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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 1

Gene

LILRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251).7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

SIGNOR Signaling Network Open Resource

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SIGNORi
Q8NHL6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 1
Short name:
LIR-1
Short name:
Leukocyte immunoglobulin-like receptor 1
Alternative name(s):
CD85 antigen-like family member J
Immunoglobulin-like transcript 2
Short name:
ILT-2
Monocyte/macrophage immunoglobulin-like receptor 7
Short name:
MIR-7
CD_antigen: CD85j1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LILRB1Imported
Synonyms:ILT21 Publication, LIR1, MIR7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6605 LILRB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604811 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NHL6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 461ExtracellularSequence analysisAdd BLAST438
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 650CytoplasmicSequence analysisAdd BLAST168

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi533Y → F: Impairs receptor phosphorylation and abolishes inhibition of serotonin release. No effect on PTPN6 binding; when associated with F-562. 1 Publication1
Mutagenesisi562Y → F: No effect on PTPN6 binding; when associated with F-533. 1 Publication1
Mutagenesisi614Y → F: No effect on PTPN6 binding. Abolishes PTPN6 binding; when associated with F-644. 1 Publication1
Mutagenesisi644Y → F: Reduces PTPN6 binding. Abolishes PTPN6 binding; when associated with F-614. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10859

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30379

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LILRB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37537910

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001482024 – 650Leukocyte immunoglobulin-like receptor subfamily B member 1Add BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 98Combined sources1 Publication
Disulfide bondi145 ↔ 197Combined sources1 Publication
Disulfide bondi157 ↔ 167Combined sources1 Publication
Disulfide bondi246 ↔ 297PROSITE-ProRule annotationCombined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi346 ↔ 397PROSITE-ProRule annotationCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei533Phosphotyrosine1 Publication1
Modified residuei614Phosphotyrosine1 Publication1
Modified residuei644Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NHL6

PeptideAtlas

More...
PeptideAtlasi
Q8NHL6

PRoteomics IDEntifications database

More...
PRIDEi
Q8NHL6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73718
73719 [Q8NHL6-2]
73720 [Q8NHL6-3]
73721 [Q8NHL6-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NHL6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NHL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in B cells, monocytes and various dendritic cell (DC) subsets including myeloid, plasmacytoid and tolerogenic DCs (at protein level) (PubMed:20448110, PubMed:9285411, PubMed:9842885, PubMed:24453251). Expressed in decidual macrophages (at protein level) (PubMed:19304799). Expressed in decidual NK cells (at protein level) (PubMed:29262349).6 Publications

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
HS_LILRB1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds PTPN6 when phosphorylated. Binds FCER1A and FCGR1A. Interacts with human cytomegalovirus/HHV-5 protein UL18. Interacts with peptide-bound HLA-G-B2M.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116070, 7 interactors

Protein interaction database and analysis system

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IntActi
Q8NHL6, 16 interactors

Molecular INTeraction database

More...
MINTi
Q8NHL6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000315997

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1650
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8NHL6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NHL6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8NHL6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 115Ig-like C2-type 1Add BLAST89
Domaini116 – 221Ig-like C2-type 2Add BLAST106
Domaini222 – 312Ig-like C2-type 3Add BLAST91
Domaini313 – 409Ig-like C2-type 4Add BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi531 – 536ITIM motif 16
Motifi560 – 565ITIM motif 26
Motifi612 – 617ITIM motif 36
Motifi642 – 647ITIM motif 46

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKJD Eukaryota
ENOG41116BR LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234395

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG074353

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NHL6

KEGG Orthology (KO)

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KOi
K06512

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0D6W

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NHL6

TreeFam database of animal gene trees

More...
TreeFami
TF336644

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NHL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ
60 70 80 90 100
GGQETQEYRL YREKKTALWI TRIPQELVKK GQFPIPSITW EHAGRYRCYY
110 120 130 140 150
GSDTAGRSES SDPLELVVTG AYIKPTLSAQ PSPVVNSGGN VILQCDSQVA
160 170 180 190 200
FDGFSLCKEG EDEHPQCLNS QPHARGSSRA IFSVGPVSPS RRWWYRCYAY
210 220 230 240 250
DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE TLTLQCGSDA
260 270 280 290 300
GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA
310 320 330 340 350
HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG
360 370 380 390 400
WMQTFLLTKE GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS
410 420 430 440 450
QSSKPYLLTH PSDPLELVVS GPSGGPSSPT TGPTSTSGPE DQPLTPTGSD
460 470 480 490 500
PQSGLGRHLG VVIGILVAVI LLLLLLLLLF LILRHRRQGK HWTSTQRKAD
510 520 530 540 550
FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKHTQ PEDGVEMDTR
560 570 580 590 600
SPHDEDPQAV TYAEVKHSRP RREMASPPSP LSGEFLDTKD RQAEEDRQMD
610 620 630 640 650
TEAAASEAPQ DVTYAQLHSL TLRREATEPP PSQEGPSPAV PSIYATLAIH
Length:650
Mass (Da):70,819
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i549196EA4ED2767C
GO
Isoform 2 (identifier: Q8NHL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-437: S → SA

Show »
Length:651
Mass (Da):70,890
Checksum:i7D4F9D838D844AA6
GO
Isoform 3 (identifier: Q8NHL6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-437: S → SA
     550-550: R → RQ

Show »
Length:652
Mass (Da):71,019
Checksum:i93AF8F021A22949D
GO
Isoform 4 (identifier: Q8NHL6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-550: R → RQ

Show »
Length:651
Mass (Da):70,948
Checksum:i3266510973E1C2A1
GO
Isoform 5 (identifier: Q8NHL6-5) [UniParc]FASTAAdd to basket
Also known as: 65 Kda, sLILRB1

The sequence of this isoform differs from the canonical sequence as follows:
     437-437: S → SA
     455-455: L → E
     456-650: Missing.

Note: May act as dominant negative regulator and block the interaction between membrane-associated isoforms and HLA-class I.1 Publication
Show »
Length:456
Mass (Da):49,356
Checksum:iDCF5CD284081A591
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RVM3F6RVM3_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB1
510Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNK9A0A0G2JNK9_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB1
510Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNR3A0A0G2JNR3_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB1
510Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MVE2A8MVE2_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB1
634Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J1W1A0A0B4J1W1_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB1
650Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D9IDM5D9IDM5_HUMAN
LIR-1
LILRB1
651Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WSX8A0A087WSX8_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB1
651Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WSV6A0A087WSV6_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB1
652Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D9IDM6D9IDM6_HUMAN
LIR-1
LILRB1
651Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNQ6A0A0G2JNQ6_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB1
652Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti557P → L in AAL36989 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01699368L → P4 PublicationsCorresponds to variant dbSNP:rs1061679Ensembl.1
Natural variantiVAR_04988893A → T2 PublicationsCorresponds to variant dbSNP:rs12460501Ensembl.1
Natural variantiVAR_016994142I → T4 PublicationsCorresponds to variant dbSNP:rs1061680Ensembl.1
Natural variantiVAR_016995155S → I4 PublicationsCorresponds to variant dbSNP:rs1061681Ensembl.1
Natural variantiVAR_059398301H → Y. Corresponds to variant dbSNP:rs1045818Ensembl.1
Natural variantiVAR_067316459L → V. Corresponds to variant dbSNP:rs1138737Ensembl.1
Natural variantiVAR_016996620L → F. Corresponds to variant dbSNP:rs634222Ensembl.1
Natural variantiVAR_067317625E → K3 PublicationsCorresponds to variant dbSNP:rs16985478Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008456437S → SA in isoform 2, isoform 3 and isoform 5. 2 Publications1
Alternative sequenceiVSP_057087455L → E in isoform 5. 1 Publication1
Alternative sequenceiVSP_057088456 – 650Missing in isoform 5. 1 PublicationAdd BLAST195
Alternative sequenceiVSP_008457550R → RQ in isoform 3 and isoform 4. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF004230 mRNA Translation: AAB67710.1
AF009220 mRNA Translation: AAB63521.1
AF009221 mRNA Translation: AAB63522.1
AF189277 Genomic DNA Translation: AAG08984.1
EU915608 mRNA Translation: ACK56074.1
HM135394 Genomic DNA Translation: ADJ55944.1
HM135401 Genomic DNA Translation: ADJ55951.1
AF283984 mRNA Translation: AAL36988.1
AF283985 mRNA Translation: AAL36989.1
AC009892 Genomic DNA No translation available.
BC015731 mRNA Translation: AAH15731.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42614.1 [Q8NHL6-3]
CCDS42615.1 [Q8NHL6-2]
CCDS42616.1 [Q8NHL6-4]
CCDS42617.1 [Q8NHL6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001075106.2, NM_001081637.2
NP_001075107.2, NM_001081638.3
NP_001075108.2, NM_001081639.3
NP_001265327.2, NM_001278398.2
NP_001265328.2, NM_001278399.2
NP_006660.4, NM_006669.6

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.667388

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000448689; ENSP00000409968; ENSG00000104972
ENST00000612636; ENSP00000479887; ENSG00000277807 [Q8NHL6-3]
ENST00000616408; ENSP00000481700; ENSG00000274669
ENST00000617686; ENSP00000478282; ENSG00000277807 [Q8NHL6-4]
ENST00000618055; ENSP00000480365; ENSG00000277807 [Q8NHL6-1]
ENST00000618681; ENSP00000479753; ENSG00000277807 [Q8NHL6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10859

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10859

UCSC genome browser

More...
UCSCi
uc032iow.2 human [Q8NHL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004230 mRNA Translation: AAB67710.1
AF009220 mRNA Translation: AAB63521.1
AF009221 mRNA Translation: AAB63522.1
AF189277 Genomic DNA Translation: AAG08984.1
EU915608 mRNA Translation: ACK56074.1
HM135394 Genomic DNA Translation: ADJ55944.1
HM135401 Genomic DNA Translation: ADJ55951.1
AF283984 mRNA Translation: AAL36988.1
AF283985 mRNA Translation: AAL36989.1
AC009892 Genomic DNA No translation available.
BC015731 mRNA Translation: AAH15731.1
CCDSiCCDS42614.1 [Q8NHL6-3]
CCDS42615.1 [Q8NHL6-2]
CCDS42616.1 [Q8NHL6-4]
CCDS42617.1 [Q8NHL6-1]
RefSeqiNP_001075106.2, NM_001081637.2
NP_001075107.2, NM_001081638.3
NP_001075108.2, NM_001081639.3
NP_001265327.2, NM_001278398.2
NP_001265328.2, NM_001278399.2
NP_006660.4, NM_006669.6
UniGeneiHs.667388

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0XX-ray2.10A25-221[»]
1P7QX-ray3.40D25-221[»]
1UFUX-ray3.00A25-221[»]
1UGNX-ray1.80A24-221[»]
1VDGX-ray2.80A/B24-220[»]
3D2UX-ray2.21D/H24-221[»]
4LL9X-ray2.69A/B/C222-417[»]
4NO0X-ray2.70D27-221[»]
5KNMX-ray3.30D24-221[»]
ProteinModelPortaliQ8NHL6
SMRiQ8NHL6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116070, 7 interactors
IntActiQ8NHL6, 16 interactors
MINTiQ8NHL6
STRINGi9606.ENSP00000315997

PTM databases

iPTMnetiQ8NHL6
PhosphoSitePlusiQ8NHL6

Polymorphism and mutation databases

BioMutaiLILRB1
DMDMi37537910

Proteomic databases

PaxDbiQ8NHL6
PeptideAtlasiQ8NHL6
PRIDEiQ8NHL6
ProteomicsDBi73718
73719 [Q8NHL6-2]
73720 [Q8NHL6-3]
73721 [Q8NHL6-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10859
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000448689; ENSP00000409968; ENSG00000104972
ENST00000612636; ENSP00000479887; ENSG00000277807 [Q8NHL6-3]
ENST00000616408; ENSP00000481700; ENSG00000274669
ENST00000617686; ENSP00000478282; ENSG00000277807 [Q8NHL6-4]
ENST00000618055; ENSP00000480365; ENSG00000277807 [Q8NHL6-1]
ENST00000618681; ENSP00000479753; ENSG00000277807 [Q8NHL6-2]
GeneIDi10859
KEGGihsa:10859
UCSCiuc032iow.2 human [Q8NHL6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10859
DisGeNETi10859

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LILRB1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0137208
HGNCiHGNC:6605 LILRB1
MIMi604811 gene
neXtProtiNX_Q8NHL6
PharmGKBiPA30379

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKJD Eukaryota
ENOG41116BR LUCA
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiQ8NHL6
KOiK06512
OrthoDBiEOG091G0D6W
PhylomeDBiQ8NHL6
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SIGNORiQ8NHL6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LILRB1 human
EvolutionaryTraceiQ8NHL6

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LILRB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10859

Protein Ontology

More...
PROi
PR:Q8NHL6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

CleanExiHS_LILRB1

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIRB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NHL6
Secondary accession number(s): A2IXV4
, A8MXT0, O75024, O75025, Q8NHJ9, Q8NHK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: December 5, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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