LILRB4

Functionⁱ

Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462).

Receptor for FN1 (PubMed:34089617).

Receptor for apolipoprotein APOE (PubMed:30333625).

Receptor for ALCAM/CD166 (PubMed:29263213).

Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699).

Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736).

This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617).

Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213).

Induces up-regulation of CD86 on dendritic cells (PubMed:19860908).

Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462).

8 Publications

Miscellaneous

Activated by APOE on acute myeloid leukemia (AML) cells which leads to suppression of T cell proliferation and promotion of AML cell migration and infiltration (PubMed:30333625). LILRB4 signaling on AML cells is mediated by PTPN11/SHP-2 (PubMed:30333625).1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	35	Required for APOE-mediated activation of LILRB41 Publication	1
Siteⁱ	106	Required for APOE-mediated activation of LILRB41 Publication	1
Siteⁱ	121	Required for APOE-mediated activation of LILRB41 Publication	1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Adaptive immunity, Immunity

Enzyme and pathway databases

PathwayCommonsⁱ	Q8NHJ6
Reactomeⁱ	R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SignaLinkⁱ	Q8NHJ6
SIGNORⁱ	Q8NHJ6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leukocyte immunoglobulin-like receptor subfamily B member 4 Short name: B41 Publication Alternative name(s): CD85 antigen-like family member K Immunoglobulin-like transcript 3 Short name: ILT-3 Leukocyte immunoglobulin-like receptor 5 Short name: LIR-5 Monocyte inhibitory receptor HM18 CD_antigen: CD85k
Gene namesⁱ	Name:LILRB4 Synonyms:ILT3, LIR5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6608, LILRB4
MIMⁱ	604821, gene
neXtProtⁱ	NX_Q8NHJ6
VEuPathDBⁱ	HostDB:ENSG00000186818

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 259	ExtracellularSequence analysisAdd BLAST	238
Transmembraneⁱ	260 – 280	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	281 – 448	CytoplasmicSequence analysisAdd BLAST	168

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	30	T → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	35	P → A: Significant reduction in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	41	W → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	59	R → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	63	E → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	64	E → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	65	S → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	66	P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	68	P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	91	D → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	95	R → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	97	R → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	103	P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	106	W → A: Significant reduction in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	109	P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	111	D → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	112	P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	113	L → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	114	E → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	121	Y → A: Significant reduction in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	122	S → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	147	R → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	149	P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	162	H → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	164	L → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	165	L → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	167	L → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	170	E → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	183	S → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	184	P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	186	T → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	188	V → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	199	H → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	201	F → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1
Mutagenesisⁱ	202	S → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11006
PharmGKBⁱ	PA30382

Miscellaneous databases

Pharosⁱ	Q8NHJ6, Tbio

Pharosⁱ

Q8NHJ6, Tbio

Genetic variation databases

BioMutaⁱ	LILRB4
DMDMⁱ	322510117

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000014823	22 – 448	Leukocyte immunoglobulin-like receptor subfamily B member 4Add BLAST		427

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	49 ↔ 98	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	144 ↔ 195	PROSITE-ProRule annotation1 Publication
Modified residueⁱ	319	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

jPOSTⁱ	Q8NHJ6
MassIVEⁱ	Q8NHJ6
PaxDbⁱ	Q8NHJ6
PeptideAtlas More...PeptideAtlasⁱ	Q8NHJ6
PRIDEⁱ	Q8NHJ6
ProteomicsDBⁱ	73714 [Q8NHJ6-1] 73715 [Q8NHJ6-2] 73716 [Q8NHJ6-3]

PTM databases

GlyGenⁱ	Q8NHJ6, 2 sites, 3 O-linked glycans (2 sites)
iPTMnetⁱ	Q8NHJ6
PhosphoSitePlusⁱ	Q8NHJ6

Expressionⁱ

Tissue specificityⁱ

Detected on monocytes, macrophages, dendritic cells, natural killer cells and B-cells (at protein level). Expressed in the lung.5 Publications

Inductionⁱ

Induced on monocyte-derived macrophages by S.typhimurium infection (PubMed:19860908). Induced on monocytes and dendritic cells upon contact with CD8⁺CD28^- alloantigen-specific T suppressor (Ts) cells (PubMed:11875462).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000186818, Expressed in layer of synovial tissue and 167 other tissues
ExpressionAtlasⁱ	Q8NHJ6, baseline and differential
Genevisibleⁱ	Q8NHJ6, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000186818, Tissue enhanced (lung, lymphoid tissue)

HPAⁱ

ENSG00000186818, Tissue enhanced (lung, lymphoid tissue)

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

Q8NHJ6

With	#Exp.	IntAct
PTPN6 [P29350]	4	EBI-2805248,EBI-78260

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	116197, 23 interactors
IntActⁱ	Q8NHJ6, 15 interactors
STRINGⁱ	9606.ENSP00000375616

Miscellaneous databases

RNActⁱ	Q8NHJ6, protein

RNActⁱ

Q8NHJ6, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	30 – 35	Combined sources	6
Beta strandⁱ	37 – 40	Combined sources	4
Beta strandⁱ	45 – 50	Combined sources	6
Beta strandⁱ	57 – 62	Combined sources	6
Beta strandⁱ	69 – 72	Combined sources	4
Beta strandⁱ	76 – 87	Combined sources	12
Helixⁱ	90 – 92	Combined sources	3
Beta strandⁱ	94 – 102	Combined sources	9
Beta strandⁱ	105 – 107	Combined sources	3
Beta strandⁱ	113 – 118	Combined sources	6
Beta strandⁱ	125 – 130	Combined sources	6
Beta strandⁱ	132 – 135	Combined sources	4
Beta strandⁱ	140 – 157	Combined sources	18
Helixⁱ	163 – 165	Combined sources	3
Beta strandⁱ	166 – 182	Combined sources	17
Helixⁱ	187 – 189	Combined sources	3
Beta strandⁱ	191 – 198	Combined sources	8
Helixⁱ	200 – 202	Combined sources	3
Beta strandⁱ	213 – 218	Combined sources	6

Show more details

3D structure databases

SMRⁱ	Q8NHJ6
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 118	Ig-like C2-type 1Add BLAST		92
Domainⁱ	124 – 218	Ig-like C2-type 2Add BLAST		95

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	217 – 248	DisorderedSequence analysisAdd BLAST		32
Regionⁱ	297 – 448	DisorderedSequence analysisAdd BLAST		152

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	358 – 363	ITIM motif 1	6
Motifⁱ	410 – 415	ITIM motif 2	6
Motifⁱ	440 – 445	ITIM motif 3	6

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	340 – 371	Basic and acidic residuesSequence analysisAdd BLAST	32
Compositional biasⁱ	385 – 400	Basic and acidic residuesSequence analysisAdd BLAST	16
Compositional biasⁱ	410 – 429	Polar residuesSequence analysisAdd BLAST	20

Domainⁱ

Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG502RU0A, Eukaryota
InParanoidⁱ	Q8NHJ6
Database of Orthologous Groups More...OrthoDBⁱ	1000446at2759
PhylomeDBⁱ	Q8NHJ6
TreeFamⁱ	TF336644

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013151, Immunoglobulin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 1 hit
SUPFAMⁱ	SSF48726, SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 25 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8NHJ6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ 
        60         70         80         90        100
GTLEAREYRL DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY 
       110        120        130        140        150
RSPVGWSQPS DPLELVMTGA YSKPTLSALP SPLVTSGKSV TLLCQSRSPM 
       160        170        180        190        200
DTFLLIKERA AHPLLHLRSE HGAQQHQAEF PMSPVTSVHG GTYRCFSSHG 
       210        220        230        240        250
FSHYLLSHPS DPLELIVSGS LEDPRPSPTR SVSTAAGPED QPLMPTGSVP 
       260        270        280        290        300
HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR 
       310        320        330        340        350
PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRQSP 
       360        370        380        390        400
HDEDPQAVTY AKVKHSRPRR EMASPPSPLS GEFLDTKDRQ AEEDRQMDTE 
       410        420        430        440 
AAASEAPQDV TYAQLHSFTL RQKATEPPPS QEGASPAEPS VYATLAIH

Length:448

Mass (Da):49,356

Last modified:February 8, 2011 - v3

Checksum:ⁱC18C21694F283FBB

GO

Isoform 2 (identifier: Q8NHJ6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
348-348: Missing.

« Hide

        10         20         30         40         50
MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ 
        60         70         80         90        100
GTLEAREYRL DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY 
       110        120        130        140        150
RSPVGWSQPS DPLELVMTGA YSKPTLSALP SPLVTSGKSV TLLCQSRSPM 
       160        170        180        190        200
DTFLLIKERA AHPLLHLRSE HGAQQHQAEF PMSPVTSVHG GTYRCFSSHG 
       210        220        230        240        250
FSHYLLSHPS DPLELIVSGS LEDPRPSPTR SVSTAAGPED QPLMPTGSVP 
       260        270        280        290        300
HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR 
       310        320        330        340        350
PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRSPH 
       360        370        380        390        400
DEDPQAVTYA KVKHSRPRRE MASPPSPLSG EFLDTKDRQA EEDRQMDTEA 
       410        420        430        440 
AASEAPQDVT YAQLHSFTLR QKATEPPPSQ EGASPAEPSV YATLAIH

Note: Alternative use of an acceptor site.Curated

Show »

Length:447

Mass (Da):49,228

Checksum:ⁱ5DF5A3445A3AD4FF

GO

Isoform 3 (identifier: Q8NHJ6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
330-330: C → SG

« Hide

        10         20         30         40         50
MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ 
        60         70         80         90        100
GTLEAREYRL DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY 
       110        120        130        140        150
RSPVGWSQPS DPLELVMTGA YSKPTLSALP SPLVTSGKSV TLLCQSRSPM 
       160        170        180        190        200
DTFLLIKERA AHPLLHLRSE HGAQQHQAEF PMSPVTSVHG GTYRCFSSHG 
       210        220        230        240        250
FSHYLLSHPS DPLELIVSGS LEDPRPSPTR SVSTAAGPED QPLMPTGSVP 
       260        270        280        290        300
HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR 
       310        320        330        340        350
PPGAAEPEPK DGGLQRRSSP AADVQGENFS GAAVKNTQPE DGVEMDTRQS 
       360        370        380        390        400
PHDEDPQAVT YAKVKHSRPR REMASPPSPL SGEFLDTKDR QAEEDRQMDT 
       410        420        430        440 
EAAASEAPQD VTYAQLHSFT LRQKATEPPP SQEGASPAEP SVYATLAIH

Show »

Length:449

Mass (Da):49,397

Checksum:ⁱBA6F3F253EF07089

GO

Computationally mapped potential isoform sequencesⁱ

There are 25 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A0A0MSZ8	A0A0A0MSZ8_HUMAN	Leukocyte immunoglobulin-like recep... Leukocyte immunoglobulin-like receptor subfamily B member 4	LILRB4	447	Annotation score:
	C9JST2	C9JST2_HUMAN	Leukocyte immunoglobulin-like recep... Leukocyte immunoglobulin-like receptor subfamily B member 4	LILRB4	399	Annotation score:
	A0A0A0MS20	A0A0A0MS20_HUMAN	Leukocyte immunoglobulin-like recep... Leukocyte immunoglobulin-like receptor subfamily B member 4	LILRB4	449	Annotation score:
	A0A0G2JM57	A0A0G2JM57_HUMAN	Leukocyte immunoglobulin-like recep... Leukocyte immunoglobulin-like receptor subfamily B member 4	LILRB4	447	Annotation score:
	A0A0G2JMH7	A0A0G2JMH7_HUMAN	Leukocyte immunoglobulin-like recep... Leukocyte immunoglobulin-like receptor subfamily B member 4	LILRB4	449	Annotation score:
	A0A0G2JP84	A0A0G2JP84_HUMAN	Leukocyte immunoglobulin-like recep... Leukocyte immunoglobulin-like receptor subfamily B member 4	LILRB4	447	Annotation score:
	A0A0G2JPC7	A0A0G2JPC7_HUMAN	Leukocyte immunoglobulin-like recep... Leukocyte immunoglobulin-like receptor subfamily B member 4	LILRB4	447	Annotation score:
	A0A0G2JPU4	A0A0G2JPU4_HUMAN	Leukocyte immunoglobulin-like recep... Leukocyte immunoglobulin-like receptor subfamily B member 4	LILRB4	449	Annotation score:
	A0A0G2JPX5	A0A0G2JPX5_HUMAN	Leukocyte immunoglobulin-like recep... Leukocyte immunoglobulin-like receptor subfamily B member 4	LILRB4	449	Annotation score:
	A0A0G2JM38	A0A0G2JM38_HUMAN	Leukocyte immunoglobulin-like recep... Leukocyte immunoglobulin-like receptor subfamily B member 4	LILRB4	437	Annotation score:
There are more potential isoformsShow all

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_025501	5	F → L1 PublicationCorresponds to variant dbSNP:rs28366008Ensembl.	1
Natural variantⁱVAR_025502	18	R → S. Corresponds to variant dbSNP:rs11540761Ensembl.	1
Natural variantⁱVAR_047846	20	H → D1 PublicationCorresponds to variant dbSNP:rs11540762Ensembl.	1
Natural variantⁱVAR_017014	223	D → G4 PublicationsCorresponds to variant dbSNP:rs731170Ensembl.	1
Natural variantⁱVAR_025503	330	C → Y. Corresponds to variant dbSNP:rs11574575Ensembl.	1
Natural variantⁱVAR_025504	335	N → D. Corresponds to variant dbSNP:rs11574576Ensembl.	1
Natural variantⁱVAR_017015	362	K → E1 PublicationCorresponds to variant dbSNP:rs2764337Ensembl.	1
Natural variantⁱVAR_030939	362	K → T. Corresponds to variant dbSNP:rs11574589Ensembl.	1
Natural variantⁱVAR_025505	414	Q → R2 PublicationsCorresponds to variant dbSNP:rs1048801Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035939	330	C → SG in isoform 3. 1 Publication		1
Alternative sequenceⁱVSP_008460	348	Missing in isoform 2. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U91925 mRNA Translation: AAB68665.1 AF025532 mRNA Translation: AAB87666.1 AF189768 Genomic DNA Translation: AAG02024.1 AF283988 mRNA Translation: AAL36992.1 CR542048 mRNA Translation: CAG46845.1 CR609786 mRNA No translation available. AC009892 Genomic DNA No translation available. AC011515 Genomic DNA No translation available. BC026309 mRNA Translation: AAH26309.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12902.1 [Q8NHJ6-1] CCDS42618.1 [Q8NHJ6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001265355.2, NM_001278426.3 NP_001265356.2, NM_001278427.3 NP_001265357.2, NM_001278428.3 NP_001265358.2, NM_001278429.3 NP_001265359.2, NM_001278430.3

Genome annotation databases

Ensemblⁱ	ENST00000391736; ENSP00000375616; ENSG00000186818 ENST00000612454; ENSP00000479829; ENSG00000275730 ENST00000614699; ENSP00000478542; ENSG00000275730 [Q8NHJ6-3] ENST00000621693; ENSP00000482234; ENSG00000275730 [Q8NHJ6-2]
GeneIDⁱ	11006
KEGGⁱ	hsa:11006
UCSC genome browser More...UCSCⁱ	uc002qgp.5, human [Q8NHJ6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NHJ6-2	Leukocyte immunoglobulin-like receptor subfamily B member 4 (Fragment)		HUMAN		280	UniRef100_Q8NHJ6-2

Protein	Similar proteins		Species	Score	Length	Source
Q8NHJ6	Leukocyte immunoglobulin-like receptor subfamily B member 4		HUMAN		478	UniRef90_Q8NHJ6
LILRB4 isoform 3		PANTR		448
LILRB4 isoform 1		PONAB		399
Leukocyte immunoglobulin-like receptor subfamily B member 4		HUMAN		449
Leukocyte immunoglobulin-like receptor subfamily B member 4 (Fragment)		HUMAN		168
+36
Q8NHJ6-3	Leukocyte immunoglobulin-like receptor subfamily B member 4		HUMAN		449	UniRef90_Q8NHJ6-3
LILRB4 isoform 7		PANTR		449
Leukocyte immunoglobulin like receptor B4		PANPA		408
LILRB4 isoform 3		PONAB		400
Leukocyte immunoglobulin-like receptor subfamily B member 4 (Fragment)		HUMAN		131
+16

Protein	Similar proteins		Species	Score	Length	Source
Q8NHJ6	Leukocyte immunoglobulin-like receptor subfamily B member 4		HUMAN		478	UniRef50_Q8NHJ6
LILRB4 isoform 3		PANTR		448
LILRB4 isoform 1		PONAB		399
Leukocyte immunoglobulin like receptor B4		PANPA		408
Ig-like domain-containing protein		CALJA		396
+113

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U91925 mRNA Translation: AAB68665.1 AF025532 mRNA Translation: AAB87666.1 AF189768 Genomic DNA Translation: AAG02024.1 AF283988 mRNA Translation: AAL36992.1 CR542048 mRNA Translation: CAG46845.1 CR609786 mRNA No translation available. AC009892 Genomic DNA No translation available. AC011515 Genomic DNA No translation available. BC026309 mRNA Translation: AAH26309.1
CCDSⁱ	CCDS12902.1 [Q8NHJ6-1] CCDS42618.1 [Q8NHJ6-2]
RefSeqⁱ	NP_001265355.2, NM_001278426.3 NP_001265356.2, NM_001278427.3 NP_001265357.2, NM_001278428.3 NP_001265358.2, NM_001278429.3 NP_001265359.2, NM_001278430.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3P2T	X-ray	1.70	A	24-219	[»]
	6K7O	X-ray	3.00	A/P/Q/R	24-118	[»]
SMRⁱ	Q8NHJ6
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	116197, 23 interactors
IntActⁱ	Q8NHJ6, 15 interactors
STRINGⁱ	9606.ENSP00000375616

PTM databases

GlyGenⁱ	Q8NHJ6, 2 sites, 3 O-linked glycans (2 sites)
iPTMnetⁱ	Q8NHJ6
PhosphoSitePlusⁱ	Q8NHJ6

Genetic variation databases

BioMutaⁱ	LILRB4
DMDMⁱ	322510117

Proteomic databases

jPOSTⁱ	Q8NHJ6
MassIVEⁱ	Q8NHJ6
PaxDbⁱ	Q8NHJ6
PeptideAtlasⁱ	Q8NHJ6
PRIDEⁱ	Q8NHJ6
ProteomicsDBⁱ	73714 [Q8NHJ6-1] 73715 [Q8NHJ6-2] 73716 [Q8NHJ6-3]

Protocols and materials databases

Antibodypediaⁱ	35096, 297 antibodies from 28 providers
The DNASU plasmid repository More...DNASUⁱ	11006

Genome annotation databases

Ensemblⁱ	ENST00000391736; ENSP00000375616; ENSG00000186818 ENST00000612454; ENSP00000479829; ENSG00000275730 ENST00000614699; ENSP00000478542; ENSG00000275730 [Q8NHJ6-3] ENST00000621693; ENSP00000482234; ENSG00000275730 [Q8NHJ6-2]
GeneIDⁱ	11006
KEGGⁱ	hsa:11006
UCSCⁱ	uc002qgp.5, human [Q8NHJ6-1]

Organism-specific databases

CTDⁱ	11006
DisGeNETⁱ	11006
GeneCardsⁱ	LILRB4
HGNCⁱ	HGNC:6608, LILRB4
HPAⁱ	ENSG00000186818, Tissue enhanced (lung, lymphoid tissue)
MIMⁱ	604821, gene
neXtProtⁱ	NX_Q8NHJ6
PharmGKBⁱ	PA30382
VEuPathDBⁱ	HostDB:ENSG00000186818
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502RU0A, Eukaryota
InParanoidⁱ	Q8NHJ6
OrthoDBⁱ	1000446at2759
PhylomeDBⁱ	Q8NHJ6
TreeFamⁱ	TF336644

Enzyme and pathway databases

PathwayCommonsⁱ	Q8NHJ6
Reactomeⁱ	R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SignaLinkⁱ	Q8NHJ6
SIGNORⁱ	Q8NHJ6

Miscellaneous databases

BioGRID-ORCSⁱ	11006, 4 hits in 1028 CRISPR screens
ChiTaRSⁱ	LILRB4, human
GeneWikiⁱ	LILRB4
GenomeRNAiⁱ	11006
Pharosⁱ	Q8NHJ6, Tbio
Protein Ontology More...PROⁱ	PR:Q8NHJ6
RNActⁱ	Q8NHJ6, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186818, Expressed in layer of synovial tissue and 167 other tissues
ExpressionAtlasⁱ	Q8NHJ6, baseline and differential
Genevisibleⁱ	Q8NHJ6, HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013151, Immunoglobulin
Pfamⁱ	View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 1 hit
SUPFAMⁱ	SSF48726, SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 2 hits
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LIRB4_HUMAN
Accessionⁱ	Q8NHJ6Primary (citable) accession number: Q8NHJ6 Secondary accession number(s): A8MVL8 , O15468, O75021, Q6FGQ9, Q8N1C7, Q8NHL5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
	Last sequence update:	February 8, 2011
	Last modified:	February 23, 2022
	This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8NHJ6 (LIRB4_HUMAN)

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Leukocyte immunoglobulin-like receptor subfamily B member 4

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Q8NHJ6

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Keywords - Cellular componentⁱ

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Keywords - PTMⁱ

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