UniProtKB - Q8NGZ6 (OR6F1_HUMAN)
Protein
Olfactory receptor 6F1
Gene
OR6F1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 6F1Alternative name(s): Olfactory receptor OR1-38 |
Gene namesi | Name:OR6F1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15027 OR6F1 |
neXtProti | NX_Q8NGZ6 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 54 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 55 – 75 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 99 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 100 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 139 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 160 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 197 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 198 – 217 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 218 – 237 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 238 – 258 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 271 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 272 – 292 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 293 – 308 | CytoplasmicSequence analysisAdd BLAST | 16 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 343169 |
PharmGKBi | PA32585 |
Miscellaneous databases
Pharosi | Q8NGZ6 |
Polymorphism and mutation databases
BioMutai | OR6F1 |
DMDMi | 38372796 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150627 | 1 – 308 | Olfactory receptor 6F1Add BLAST | 308 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 189 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGZ6 |
PeptideAtlasi | Q8NGZ6 |
PRIDEi | Q8NGZ6 |
ProteomicsDBi | 73634 |
PTM databases
iPTMneti | Q8NGZ6 |
PhosphoSitePlusi | Q8NGZ6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169214 Expressed in 4 organ(s), highest expression level in testis |
ExpressionAtlasi | Q8NGZ6 baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410ISHC Eukaryota ENOG410Z9YX LUCA |
GeneTreei | ENSGT00970000193412 |
HOGENOMi | HOG000041364 |
InParanoidi | Q8NGZ6 |
KOi | K04257 |
OMAi | CGPRAIN |
OrthoDBi | 1214979at2759 |
PhylomeDBi | Q8NGZ6 |
TreeFami | TF337475 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGZ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTGNKTLPQ DFLLLGFPGS QTLQLSLFML FLVMYILTVS GNVAILMLVS
60 70 80 90 100
TSHQLHTPMY FFLSNLSFLE IWYTTAAVPK ALAILLGRSQ TISFTSCLLQ
110 120 130 140 150
MYFVFSLGCT EYFLLAAMAY DRCLAICYPL HYGAIMSSLL SAQLALGSWV
160 170 180 190 200
CGFVAIAVPT ALISGLSFCG PRAINHFFCD IAPWIALACT NTQAVELVAF
210 220 230 240 250
VIAVVVILSS CLITFVSYVY IISTILRIPS ASGRSKAFST CSSHLTVVLI
260 270 280 290 300
WYGSTVFLHV RTSIKDALDL IKAVHVLNTV VTPVLNPFIY TLRNKEVRET
LLKKWKGK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062051 | 13 | L → P. Corresponds to variant dbSNP:rs60303431Ensembl. | 1 | |
Natural variantiVAR_053221 | 159 | P → A. Corresponds to variant dbSNP:rs6665599Ensembl. | 1 | |
Natural variantiVAR_034247 | 215 | F → L. Corresponds to variant dbSNP:rs2282316Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065619 Genomic DNA Translation: BAC05846.1 CH471148 Genomic DNA Translation: EAW77199.1 BC137142 mRNA Translation: AAI37143.1 BC137143 mRNA Translation: AAI37144.1 AF399604 Genomic DNA Translation: AAK95089.1 BK004460 Genomic DNA Translation: DAA04858.1 |
CCDSi | CCDS31095.1 |
RefSeqi | NP_001005286.1, NM_001005286.1 |
Genome annotation databases
Ensembli | ENST00000302084; ENSP00000305640; ENSG00000169214 ENST00000641444; ENSP00000493324; ENSG00000169214 ENST00000641470; ENSP00000493342; ENSG00000169214 |
GeneIDi | 343169 |
KEGGi | hsa:343169 |
UCSCi | uc001idj.1 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065619 Genomic DNA Translation: BAC05846.1 CH471148 Genomic DNA Translation: EAW77199.1 BC137142 mRNA Translation: AAI37143.1 BC137143 mRNA Translation: AAI37144.1 AF399604 Genomic DNA Translation: AAK95089.1 BK004460 Genomic DNA Translation: DAA04858.1 |
CCDSi | CCDS31095.1 |
RefSeqi | NP_001005286.1, NM_001005286.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000305640 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q8NGZ6 |
PhosphoSitePlusi | Q8NGZ6 |
Polymorphism and mutation databases
BioMutai | OR6F1 |
DMDMi | 38372796 |
Proteomic databases
PaxDbi | Q8NGZ6 |
PeptideAtlasi | Q8NGZ6 |
PRIDEi | Q8NGZ6 |
ProteomicsDBi | 73634 |
Genome annotation databases
Ensembli | ENST00000302084; ENSP00000305640; ENSG00000169214 ENST00000641444; ENSP00000493324; ENSG00000169214 ENST00000641470; ENSP00000493342; ENSG00000169214 |
GeneIDi | 343169 |
KEGGi | hsa:343169 |
UCSCi | uc001idj.1 human |
Organism-specific databases
CTDi | 343169 |
DisGeNETi | 343169 |
GeneCardsi | OR6F1 |
HGNCi | HGNC:15027 OR6F1 |
neXtProti | NX_Q8NGZ6 |
PharmGKBi | PA32585 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410ISHC Eukaryota ENOG410Z9YX LUCA |
GeneTreei | ENSGT00970000193412 |
HOGENOMi | HOG000041364 |
InParanoidi | Q8NGZ6 |
KOi | K04257 |
OMAi | CGPRAIN |
OrthoDBi | 1214979at2759 |
PhylomeDBi | Q8NGZ6 |
TreeFami | TF337475 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR6F1 |
GenomeRNAii | 343169 |
Pharosi | Q8NGZ6 |
PROi | PR:Q8NGZ6 |
Gene expression databases
Bgeei | ENSG00000169214 Expressed in 4 organ(s), highest expression level in testis |
ExpressionAtlasi | Q8NGZ6 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OR6F1_HUMAN | |
Accessioni | Q8NGZ6Primary (citable) accession number: Q8NGZ6 Secondary accession number(s): B2RNV6, Q6IF02, Q96R39 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | September 18, 2019 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations