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Protein

Olfactory receptor 52E5

Gene

OR52E5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52E5
Gene namesi
Name:OR52E5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000277932.1
HGNCiHGNC:15214 OR52E5
neXtProtiNX_Q8NH55

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 56CytoplasmicSequence analysis5
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 144CytoplasmicSequence analysisAdd BLAST22
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 195ExtracellularSequence analysisAdd BLAST30
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 238CytoplasmicSequence analysisAdd BLAST22
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 327CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi557952596

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507741 – 327Olfactory receptor 52E5Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NH55
ProteomicsDBi73663

Structurei

3D structure databases

ProteinModelPortaliQ8NH55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00910000144038
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NH55
OMAiICTGLES
OrthoDBiEOG091G0AZH

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHTNNTQFH PSTFLVVGVP GLEDVHVWIG FPFFAVYLTA LLGNIIILFV
60 70 80 90 100
IQTEQSLHQP MFYFLAMLAG TDLGLSTATI PKMLGIFWFN LGEIAFGACI
110 120 130 140 150
TQMYTIHICT GLESVVLTVT GIDRYIAICN PLRYSMILTN KVIAILGIVI
160 170 180 190 200
IVRTLVFVTP FTFLILRLPF CGVRIIPHTY CEHMGLAKLA CASINVIYGL
210 220 230 240 250
IAFSVGYIDI SVIGFSYVQI LRAVFHLPAW DARPKALSTC GSHVCVMLAF
260 270 280 290 300
YLPALFSFMT HRFGHNIPHY IHILLANLYV VFPPALNSVI YGVKTKQIRE
310 320
QVLRILNPKS FWHFDPKRIF HNNSVRQ
Length:327
Mass (Da):36,851
Last modified:November 13, 2013 - v2
Checksum:i3FA0D6A2EF981C0D
GO

Sequence cautioni

The sequence BAC05782 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034338165I → T. Corresponds to variant dbSNP:rs17234326Ensembl.1
Natural variantiVAR_034339209D → G. Corresponds to variant dbSNP:rs16926732Ensembl.1
Natural variantiVAR_034340234P → L. Corresponds to variant dbSNP:rs7106300Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065536 Genomic DNA Translation: BAC05782.1 Sequence problems.

Genome annotation databases

EnsembliENST00000610445; ENSP00000480583; ENSG00000277932
UCSCiuc057yiu.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065536 Genomic DNA Translation: BAC05782.1 Sequence problems.

3D structure databases

ProteinModelPortaliQ8NH55
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi557952596

Proteomic databases

PRIDEiQ8NH55
ProteomicsDBi73663

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610445; ENSP00000480583; ENSG00000277932
UCSCiuc057yiu.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000277932.1
GeneCardsiOR52E5
HGNCiHGNC:15214 OR52E5
neXtProtiNX_Q8NH55
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00910000144038
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NH55
OMAiICTGLES
OrthoDBiEOG091G0AZH

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

PROiPR:Q8NH55

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO52E5_HUMAN
AccessioniPrimary (citable) accession number: Q8NH55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 13, 2013
Last modified: June 20, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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