Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 2T4

Gene

OR2T4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-29 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T4
Alternative name(s):
Olfactory receptor OR1-60
Gene namesi
Name:OR2T4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000196944.3
HGNCiHGNC:15016 OR2T4
neXtProtiNX_Q8NH00

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 81Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini82 – 89CytoplasmicSequence analysis8
Transmembranei90 – 111Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini112 – 132ExtracellularSequence analysisAdd BLAST21
Transmembranei133 – 152Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini153 – 171CytoplasmicSequence analysisAdd BLAST19
Transmembranei172 – 190Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini191 – 227ExtracellularSequence analysisAdd BLAST37
Transmembranei228 – 251Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini252 – 268CytoplasmicSequence analysisAdd BLAST17
Transmembranei269 – 291Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini292 – 304ExtracellularSequence analysisAdd BLAST13
Transmembranei305 – 324Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini325 – 348CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876557

Polymorphism and mutation databases

BioMutaiOR2T4
DMDMi229462930

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504991 – 348Olfactory receptor 2T4Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi129 ↔ 221PROSITE-ProRule annotation
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH00
PRIDEiQ8NH00
ProteomicsDBi73636

PTM databases

iPTMnetiQ8NH00
PhosphoSitePlusiQ8NH00

Expressioni

Gene expression databases

BgeeiENSG00000196944 Expressed in 3 organ(s), highest expression level in substantia nigra
CleanExiHS_OR2T4
ExpressionAtlasiQ8NH00 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355431

Structurei

3D structure databases

ProteinModelPortaliQ8NH00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVTG Eukaryota
ENOG41114MM LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH00
KOiK04257
OMAiQISAPEC
OrthoDBiEOG091G0DUZ
PhylomeDBiQ8NH00
TreeFamiTF337295

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8NH00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNITWMASH TGWSDFILMG LFRQSKHPMA NITWMANHTG WSDFILLGLF
60 70 80 90 100
RQSKHPALLC VVIFVVFLMA LSGNAVLILL IHCDAHLHTP MYFFISQLSL
110 120 130 140 150
MDMAYISVTV PKMLLDQVMG VNKISAPECG MQMFFYVTLA GSEFFLLATM
160 170 180 190 200
AYDRYVAICH PLRYPVLMNH RVCLFLSSGC WFLGSVDGFT FTPITMTFPF
210 220 230 240 250
RGSREIHHFF CEVPAVLNLS CSDTSLYEIF MYLCCVLMLL IPVVIISSSY
260 270 280 290 300
LLILLTIHGM NSAEGRKKAF ATCSSHLTVV ILFYGAAIYT YMLPSSYHTP
310 320 330 340
EKDMMVSVFY TILTPVVNPL IYSLRNKDVM GALKKMLTVE PAFQKAME
Length:348
Mass (Da):39,414
Last modified:May 5, 2009 - v2
Checksum:i93469A947E1E0618
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2C9F2M9A0A2C9F2M9_HUMAN
Olfactory receptor
OR2T4
320Annotation score:

Sequence cautioni

The sequence BAC05842 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06202731N → S. Corresponds to variant dbSNP:rs57795102Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065615 Genomic DNA Translation: BAC05842.1 Different initiation.
AC138089 Genomic DNA No translation available.
BK004464 Genomic DNA Translation: DAA04862.1
CCDSiCCDS31113.1
RefSeqiNP_001004696.1, NM_001004696.1
UniGeneiHs.553586

Genome annotation databases

EnsembliENST00000366475; ENSP00000355431; ENSG00000196944
ENST00000621754; ENSP00000478105; ENSG00000274870
ENST00000622637; ENSP00000484014; ENSG00000275617
GeneIDi127074
KEGGihsa:127074
UCSCiuc001ieh.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065615 Genomic DNA Translation: BAC05842.1 Different initiation.
AC138089 Genomic DNA No translation available.
BK004464 Genomic DNA Translation: DAA04862.1
CCDSiCCDS31113.1
RefSeqiNP_001004696.1, NM_001004696.1
UniGeneiHs.553586

3D structure databases

ProteinModelPortaliQ8NH00
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355431

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH00
PhosphoSitePlusiQ8NH00

Polymorphism and mutation databases

BioMutaiOR2T4
DMDMi229462930

Proteomic databases

PaxDbiQ8NH00
PRIDEiQ8NH00
ProteomicsDBi73636

Protocols and materials databases

DNASUi127074
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366475; ENSP00000355431; ENSG00000196944
ENST00000621754; ENSP00000478105; ENSG00000274870
ENST00000622637; ENSP00000484014; ENSG00000275617
GeneIDi127074
KEGGihsa:127074
UCSCiuc001ieh.1 human

Organism-specific databases

CTDi127074
EuPathDBiHostDB:ENSG00000196944.3
GeneCardsiOR2T4
HGNCiHGNC:15016 OR2T4
neXtProtiNX_Q8NH00
PharmGKBiPA134876557
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVTG Eukaryota
ENOG41114MM LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH00
KOiK04257
OMAiQISAPEC
OrthoDBiEOG091G0DUZ
PhylomeDBiQ8NH00
TreeFamiTF337295

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR2T4
GenomeRNAii127074
PROiPR:Q8NH00

Gene expression databases

BgeeiENSG00000196944 Expressed in 3 organ(s), highest expression level in substantia nigra
CleanExiHS_OR2T4
ExpressionAtlasiQ8NH00 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR2T4_HUMAN
AccessioniPrimary (citable) accession number: Q8NH00
Secondary accession number(s): Q6IEZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: September 12, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again