UniProtKB - Q8NH80 (O10D3_HUMAN)
Protein
Putative olfactory receptor 10D3
Gene
OR10D3
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
Caution
Could be the product of a pseudogene.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Putative olfactory receptor 10D3Alternative name(s): HTPCRX09 Olfactory receptor OR11-293 |
Gene namesi | Name:OR10D3 Synonyms:OR10D3P |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197309.2 |
HGNCi | HGNC:8168 OR10D3 |
neXtProti | NX_Q8NH80 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 27 – 47 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 48 – 57 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 58 – 78 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 97 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 98 – 118 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 139 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 140 – 160 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 197 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 198 – 218 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 219 – 239 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 240 – 260 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 261 – 266 | ExtracellularSequence analysis | 6 | |
Transmembranei | 267 – 287 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 288 – 312 | CytoplasmicSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349228 | 1 – 312 | Putative olfactory receptor 10D3Add BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 97 ↔ 179 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q8NH80 |
PRIDEi | Q8NH80 |
ProteomicsDBi | 73681 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197309 Expressed in 3 organ(s), highest expression level in right testis |
Genevisiblei | Q8NH80 HS |
Organism-specific databases
HPAi | HPA049991 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IE50 Eukaryota ENOG4111430 LUCA |
GeneTreei | ENSGT00940000153281 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NH80 |
OMAi | FLPFYAC |
PhylomeDBi | Q8NH80 |
TreeFami | TF336512 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NH80-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVKNCCMVT EFILLGIPHT EGLEMTLFVL FLPFYACTLL GNVSILVAVM
60 70 80 90 100
SSARLHTPMY FFLGNLSVFD MGFSSVTCPK MLLYLMGLSR LISYKDCVCQ
110 120 130 140 150
LFFFHFLGSI ECFLFTVMAY DRFTAICYPL RYTVIMNPRI CVALAVGTWL
160 170 180 190 200
LGCIHSSILT SLTFTLPYCG PNEVDHFFCD IPALLPLACA DTSLAQRVSF
210 220 230 240 250
TNVGLISLVC FLLILLSYTR ITISILSIRT TEGRRRAFST CSAHLIAILC
260 270 280 290 300
AYGPIITVYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKTALK
310
TILHRTGHVP ES
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 134 | V → A in X64983 (PubMed:1370859).Curated | 1 | |
Sequence conflicti | 202 | N → S in X64983 (PubMed:1370859).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065509 Genomic DNA Translation: BAC05757.1 X64983 mRNA No translation available. BK004425 Genomic DNA Translation: DAA04823.1 |
CCDSi | CCDS86257.1 |
UniGenei | Hs.538726 |
Genome annotation databases
Ensembli | ENST00000318666; ENSP00000323895; ENSG00000197309 ENST00000641351; ENSP00000493028; ENSG00000197309 ENST00000641546; ENSP00000493231; ENSG00000197309 |
UCSCi | uc001pzv.3 human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065509 Genomic DNA Translation: BAC05757.1 X64983 mRNA No translation available. BK004425 Genomic DNA Translation: DAA04823.1 |
CCDSi | CCDS86257.1 |
UniGenei | Hs.538726 |
3D structure databases
ProteinModelPortali | Q8NH80 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000323895 |
Protein family/group databases
GPCRDBi | Search... |
Polymorphism and mutation databases
BioMutai | OR10D3 |
DMDMi | 74760322 |
Proteomic databases
PaxDbi | Q8NH80 |
PRIDEi | Q8NH80 |
ProteomicsDBi | 73681 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000318666; ENSP00000323895; ENSG00000197309 ENST00000641351; ENSP00000493028; ENSG00000197309 ENST00000641546; ENSP00000493231; ENSG00000197309 |
UCSCi | uc001pzv.3 human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197309.2 |
GeneCardsi | OR10D3 |
HGNCi | HGNC:8168 OR10D3 |
HPAi | HPA049991 |
neXtProti | NX_Q8NH80 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IE50 Eukaryota ENOG4111430 LUCA |
GeneTreei | ENSGT00940000153281 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NH80 |
OMAi | FLPFYAC |
PhylomeDBi | Q8NH80 |
TreeFami | TF336512 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
PROi | PR:Q8NH80 |
Gene expression databases
Bgeei | ENSG00000197309 Expressed in 3 organ(s), highest expression level in right testis |
Genevisiblei | Q8NH80 HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | O10D3_HUMAN | |
Accessioni | Q8NH80Primary (citable) accession number: Q8NH80 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | October 1, 2002 | |
Last modified: | January 16, 2019 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries