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Protein

Olfactory receptor 8S1

Gene

OR8S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8S1
Gene namesi
Name:OR8S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000197376.2
HGNCiHGNC:19628 OR8S1
neXtProtiNX_Q8NH09

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 359CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi341568
PharmGKBiPA134896911

Polymorphism and mutation databases

BioMutaiOR8S1
DMDMi296439256

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506741 – 359Olfactory receptor 8S1Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH09
PRIDEiQ8NH09
ProteomicsDBi73645

PTM databases

iPTMnetiQ8NH09
PhosphoSitePlusiQ8NH09

Expressioni

Gene expression databases

BgeeiENSG00000197376 Expressed in 25 organ(s), highest expression level in right ovary
CleanExiHS_OR8S1
ExpressionAtlasiQ8NH09 differential

Organism-specific databases

HPAiHPA045595

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310632

Structurei

3D structure databases

ProteinModelPortaliQ8NH09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVNF Eukaryota
ENOG41116B6 LUCA
GeneTreeiENSGT00440000034852
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NH09
KOiK04257
OMAiSVQYTVV
OrthoDBiEOG091G0E8E
PhylomeDBiQ8NH09
TreeFamiTF338386

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NH09-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGNHSTIT EFLLLGLSAD PNIRALLFVL FLGIYLLTIM ENLMLLLMIR
60 70 80 90 100
ADSCLHKPMY FFLSHLSFVD LCFSSVIVPK MLENLLSQRK TISVEGCLAQ
110 120 130 140 150
VFFVFVTAGT EACLLSGMAY DRHAAICRPL LYGQIMGKQL YMHLVWGSWG
160 170 180 190 200
LGFLDALINV LLAVNMVFCE AKIIHHYSYE MPSLLPLSCS DISRSLIALL
210 220 230 240 250
CSTLLHGLGN FLLVFLSYTR IISTILSISS TSGRSKAFST CSAHLTAVTL
260 270 280 290 300
YYGSGLLRHL MPNSGSPIEL IFSVQYTVVT PMLNSLIYSL KNKEVKGERS
310 320 330 340 350
LRDSSHLPQL HKGQARWKRP AFTEGRREPG HPELSIPVTP QPQGACACSA

LRAAPTALP
Length:359
Mass (Da):39,645
Last modified:May 18, 2010 - v2
Checksum:iC8A0D6B7E2977643
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YFL9A0A286YFL9_HUMAN
Olfactory receptor
OR8S1
312Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127C → R in BAC05832 (Ref. 1) Curated1
Sequence conflicti198A → V in BAC05832 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03427548M → V1 PublicationCorresponds to variant dbSNP:rs2731073Ensembl.1
Natural variantiVAR_05756682L → P. Corresponds to variant dbSNP:rs4075258Ensembl.1
Natural variantiVAR_057567128R → C. Corresponds to variant dbSNP:rs12425460Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065604 Genomic DNA Translation: BAC05832.1
AC089987 Genomic DNA No translation available.
CCDSiCCDS31789.1
RefSeqiNP_001005203.2, NM_001005203.2
UniGeneiHs.524373

Genome annotation databases

EnsembliENST00000310194; ENSP00000310632; ENSG00000284723
GeneIDi341568
KEGGihsa:341568
UCSCiuc010slu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065604 Genomic DNA Translation: BAC05832.1
AC089987 Genomic DNA No translation available.
CCDSiCCDS31789.1
RefSeqiNP_001005203.2, NM_001005203.2
UniGeneiHs.524373

3D structure databases

ProteinModelPortaliQ8NH09
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310632

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH09
PhosphoSitePlusiQ8NH09

Polymorphism and mutation databases

BioMutaiOR8S1
DMDMi296439256

Proteomic databases

PaxDbiQ8NH09
PRIDEiQ8NH09
ProteomicsDBi73645

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310194; ENSP00000310632; ENSG00000284723
GeneIDi341568
KEGGihsa:341568
UCSCiuc010slu.2 human

Organism-specific databases

CTDi341568
DisGeNETi341568
EuPathDBiHostDB:ENSG00000197376.2
GeneCardsiOR8S1
HGNCiHGNC:19628 OR8S1
HPAiHPA045595
neXtProtiNX_Q8NH09
PharmGKBiPA134896911
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVNF Eukaryota
ENOG41116B6 LUCA
GeneTreeiENSGT00440000034852
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NH09
KOiK04257
OMAiSVQYTVV
OrthoDBiEOG091G0E8E
PhylomeDBiQ8NH09
TreeFamiTF338386

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GenomeRNAii341568
PROiPR:Q8NH09

Gene expression databases

BgeeiENSG00000197376 Expressed in 25 organ(s), highest expression level in right ovary
CleanExiHS_OR8S1
ExpressionAtlasiQ8NH09 differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR8S1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: October 10, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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