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Protein

Olfactory receptor 2T11

Gene

OR2T11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T11
Alternative name(s):
Olfactory receptor OR1-65
Gene namesi
Name:OR2T11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000183130.3
HGNCiHGNC:19574 OR2T11
neXtProtiNX_Q8NH01

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 46Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 76Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini77 – 97ExtracellularSequence analysisAdd BLAST21
Transmembranei98 – 117Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini118 – 136CytoplasmicSequence analysisAdd BLAST19
Transmembranei137 – 155Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini156 – 192ExtracellularSequence analysisAdd BLAST37
Transmembranei193 – 216Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini217 – 233CytoplasmicSequence analysisAdd BLAST17
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 316CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948800

Polymorphism and mutation databases

BioMutaiOR2T11
DMDMi38503049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505031 – 316Olfactory receptor 2T11Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH01
PeptideAtlasiQ8NH01
PRIDEiQ8NH01
ProteomicsDBi73637

Expressioni

Gene expression databases

BgeeiENSG00000183130 Expressed in 1 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_OR2T11

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328934

Structurei

3D structure databases

ProteinModelPortaliQ8NH01
SMRiQ8NH01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYV Eukaryota
ENOG411199U LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH01
KOiK04257
OMAiTFFICTT
OrthoDBiEOG091G0ECW
PhylomeDBiQ8NH01
TreeFamiTF337295

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH01-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNTSSSDFT LLGLLVNSEA AGIVFTVILA VFLGAVTANL VMIFLIQVDS
60 70 80 90 100
RLHTPMYFLL SQLSIMDTLF ICTTVPKLLA DMVSKEKIIS FVACGIQIFL
110 120 130 140 150
YLTMIGSEFF LLGLMAYDCY VAVCNPLRYP VLMNRKKCLL LAAGAWFGGS
160 170 180 190 200
LDGFLLTPIT MNVPYCGSRS INHFFCEIPA VLKLACADTS LYETLMYICC
210 220 230 240 250
VLMLLIPISI ISTSYSLILL TIHRMPSAEG RKKAFTTCSS HLTVVSIFYG
260 270 280 290 300
AAFYTYVLPQ SFHTPEQDKV VSAFYTIVTP MLNPLIYSLR NKDVIGAFKK
310
VFACCSSAQK VATSDA
Length:316
Mass (Da):34,797
Last modified:October 1, 2002 - v1
Checksum:iE785C0F88F405FD8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053155119C → R3 PublicationsCorresponds to variant dbSNP:rs1892443Ensembl.1
Natural variantiVAR_053156309Q → R3 PublicationsCorresponds to variant dbSNP:rs1892442Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065614 Genomic DNA Translation: BAC05841.1
KP290143 Genomic DNA Translation: ALI87331.1
KP290144 Genomic DNA Translation: ALI87332.1
CH471257 Genomic DNA Translation: EAW57529.1
BC140749 mRNA Translation: AAI40750.1
BK004476 Genomic DNA Translation: DAA04874.1
RefSeqiNP_001001964.1, NM_001001964.1
UniGeneiHs.626619

Genome annotation databases

EnsembliENST00000625105; ENSP00000485455; ENSG00000279301
ENST00000641193; ENSP00000492951; ENSG00000279301
GeneIDi127077
KEGGihsa:127077
UCSCiuc001ier.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065614 Genomic DNA Translation: BAC05841.1
KP290143 Genomic DNA Translation: ALI87331.1
KP290144 Genomic DNA Translation: ALI87332.1
CH471257 Genomic DNA Translation: EAW57529.1
BC140749 mRNA Translation: AAI40750.1
BK004476 Genomic DNA Translation: DAA04874.1
RefSeqiNP_001001964.1, NM_001001964.1
UniGeneiHs.626619

3D structure databases

ProteinModelPortaliQ8NH01
SMRiQ8NH01
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328934

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2T11
DMDMi38503049

Proteomic databases

PaxDbiQ8NH01
PeptideAtlasiQ8NH01
PRIDEiQ8NH01
ProteomicsDBi73637

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000625105; ENSP00000485455; ENSG00000279301
ENST00000641193; ENSP00000492951; ENSG00000279301
GeneIDi127077
KEGGihsa:127077
UCSCiuc001ier.1 human

Organism-specific databases

CTDi127077
EuPathDBiHostDB:ENSG00000183130.3
GeneCardsiOR2T11
HGNCiHGNC:19574 OR2T11
neXtProtiNX_Q8NH01
PharmGKBiPA134948800
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGYV Eukaryota
ENOG411199U LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH01
KOiK04257
OMAiTFFICTT
OrthoDBiEOG091G0ECW
PhylomeDBiQ8NH01
TreeFamiTF337295

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR2T11
GenomeRNAii127077
PROiPR:Q8NH01

Gene expression databases

BgeeiENSG00000183130 Expressed in 1 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_OR2T11

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO2T11_HUMAN
AccessioniPrimary (citable) accession number: Q8NH01
Secondary accession number(s): B9EIN4, Q6IEY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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