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Protein

Olfactory receptor 2T29

Gene

OR2T29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T29
Gene namesi
Name:OR2T29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000182783.4
HGNCiHGNC:31253 OR2T29
neXtProtiNX_Q8NH02

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 53Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini54 – 61CytoplasmicSequence analysis8
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 104ExtracellularSequence analysisAdd BLAST21
Transmembranei105 – 124Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 162Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini163 – 199ExtracellularSequence analysisAdd BLAST37
Transmembranei200 – 223Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini224 – 240CytoplasmicSequence analysisAdd BLAST17
Transmembranei241 – 263Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini264 – 276ExtracellularSequence analysisAdd BLAST13
Transmembranei277 – 296Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini297 – 315CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876557

Polymorphism and mutation databases

BioMutaiOR2T29
DMDMi38372798

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505061 – 315Olfactory receptor 2T29Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH02
PRIDEiQ8NH02
ProteomicsDBi73638

PTM databases

iPTMnetiQ8NH02
PhosphoSitePlusiQ8NH02

Expressioni

Gene expression databases

BgeeiENSG00000182783
CleanExiHS_OR2T29

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331774

Structurei

3D structure databases

ProteinModelPortaliQ8NH02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVTG Eukaryota
ENOG41114MM LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH02
KOiK04257
OMAiITGMANH
OrthoDBiEOG091G0DUZ
PhylomeDBiQ8NH02
TreeFamiTF337295

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANITRMANH TGRLDFILMG LFRQSKHPAL LSVVIFVVFL KALSGNAVLI
60 70 80 90 100
LLIHCDAHLH SPMYFFISQL SLMDMAYISV TVPKMLLDQV MGVNKVSAPE
110 120 130 140 150
CGMQMFLYLT LAGSEFFLLA TMAYDRYVAI CHPLRYPVLM NHRVCLFLAS
160 170 180 190 200
GCWFLGSVDG FMLTPITMSF PFCRSWEIHH FFCEVPAVTI LSCSDTSLYE
210 220 230 240 250
TLMYLCCVLM LLIPVTIISS SYLLILLTVH RMNSAEGRKK AFATCSSHLT
260 270 280 290 300
VVILFYGAAV YTYMLPSSYH TPEKDMMVSV FYTILTPVLN PLIYSLRNKD
310
VMGALKKMLT VRFVL
Length:315
Mass (Da):35,595
Last modified:October 10, 2003 - v2
Checksum:iE8AFED7EC21079CD
GO

Sequence cautioni

The sequence BAC05840 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065613 Genomic DNA Translation: BAC05840.1 Different initiation.
CCDSiCCDS55695.1
RefSeqiNP_001004694.2, NM_001004694.2
UniGeneiHs.553707

Genome annotation databases

EnsembliENST00000328570; ENSP00000331774; ENSG00000182783
ENST00000641069; ENSP00000492895; ENSG00000182783
GeneIDi343563
KEGGihsa:343563
UCSCiuc001ieo.2 human

Similar proteinsi

Entry informationi

Entry nameiO2T29_HUMAN
AccessioniPrimary (citable) accession number: Q8NH02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 20, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

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