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Protein

Olfactory receptor 4K13

Gene

OR4K13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4K13
Alternative name(s):
Olfactory receptor OR14-27
Gene namesi
Name:OR4K13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000176253.2
HGNCiHGNC:15351 OR4K13
neXtProtiNX_Q8NH42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 304CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32312

Polymorphism and mutation databases

BioMutaiOR4K13
DMDMi38372805

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505561 – 304Olfactory receptor 4K13Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH42
PeptideAtlasiQ8NH42
PRIDEiQ8NH42
ProteomicsDBi73655

PTM databases

iPTMnetiQ8NH42
PhosphoSitePlusiQ8NH42

Expressioni

Gene expression databases

CleanExiHS_OR4K13
ExpressionAtlasiQ8NH42 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319322

Structurei

3D structure databases

ProteinModelPortaliQ8NH42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J93M Eukaryota
ENOG4111DRE LUCA
GeneTreeiENSGT00900000140841
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH42
KOiK04257
OMAiIIYSVRH
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NH42
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERANHSVVS EFILLGLSKS QNLQILFFLG FSVVFVGIVL GNLLILVTVT
60 70 80 90 100
FDSLLHTPMY FLLSNLSCID MILASFATPK MIVDFLRERK TISWWGCYSQ
110 120 130 140 150
MFFMHLLGGS EMMLLVAMAI DRYVAICKPL HYMTIMSPRV LTGLLLSSYA
160 170 180 190 200
VGFVHSSSQM AFMLTLPFCG PNVIDSFFCD LPLVIKLACK DTYILQLLVI
210 220 230 240 250
ADSGLLSLVC FLLLLVSYGV IIFSVRYRAA SRSSKAFSTL SAHITVVTLF
260 270 280 290 300
FAPCVFIYVW PFSRYSVDKI LSVFYTIFTP LLNPIIYTLR NQEVKAAIKK

RLCI
Length:304
Mass (Da):34,261
Last modified:October 1, 2002 - v1
Checksum:iCF943D6F010C80C9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053172292Q → K. Corresponds to variant dbSNP:rs17277025Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065559 Genomic DNA Translation: BAC05797.1
BK004449 Genomic DNA Translation: DAA04847.1
CCDSiCCDS32028.1
RefSeqiNP_001004714.1, NM_001004714.1
UniGeneiHs.553573

Genome annotation databases

EnsembliENST00000315693; ENSP00000319322; ENSG00000176253
ENST00000641664; ENSP00000493405; ENSG00000176253
ENST00000641904; ENSP00000492930; ENSG00000176253
GeneIDi390433
KEGGihsa:390433
UCSCiuc010tkz.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065559 Genomic DNA Translation: BAC05797.1
BK004449 Genomic DNA Translation: DAA04847.1
CCDSiCCDS32028.1
RefSeqiNP_001004714.1, NM_001004714.1
UniGeneiHs.553573

3D structure databases

ProteinModelPortaliQ8NH42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319322

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH42
PhosphoSitePlusiQ8NH42

Polymorphism and mutation databases

BioMutaiOR4K13
DMDMi38372805

Proteomic databases

PaxDbiQ8NH42
PeptideAtlasiQ8NH42
PRIDEiQ8NH42
ProteomicsDBi73655

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315693; ENSP00000319322; ENSG00000176253
ENST00000641664; ENSP00000493405; ENSG00000176253
ENST00000641904; ENSP00000492930; ENSG00000176253
GeneIDi390433
KEGGihsa:390433
UCSCiuc010tkz.3 human

Organism-specific databases

CTDi390433
EuPathDBiHostDB:ENSG00000176253.2
GeneCardsiOR4K13
HGNCiHGNC:15351 OR4K13
neXtProtiNX_Q8NH42
PharmGKBiPA32312
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J93M Eukaryota
ENOG4111DRE LUCA
GeneTreeiENSGT00900000140841
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH42
KOiK04257
OMAiIIYSVRH
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NH42
TreeFamiTF337251

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR4K13
GenomeRNAii390433
PROiPR:Q8NH42

Gene expression databases

CleanExiHS_OR4K13
ExpressionAtlasiQ8NH42 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR4KD_HUMAN
AccessioniPrimary (citable) accession number: Q8NH42
Secondary accession number(s): Q6IF13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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