UniProtKB - Q8NH53 (O52N1_HUMAN)
Protein
Olfactory receptor 52N1
Gene
OR52N1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q8NH53 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 52N1Alternative name(s): Olfactory receptor OR11-61 |
Gene namesi | Name:OR52N1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000181001.1 |
HGNCi | HGNC:14853, OR52N1 |
neXtProti | NX_Q8NH53 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 56 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 57 – 77 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 101 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 102 – 122 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 123 – 141 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 142 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 198 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 199 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 239 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 240 – 260 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 261 – 276 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 277 – 297 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 298 – 320 | CytoplasmicSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000181001 |
PharmGKBi | PA32425 |
Miscellaneous databases
Pharosi | Q8NH53, Tdark |
Polymorphism and mutation databases
BioMutai | OR52N1 |
DMDMi | 38372811 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150786 | 1 – 320 | Olfactory receptor 52N1Add BLAST | 320 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 99 ↔ 191 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NH53 |
PRIDEi | Q8NH53 |
ProteomicsDBi | 73661 |
PTM databases
GlyGeni | Q8NH53, 1 site |
iPTMneti | Q8NH53 |
PhosphoSitePlusi | Q8NH53 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181001, Expressed in lower esophagus muscularis layer and 22 other tissues |
Organism-specific databases
HPAi | ENSG00000181001, Tissue enhanced (adipose tissue, bone marrow) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122676, 1 interactor |
STRINGi | 9606.ENSP00000322823 |
Miscellaneous databases
RNActi | Q8NH53, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QV28, Eukaryota |
GeneTreei | ENSGT01010000222353 |
HOGENOMi | CLU_012526_0_0_1 |
InParanoidi | Q8NH53 |
OMAi | IRFFLKG |
OrthoDBi | 884779at2759 |
PhylomeDBi | Q8NH53 |
TreeFami | TF343679 |
Family and domain databases
InterProi | View protein in InterPro IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NH53-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFLNGTSLT PASFILNGIP GLEDVHLWIS FPLCTMYSIA ITGNFGLMYL
60 70 80 90 100
IYCDEALHRP MYVFLALLSF TDVLMCTSTL PNTLFILWFN LKEIDFKACL
110 120 130 140 150
AQMFFVHTFT GMESGVLMLM ALDHCVAICF PLRYATILTN SVIAKAGFLT
160 170 180 190 200
FLRGVMLVIP STFLTKRLPY CKGNVIPHTY CDHMSVAKIS CGNVRVNAIY
210 220 230 240 250
GLIVALLIGG FDILCITISY TMILQAVVSL SSADARQKAF STCTAHFCAI
260 270 280 290 300
VLTYVPAFFT FFTHHFGGHT IPLHIHIIMA NLYLLMPPTM NPIVYGVKTR
310 320
QVRESVIRFF LKGKDNSHNF
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053335 | 79 | T → N. Corresponds to variant dbSNP:rs12365487Ensembl. | 1 | |
Natural variantiVAR_053336 | 101 | A → T. Corresponds to variant dbSNP:rs10742787Ensembl. | 1 | |
Natural variantiVAR_053337 | 125 | C → Y. Corresponds to variant dbSNP:rs10769224Ensembl. | 1 | |
Natural variantiVAR_024149 | 167 | R → C. Corresponds to variant dbSNP:rs7948009Ensembl. | 1 | |
Natural variantiVAR_034351 | 247 | F → I. Corresponds to variant dbSNP:rs7934670Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065538 Genomic DNA Translation: BAC05784.1 BK004306 Genomic DNA Translation: DAA04704.1 |
CCDSi | CCDS31398.1 |
RefSeqi | NP_001001913.1, NM_001001913.1 |
Genome annotation databases
Ensembli | ENST00000317078; ENSP00000322823; ENSG00000181001 ENST00000641645; ENSP00000493272; ENSG00000181001 |
GeneIDi | 79473 |
KEGGi | hsa:79473 |
UCSCi | uc010qzo.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065538 Genomic DNA Translation: BAC05784.1 BK004306 Genomic DNA Translation: DAA04704.1 |
CCDSi | CCDS31398.1 |
RefSeqi | NP_001001913.1, NM_001001913.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122676, 1 interactor |
STRINGi | 9606.ENSP00000322823 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8NH53, 1 site |
iPTMneti | Q8NH53 |
PhosphoSitePlusi | Q8NH53 |
Polymorphism and mutation databases
BioMutai | OR52N1 |
DMDMi | 38372811 |
Proteomic databases
PaxDbi | Q8NH53 |
PRIDEi | Q8NH53 |
ProteomicsDBi | 73661 |
Protocols and materials databases
Antibodypediai | 57908, 57 antibodies |
Genome annotation databases
Ensembli | ENST00000317078; ENSP00000322823; ENSG00000181001 ENST00000641645; ENSP00000493272; ENSG00000181001 |
GeneIDi | 79473 |
KEGGi | hsa:79473 |
UCSCi | uc010qzo.2, human |
Organism-specific databases
CTDi | 79473 |
EuPathDBi | HostDB:ENSG00000181001.1 |
GeneCardsi | OR52N1 |
HGNCi | HGNC:14853, OR52N1 |
HPAi | ENSG00000181001, Tissue enhanced (adipose tissue, bone marrow) |
neXtProti | NX_Q8NH53 |
OpenTargetsi | ENSG00000181001 |
PharmGKBi | PA32425 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QV28, Eukaryota |
GeneTreei | ENSGT01010000222353 |
HOGENOMi | CLU_012526_0_0_1 |
InParanoidi | Q8NH53 |
OMAi | IRFFLKG |
OrthoDBi | 884779at2759 |
PhylomeDBi | Q8NH53 |
TreeFami | TF343679 |
Enzyme and pathway databases
PathwayCommonsi | Q8NH53 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 79473, 2 hits in 459 CRISPR screens |
GeneWikii | OR52N1 |
GenomeRNAii | 79473 |
Pharosi | Q8NH53, Tdark |
PROi | PR:Q8NH53 |
RNActi | Q8NH53, protein |
Gene expression databases
Bgeei | ENSG00000181001, Expressed in lower esophagus muscularis layer and 22 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O52N1_HUMAN | |
Accessioni | Q8NH53Primary (citable) accession number: Q8NH53 Secondary accession number(s): Q6IFF6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries