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Protein

Olfactory receptor 10A6

Gene

OR10A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A6
Alternative name(s):
Olfactory receptor OR11-96
Gene namesi
Name:OR10A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175393.3
HostDB:ENSG00000279000.1
HGNCiHGNC:15132 OR10A6
neXtProtiNX_Q8NH74

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31954

Polymorphism and mutation databases

BioMutaiOR10A6
DMDMi38372823

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506891 – 314Olfactory receptor 10A6Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH74
PeptideAtlasiQ8NH74
PRIDEiQ8NH74
ProteomicsDBi73677

Expressioni

Gene expression databases

BgeeiENSG00000175393 Expressed in 2 organ(s), highest expression level in skin of leg
CleanExiHS_OR10A6
ExpressionAtlasiQ8NH74 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312470

Structurei

3D structure databases

ProteinModelPortaliQ8NH74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK8 Eukaryota
ENOG410YDA3 LUCA
GeneTreeiENSGT00760000119002
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH74
KOiK04257
OMAiGTVQTSW
OrthoDBiEOG091G0FFM
PhylomeDBiQ8NH74
TreeFamiTF337350

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERQNQSCVV EFILLGFSNY PELQGQLFVA FLVIYLVTLI GNAIIIVIVS
60 70 80 90 100
LDQSLHVPMY LFLLNLSVVD LSFSAVIMPE MLVVLSTEKT TISFGGCFAQ
110 120 130 140 150
MYFILLFGGA ECFLLGAMAY DRFAAICHPL NYQMIMNKGV FMKLIIFSWA
160 170 180 190 200
LGFMLGTVQT SWVSSFPFCG LNEINHISCE TPAVLELACA DTFLFEIYAF
210 220 230 240 250
TGTFLIILVP FLLILLSYIR VLFAILKMPS TTGRQKAFST CAAHLTSVTL
260 270 280 290 300
FYGTASMTYL QPKSGYSPET KKVMSLSYSL LTPLLNLLIY SLRNSEMKRA
310
LMKLWRRRVV LHTI
Length:314
Mass (Da):35,318
Last modified:October 1, 2002 - v1
Checksum:i22453498F86381FB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053263117A → V. Corresponds to variant dbSNP:rs7928451Ensembl.1
Natural variantiVAR_053264140V → G. Corresponds to variant dbSNP:rs7933807Ensembl.1
Natural variantiVAR_053265287L → P. Corresponds to variant dbSNP:rs4758258Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065515 Genomic DNA Translation: BAC05763.1
BK004403 Genomic DNA Translation: DAA04801.1
RefSeqiNP_001004461.1, NM_001004461.1
UniGeneiHs.528593

Genome annotation databases

EnsembliENST00000622207; ENSP00000478945; ENSG00000276451
ENST00000623991; ENSP00000485518; ENSG00000279000
ENST00000625231; ENSP00000486810; ENSG00000280899
ENST00000641238; ENSP00000493068; ENSG00000279000
ENST00000641640; ENSP00000493246; ENSG00000280899
ENST00000641884; ENSP00000493158; ENSG00000280899
ENST00000642108; ENSP00000492919; ENSG00000279000
GeneIDi390093
KEGGihsa:390093
UCSCiuc010rbh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065515 Genomic DNA Translation: BAC05763.1
BK004403 Genomic DNA Translation: DAA04801.1
RefSeqiNP_001004461.1, NM_001004461.1
UniGeneiHs.528593

3D structure databases

ProteinModelPortaliQ8NH74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312470

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR10A6
DMDMi38372823

Proteomic databases

PaxDbiQ8NH74
PeptideAtlasiQ8NH74
PRIDEiQ8NH74
ProteomicsDBi73677

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000622207; ENSP00000478945; ENSG00000276451
ENST00000623991; ENSP00000485518; ENSG00000279000
ENST00000625231; ENSP00000486810; ENSG00000280899
ENST00000641238; ENSP00000493068; ENSG00000279000
ENST00000641640; ENSP00000493246; ENSG00000280899
ENST00000641884; ENSP00000493158; ENSG00000280899
ENST00000642108; ENSP00000492919; ENSG00000279000
GeneIDi390093
KEGGihsa:390093
UCSCiuc010rbh.2 human

Organism-specific databases

CTDi390093
EuPathDBiHostDB:ENSG00000175393.3
HostDB:ENSG00000279000.1
GeneCardsiOR10A6
HGNCiHGNC:15132 OR10A6
neXtProtiNX_Q8NH74
PharmGKBiPA31954
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKK8 Eukaryota
ENOG410YDA3 LUCA
GeneTreeiENSGT00760000119002
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH74
KOiK04257
OMAiGTVQTSW
OrthoDBiEOG091G0FFM
PhylomeDBiQ8NH74
TreeFamiTF337350

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10A6
GenomeRNAii390093
PROiPR:Q8NH74

Gene expression databases

BgeeiENSG00000175393 Expressed in 2 organ(s), highest expression level in skin of leg
CleanExiHS_OR10A6
ExpressionAtlasiQ8NH74 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10A6_HUMAN
AccessioniPrimary (citable) accession number: Q8NH74
Secondary accession number(s): Q6IF59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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