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Protein

Olfactory receptor 51F2

Gene

OR51F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51F2
Alternative name(s):
Olfactory receptor OR11-23
Gene namesi
Name:OR51F2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176925.6
HGNCiHGNC:15197 OR51F2
neXtProtiNX_Q8NH61

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 68CytoplasmicSequence analysis8
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 113ExtracellularSequence analysisAdd BLAST24
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 153CytoplasmicSequence analysisAdd BLAST19
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 210ExtracellularSequence analysisAdd BLAST36
Transmembranei211 – 231Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini232 – 251CytoplasmicSequence analysisAdd BLAST20
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 287ExtracellularSequence analysisAdd BLAST15
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 342CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176925
PharmGKBiPA32375

Polymorphism and mutation databases

BioMutaiOR51F2
DMDMi223590112

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507531 – 342Olfactory receptor 51F2Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 203PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH61
PRIDEiQ8NH61
ProteomicsDBi73668

PTM databases

iPTMnetiQ8NH61
PhosphoSitePlusiQ8NH61

Expressioni

Gene expression databases

BgeeiENSG00000176925 Expressed in 1 organ(s), highest expression level in prostate gland
CleanExiHS_OR51F2

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323952

Structurei

3D structure databases

ProteinModelPortaliQ8NH61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9RU Eukaryota
ENOG41115KG LUCA
GeneTreeiENSGT00920000148992
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NH61
KOiK04257
OMAiSFCSSMV
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH61
TreeFamiTF342735

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8NH61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTETSLSSQC FPMSVLNNTI AEPLIFLLMG IPGLKATQYW ISIPFCLLYV
60 70 80 90 100
VAVSGNSMIL FVVLCERSLH KPMYYFLSML SATDLSLSLC TLSTTLGVFW
110 120 130 140 150
FEAREINLNA CIAQMFFLHG FTFMESGVLL AMAFDRFVAI CYPLRYTTIL
160 170 180 190 200
TNARIAKIGM SMLIRNVAVM LPVMLFVKRL SFCSSMVLSH SYCYHVDLIQ
210 220 230 240 250
LSCTDNRINS ILGLFALLST TGFDCPCILL SYILIIRSVL SIASSEERRK
260 270 280 290 300
AFNTCTSHIS AVSIFYLPLI SLSLVHRYGH SAPPFVHIIM ANVFLLIPPV
310 320 330 340
LNPIIYSVKI KQIQKAIIKV LIQKHSKSNH QLFLIRDKAI YE
Length:342
Mass (Da):38,518
Last modified:February 10, 2009 - v2
Checksum:iCA3D91DB7B59EFB8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2C9F2M5A0A2C9F2M5_HUMAN
Olfactory receptor
OR51F2
330Annotation score:

Sequence cautioni

The sequence BAC05776 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065529 Genomic DNA Translation: BAC05776.1 Different initiation.
AC103710 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68826.1
BC136877 mRNA Translation: AAI36878.1
BK004281 Genomic DNA Translation: DAA04679.1
CCDSiCCDS31361.1
RefSeqiNP_001004753.1, NM_001004753.1
UniGeneiHs.553562

Genome annotation databases

EnsembliENST00000641672; ENSP00000493050; ENSG00000176925
GeneIDi119694
KEGGihsa:119694
UCSCiuc010qyn.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065529 Genomic DNA Translation: BAC05776.1 Different initiation.
AC103710 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68826.1
BC136877 mRNA Translation: AAI36878.1
BK004281 Genomic DNA Translation: DAA04679.1
CCDSiCCDS31361.1
RefSeqiNP_001004753.1, NM_001004753.1
UniGeneiHs.553562

3D structure databases

ProteinModelPortaliQ8NH61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323952

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH61
PhosphoSitePlusiQ8NH61

Polymorphism and mutation databases

BioMutaiOR51F2
DMDMi223590112

Proteomic databases

PaxDbiQ8NH61
PRIDEiQ8NH61
ProteomicsDBi73668

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000641672; ENSP00000493050; ENSG00000176925
GeneIDi119694
KEGGihsa:119694
UCSCiuc010qyn.2 human

Organism-specific databases

CTDi119694
EuPathDBiHostDB:ENSG00000176925.6
GeneCardsiOR51F2
HGNCiHGNC:15197 OR51F2
neXtProtiNX_Q8NH61
OpenTargetsiENSG00000176925
PharmGKBiPA32375
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9RU Eukaryota
ENOG41115KG LUCA
GeneTreeiENSGT00920000148992
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NH61
KOiK04257
OMAiSFCSSMV
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH61
TreeFamiTF342735

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR51F2
GenomeRNAii119694
PROiPR:Q8NH61

Gene expression databases

BgeeiENSG00000176925 Expressed in 1 organ(s), highest expression level in prostate gland
CleanExiHS_OR51F2

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO51F2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH61
Secondary accession number(s): Q6IFI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: September 12, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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