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Protein

Olfactory receptor 4Q3

Gene

OR4Q3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4Q3
Alternative name(s):
Olfactory receptor 4Q4
Olfactory receptor OR14-3
Gene namesi
Name:OR4Q3
Synonyms:C14orf13, OR4Q4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000182652.1
HGNCiHGNC:15426 OR4Q3
neXtProtiNX_Q8NH05

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 58CytoplasmicSequence analysis9
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 101ExtracellularSequence analysisAdd BLAST21
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 159Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 220Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini221 – 236CytoplasmicSequence analysisAdd BLAST16
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 270ExtracellularSequence analysisAdd BLAST11
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 313CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32340

Polymorphism and mutation databases

BioMutaiOR4Q3
DMDMi38372800

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505671 – 313Olfactory receptor 4Q3Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH05
PeptideAtlasiQ8NH05
PRIDEiQ8NH05
ProteomicsDBi73641

Expressioni

Gene expression databases

BgeeiENSG00000182652
CleanExiHS_OR4Q3
ExpressionAtlasiQ8NH05 baseline and differential

Organism-specific databases

HPAiHPA049924

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330049

Structurei

3D structure databases

ProteinModelPortaliQ8NH05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGKW Eukaryota
ENOG4111BJW LUCA
GeneTreeiENSGT00920000148993
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH05
KOiK04257
OMAiITLRTHF
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NH05
TreeFamiTF337350

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEQDSNVT EFVLLGLSSS WELQLFLFLL FLFFYIAIVL GNLLIVVTVQ
60 70 80 90 100
AHAHLLQSPM YYFLGHLSFI DLCLSCVTVP KMLGDFLQQG KSISFSGCLA
110 120 130 140 150
QIYFLHFLGA SEMFLLTVMA YDRYVAICNP LRYLTVMNPQ LCLWLVLACW
160 170 180 190 200
CGGFIHSIMQ VILVIQLPFC GPNELDNFYC DVPQVIKLAC MDTYVVEVLV
210 220 230 240 250
IANSGLLSLV CFLVLLFSYA IILITLRTHF CQGQNKVFST CASHLTVVSL
260 270 280 290 300
IFVPCVFIYL RPFCSFSVDK IFSLFYTVIT PMLNPLIYTL RNTDMKTAMK
310
KLRIKPCGIP LPC
Length:313
Mass (Da):35,491
Last modified:October 1, 2002 - v1
Checksum:i5990F692887115DD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053176135T → A. Corresponds to variant dbSNP:rs17210864Ensembl.1
Natural variantiVAR_053177238F → L. Corresponds to variant dbSNP:rs12896533Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065609 Genomic DNA Translation: BAC05836.1
BK004488 Genomic DNA Translation: DAA04886.1
CCDSiCCDS32020.1
RefSeqiNP_751944.1, NM_172194.1
UniGeneiHs.553828

Genome annotation databases

EnsembliENST00000331723; ENSP00000330049; ENSG00000182652
GeneIDi441669
KEGGihsa:441669
UCSCiuc010tkt.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4Q3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH05
Secondary accession number(s): Q6IEX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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