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Entry version 132 (17 Jun 2020)
Sequence version 2 (16 Sep 2015)
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Protein

Tubulin polyglutamylase TTLL11

Gene

TTLL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Generates long side-chains (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei385ATPBy similarity1
Binding sitei387ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi372 – 375ATP bindingBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin polyglutamylase TTLL11 (EC:6.-.-.-By similarity)
Alternative name(s):
Tubulin--tyrosine ligase-like protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTLL11
Synonyms:C9orf20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000175764.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18113 TTLL11

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NHH1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi578 – 581KKKR → EEEE: Decreased binding to microtubules and polyglutamylase activity; when associated with E-416 and E-419. 1 Publication4

Organism-specific databases

DisGeNET

More...
DisGeNETi
158135

Open Targets

More...
OpenTargetsi
ENSG00000175764

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25977

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NHH1 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTLL11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73920150

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124451 – 800Tubulin polyglutamylase TTLL11Add BLAST800

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NHH1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NHH1

PeptideAtlas

More...
PeptideAtlasi
Q8NHH1

PRoteomics IDEntifications database

More...
PRIDEi
Q8NHH1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
29811
73708

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NHH1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NHH1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175764 Expressed in C1 segment of cervical spinal cord and 118 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NHH1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NHH1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000175764 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127650, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NHH1, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8NHH1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321346

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NHH1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NHH1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini218 – 570TTLPROSITE-ProRule annotationAdd BLAST353

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni557 – 628c-MTBD region1 PublicationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.By similarity1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2158 Eukaryota
ENOG410XNWC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156689

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_532730_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NHH1

KEGG Orthology (KO)

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KOi
K16604

Identification of Orthologs from Complete Genome Data

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OMAi
DCNANPE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NHH1

TreeFam database of animal gene trees

More...
TreeFami
TF313087

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR004344 TTL/TTLL_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03133 TTL, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51221 TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NHH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAASVTGR VTWAASPMRS LGLGRRLSLP GPRLDAVTAA VNPSLSDHGN
60 70 80 90 100
GLGRGTRGSG CSGGSLVADW GGGAAAAAAV ALALAPALST MRRGSSESEL
110 120 130 140 150
AARWEAEAVA AAKAAAKAEA EATAETVAEQ VRVDAGAAGE PECKAGEEQP
160 170 180 190 200
KVLAPAPAQP SAAEEGNTQV LQRPPPTLPP SKPKPVQGLC PHGKPRDKGR
210 220 230 240 250
SCKRSSGHGS GENGSQRPVT VDSSKARTSL DALKISIRQL KWKEFPFGRR
260 270 280 290 300
LPCDIYWHGV SFHDNDIFSG QVNKFPGMTE MVRKITLSRA VRTMQNLFPE
310 320 330 340 350
EYNFYPRSWI LPDEFQLFVA QVQMVKDDDP SWKPTFIVKP DGGCQGDGIY
360 370 380 390 400
LIKDPSDIRL AGTLQSRPAV VQEYICKPLL IDKLKFDIRL YVLLKSLDPL
410 420 430 440 450
EIYIAKDGLS RFCTEPYQEP TPKNLHRIFM HLTNYSLNIH SGNFIHSDSA
460 470 480 490 500
STGSKRTFSS ILCRLSSKGV DIKKVWSDII SVVIKTVIAL TPELKVFYQS
510 520 530 540 550
DIPTGRPGPT CFQILGFDIL LMKNLKPILL EVNANPSMRI EHEHELSPGV
560 570 580 590 600
FENVPSLVDE EVKVAVIRDT LRLMDPLKKK RENQSQQLEK PFAGKEDALD
610 620 630 640 650
GELTSAPDCN ANPEAHLPSI CLKQVFPKYA KQFNYLRLVD RMANLFIRFL
660 670 680 690 700
GIKGTMKLGP TGFRTFIRSC KLSSSSLSMA AVDILYIDIT RRWNSMTLDQ
710 720 730 740 750
RDSGMCLQAF VEAFFFLAQR KFKMLPLHEQ VASLIDLCEY HLSLLDEKRL
760 770 780 790 800
VCGRGVPSGG RPPHRGPPQE PSPSAQPAGD NPPPRTSCAN KLSHPRHTLS
Length:800
Mass (Da):87,612
Last modified:September 16, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB9C75CC06124C27
GO
Isoform 2 (identifier: Q8NHH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-538: ILGFDILLMKNLKPILLEVNANPSM → VTIASSQPAFPALTGLKRALWLRVG
     539-800: Missing.

Show »
Length:538
Mass (Da):58,035
Checksum:i0F23492469C2B0A7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVF6A0A087WVF6_HUMAN
Tubulin polyglutamylase TTLL11
TTLL11
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU58A0A087WU58_HUMAN
Tubulin polyglutamylase TTLL11
TTLL11
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUG8A0A087WUG8_HUMAN
Tubulin polyglutamylase TTLL11
TTLL11
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_057853514 – 538ILGFD…ANPSM → VTIASSQPAFPALTGLKRAL WLRVG in isoform 2. Add BLAST25
Alternative sequenceiVSP_057854539 – 800Missing in isoform 2. Add BLAST262

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF521886 mRNA Translation: AAM81328.1
AL162423 Genomic DNA No translation available.
AL442634 Genomic DNA No translation available.
AL445587 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48012.1 [Q8NHH1-1]
CCDS6834.2 [Q8NHH1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001132914.1, NM_001139442.1 [Q8NHH1-1]
NP_919228.2, NM_194252.2 [Q8NHH1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000321582; ENSP00000321346; ENSG00000175764 [Q8NHH1-1]
ENST00000373776; ENSP00000362881; ENSG00000175764 [Q8NHH1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
158135

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:158135

UCSC genome browser

More...
UCSCi
uc004blt.2 human [Q8NHH1-1]
uc011lyl.3 human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521886 mRNA Translation: AAM81328.1
AL162423 Genomic DNA No translation available.
AL442634 Genomic DNA No translation available.
AL445587 Genomic DNA No translation available.
CCDSiCCDS48012.1 [Q8NHH1-1]
CCDS6834.2 [Q8NHH1-2]
RefSeqiNP_001132914.1, NM_001139442.1 [Q8NHH1-1]
NP_919228.2, NM_194252.2 [Q8NHH1-2]

3D structure databases

SMRiQ8NHH1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127650, 6 interactors
IntActiQ8NHH1, 2 interactors
MINTiQ8NHH1
STRINGi9606.ENSP00000321346

PTM databases

iPTMnetiQ8NHH1
PhosphoSitePlusiQ8NHH1

Polymorphism and mutation databases

BioMutaiTTLL11
DMDMi73920150

Proteomic databases

MassIVEiQ8NHH1
PaxDbiQ8NHH1
PeptideAtlasiQ8NHH1
PRIDEiQ8NHH1
ProteomicsDBi29811
73708

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
53016 16 antibodies

Genome annotation databases

EnsembliENST00000321582; ENSP00000321346; ENSG00000175764 [Q8NHH1-1]
ENST00000373776; ENSP00000362881; ENSG00000175764 [Q8NHH1-2]
GeneIDi158135
KEGGihsa:158135
UCSCiuc004blt.2 human [Q8NHH1-1]
uc011lyl.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
158135
DisGeNETi158135
EuPathDBiHostDB:ENSG00000175764.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTLL11
HGNCiHGNC:18113 TTLL11
HPAiENSG00000175764 Tissue enhanced (brain)
neXtProtiNX_Q8NHH1
OpenTargetsiENSG00000175764
PharmGKBiPA25977

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2158 Eukaryota
ENOG410XNWC LUCA
GeneTreeiENSGT00940000156689
HOGENOMiCLU_532730_0_0_1
InParanoidiQ8NHH1
KOiK16604
OMAiDCNANPE
PhylomeDBiQ8NHH1
TreeFamiTF313087

Enzyme and pathway databases

ReactomeiR-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
158135 2 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TTLL11 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
158135
PharosiQ8NHH1 Tdark

Protein Ontology

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PROi
PR:Q8NHH1
RNActiQ8NHH1 protein

Gene expression databases

BgeeiENSG00000175764 Expressed in C1 segment of cervical spinal cord and 118 other tissues
ExpressionAtlasiQ8NHH1 baseline and differential
GenevisibleiQ8NHH1 HS

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR004344 TTL/TTLL_fam
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTL11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NHH1
Secondary accession number(s): F8W6M1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: September 16, 2015
Last modified: June 17, 2020
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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