OR10D3

Functionⁱ

Odorant receptor.Curated

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functionⁱ

G protein-coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative olfactory receptor 10D3 Alternative name(s): HTPCRX09 Olfactory receptor OR11-293
Gene namesⁱ	Name:OR10D3 Synonyms:OR10D3P
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197309.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8168 OR10D3
neXtProtⁱ	NX_Q8NH80

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 26	ExtracellularSequence analysisAdd BLAST	26
Transmembraneⁱ	27 – 47	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	48 – 57	CytoplasmicSequence analysis	10
Transmembraneⁱ	58 – 78	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	79 – 97	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	98 – 118	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	119 – 139	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	140 – 160	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	161 – 197	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	198 – 218	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	219 – 239	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	240 – 260	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	261 – 266	ExtracellularSequence analysis	6
Transmembraneⁱ	267 – 287	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	288 – 312	CytoplasmicSequence analysisAdd BLAST	25

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Polymorphism and mutation databases

DMDMⁱ	74760322

DMDMⁱ

74760322

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000349228	1 – 312	Putative olfactory receptor 10D3Add BLAST		312

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	97 ↔ 179	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	Q8NH80
PRIDEⁱ	Q8NH80
ProteomicsDBⁱ	73681

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000197309 Expressed in 3 organ(s), highest expression level in right testis
Genevisibleⁱ	Q8NH80 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049991

HPAⁱ

HPA049991

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000323895

STRINGⁱ

9606.ENSP00000323895

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NH80
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IE50 Eukaryota ENOG4111430 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119161
HOGENOMⁱ	HOG000041362
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NH80
OMAⁱ	FLPFYAC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH
PhylomeDBⁱ	Q8NH80
TreeFamⁱ	TF336512

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NH80-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEVKNCCMVT EFILLGIPHT EGLEMTLFVL FLPFYACTLL GNVSILVAVM 
        60         70         80         90        100
SSARLHTPMY FFLGNLSVFD MGFSSVTCPK MLLYLMGLSR LISYKDCVCQ 
       110        120        130        140        150
LFFFHFLGSI ECFLFTVMAY DRFTAICYPL RYTVIMNPRI CVALAVGTWL 
       160        170        180        190        200
LGCIHSSILT SLTFTLPYCG PNEVDHFFCD IPALLPLACA DTSLAQRVSF 
       210        220        230        240        250
TNVGLISLVC FLLILLSYTR ITISILSIRT TEGRRRAFST CSAHLIAILC 
       260        270        280        290        300
AYGPIITVYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKTALK 
       310 
TILHRTGHVP ES

Length:312

Mass (Da):34,812

Last modified:October 1, 2002 - v1

Checksum:ⁱ2C08D37947CA71AC

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	134	V → A in X64983 (PubMed:1370859).Curated		1
Sequence conflictⁱ	202	N → S in X64983 (PubMed:1370859).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065509 Genomic DNA Translation: BAC05757.1 X64983 mRNA No translation available. BK004425 Genomic DNA Translation: DAA04823.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS86257.1
UniGeneⁱ	Hs.538726

Genome annotation databases

Ensemblⁱ	ENST00000318666; ENSP00000323895; ENSG00000197309 ENST00000641351; ENSP00000493028; ENSG00000197309 ENST00000641546; ENSP00000493231; ENSG00000197309
UCSC genome browser More...UCSCⁱ	uc001pzv.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NH80	Olfactory receptor family 10 subfamily D member 3 (putative)		GORGO		312	UniRef90_Q8NH80
Uncharacterized protein		ICTTR		312
UPI000E5602FF		UROPR		325
UPI00080A42A6		Cebus capucinus imitator		315
UPI000762734B		MARMA		312
+1

Protein	Similar proteins		Species	Score	Length	Source
Q8NH80	Olfactory receptor 10G7		HUMAN		311	UniRef50_Q8NGN6
Uncharacterized protein		MACFA		311
Uncharacterized protein		CALJA		311
Uncharacterized protein		MACMU		311
Uncharacterized protein		MACNE		311
+233

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065509 Genomic DNA Translation: BAC05757.1 X64983 mRNA No translation available. BK004425 Genomic DNA Translation: DAA04823.1
CCDSⁱ	CCDS86257.1
UniGeneⁱ	Hs.538726

3D structure databases

ProteinModelPortalⁱ	Q8NH80
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000323895

STRINGⁱ

9606.ENSP00000323895

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Polymorphism and mutation databases

DMDMⁱ	74760322

DMDMⁱ

74760322

Proteomic databases

PaxDbⁱ	Q8NH80
PRIDEⁱ	Q8NH80
ProteomicsDBⁱ	73681

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000318666; ENSP00000323895; ENSG00000197309 ENST00000641351; ENSP00000493028; ENSG00000197309 ENST00000641546; ENSP00000493231; ENSG00000197309
UCSCⁱ	uc001pzv.3 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197309.2
GeneCardsⁱ	OR10D3
HGNCⁱ	HGNC:8168 OR10D3
HPAⁱ	HPA049991
neXtProtⁱ	NX_Q8NH80
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IE50 Eukaryota ENOG4111430 LUCA
GeneTreeⁱ	ENSGT00760000119161
HOGENOMⁱ	HOG000041362
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NH80
OMAⁱ	FLPFYAC
OrthoDBⁱ	EOG091G0AZH
PhylomeDBⁱ	Q8NH80
TreeFamⁱ	TF336512

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8NH80

PROⁱ

PR:Q8NH80

Gene expression databases

Bgeeⁱ	ENSG00000197309 Expressed in 3 organ(s), highest expression level in right testis
Genevisibleⁱ	Q8NH80 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O10D3_HUMAN
Accessionⁱ	Q8NH80Primary (citable) accession number: Q8NH80
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NH80 (O10D3_HUMAN)

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Putative olfactory receptor 10D3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ