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Protein

Olfactory receptor 1L3

Gene

OR1L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L3
Alternative name(s):
Olfactory receptor 9-D
Short name:
OR9-D
Olfactory receptor OR9-28
Gene namesi
Name:OR1L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000171481.3
HGNCiHGNC:8215 OR1L3
neXtProtiNX_Q8NH93

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 196ExtracellularSequence analysisAdd BLAST38
Transmembranei197 – 219Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 271ExtracellularSequence analysisAdd BLAST12
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 324CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32085

Polymorphism and mutation databases

BioMutaiOR1L3
DMDMi38372830

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504431 – 324Olfactory receptor 1L3Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8NH93
PaxDbiQ8NH93
PeptideAtlasiQ8NH93
PRIDEiQ8NH93
ProteomicsDBi73689

Expressioni

Gene expression databases

BgeeiENSG00000171481 Expressed in 2 organ(s), highest expression level in lung
CleanExiHS_OR1L3
ExpressionAtlasiQ8NH93 baseline and differential

Organism-specific databases

HPAiHPA058878

Interactioni

Protein-protein interaction databases

IntActiQ8NH93, 1 interactor
STRINGi9606.ENSP00000302863

Structurei

3D structure databases

ProteinModelPortaliQ8NH93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFXJ Eukaryota
ENOG41114P7 LUCA
GeneTreeiENSGT00910000144098
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NH93
KOiK04257
OMAiITFSYLH
OrthoDBiEOG091G0B53
PhylomeDBiQ8NH93
TreeFamiTF341149

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMSNLTRLS EFILLGLSSR SEDQRPLFAL FLIIYLVTLM GNLLIILAIH
60 70 80 90 100
SDPRLQNPMY FFLSILSFAD ICYTTVIVPK MLVNFLSEKK TISYAECLAQ
110 120 130 140 150
MYFFLVFGNI DSYLLAAMAI NRCVAICNPF HYVTVMNRRC CVLLLAFPIT
160 170 180 190 200
FSYFHSLLHV LLVNRLTFCT SNVIHHFFCD VNPVLKLSCS STFVNEIVAM
210 220 230 240 250
TEGLASVMAP FVCIIISYLR ILIAVLKIPS AAGKHKAFST CSSHLTVVIL
260 270 280 290 300
FYGSISYVYL QPLSSYTVKD RIATINYTVL TSVLNPFIYS LRNKDMKRGL
310 320
QKLINKIKSQ MSRFSTKTNK ICGP
Length:324
Mass (Da):36,633
Last modified:October 1, 2002 - v1
Checksum:i088889EBE28353F8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05997954R → G. Corresponds to variant dbSNP:rs12379744Ensembl.1
Natural variantiVAR_034169106V → A. Corresponds to variant dbSNP:rs16912096Ensembl.1
Natural variantiVAR_034170121N → D. Corresponds to variant dbSNP:rs16912099Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065492 Genomic DNA Translation: BAC05744.1
AL162254 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87541.1
BC136857 mRNA Translation: AAI36858.1
BC136859 mRNA Translation: AAI36860.1
BK004231 Genomic DNA Translation: DAA04629.1
CCDSiCCDS35128.1
RefSeqiNP_001005234.1, NM_001005234.1
UniGeneiHs.626839

Genome annotation databases

EnsembliENST00000304820; ENSP00000302863; ENSG00000171481
GeneIDi26735
KEGGihsa:26735
UCSCiuc011lzb.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065492 Genomic DNA Translation: BAC05744.1
AL162254 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87541.1
BC136857 mRNA Translation: AAI36858.1
BC136859 mRNA Translation: AAI36860.1
BK004231 Genomic DNA Translation: DAA04629.1
CCDSiCCDS35128.1
RefSeqiNP_001005234.1, NM_001005234.1
UniGeneiHs.626839

3D structure databases

ProteinModelPortaliQ8NH93
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NH93, 1 interactor
STRINGi9606.ENSP00000302863

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR1L3
DMDMi38372830

Proteomic databases

MaxQBiQ8NH93
PaxDbiQ8NH93
PeptideAtlasiQ8NH93
PRIDEiQ8NH93
ProteomicsDBi73689

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304820; ENSP00000302863; ENSG00000171481
GeneIDi26735
KEGGihsa:26735
UCSCiuc011lzb.2 human

Organism-specific databases

CTDi26735
EuPathDBiHostDB:ENSG00000171481.3
GeneCardsiOR1L3
HGNCiHGNC:8215 OR1L3
HPAiHPA058878
neXtProtiNX_Q8NH93
PharmGKBiPA32085
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFXJ Eukaryota
ENOG41114P7 LUCA
GeneTreeiENSGT00910000144098
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NH93
KOiK04257
OMAiITFSYLH
OrthoDBiEOG091G0B53
PhylomeDBiQ8NH93
TreeFamiTF341149

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR1L3
GenomeRNAii26735
PROiPR:Q8NH93

Gene expression databases

BgeeiENSG00000171481 Expressed in 2 organ(s), highest expression level in lung
CleanExiHS_OR1L3
ExpressionAtlasiQ8NH93 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR1L3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH93
Secondary accession number(s): B2RNF4, Q6IFN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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