Small VCP/p97-interacting protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase binding Source: ParkinsonsUK-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation."
    Ballar P., Zhong Y., Nagahama M., Tagaya M., Shen Y., Fang S.
    J. Biol. Chem. 282:33908-33914(2007) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP)."
    Wu J., Peng D., Voehler M., Sanders C.R., Li J.
    Biochem. Biophys. Res. Commun. 440:173-178(2013) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• negative regulation of ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation."
    Ballar P., Zhong Y., Nagahama M., Tagaya M., Shen Y., Fang S.
    J. Biol. Chem. 282:33908-33914(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein complex assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation."
    Ballar P., Zhong Y., Nagahama M., Tagaya M., Shen Y., Fang S.
    J. Biol. Chem. 282:33908-33914(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "Identification of ERAD components essential for dislocation of the null Hong Kong variant of alpha-1-antitrypsin (NHK)."
    Zhong Y., Shen H., Wang Y., Yang Y., Yang P., Fang S.
    Biochem. Biophys. Res. Commun. 458:424-428(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly Source: Ensembl
• neutrophil degranulation Source: Reactome
• positive regulation of autophagy Source: UniProtKBInferred from mutant phenotypeⁱ
  • "SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy."
    Wang Y., Ballar P., Zhong Y., Zhang X., Liu C., Zhang Y.J., Monteiro M.J., Li J., Fang S.
    PLoS ONE 6:e24478-e24478(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein lipidation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy."
    Wang Y., Ballar P., Zhong Y., Zhang X., Liu C., Zhang Y.J., Monteiro M.J., Li J., Fang S.
    PLoS ONE 6:e24478-e24478(2011) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• ATPase binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation."
    Ballar P., Zhong Y., Nagahama M., Tagaya M., Shen Y., Fang S.
    J. Biol. Chem. 282:33908-33914(2007) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP)."
    Wu J., Peng D., Voehler M., Sanders C.R., Li J.
    Biochem. Biophys. Res. Commun. 440:173-178(2013) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MGLCFPCPGE SAPPTPDLEE KRAKLAEAAE RRQKEAASRG ILDVQSVQEK 
        60         70 
RKKKEKIEKQ IATSGPPPEG GLRWTVS                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Human chromosome 11
   Human chromosome 11: entries, gene names and cross-references to MIM