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Protein

Olfactory receptor 10AC1

Gene

OR10AC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.By similarity

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10AC1
Alternative name(s):
Olfactory receptor OR7-5
Gene namesi
Name:OR10AC1
Synonyms:OR10AC1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14758 OR10AC1
neXtProtiNX_Q8NH08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 57CytoplasmicSequence analysis10
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 101ExtracellularSequence analysisAdd BLAST23
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 147CytoplasmicSequence analysisAdd BLAST25
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 171ExtracellularSequence analysis3
Transmembranei172 – 192Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini193 – 200CytoplasmicSequence analysis8
Transmembranei201 – 221Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini222 – 243ExtracellularSequence analysisAdd BLAST22
Transmembranei244 – 264Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini265 – 325CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi281185475

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003493811 – 325Olfactory receptor 10AC1Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8NH08
ProteomicsDBi73644

Structurei

3D structure databases

ProteinModelPortaliQ8NH08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625
InParanoidiQ8NH08
PhylomeDBiQ8NH08

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSPSNATVP CGFLLQGFSE FPHLRPVLFL LLLGVHLATL GGNLLILVAV
60 70 80 90 100
ASMPSRQPML LFLCQLSAIE LCYTLVVVPR SLVDLSTPGH RRGSPISFLS
110 120 130 140 150
CAFQMQMFVA LGGAECFLLA AMAYDRYVAI CHPLRYAAVV TPGLCARLAL
160 170 180 190 200
ACCLRGLAVS VGLTVAIFHL PFCGSRLLLH FFCDITALLH LACTRSYADE
210 220 230 240 250
LPLLGACLVL LLLPSVLILA SYGAIAAALR RLRCPKGRGK AASTCALHLA
260 270 280 290 300
VTFLHYGCAT FMYVRPRASY SPRLDRTLAL VYTNVTPLLC PLIYSLRNRE
310 320
ITAALSRVLG RRRPGQAPGG DLREL
Length:325
Mass (Da):35,157
Last modified:December 15, 2009 - v2
Checksum:i08D0D6F3D72C3B05
GO

Sequence cautioni

The sequence BAC05833 differs from that shown. Reason: Erroneous gene model prediction.Curated

Polymorphismi

A stop codon due to a single nucleotide insertion in the gene coding for this protein at position Ile-90 is responsible for functional diversity thus producing a pseudogene.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065605 Genomic DNA Translation: BAC05833.1 Sequence problems.
BK004748 Genomic DNA No translation available.

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065605 Genomic DNA Translation: BAC05833.1 Sequence problems.
BK004748 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliQ8NH08
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi281185475

Proteomic databases

PRIDEiQ8NH08
ProteomicsDBi73644

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR10AC1
HGNCiHGNC:14758 OR10AC1
neXtProtiNX_Q8NH08
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625
InParanoidiQ8NH08
PhylomeDBiQ8NH08

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

PROiPR:Q8NH08

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10AC_HUMAN
AccessioniPrimary (citable) accession number: Q8NH08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 15, 2009
Last modified: November 7, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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