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Protein

Olfactory receptor 5J2

Gene

OR5J2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5J2
Alternative name(s):
Olfactory receptor OR11-266
Gene namesi
Name:OR5J2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000174957.1
HGNCiHGNC:19612 OR5J2
neXtProtiNX_Q8NH18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982020

Polymorphism and mutation databases

BioMutaiOR5J2
DMDMi38372500

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505991 – 312Olfactory receptor 5J2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH18
PeptideAtlasiQ8NH18
PRIDEiQ8NH18
ProteomicsDBi73648

PTM databases

PhosphoSitePlusiQ8NH18

Expressioni

Gene expression databases

BgeeiENSG00000174957
CleanExiHS_OR5J2
ExpressionAtlasiQ8NH18 baseline and differential
GenevisibleiQ8NH18 HS

Organism-specific databases

HPAiHPA059466

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310788

Structurei

3D structure databases

ProteinModelPortaliQ8NH18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU6 Eukaryota
ENOG4111BJM LUCA
GeneTreeiENSGT00910000144165
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NH18
KOiK04257
OMAiCIVQHLF
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH18
TreeFamiTF352748

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDNFTVVT EFILLGLTDH AELKAVLFVV FLVIYAITLL RNLGMILLIQ
60 70 80 90 100
ITSKLHTPMY FLLSCLSFVD ACYSSAIAPK MLVNLLVVKA TISFSACMVQ
110 120 130 140 150
HLCFGVFITT EGFLLSVMAY DRYVAIVSPL LYTVAMSDRK CVELVTGSWI
160 170 180 190 200
GGIVNTLIHT ISLRRLSFCR LNAVSHFFCD IPSLLKLSCS DTSMNELLLL
210 220 230 240 250
TFSGVIAMAT FLTVIISYIF IAFASLRIHS ASGRQQAFST CASHLTAVTI
260 270 280 290 300
FYGTLIFSYI QPSSQYFVEQ EKVVSMFYTL GIPMLNLLIH SLRNKDVKEA
310
VKRAIEMKHF LC
Length:312
Mass (Da):34,808
Last modified:October 1, 2002 - v1
Checksum:iF21D7E3DB3D02B70
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034226136M → I. Corresponds to variant dbSNP:rs12279899Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065595 Genomic DNA Translation: BAC05823.1
BK004517 Genomic DNA Translation: DAA04915.1
CCDSiCCDS31522.1
RefSeqiNP_001005492.1, NM_001005492.1
UniGeneiHs.537145

Genome annotation databases

EnsembliENST00000312298; ENSP00000310788; ENSG00000174957
GeneIDi282775
KEGGihsa:282775
UCSCiuc010rjb.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR5J2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH18
Secondary accession number(s): Q6IEU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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