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Protein

Olfactory receptor 14A16

Gene

OR14A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 14A16
Alternative name(s):
Olfactory receptor 5AT1
Olfactory receptor OR1-45
Gene namesi
Name:OR14A16
Synonyms:OR5AT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000196772.3
HGNCiHGNC:15022 OR14A16
neXtProtiNX_Q8NHC5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 131CytoplasmicSequence analysisAdd BLAST13
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 194ExtracellularSequence analysisAdd BLAST42
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 255Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini256 – 268ExtracellularSequence analysisAdd BLAST13
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 309CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196772
PharmGKBiPA162398441

Polymorphism and mutation databases

BioMutaiOR14A16
DMDMi38372837

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505811 – 309Olfactory receptor 14A16Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHC5
PRIDEiQ8NHC5
ProteomicsDBi73699

PTM databases

iPTMnetiQ8NHC5
PhosphoSitePlusiQ8NHC5

Expressioni

Gene expression databases

BgeeiENSG00000196772 Expressed in 2 organ(s), highest expression level in right testis
CleanExiHS_OR14A16

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000350248

Structurei

3D structure databases

ProteinModelPortaliQ8NHC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEM2 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00760000118849
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NHC5
KOiK04257
OMAiFCCFIVI
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NHC5
TreeFamiTF352740

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NHC5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANLTIVTEF ILMGFSTNKN MCILHSILFL LIYLCALMGN VLIIMITTLD
60 70 80 90 100
HHLHTPVYFF LKNLSFLDLC LISVTAPKSI ANSLIHNNSI SFLGCVSQVF
110 120 130 140 150
LLLSSASAEL LLLTVMSFDR YTAICHPLHY DVIMDRSTCV QRATVSWLYG
160 170 180 190 200
GLIAVMHTAG TFSLSYCGSN MVHQFFCDIP QLLAISCSEN LIREIALILI
210 220 230 240 250
NVVLDFCCFI VIIITYVHVF STVKKIPSTE GQSKAYSICL PHLLVVLFLS
260 270 280 290 300
TGFIAYLKPA SESPSILDAV ISVFYTMLPP TFNPIIYSLR NKAIKVALGM

LIKGKLTKK
Length:309
Mass (Da):34,307
Last modified:October 1, 2002 - v1
Checksum:iC5A4E2C8E8A06A76
GO

Sequence cautioni

The sequence DAA04764 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043796238I → T. Corresponds to variant dbSNP:rs6695283Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065441 Genomic DNA Translation: BAC05708.1
BK004366 Genomic DNA Translation: DAA04764.1 Different initiation.
CCDSiCCDS31097.1
RefSeqiNP_001001966.1, NM_001001966.1
UniGeneiHs.626620

Genome annotation databases

EnsembliENST00000357627; ENSP00000350248; ENSG00000196772
ENST00000641093; ENSP00000493024; ENSG00000196772
GeneIDi284532
KEGGihsa:284532
UCSCiuc001idm.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065441 Genomic DNA Translation: BAC05708.1
BK004366 Genomic DNA Translation: DAA04764.1 Different initiation.
CCDSiCCDS31097.1
RefSeqiNP_001001966.1, NM_001001966.1
UniGeneiHs.626620

3D structure databases

ProteinModelPortaliQ8NHC5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000350248

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NHC5
PhosphoSitePlusiQ8NHC5

Polymorphism and mutation databases

BioMutaiOR14A16
DMDMi38372837

Proteomic databases

PaxDbiQ8NHC5
PRIDEiQ8NHC5
ProteomicsDBi73699

Protocols and materials databases

DNASUi284532
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357627; ENSP00000350248; ENSG00000196772
ENST00000641093; ENSP00000493024; ENSG00000196772
GeneIDi284532
KEGGihsa:284532
UCSCiuc001idm.1 human

Organism-specific databases

CTDi284532
EuPathDBiHostDB:ENSG00000196772.3
GeneCardsiOR14A16
HGNCiHGNC:15022 OR14A16
neXtProtiNX_Q8NHC5
OpenTargetsiENSG00000196772
PharmGKBiPA162398441
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEM2 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00760000118849
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NHC5
KOiK04257
OMAiFCCFIVI
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NHC5
TreeFamiTF352740

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR5AT1
GenomeRNAii284532
PROiPR:Q8NHC5

Gene expression databases

BgeeiENSG00000196772 Expressed in 2 organ(s), highest expression level in right testis
CleanExiHS_OR14A16

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO14AG_HUMAN
AccessioniPrimary (citable) accession number: Q8NHC5
Secondary accession number(s): Q6IF96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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