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Protein

Putative olfactory receptor 10D3

Gene

OR10D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Odorant receptor.Curated

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 10D3
Alternative name(s):
HTPCRX09
Olfactory receptor OR11-293
Gene namesi
Name:OR10D3
Synonyms:OR10D3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000197309.2
HGNCiHGNC:8168 OR10D3
neXtProtiNX_Q8NH80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 57CytoplasmicSequence analysis10
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 97ExtracellularSequence analysisAdd BLAST19
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 239CytoplasmicSequence analysisAdd BLAST21
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 266ExtracellularSequence analysis6
Transmembranei267 – 287Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini288 – 312CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74760322

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003492281 – 312Putative olfactory receptor 10D3Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NH80
PRIDEiQ8NH80
ProteomicsDBi73681

Expressioni

Gene expression databases

BgeeiENSG00000197309 Expressed in 3 organ(s), highest expression level in right testis
GenevisibleiQ8NH80 HS

Organism-specific databases

HPAiHPA049991

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323895

Structurei

3D structure databases

ProteinModelPortaliQ8NH80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE50 Eukaryota
ENOG4111430 LUCA
GeneTreeiENSGT00760000119161
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH80
OMAiFLPFYAC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH80
TreeFamiTF336512

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKNCCMVT EFILLGIPHT EGLEMTLFVL FLPFYACTLL GNVSILVAVM
60 70 80 90 100
SSARLHTPMY FFLGNLSVFD MGFSSVTCPK MLLYLMGLSR LISYKDCVCQ
110 120 130 140 150
LFFFHFLGSI ECFLFTVMAY DRFTAICYPL RYTVIMNPRI CVALAVGTWL
160 170 180 190 200
LGCIHSSILT SLTFTLPYCG PNEVDHFFCD IPALLPLACA DTSLAQRVSF
210 220 230 240 250
TNVGLISLVC FLLILLSYTR ITISILSIRT TEGRRRAFST CSAHLIAILC
260 270 280 290 300
AYGPIITVYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKTALK
310
TILHRTGHVP ES
Length:312
Mass (Da):34,812
Last modified:October 1, 2002 - v1
Checksum:i2C08D37947CA71AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134V → A in X64983 (PubMed:1370859).Curated1
Sequence conflicti202N → S in X64983 (PubMed:1370859).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065509 Genomic DNA Translation: BAC05757.1
X64983 mRNA No translation available.
BK004425 Genomic DNA Translation: DAA04823.1
CCDSiCCDS86257.1
UniGeneiHs.538726

Genome annotation databases

EnsembliENST00000318666; ENSP00000323895; ENSG00000197309
ENST00000641351; ENSP00000493028; ENSG00000197309
ENST00000641546; ENSP00000493231; ENSG00000197309
UCSCiuc001pzv.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065509 Genomic DNA Translation: BAC05757.1
X64983 mRNA No translation available.
BK004425 Genomic DNA Translation: DAA04823.1
CCDSiCCDS86257.1
UniGeneiHs.538726

3D structure databases

ProteinModelPortaliQ8NH80
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323895

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi74760322

Proteomic databases

PaxDbiQ8NH80
PRIDEiQ8NH80
ProteomicsDBi73681

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318666; ENSP00000323895; ENSG00000197309
ENST00000641351; ENSP00000493028; ENSG00000197309
ENST00000641546; ENSP00000493231; ENSG00000197309
UCSCiuc001pzv.3 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000197309.2
GeneCardsiOR10D3
HGNCiHGNC:8168 OR10D3
HPAiHPA049991
neXtProtiNX_Q8NH80
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE50 Eukaryota
ENOG4111430 LUCA
GeneTreeiENSGT00760000119161
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH80
OMAiFLPFYAC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH80
TreeFamiTF336512

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

PROiPR:Q8NH80

Gene expression databases

BgeeiENSG00000197309 Expressed in 3 organ(s), highest expression level in right testis
GenevisibleiQ8NH80 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10D3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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