UniProtKB - Q8NHC7 (O14CZ_HUMAN)
Protein
Olfactory receptor 14C36
Gene
OR14C36
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- odorant binding Source: GO_Central
- olfactory receptor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
- sensory perception of smell Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 14C36Alternative name(s): Olfactory receptor 5BF1 Olfactory receptor OR1-59 |
Gene namesi | Name:OR14C36 Synonyms:OR5BF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177174.1 |
HGNCi | HGNC:15026 OR14C36 |
neXtProti | NX_Q8NHC7 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 23 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 24 – 44 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 45 – 52 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 53 – 73 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 74 – 97 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 98 – 118 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 137 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 138 – 158 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 159 – 194 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 195 – 215 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 216 – 235 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 236 – 256 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 269 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 270 – 290 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 291 – 312 | CytoplasmicSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000177174 |
PharmGKBi | PA162398442 |
Polymorphism and mutation databases
BioMutai | OR14C36 |
DMDMi | 38503051 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150589 | 1 – 312 | Olfactory receptor 14C36Add BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 95 ↔ 187 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q8NHC7 |
PaxDbi | Q8NHC7 |
PRIDEi | Q8NHC7 |
ProteomicsDBi | 73701 |
PTM databases
iPTMneti | Q8NHC7 |
PhosphoSitePlusi | Q8NHC7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177174 Expressed in 3 organ(s), highest expression level in hypothalamus |
Interactioni
Protein-protein interaction databases
IntActi | Q8NHC7, 1 interactor |
STRINGi | 9606.ENSP00000324534 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IJCG Eukaryota ENOG41120HT LUCA |
GeneTreei | ENSGT00940000153129 |
HOGENOMi | HOG000041364 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NHC7 |
KOi | K04257 |
OMAi | RIFYSEN |
OrthoDBi | 1077347at2759 |
PhylomeDBi | Q8NHC7 |
TreeFami | TF337248 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NHC7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPNSTTVMEF LLMRFSDVWT LQILHSASFF MLYLVTLMGN ILIVTVTTCD
60 70 80 90 100
SSLHMPMYFF LRNLSILDAC YISVTVPTSC VNSLLDSTTI SKAGCVAQVF
110 120 130 140 150
LVVFFVYVEL LFLTIMAHDR YVAVCQPLHY PVIVNSRICI QMTLASLLSG
160 170 180 190 200
LVYAGMHTGS TFQLPFCRSN VIHQFFCDIP SLLKLSCSDT FSNEVMIVVS
210 220 230 240 250
ALGVGGGCFI FIIRSYIHIF STVLGFPRGA DRTKAFSTCI PHILVVSVFL
260 270 280 290 300
SSCSSVYLRP PAIPAATQDL ILSGFYSIMP PLFNPIIYSL RNKQIKVAIK
310
KIMKRIFYSE NV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062070 | 141 | Q → R. Corresponds to variant dbSNP:rs28448343Ensembl. | 1 | |
Natural variantiVAR_062071 | 225 | G → R. Corresponds to variant dbSNP:rs28377739Ensembl. | 1 | |
Natural variantiVAR_062072 | 231 | D → Y. Corresponds to variant dbSNP:rs28545014Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065439 Genomic DNA Translation: BAC05706.1 AL450303 Genomic DNA No translation available. BK004466 Genomic DNA Translation: DAA04864.1 |
CCDSi | CCDS31112.1 |
RefSeqi | NP_001001918.1, NM_001001918.1 |
UniGenei | Hs.553583 |
Genome annotation databases
Ensembli | ENST00000317861; ENSP00000324534; ENSG00000177174 |
GeneIDi | 127066 |
KEGGi | hsa:127066 |
UCSCi | uc010pzl.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065439 Genomic DNA Translation: BAC05706.1 AL450303 Genomic DNA No translation available. BK004466 Genomic DNA Translation: DAA04864.1 |
CCDSi | CCDS31112.1 |
RefSeqi | NP_001001918.1, NM_001001918.1 |
UniGenei | Hs.553583 |
3D structure databases
ProteinModelPortali | Q8NHC7 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | Q8NHC7, 1 interactor |
STRINGi | 9606.ENSP00000324534 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q8NHC7 |
PhosphoSitePlusi | Q8NHC7 |
Polymorphism and mutation databases
BioMutai | OR14C36 |
DMDMi | 38503051 |
Proteomic databases
MaxQBi | Q8NHC7 |
PaxDbi | Q8NHC7 |
PRIDEi | Q8NHC7 |
ProteomicsDBi | 73701 |
Protocols and materials databases
DNASUi | 127066 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000317861; ENSP00000324534; ENSG00000177174 |
GeneIDi | 127066 |
KEGGi | hsa:127066 |
UCSCi | uc010pzl.2 human |
Organism-specific databases
CTDi | 127066 |
EuPathDBi | HostDB:ENSG00000177174.1 |
GeneCardsi | OR14C36 |
HGNCi | HGNC:15026 OR14C36 |
neXtProti | NX_Q8NHC7 |
OpenTargetsi | ENSG00000177174 |
PharmGKBi | PA162398442 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IJCG Eukaryota ENOG41120HT LUCA |
GeneTreei | ENSGT00940000153129 |
HOGENOMi | HOG000041364 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NHC7 |
KOi | K04257 |
OMAi | RIFYSEN |
OrthoDBi | 1077347at2759 |
PhylomeDBi | Q8NHC7 |
TreeFami | TF337248 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR5BF1 |
GenomeRNAii | 127066 |
PROi | PR:Q8NHC7 |
Gene expression databases
Bgeei | ENSG00000177174 Expressed in 3 organ(s), highest expression level in hypothalamus |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | O14CZ_HUMAN | |
Accessioni | Q8NHC7Primary (citable) accession number: Q8NHC7 Secondary accession number(s): Q6IEZ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 21, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 13, 2019 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries