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Protein

Olfactory receptor 5K2

Gene

OR5K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5K2
Alternative name(s):
Olfactory receptor OR3-9
Gene namesi
Name:OR5K2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000231861.2
HGNCiHGNC:14774 OR5K2
neXtProtiNX_Q8NHB8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 316CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32543

Polymorphism and mutation databases

BioMutaiOR5K2
DMDMi134047867

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506011 – 316Olfactory receptor 5K2Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHB8
PeptideAtlasiQ8NHB8
PRIDEiQ8NHB8
ProteomicsDBi73697

PTM databases

iPTMnetiQ8NHB8
PhosphoSitePlusiQ8NHB8

Expressioni

Gene expression databases

BgeeiENSG00000231861
CleanExiHS_OR5K2
ExpressionAtlasiQ8NHB8 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ8NHB8, 1 interactor
STRINGi9606.ENSP00000393889

Structurei

3D structure databases

ProteinModelPortaliQ8NHB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9MS Eukaryota
ENOG41116R8 LUCA
GeneTreeiENSGT00550000074564
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NHB8
KOiK04257
OMAiIQIFTIC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NHB8
TreeFamiTF352737

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NHB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEENHTMKN EFILTGFTDH PELKTLLFVV FFAIYLITVV GNISLVALIF
60 70 80 90 100
THCRLHTPMY IFLGNLALVD SCCACAITPK MLENFFSEGK RISLYECAVQ
110 120 130 140 150
FYFLCTVETA DCFLLAAVAY DRYVAICNPL QYHIMMSKKL CIQMTTGAFI
160 170 180 190 200
AGNLHSMIHV GLVFRLVFCG LNHINHFYCD TLPLYRLSCV DPFINELVLF
210 220 230 240 250
IFSGSVQVFT IGSVLISYLY ILLTIFRMKS KEGRAKAFST CASHFSSVSL
260 270 280 290 300
FYGSIFFLYI RPNLLEEGGN DIPAAILFTI VVPLLNPFIY SLRNKEVISV
310
LRKILLKIKS QGSVNK
Length:316
Mass (Da):35,763
Last modified:March 20, 2007 - v3
Checksum:i3FB40EFC6C9DA2A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53C → R in AC074274 (PubMed:16641997).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065457 Genomic DNA Translation: BAC05717.1
AC074274 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79861.1
BC136724 mRNA Translation: AAI36725.1
BC136725 mRNA Translation: AAI36726.1
BK004415 Genomic DNA Translation: DAA04813.1
CCDSiCCDS33804.1
RefSeqiNP_001004737.1, NM_001004737.1
UniGeneiHs.632558

Genome annotation databases

EnsembliENST00000427338; ENSP00000393889; ENSG00000231861
GeneIDi402135
KEGGihsa:402135
UCSCiuc011bgx.3 human

Similar proteinsi

Entry informationi

Entry nameiOR5K2_HUMAN
AccessioniPrimary (citable) accession number: Q8NHB8
Secondary accession number(s): B2RN70, Q6IF47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 20, 2007
Last modified: June 20, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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