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Protein

Olfactory receptor 11H2

Gene

OR11H2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H2
Alternative name(s):
Olfactory receptor OR14-1
Gene namesi
Name:OR11H2
Synonyms:C14orf15, OR11H2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000258453.2
HGNCiHGNC:14716 OR11H2
neXtProtiNX_Q8NH07

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 72CytoplasmicSequence analysis7
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 112ExtracellularSequence analysisAdd BLAST19
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 158CytoplasmicSequence analysisAdd BLAST25
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 216ExtracellularSequence analysisAdd BLAST37
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 259CytoplasmicSequence analysisAdd BLAST22
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini281 – 287ExtracellularSequence analysis7
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 326CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiOR11H2
DMDMi74760292

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003329631 – 326Olfactory receptor 11H2Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NH07
ProteomicsDBi73643

Expressioni

Gene expression databases

BgeeiENSG00000258453

Organism-specific databases

HPAiHPA047370

Structurei

3D structure databases

ProteinModelPortaliQ8NH07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFEZ Eukaryota
ENOG411183S LUCA
GeneTreeiENSGT00890000139362
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH07
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH07

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPLTLHVTG LMNVSEPNSS FAFVNEFILQ GFSCEWTIQI FLFSLFTTIY
60 70 80 90 100
ALTITGNGAI AFVLWCDRRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF
110 120 130 140 150
LSEKKNISFA GCFLQFYFFF SLGTSECLLL TVMAFDQYLA ICRPLLYPNI
160 170 180 190 200
MTGHLYAKLV ILCWVCGFLW FLIPIVLISQ KPFCGPNIID HVVCDPGPLF
210 220 230 240 250
ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAV LGMPSSTGRH
260 270 280 290 300
KAFSTCGSHL AVVSLCYSPL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF
310 320
NPLIYSLQNK EIKAALRKVL GSSNII
Length:326
Mass (Da):36,531
Last modified:October 1, 2002 - v1
Checksum:iDC3B61F0F1A088D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065607 Genomic DNA Translation: BAC05834.1
BK004489 Genomic DNA Translation: DAA04887.1
CCDSiCCDS76655.1
RefSeqiNP_001184216.1, NM_001197287.1
UniGeneiHs.554706

Genome annotation databases

EnsembliENST00000641517; ENSP00000492923; ENSG00000258453
GeneIDi79334
KEGGihsa:79334
UCSCiuc058yqs.1 human

Similar proteinsi

Entry informationi

Entry nameiO11H2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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