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Protein

Olfactory receptor 10AG1

Gene

OR10AG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10AG1
Alternative name(s):
Olfactory receptor OR11-160
Gene namesi
Name:OR10AG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000174970.3
HGNCiHGNC:19607 OR10AG1
neXtProtiNX_Q8NH19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini38 – 45CytoplasmicSequence analysis8
Transmembranei46 – 66Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini67 – 90ExtracellularSequence analysisAdd BLAST24
Transmembranei91 – 111Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini112 – 130CytoplasmicSequence analysisAdd BLAST19
Transmembranei131 – 151Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini152 – 188ExtracellularSequence analysisAdd BLAST37
Transmembranei189 – 208Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini209 – 228CytoplasmicSequence analysisAdd BLAST20
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 262ExtracellularSequence analysisAdd BLAST13
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 301CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134929321

Polymorphism and mutation databases

BioMutaiOR10AG1
DMDMi38503050

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506921 – 301Olfactory receptor 10AG1Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi88 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH19
PeptideAtlasiQ8NH19
PRIDEiQ8NH19
ProteomicsDBi73649

PTM databases

iPTMnetiQ8NH19
PhosphoSitePlusiQ8NH19

Expressioni

Gene expression databases

CleanExiHS_OR10AG1
ExpressionAtlasiQ8NH19 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ8NH19, 5 interactors
STRINGi9606.ENSP00000311477

Structurei

3D structure databases

ProteinModelPortaliQ8NH19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJMK Eukaryota
ENOG410YADW LUCA
GeneTreeiENSGT00760000119002
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH19
KOiK04257
OMAiNQSEGVG
OrthoDBiEOG091G0D7T
PhylomeDBiQ8NH19
TreeFamiTF337350

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8NH19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFVLLGFSD IPNLHWMLFS IFLLMYLMIL MCNGIIILLI KIHPALQTPM
60 70 80 90 100
YFFLSNFSLL EICYVTIIIP RMLMDIWTQK GNISLFACAT QMCFFLMLGG
110 120 130 140 150
TECLLLTVMA YDRYVAICKP LQYPLVMNHK VCIQLIIASW TITIPVVIGE
160 170 180 190 200
TCQIFLLPFC GTNTINHFFC DIPPILKLAC GNIFVNEITV HVVAVVFITV
210 220 230 240 250
PFLLIVVSYG KIISNILKLS SARGKAKAFS TCSSHLIVVI LFFGAGTITY
260 270 280 290 300
LQPKPHQFQR MGKLISLFYT ILIPTLNPII YTLRNKDIMV ALRKLLAKLL

T
Length:301
Mass (Da):34,105
Last modified:October 1, 2002 - v1
Checksum:iBDDC23BD2F3D6822
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2U3TZR9A0A2U3TZR9_HUMAN
Olfactory receptor
OR10AG1
321Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065594 Genomic DNA Translation: BAC05822.1
CH471076 Genomic DNA Translation: EAW73692.1
BC136890 mRNA Translation: AAI36891.1
BC136891 mRNA Translation: AAI36892.1
BK004519 Genomic DNA Translation: DAA04917.1
CCDSiCCDS31514.1
RefSeqiNP_001005491.1, NM_001005491.1
UniGeneiHs.554525

Genome annotation databases

EnsembliENST00000312345; ENSP00000311477; ENSG00000174970
GeneIDi282770
KEGGihsa:282770
UCSCiuc010rit.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065594 Genomic DNA Translation: BAC05822.1
CH471076 Genomic DNA Translation: EAW73692.1
BC136890 mRNA Translation: AAI36891.1
BC136891 mRNA Translation: AAI36892.1
BK004519 Genomic DNA Translation: DAA04917.1
CCDSiCCDS31514.1
RefSeqiNP_001005491.1, NM_001005491.1
UniGeneiHs.554525

3D structure databases

ProteinModelPortaliQ8NH19
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NH19, 5 interactors
STRINGi9606.ENSP00000311477

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH19
PhosphoSitePlusiQ8NH19

Polymorphism and mutation databases

BioMutaiOR10AG1
DMDMi38503050

Proteomic databases

PaxDbiQ8NH19
PeptideAtlasiQ8NH19
PRIDEiQ8NH19
ProteomicsDBi73649

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312345; ENSP00000311477; ENSG00000174970
GeneIDi282770
KEGGihsa:282770
UCSCiuc010rit.2 human

Organism-specific databases

CTDi282770
EuPathDBiHostDB:ENSG00000174970.3
GeneCardsiOR10AG1
HGNCiHGNC:19607 OR10AG1
neXtProtiNX_Q8NH19
PharmGKBiPA134929321
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJMK Eukaryota
ENOG410YADW LUCA
GeneTreeiENSGT00760000119002
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH19
KOiK04257
OMAiNQSEGVG
OrthoDBiEOG091G0D7T
PhylomeDBiQ8NH19
TreeFamiTF337350

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10AG1
GenomeRNAii282770
PROiPR:Q8NH19

Gene expression databases

CleanExiHS_OR10AG1
ExpressionAtlasiQ8NH19 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10AG_HUMAN
AccessioniPrimary (citable) accession number: Q8NH19
Secondary accession number(s): B2RNH4, Q6IEU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2002
Last modified: July 18, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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