366271; ENSG00000089094 [Q8NHM5-1] ENST00000611216; ENSP00000480847; ENSG00000089094 [Q8NHM5-5]
GeneIDⁱ	84678
KEGGⁱ	hsa:84678
UCSC genome browser More...UCSCⁱ	uc058uhm.1 human [Q8NHM5-1] uc058uhn.1 human

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NHM5	Lysine-specific demethylase 2B		HUMAN		704	UniRef100_Q8NHM5

Protein	Similar proteins		Species	Score	Length	Source
Q8NHM5	Lysine-specific demethylase 2B		MOUSE		1309	UniRef90_Q6P1G2
Uncharacterized protein		RHIBE		1369
Uncharacterized protein		Cebus capucinus imitator		1349
Lysine demethylase 2B		CHLSB		1348
Lysine demethylase 2B		FELCA		1343
+380
Q8NHM5-2	KDM2B isoform 3		PONAB		1328	UniRef90_Q8NHM5-2
Uncharacterized protein		RHIBE		1313
Uncharacterized protein		PANPA		1307
Uncharacterized protein		MACNE		1307
Uncharacterized protein		PAPAN		1307
+73
Q8NHM5-4	Lysine demethylase 2B		SAIBB		1298	UniRef90_Q8NHM5-4
Lysine-specific demethylase 2B		TUPCH		1284
Lysine demethylase 2B		CANLF		1275
Uncharacterized protein		PROCO		1274
lysine-specific demethylase 2B isoform X2		ODORO		1273
+70
Q8NHM5-5	Isoform 3 of Lysine-specific demethylase 2B		MOUSE		656	UniRef90_Q6P1G2-3
Lysine demethylase 2B		FELCA		567
Uncharacterized protein		PROCO		561
Uncharacterized protein		COLAP		559
KDM2B isoform 2		PONAB		559
+9

Protein	Similar proteins		Species	Score	Length	Source
Q8NHM5	Lysine-specific demethylase 2B		MOUSE		1309	UniRef50_Q6P1G2
Uncharacterized protein		RHIBE		1369
Uncharacterized protein		Cebus capucinus imitator		1349
Lysine demethylase 2B		CHLSB		1348
Lysine demethylase 2B		FELCA		1343
+799
Q8NHM5-5	Isoform 3 of Lysine-specific demethylase 2B		MOUSE		656	UniRef50_Q6P1G2-3
Lysine demethylase 2B		FELCA		567
Uncharacterized protein		PROCO		561
Uncharacterized protein		CERAT		559
Uncharacterized protein		Cebus capucinus imitator		559
+28

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ459424 mRNA Translation: CAD30700.1 AK027440 mRNA Translation: BAB55112.1 Different initiation. AK027692 mRNA Translation: BAB55301.1 Different initiation. AK074718 mRNA Translation: BAC11159.1 Different initiation. AK127328 mRNA Translation: BAG54483.1 AC048337 Genomic DNA No translation available. AC073650 Genomic DNA No translation available. AC145422 Genomic DNA No translation available. KC877509 Genomic DNA No translation available. BC008735 mRNA Translation: AAH08735.2 Different initiation. BC115379 mRNA Translation: AAI15380.1 AL133572 mRNA Translation: CAB63721.2 AB031230 mRNA Translation: BAA97672.1
CCDSⁱ	CCDS41849.1 [Q8NHM5-4] CCDS41850.1 [Q8NHM5-1]
PIRⁱ	T43477
RefSeqⁱ	NP_001005366.1, NM_001005366.1 [Q8NHM5-4] NP_115979.3, NM_032590.4 [Q8NHM5-1]
UniGeneⁱ	Hs.524800

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4O64	X-ray	2.13	A/B/C	607-723	[»]
	5JH5	X-ray	2.55	A	1059-1336	[»]
	6BVA	X-ray	2.66	E/F	1060-1104	[»]
ProteinModelPortalⁱ	Q8NHM5
SMRⁱ	Q8NHM5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124197, 26 interactors
CORUMⁱ	Q8NHM5
IntActⁱ	Q8NHM5, 12 interactors
STRINGⁱ	9606.ENSP00000366271

Chemistry databases

BindingDBⁱ	Q8NHM5
ChEMBLⁱ	CHEMBL3779760

PTM databases

iPTMnetⁱ	Q8NHM5
PhosphoSitePlusⁱ	Q8NHM5

Polymorphism and mutation databases

BioMutaⁱ	KDM2B
DMDMⁱ	51316032

Proteomic databases

EPDⁱ	Q8NHM5
MaxQBⁱ	Q8NHM5
PaxDbⁱ	Q8NHM5
PeptideAtlasⁱ	Q8NHM5
PRIDEⁱ	Q8NHM5
ProteomicsDBⁱ	73723 73724 [Q8NHM5-2] 73725 [Q8NHM5-3] 73726 [Q8NHM5-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000377069; ENSP00000366269; ENSG00000089094 [Q8NHM5-4] ENST00000377071; ENSP00000366271; ENSG00000089094 [Q8NHM5-1] ENST00000611216; ENSP00000480847; ENSG00000089094 [Q8NHM5-5]
GeneIDⁱ	84678
KEGGⁱ	hsa:84678
UCSCⁱ	uc058uhm.1 human [Q8NHM5-1] uc058uhn.1 human

Organism-specific databases

CTDⁱ	84678
DisGeNETⁱ	84678
EuPathDBⁱ	HostDB:ENSG00000089094.16
GeneCardsⁱ	KDM2B
HGNCⁱ	HGNC:13610 KDM2B
HPAⁱ	HPA071257
MIMⁱ	609078 gene
neXtProtⁱ	NX_Q8NHM5
OpenTargetsⁱ	ENSG00000089094
PharmGKBⁱ	PA164721242
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1633 Eukaryota KOG1947 Eukaryota ENOG410XQXU LUCA
GeneTreeⁱ	ENSGT00550000074396
HOGENOMⁱ	HOG000007396
HOVERGENⁱ	HBG051671
InParanoidⁱ	Q8NHM5
KOⁱ	K10276
OMAⁱ	NYDYKPR
OrthoDBⁱ	EOG091G00M1
PhylomeDBⁱ	Q8NHM5
TreeFamⁱ	TF106480

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214842 HDMs demethylate histones
SignaLinkⁱ	Q8NHM5
SIGNORⁱ	Q8NHM5

Miscellaneous databases

ChiTaRSⁱ	KDM2B human
GenomeRNAiⁱ	84678
Protein Ontology More...PROⁱ	PR:Q8NHM5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000089094 Expressed in 196 organ(s), highest expression level in female gonad
CleanExⁱ	HS_FBXL10
ExpressionAtlasⁱ	Q8NHM5 baseline and differential
Genevisibleⁱ	Q8NHM5 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001810 F-box_dom IPR003347 JmjC_dom IPR006553 Leu-rich_rpt_Cys-con_subtyp IPR032675 LRR_dom_sf IPR002857 Znf_CXXC IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
Pfamⁱ	View protein in Pfam PF00646 F-box, 1 hit PF16866 PHD_4, 1 hit PF02008 zf-CXXC, 1 hit
SMARTⁱ	View protein in SMART SM00558 JmjC, 1 hit SM00367 LRR_CC, 6 hits SM00249 PHD, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS51184 JMJC, 1 hit PS51058 ZF_CXXC, 1 hit PS50016 ZF_PHD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KDM2B_HUMAN
Accessionⁱ	Q8NHM5Primary (citable) accession number: Q8NHM5 Secondary accession number(s): A8MRS1 Q9UF75
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q8NHM5 (KDM2B_HUMAN)

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Lysine-specific demethylase 2B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Enzyme and pathway databases

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Protocols and materials databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ