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Protein

Olfactory receptor 4F5

Gene

OR4F5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4F5
Gene namesi
Name:OR4F5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000186092.4
HGNCiHGNC:14825 OR4F5
neXtProtiNX_Q8NH21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18ExtracellularSequence analysisAdd BLAST18
Transmembranei19 – 42Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini43 – 50CytoplasmicSequence analysis8
Transmembranei51 – 72Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini73 – 93ExtracellularSequence analysisAdd BLAST21
Transmembranei94 – 113Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini114 – 132CytoplasmicSequence analysisAdd BLAST19
Transmembranei133 – 151Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini152 – 188ExtracellularSequence analysisAdd BLAST37
Transmembranei189 – 212Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini213 – 228CytoplasmicSequence analysisAdd BLAST16
Transmembranei229 – 251Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini252 – 262ExtracellularSequence analysisAdd BLAST11
Transmembranei263 – 282Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini283 – 305CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32291

Polymorphism and mutation databases

BioMutaiOR4F5
DMDMi38372801

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505471 – 305Olfactory receptor 4F5Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi90 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NH21
PRIDEiQ8NH21
ProteomicsDBi73650

PTM databases

iPTMnetiQ8NH21
PhosphoSitePlusiQ8NH21

Expressioni

Gene expression databases

BgeeiENSG00000186092 Expressed in 6 organ(s), highest expression level in female gonad
CleanExiHS_OR4F5

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334393

Structurei

3D structure databases

ProteinModelPortaliQ8NH21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9XX Eukaryota
ENOG411192Y LUCA
GeneTreeiENSGT00900000140841
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH21
KOiK04257
OMAiGNCLILA
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NH21
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NH21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTEFIFLGL SDSQELQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS
60 70 80 90 100
PMYFLLANLS LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF
110 120 130 140 150
GGSEMVILIA MGFDRYIAIC KPLHYTTIMC GNACVGIMAV TWGIGFLHSV
160 170 180 190 200
SQLAFAVHLL FCGPNEVDSF YCDLPRVIKL ACTDTYRLDI MVIANSGVLT
210 220 230 240 250
VCSFVLLIIS YTIILMTIQH RPLDKSSKAL STLTAHITVV LLFFGPCVFI
260 270 280 290 300
YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRQLRKWDAH

SSVKF
Length:305
Mass (Da):34,330
Last modified:October 1, 2002 - v1
Checksum:i70E99D068AB2DD59
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2U3U0J3A0A2U3U0J3_HUMAN
Olfactory receptor
OR4F5
326Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065592 Genomic DNA Translation: BAC05820.1
AL627309 Genomic DNA No translation available.
CCDSiCCDS30547.1
RefSeqiNP_001005484.1, NM_001005484.1
UniGeneiHs.554500

Genome annotation databases

EnsembliENST00000335137; ENSP00000334393; ENSG00000186092
GeneIDi79501
KEGGihsa:79501
UCSCiuc001aal.1 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065592 Genomic DNA Translation: BAC05820.1
AL627309 Genomic DNA No translation available.
CCDSiCCDS30547.1
RefSeqiNP_001005484.1, NM_001005484.1
UniGeneiHs.554500

3D structure databases

ProteinModelPortaliQ8NH21
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334393

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH21
PhosphoSitePlusiQ8NH21

Polymorphism and mutation databases

BioMutaiOR4F5
DMDMi38372801

Proteomic databases

PaxDbiQ8NH21
PRIDEiQ8NH21
ProteomicsDBi73650

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335137; ENSP00000334393; ENSG00000186092
GeneIDi79501
KEGGihsa:79501
UCSCiuc001aal.1 human

Organism-specific databases

CTDi79501
EuPathDBiHostDB:ENSG00000186092.4
GeneCardsiOR4F5
HGNCiHGNC:14825 OR4F5
neXtProtiNX_Q8NH21
PharmGKBiPA32291
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9XX Eukaryota
ENOG411192Y LUCA
GeneTreeiENSGT00900000140841
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH21
KOiK04257
OMAiGNCLILA
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NH21
TreeFamiTF337251

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

ChiTaRSiOR4F5 human
GenomeRNAii79501
PROiPR:Q8NH21

Gene expression databases

BgeeiENSG00000186092 Expressed in 6 organ(s), highest expression level in female gonad
CleanExiHS_OR4F5

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR4F5_HUMAN
AccessioniPrimary (citable) accession number: Q8NH21
Secondary accession number(s): Q5VT22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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