UniProtKB - Q8NHJ6 (LIRB4_HUMAN)
Leukocyte immunoglobulin-like receptor subfamily B member 4
LILRB4
Functioni
Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462).
Receptor for FN1 (PubMed:34089617).
Receptor for apolipoprotein APOE (PubMed:30333625).
Receptor for ALCAM/CD166 (PubMed:29263213).
Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699).
Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736).
This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617).
Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213).
Induces up-regulation of CD86 on dendritic cells (PubMed:19860908).
Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462).
8 PublicationsMiscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 35 | Required for APOE-mediated activation of LILRB41 Publication | 1 | |
Sitei | 106 | Required for APOE-mediated activation of LILRB41 Publication | 1 | |
Sitei | 121 | Required for APOE-mediated activation of LILRB41 Publication | 1 |
GO - Molecular functioni
- apolipoprotein binding Source: UniProtKB
- fibronectin binding Source: UniProtKB
- protein phosphatase binding Source: ARUK-UCL
- signaling receptor inhibitor activity Source: ARUK-UCL
- transmembrane receptor protein tyrosine kinase inhibitor activity Source: ARUK-UCL
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- Fc receptor mediated inhibitory signaling pathway Source: ARUK-UCL
- interleukin-10-mediated signaling pathway Source: ARUK-UCL
- negative regulation of activated T cell proliferation Source: ARUK-UCL
- negative regulation of chemokine production Source: ARUK-UCL
- negative regulation of cytokine production involved in inflammatory response Source: ARUK-UCL
- negative regulation of cytotoxic T cell differentiation Source: ARUK-UCL
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: ARUK-UCL
- negative regulation of interferon-gamma production Source: ARUK-UCL
- negative regulation of interleukin-10 production Source: ARUK-UCL
- negative regulation of interleukin-1 beta production Source: ARUK-UCL
- negative regulation of interleukin-2 production Source: ARUK-UCL
- negative regulation of interleukin-5 production Source: ARUK-UCL
- negative regulation of interleukin-6 production Source: ARUK-UCL
- negative regulation of IP-10 production Source: ARUK-UCL
- negative regulation of MAPK cascade Source: ARUK-UCL
- negative regulation of monocyte activation Source: UniProtKB
- negative regulation of osteoclast differentiation Source: UniProtKB
- negative regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- negative regulation of protein localization to nucleus Source: BHF-UCL
- negative regulation of protein tyrosine kinase activity Source: ARUK-UCL
- negative regulation of signaling receptor activity Source: ARUK-UCL
- negative regulation of T cell costimulation Source: ARUK-UCL
- negative regulation of T cell cytokine production Source: ARUK-UCL
- negative regulation of T cell proliferation Source: ARUK-UCL
- negative regulation of T cell receptor signaling pathway Source: BHF-UCL
- negative regulation of tumor necrosis factor production Source: UniProtKB
- positive regulation of CD8-positive, alpha-beta T cell differentiation Source: ARUK-UCL
- positive regulation of regulatory T cell differentiation Source: ARUK-UCL
- positive regulation of T cell anergy Source: ARUK-UCL
- receptor internalization Source: ARUK-UCL
- tolerance induction Source: ARUK-UCL
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q8NHJ6 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | Q8NHJ6 |
SIGNORi | Q8NHJ6 |
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte immunoglobulin-like receptor subfamily B member 4Short name: B41 Publication Alternative name(s): CD85 antigen-like family member K Immunoglobulin-like transcript 3 Short name: ILT-3 Leukocyte immunoglobulin-like receptor 5 Short name: LIR-5 Monocyte inhibitory receptor HM18 CD_antigen: CD85k |
Gene namesi | Name:LILRB4 Synonyms:ILT3, LIR5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6608, LILRB4 |
MIMi | 604821, gene |
neXtProti | NX_Q8NHJ6 |
VEuPathDBi | HostDB:ENSG00000186818 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein 1 Publication
Note: Ligand binding leads to internalization and translocation to an antigen-processing compartment.1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- integral component of the cytoplasmic side of the plasma membrane Source: ARUK-UCL
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 259 | ExtracellularSequence analysisAdd BLAST | 238 | |
Transmembranei | 260 – 280 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 281 – 448 | CytoplasmicSequence analysisAdd BLAST | 168 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 30 | T → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 35 | P → A: Significant reduction in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 41 | W → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 59 | R → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 63 | E → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 64 | E → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 65 | S → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 66 | P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 68 | P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 91 | D → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 95 | R → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 97 | R → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 103 | P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 106 | W → A: Significant reduction in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 109 | P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 111 | D → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 112 | P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 113 | L → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 114 | E → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 121 | Y → A: Significant reduction in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 122 | S → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 147 | R → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 149 | P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 162 | H → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 164 | L → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 165 | L → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 167 | L → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 170 | E → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 183 | S → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 184 | P → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 186 | T → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 188 | V → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 199 | H → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 201 | F → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 | |
Mutagenesisi | 202 | S → A: No significant change in APOE-mediated activation of LILRB4. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 11006 |
PharmGKBi | PA30382 |
Miscellaneous databases
Pharosi | Q8NHJ6, Tbio |
Genetic variation databases
BioMutai | LILRB4 |
DMDMi | 322510117 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000014823 | 22 – 448 | Leukocyte immunoglobulin-like receptor subfamily B member 4Add BLAST | 427 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 98 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 144 ↔ 195 | PROSITE-ProRule annotation1 Publication | ||
Modified residuei | 319 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
jPOSTi | Q8NHJ6 |
MassIVEi | Q8NHJ6 |
PaxDbi | Q8NHJ6 |
PeptideAtlasi | Q8NHJ6 |
PRIDEi | Q8NHJ6 |
ProteomicsDBi | 73714 [Q8NHJ6-1] 73715 [Q8NHJ6-2] 73716 [Q8NHJ6-3] |
PTM databases
GlyGeni | Q8NHJ6, 2 sites, 3 O-linked glycans (2 sites) |
iPTMneti | Q8NHJ6 |
PhosphoSitePlusi | Q8NHJ6 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000186818, Expressed in layer of synovial tissue and 167 other tissues |
ExpressionAtlasi | Q8NHJ6, baseline and differential |
Genevisiblei | Q8NHJ6, HS |
Organism-specific databases
HPAi | ENSG00000186818, Tissue enhanced (lung, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with PTPN6.
2 PublicationsBinary interactionsi
Q8NHJ6
With | #Exp. | IntAct |
---|---|---|
PTPN6 [P29350] | 4 | EBI-2805248,EBI-78260 |
GO - Molecular functioni
- apolipoprotein binding Source: UniProtKB
- fibronectin binding Source: UniProtKB
- protein phosphatase binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 116197, 23 interactors |
IntActi | Q8NHJ6, 15 interactors |
STRINGi | 9606.ENSP00000375616 |
Miscellaneous databases
RNActi | Q8NHJ6, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8NHJ6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 118 | Ig-like C2-type 1Add BLAST | 92 | |
Domaini | 124 – 218 | Ig-like C2-type 2Add BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 217 – 248 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 297 – 448 | DisorderedSequence analysisAdd BLAST | 152 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 358 – 363 | ITIM motif 1 | 6 | |
Motifi | 410 – 415 | ITIM motif 2 | 6 | |
Motifi | 440 – 445 | ITIM motif 3 | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 340 – 371 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 385 – 400 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 410 – 429 | Polar residuesSequence analysisAdd BLAST | 20 |
Domaini
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RU0A, Eukaryota |
InParanoidi | Q8NHJ6 |
OrthoDBi | 1000446at2759 |
PhylomeDBi | Q8NHJ6 |
TreeFami | TF336644 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 25 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ
60 70 80 90 100
GTLEAREYRL DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY
110 120 130 140 150
RSPVGWSQPS DPLELVMTGA YSKPTLSALP SPLVTSGKSV TLLCQSRSPM
160 170 180 190 200
DTFLLIKERA AHPLLHLRSE HGAQQHQAEF PMSPVTSVHG GTYRCFSSHG
210 220 230 240 250
FSHYLLSHPS DPLELIVSGS LEDPRPSPTR SVSTAAGPED QPLMPTGSVP
260 270 280 290 300
HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR
310 320 330 340 350
PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRQSP
360 370 380 390 400
HDEDPQAVTY AKVKHSRPRR EMASPPSPLS GEFLDTKDRQ AEEDRQMDTE
410 420 430 440
AAASEAPQDV TYAQLHSFTL RQKATEPPPS QEGASPAEPS VYATLAIH
Computationally mapped potential isoform sequencesi
There are 25 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSZ8 | A0A0A0MSZ8_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB4 | 447 | Annotation score: | ||
C9JST2 | C9JST2_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB4 | 399 | Annotation score: | ||
A0A0A0MS20 | A0A0A0MS20_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB4 | 449 | Annotation score: | ||
A0A0G2JM57 | A0A0G2JM57_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB4 | 447 | Annotation score: | ||
A0A0G2JMH7 | A0A0G2JMH7_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB4 | 449 | Annotation score: | ||
A0A0G2JP84 | A0A0G2JP84_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB4 | 447 | Annotation score: | ||
A0A0G2JPC7 | A0A0G2JPC7_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB4 | 447 | Annotation score: | ||
A0A0G2JPU4 | A0A0G2JPU4_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB4 | 449 | Annotation score: | ||
A0A0G2JPX5 | A0A0G2JPX5_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB4 | 449 | Annotation score: | ||
A0A0G2JM38 | A0A0G2JM38_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB4 | 437 | Annotation score: | ||
There are more potential isoformsShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025501 | 5 | F → L1 PublicationCorresponds to variant dbSNP:rs28366008Ensembl. | 1 | |
Natural variantiVAR_025502 | 18 | R → S. Corresponds to variant dbSNP:rs11540761Ensembl. | 1 | |
Natural variantiVAR_047846 | 20 | H → D1 PublicationCorresponds to variant dbSNP:rs11540762Ensembl. | 1 | |
Natural variantiVAR_017014 | 223 | D → G4 PublicationsCorresponds to variant dbSNP:rs731170Ensembl. | 1 | |
Natural variantiVAR_025503 | 330 | C → Y. Corresponds to variant dbSNP:rs11574575Ensembl. | 1 | |
Natural variantiVAR_025504 | 335 | N → D. Corresponds to variant dbSNP:rs11574576Ensembl. | 1 | |
Natural variantiVAR_017015 | 362 | K → E1 PublicationCorresponds to variant dbSNP:rs2764337Ensembl. | 1 | |
Natural variantiVAR_030939 | 362 | K → T. Corresponds to variant dbSNP:rs11574589Ensembl. | 1 | |
Natural variantiVAR_025505 | 414 | Q → R2 PublicationsCorresponds to variant dbSNP:rs1048801Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035939 | 330 | C → SG in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_008460 | 348 | Missing in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91925 mRNA Translation: AAB68665.1 AF025532 mRNA Translation: AAB87666.1 AF189768 Genomic DNA Translation: AAG02024.1 AF283988 mRNA Translation: AAL36992.1 CR542048 mRNA Translation: CAG46845.1 CR609786 mRNA No translation available. AC009892 Genomic DNA No translation available. AC011515 Genomic DNA No translation available. BC026309 mRNA Translation: AAH26309.1 |
CCDSi | CCDS12902.1 [Q8NHJ6-1] CCDS42618.1 [Q8NHJ6-2] |
RefSeqi | NP_001265355.2, NM_001278426.3 NP_001265356.2, NM_001278427.3 NP_001265357.2, NM_001278428.3 NP_001265358.2, NM_001278429.3 NP_001265359.2, NM_001278430.3 |
Genome annotation databases
Ensembli | ENST00000391736; ENSP00000375616; ENSG00000186818 ENST00000612454; ENSP00000479829; ENSG00000275730 ENST00000614699; ENSP00000478542; ENSG00000275730 [Q8NHJ6-3] ENST00000621693; ENSP00000482234; ENSG00000275730 [Q8NHJ6-2] |
GeneIDi | 11006 |
KEGGi | hsa:11006 |
UCSCi | uc002qgp.5, human [Q8NHJ6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91925 mRNA Translation: AAB68665.1 AF025532 mRNA Translation: AAB87666.1 AF189768 Genomic DNA Translation: AAG02024.1 AF283988 mRNA Translation: AAL36992.1 CR542048 mRNA Translation: CAG46845.1 CR609786 mRNA No translation available. AC009892 Genomic DNA No translation available. AC011515 Genomic DNA No translation available. BC026309 mRNA Translation: AAH26309.1 |
CCDSi | CCDS12902.1 [Q8NHJ6-1] CCDS42618.1 [Q8NHJ6-2] |
RefSeqi | NP_001265355.2, NM_001278426.3 NP_001265356.2, NM_001278427.3 NP_001265357.2, NM_001278428.3 NP_001265358.2, NM_001278429.3 NP_001265359.2, NM_001278430.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3P2T | X-ray | 1.70 | A | 24-219 | [»] | |
6K7O | X-ray | 3.00 | A/P/Q/R | 24-118 | [»] | |
SMRi | Q8NHJ6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116197, 23 interactors |
IntActi | Q8NHJ6, 15 interactors |
STRINGi | 9606.ENSP00000375616 |
PTM databases
GlyGeni | Q8NHJ6, 2 sites, 3 O-linked glycans (2 sites) |
iPTMneti | Q8NHJ6 |
PhosphoSitePlusi | Q8NHJ6 |
Genetic variation databases
BioMutai | LILRB4 |
DMDMi | 322510117 |
Proteomic databases
jPOSTi | Q8NHJ6 |
MassIVEi | Q8NHJ6 |
PaxDbi | Q8NHJ6 |
PeptideAtlasi | Q8NHJ6 |
PRIDEi | Q8NHJ6 |
ProteomicsDBi | 73714 [Q8NHJ6-1] 73715 [Q8NHJ6-2] 73716 [Q8NHJ6-3] |
Protocols and materials databases
Antibodypediai | 35096, 297 antibodies from 28 providers |
DNASUi | 11006 |
Genome annotation databases
Ensembli | ENST00000391736; ENSP00000375616; ENSG00000186818 ENST00000612454; ENSP00000479829; ENSG00000275730 ENST00000614699; ENSP00000478542; ENSG00000275730 [Q8NHJ6-3] ENST00000621693; ENSP00000482234; ENSG00000275730 [Q8NHJ6-2] |
GeneIDi | 11006 |
KEGGi | hsa:11006 |
UCSCi | uc002qgp.5, human [Q8NHJ6-1] |
Organism-specific databases
CTDi | 11006 |
DisGeNETi | 11006 |
GeneCardsi | LILRB4 |
HGNCi | HGNC:6608, LILRB4 |
HPAi | ENSG00000186818, Tissue enhanced (lung, lymphoid tissue) |
MIMi | 604821, gene |
neXtProti | NX_Q8NHJ6 |
PharmGKBi | PA30382 |
VEuPathDBi | HostDB:ENSG00000186818 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU0A, Eukaryota |
InParanoidi | Q8NHJ6 |
OrthoDBi | 1000446at2759 |
PhylomeDBi | Q8NHJ6 |
TreeFami | TF336644 |
Enzyme and pathway databases
PathwayCommonsi | Q8NHJ6 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
SignaLinki | Q8NHJ6 |
SIGNORi | Q8NHJ6 |
Miscellaneous databases
BioGRID-ORCSi | 11006, 4 hits in 1028 CRISPR screens |
ChiTaRSi | LILRB4, human |
GeneWikii | LILRB4 |
GenomeRNAii | 11006 |
Pharosi | Q8NHJ6, Tbio |
PROi | PR:Q8NHJ6 |
RNActi | Q8NHJ6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186818, Expressed in layer of synovial tissue and 167 other tissues |
ExpressionAtlasi | Q8NHJ6, baseline and differential |
Genevisiblei | Q8NHJ6, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF13895, Ig_2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LIRB4_HUMAN | |
Accessioni | Q8NHJ6Primary (citable) accession number: Q8NHJ6 Secondary accession number(s): A8MVL8 Q8NHL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | February 8, 2011 | |
Last modified: | February 23, 2022 | |
This is version 169 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references