UniProtKB - Q8NHG7 (SVIP_HUMAN)
Protein
Small VCP/p97-interacting protein
Gene
SVIP
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATPase binding Source: ParkinsonsUK-UCL
- protein self-association Source: UniProtKB
GO - Biological processi
- negative regulation of ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
- negative regulation of protein-containing complex assembly Source: UniProtKB
- negative regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
- negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly Source: GO_Central
- neutrophil degranulation Source: Reactome
- positive regulation of autophagy Source: UniProtKB
- positive regulation of protein lipidation Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q8NHG7 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Small VCP/p97-interacting protein |
Gene namesi | Name:SVIP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25238, SVIP |
neXtProti | NX_Q8NHG7 |
VEuPathDBi | HostDB:ENSG00000198168.8 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity
Endoplasmic reticulum
- Smooth endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Other locations
- Membrane Curated; Lipid-anchor Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
- smooth endoplasmic reticulum membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- anchored component of membrane Source: ParkinsonsUK-UCL
- secretory granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 258010 |
OpenTargetsi | ENSG00000198168 |
PharmGKBi | PA164726394 |
Miscellaneous databases
Pharosi | Q8NHG7, Tbio |
Genetic variation databases
BioMutai | SVIP |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000072337 | 2 – 77 | Small VCP/p97-interacting proteinAdd BLAST | 76 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 | |
Modified residuei | 46 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Lipoprotein, Myristate, PhosphoproteinProteomic databases
EPDi | Q8NHG7 |
jPOSTi | Q8NHG7 |
MassIVEi | Q8NHG7 |
MaxQBi | Q8NHG7 |
PaxDbi | Q8NHG7 |
PeptideAtlasi | Q8NHG7 |
PRIDEi | Q8NHG7 |
ProteomicsDBi | 73706 |
PTM databases
iPTMneti | Q8NHG7 |
PhosphoSitePlusi | Q8NHG7 |
SwissPalmi | Q8NHG7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198168, Expressed in C1 segment of cervical spinal cord and 219 other tissues |
Genevisiblei | Q8NHG7, HS |
Organism-specific databases
HPAi | ENSG00000198168, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts (via VIM motif) with VCP.
1 PublicationBinary interactionsi
Q8NHG7
With | #Exp. | IntAct |
---|---|---|
UBXN6 [Q9BZV1] | 3 | EBI-2513231,EBI-1993899 |
GO - Molecular functioni
- ATPase binding Source: ParkinsonsUK-UCL
- protein self-association Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 129222, 22 interactors |
CORUMi | Q8NHG7 |
IntActi | Q8NHG7, 12 interactors |
MINTi | Q8NHG7 |
STRINGi | 9606.ENSP00000346130 |
Miscellaneous databases
RNActi | Q8NHG7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 21 – 33 | VCP/p97-interacting motif (VIM)1 PublicationAdd BLAST | 13 |
Sequence similaritiesi
Belongs to the SVIP family.Curated
Phylogenomic databases
eggNOGi | ENOG502S5MU, Eukaryota |
GeneTreei | ENSGT00390000007067 |
HOGENOMi | CLU_174267_1_0_1 |
InParanoidi | Q8NHG7 |
OMAi | CCGQSAE |
PhylomeDBi | Q8NHG7 |
Family and domain databases
InterProi | View protein in InterPro IPR031632, SVIP |
PANTHERi | PTHR35269, PTHR35269, 1 hit |
Pfami | View protein in Pfam PF15811, SVIP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8NHG7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLCFPCPGE SAPPTPDLEE KRAKLAEAAE RRQKEAASRG ILDVQSVQEK
60 70
RKKKEKIEKQ IATSGPPPEG GLRWTVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF527534 mRNA Translation: AAM88869.1 |
CCDSi | CCDS41627.1 |
RefSeqi | NP_001307269.1, NM_001320340.1 NP_001307271.1, NM_001320342.1 NP_683691.1, NM_148893.2 |
Genome annotation databases
Ensembli | ENST00000354193; ENSP00000346130; ENSG00000198168 |
GeneIDi | 258010 |
KEGGi | hsa:258010 |
UCSCi | uc001mqp.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF527534 mRNA Translation: AAM88869.1 |
CCDSi | CCDS41627.1 |
RefSeqi | NP_001307269.1, NM_001320340.1 NP_001307271.1, NM_001320342.1 NP_683691.1, NM_148893.2 |
3D structure databases
BMRBi | Q8NHG7 |
SMRi | Q8NHG7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129222, 22 interactors |
CORUMi | Q8NHG7 |
IntActi | Q8NHG7, 12 interactors |
MINTi | Q8NHG7 |
STRINGi | 9606.ENSP00000346130 |
PTM databases
iPTMneti | Q8NHG7 |
PhosphoSitePlusi | Q8NHG7 |
SwissPalmi | Q8NHG7 |
Genetic variation databases
BioMutai | SVIP |
Proteomic databases
EPDi | Q8NHG7 |
jPOSTi | Q8NHG7 |
MassIVEi | Q8NHG7 |
MaxQBi | Q8NHG7 |
PaxDbi | Q8NHG7 |
PeptideAtlasi | Q8NHG7 |
PRIDEi | Q8NHG7 |
ProteomicsDBi | 73706 |
Protocols and materials databases
Antibodypediai | 48732, 7 antibodies |
Genome annotation databases
Ensembli | ENST00000354193; ENSP00000346130; ENSG00000198168 |
GeneIDi | 258010 |
KEGGi | hsa:258010 |
UCSCi | uc001mqp.5, human |
Organism-specific databases
CTDi | 258010 |
DisGeNETi | 258010 |
GeneCardsi | SVIP |
HGNCi | HGNC:25238, SVIP |
HPAi | ENSG00000198168, Tissue enhanced (brain) |
neXtProti | NX_Q8NHG7 |
OpenTargetsi | ENSG00000198168 |
PharmGKBi | PA164726394 |
VEuPathDBi | HostDB:ENSG00000198168.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S5MU, Eukaryota |
GeneTreei | ENSGT00390000007067 |
HOGENOMi | CLU_174267_1_0_1 |
InParanoidi | Q8NHG7 |
OMAi | CCGQSAE |
PhylomeDBi | Q8NHG7 |
Enzyme and pathway databases
PathwayCommonsi | Q8NHG7 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 258010, 13 hits in 873 CRISPR screens |
ChiTaRSi | SVIP, human |
GenomeRNAii | 258010 |
Pharosi | Q8NHG7, Tbio |
PROi | PR:Q8NHG7 |
RNActi | Q8NHG7, protein |
Gene expression databases
Bgeei | ENSG00000198168, Expressed in C1 segment of cervical spinal cord and 219 other tissues |
Genevisiblei | Q8NHG7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031632, SVIP |
PANTHERi | PTHR35269, PTHR35269, 1 hit |
Pfami | View protein in Pfam PF15811, SVIP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SVIP_HUMAN | |
Accessioni | Q8NHG7Primary (citable) accession number: Q8NHG7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families