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Protein

Olfactory receptor 4K15

Gene

OR4K15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4K15
Alternative name(s):
Olfactory receptor OR14-20
Gene namesi
Name:OR4K15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000169488.5
HGNCiHGNC:15353 OR4K15
neXtProtiNX_Q8NH41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49ExtracellularSequence analysisAdd BLAST49
Transmembranei50 – 73Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini74 – 81CytoplasmicSequence analysis8
Transmembranei82 – 103Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini104 – 124ExtracellularSequence analysisAdd BLAST21
Transmembranei125 – 144Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini145 – 163CytoplasmicSequence analysisAdd BLAST19
Transmembranei164 – 182Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini183 – 219ExtracellularSequence analysisAdd BLAST37
Transmembranei220 – 243Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini244 – 259CytoplasmicSequence analysisAdd BLAST16
Transmembranei260 – 282Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini283 – 293ExtracellularSequence analysisAdd BLAST11
Transmembranei294 – 313Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini314 – 348CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32314

Polymorphism and mutation databases

BioMutaiOR4K15
DMDMi229462931

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505581 – 348Olfactory receptor 4K15Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 213PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH41
PeptideAtlasiQ8NH41
PRIDEiQ8NH41
ProteomicsDBi73654

PTM databases

iPTMnetiQ8NH41
PhosphoSitePlusiQ8NH41

Expressioni

Gene expression databases

CleanExiHS_OR4K15

Organism-specific databases

HPAiHPA055732

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304077

Structurei

3D structure databases

ProteinModelPortaliQ8NH41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJT Eukaryota
ENOG41113GX LUCA
GeneTreeiENSGT00900000140841
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH41
KOiK04257
OMAiPKSMNET
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NH41
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTSLTDLCF SPIQVAEIKS LPKSMNETNH SRVTEFVLLG LSSSRELQPF
60 70 80 90 100
LFLTFSLLYL AILLGNFLII LTVTSDSRLH TPMYFLLANL SFIDVCVASF
110 120 130 140 150
ATPKMIADFL VERKTISFDA CLAQIFFVHL FTGSEMVLLV SMAYDRYVAI
160 170 180 190 200
CKPLHYMTVM SRRVCVVLVL ISWFVGFIHT TSQLAFTVNL PFCGPNKVDS
210 220 230 240 250
FFCDLPLVTK LACIDTYVVS LLIVADSGFL SLSSFLLLVV SYTVILVTVR
260 270 280 290 300
NRSSASMAKA RSTLTAHITV VTLFFGPCIF IYVWPFSSYS VDKVLAVFYT
310 320 330 340
IFTLILNPVI YTLRNKEVKA AMSKLKSRYL KPSQVSVVIR NVLFLETK
Length:348
Mass (Da):39,088
Last modified:May 5, 2009 - v2
Checksum:iDD01134EFC5D5F91
GO

Sequence cautioni

The sequence BAC05798 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05506089N → S1 PublicationCorresponds to variant dbSNP:rs4060024Ensembl.1
Natural variantiVAR_055061112E → V1 PublicationCorresponds to variant dbSNP:rs3861512Ensembl.1
Natural variantiVAR_055062117S → A1 PublicationCorresponds to variant dbSNP:rs3861513Ensembl.1
Natural variantiVAR_055063255A → E1 PublicationCorresponds to variant dbSNP:rs10135246Ensembl.1
Natural variantiVAR_055064304L → P1 PublicationCorresponds to variant dbSNP:rs2153466Ensembl.1
Natural variantiVAR_055065310I → M1 PublicationCorresponds to variant dbSNP:rs10135467Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065560 Genomic DNA Translation: BAC05798.1 Different initiation.
AL359218 Genomic DNA No translation available.
BC140726 mRNA Translation: AAI40727.1
BK004468 Genomic DNA Translation: DAA04866.1
CCDSiCCDS32026.1
RefSeqiNP_001005486.1, NM_001005486.1
UniGeneiHs.554583

Genome annotation databases

EnsembliENST00000305051; ENSP00000304077; ENSG00000169488
GeneIDi81127
KEGGihsa:81127
UCSCiuc010tkx.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4KF_HUMAN
AccessioniPrimary (citable) accession number: Q8NH41
Secondary accession number(s): B9EIL3, Q6IEZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: June 20, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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