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Protein

Olfactory receptor 4X1

Gene

OR4X1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4X1
Alternative name(s):
Olfactory receptor OR11-104
Gene namesi
Name:OR4X1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176567.1
HostDB:ENSG00000279260.1
HGNCiHGNC:14854 OR4X1
neXtProtiNX_Q8NH49

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 287Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini288 – 305CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176567
PharmGKBiPA32350

Polymorphism and mutation databases

BioMutaiOR4X1
DMDMi38372808

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505701 – 305Olfactory receptor 4X1Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH49
PRIDEiQ8NH49
ProteomicsDBi73658

Expressioni

Gene expression databases

CleanExiHS_OR4X1

Interactioni

Protein-protein interaction databases

BioGridi133405, 1 interactor
STRINGi9606.ENSP00000321506

Structurei

3D structure databases

ProteinModelPortaliQ8NH49
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8UZ Eukaryota
ENOG41115MI LUCA
GeneTreeiENSGT00920000148993
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH49
KOiK04257
OMAiMRPCVTL
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NH49
TreeFamiTF337350

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATNNVTEI IFVGFSQNWS EQRVISVMFL LMYTAVVLGN GLIVVTILAS
60 70 80 90 100
KVLTSPMYFF LSYLSFVEIC YCSVMAPKLI FDSFIKRKVI SLKGCLTQMF
110 120 130 140 150
SLHFFGGTEA FLLMVMAYDR YVAICKPLHY MAIMNQRMCG LLVRIAWGGG
160 170 180 190 200
LLHSVGQTFL IFQLPFCGPN IMDHYFCDVH PVLELACADT FFISLLIITN
210 220 230 240 250
GGSISVVSFF VLMASYLIIL HFLRSHNLEG QHKALSTCAS HVTVVDLFFI
260 270 280 290 300
PCSLVYIRPC VTLPADKIVA VFYTVVTPLL NPVIYSFRNA EVKNAMRRFI

GGKVI
Length:305
Mass (Da):34,222
Last modified:October 1, 2002 - v1
Checksum:i730C81DE29E63D92
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053178144R → G. Corresponds to variant dbSNP:rs1503193Ensembl.1
Natural variantiVAR_034210165P → L. Corresponds to variant dbSNP:rs16905753Ensembl.1
Natural variantiVAR_053179196L → Q. Corresponds to variant dbSNP:rs12798361Ensembl.1
Natural variantiVAR_034211246D → N. Corresponds to variant dbSNP:rs17199104Ensembl.1
Natural variantiVAR_034212282P → S. Corresponds to variant dbSNP:rs10838852Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065544 Genomic DNA Translation: BAC05789.1
BK004388 Genomic DNA Translation: DAA04786.1
CCDSiCCDS31487.1
RefSeqiNP_001004726.1, NM_001004726.1
UniGeneiHs.553742

Genome annotation databases

EnsembliENST00000320048; ENSP00000321506; ENSG00000176567
GeneIDi390113
KEGGihsa:390113
UCSCiuc010rht.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4X1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH49
Secondary accession number(s): Q6IF74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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