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Protein

Olfactory receptor 2T27

Gene

OR2T27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T27
Alternative name(s):
Olfactory receptor OR1-67
Gene namesi
Name:OR2T27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000187701.3
HGNCiHGNC:31252 OR2T27
neXtProtiNX_Q8NH04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 60CytoplasmicSequence analysisAdd BLAST17
Transmembranei61 – 83Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini84 – 97ExtracellularSequence analysisAdd BLAST14
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 244CytoplasmicSequence analysisAdd BLAST26
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 271ExtracellularSequence analysis6
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 317CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945560

Polymorphism and mutation databases

BioMutaiOR2T27
DMDMi73621333

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505051 – 317Olfactory receptor 2T27Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH04
PeptideAtlasiQ8NH04
PRIDEiQ8NH04
ProteomicsDBi73640

PTM databases

iPTMnetiQ8NH04
PhosphoSitePlusiQ8NH04

Expressioni

Gene expression databases

CleanExiHS_OR2T27

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342008

Structurei

3D structure databases

ProteinModelPortaliQ8NH04
SMRiQ8NH04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ8C Eukaryota
ENOG41120HT LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH04
KOiK04257
OMAiCIMMLLI
OrthoDBiEOG091G0ECW
PhylomeDBiQ8NH04
TreeFamiTF337295

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQSNYSVYA DFILLGLFSN ARFPWLLFAL ILLVFLTSIA SNVVKIILIH
60 70 80 90 100
IDSRLHTPMY FLLSQLSLRD ILYISTIVPK MLVDQVMSQR AISFAGCTAQ
110 120 130 140 150
HFLYLTLAGA EFFLLGLMSY DRYVAICNPL HYPVLMSRKI CWLIVAAAWL
160 170 180 190 200
GGSIDGFLLT PVTMQFPFCA SREINHFFCE VPALLKLSCT DTSAYETAMY
210 220 230 240 250
VCCIMMLLIP FSVISGSYTR ILITVYRMSE AEGRGKAVAT CSSHMVVVSL
260 270 280 290 300
FYGAAMYTYV LPHSYHTPEQ DKAVSAFYTI LTPMLNPLIY SLRNKDVTGA
310
LQKVVGRCVS SGKVTTF
Length:317
Mass (Da):35,514
Last modified:October 1, 2002 - v1
Checksum:iE271C5F00CFDE7F7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05315836L → V. Corresponds to variant dbSNP:rs1782242Ensembl.1
Natural variantiVAR_06203045K → M. Corresponds to variant dbSNP:rs28533004Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065611 Genomic DNA Translation: BAC05838.1
BK004474 Genomic DNA Translation: DAA04872.1
CCDSiCCDS31124.1
RefSeqiNP_001001824.1, NM_001001824.1
UniGeneiHs.553814

Genome annotation databases

EnsembliENST00000344889; ENSP00000342008; ENSG00000187701
ENST00000460972; ENSP00000493412; ENSG00000187701
ENST00000641652; ENSP00000493434; ENSG00000187701
GeneIDi403239
KEGGihsa:403239
UCSCiuc010pzo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065611 Genomic DNA Translation: BAC05838.1
BK004474 Genomic DNA Translation: DAA04872.1
CCDSiCCDS31124.1
RefSeqiNP_001001824.1, NM_001001824.1
UniGeneiHs.553814

3D structure databases

ProteinModelPortaliQ8NH04
SMRiQ8NH04
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342008

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH04
PhosphoSitePlusiQ8NH04

Polymorphism and mutation databases

BioMutaiOR2T27
DMDMi73621333

Proteomic databases

PaxDbiQ8NH04
PeptideAtlasiQ8NH04
PRIDEiQ8NH04
ProteomicsDBi73640

Protocols and materials databases

DNASUi403239
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344889; ENSP00000342008; ENSG00000187701
ENST00000460972; ENSP00000493412; ENSG00000187701
ENST00000641652; ENSP00000493434; ENSG00000187701
GeneIDi403239
KEGGihsa:403239
UCSCiuc010pzo.2 human

Organism-specific databases

CTDi403239
EuPathDBiHostDB:ENSG00000187701.3
GeneCardsiOR2T27
HGNCiHGNC:31252 OR2T27
neXtProtiNX_Q8NH04
PharmGKBiPA134945560
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ8C Eukaryota
ENOG41120HT LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH04
KOiK04257
OMAiCIMMLLI
OrthoDBiEOG091G0ECW
PhylomeDBiQ8NH04
TreeFamiTF337295

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR2T27
GenomeRNAii403239
PROiPR:Q8NH04

Gene expression databases

CleanExiHS_OR2T27

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO2T27_HUMAN
AccessioniPrimary (citable) accession number: Q8NH04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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