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Protein

Olfactory receptor 52J3

Gene

OR52J3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52J3
Alternative name(s):
Olfactory receptor OR11-32
Gene namesi
Name:OR52J3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000205495.1
HGNCiHGNC:14799 OR52J3
neXtProtiNX_Q8NH60

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 274ExtracellularSequence analysisAdd BLAST15
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 311CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205495
PharmGKBiPA32416

Polymorphism and mutation databases

BioMutaiOR52J3
DMDMi296439249

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507801 – 311Olfactory receptor 52J3Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH60
PRIDEiQ8NH60
ProteomicsDBi73667

PTM databases

iPTMnetiQ8NH60
PhosphoSitePlusiQ8NH60

Expressioni

Gene expression databases

BgeeiENSG00000205495
CleanExiHS_OR52J3

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369728

Structurei

3D structure databases

ProteinModelPortaliQ8NH60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9ST Eukaryota
ENOG411193D LUCA
GeneTreeiENSGT00910000144038
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NH60
KOiK04257
OMAiVHMWISL
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH60
TreeFamiTF343679

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYHNKSIFH PVTFFLIGIP GLEDFHMWIS GPFCSVYLVA LLGNATILLV
60 70 80 90 100
IKVEQTLREP MFYFLAILST IDLALSTTSV PRMLGIFWFD AHEINYGACV
110 120 130 140 150
AQMFLIHAFT GMEAEVLLAM AFDRYVAVCA PLHYATILTS QVLVGISMCI
160 170 180 190 200
VIRPVLLTLP MVYLIYRLPF CQAHIIAHSY CEHMGIAKLS CGNIRINGIY
210 220 230 240 250
GLFVVSFFVL NLVLIGISYV YILRAVFRLP SHDAQLKALS TCGAHVGVIC
260 270 280 290 300
VFYIPSVFSF LTHRFGHQIP GYIHILVANL YLIIPPSLNP IIYGVRTKQI
310
RERVLYVFTK K
Length:311
Mass (Da):35,091
Last modified:May 18, 2010 - v2
Checksum:i8830E9F7A54B3D33
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03434377T → A3 PublicationsCorresponds to variant dbSNP:rs2500016Ensembl.1
Natural variantiVAR_034344128V → I3 PublicationsCorresponds to variant dbSNP:rs2500017Ensembl.1
Natural variantiVAR_034345141Q → L3 PublicationsCorresponds to variant dbSNP:rs2500018Ensembl.1
Natural variantiVAR_034346226V → I. Corresponds to variant dbSNP:rs17350764Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065530 Genomic DNA Translation: BAC05777.1
AC113331 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68813.1
BK004318 Genomic DNA Translation: DAA04716.1
CCDSiCCDS31370.1
RefSeqiNP_001001916.2, NM_001001916.2
UniGeneiHs.553558

Genome annotation databases

EnsembliENST00000380370; ENSP00000369728; ENSG00000205495
GeneIDi119679
KEGGihsa:119679
UCSCiuc010qyv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO52J3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH60
Secondary accession number(s): Q6IFE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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