UniProtKB - Q8NGY6 (OR6N2_HUMAN)
Protein
Olfactory receptor 6N2
Gene
OR6N2
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 6N2Alternative name(s): Olfactory receptor OR1-23 |
Gene namesi | Name:OR6N2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000188340.1 |
HGNCi | HGNC:15035 OR6N2 |
neXtProti | NX_Q8NGY6 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 54 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 55 – 75 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 99 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 100 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 139 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 160 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 197 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 198 – 217 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 218 – 237 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 238 – 258 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 271 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 272 – 292 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 293 – 317 | CytoplasmicSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000188340 |
PharmGKBi | PA32600 |
Polymorphism and mutation databases
BioMutai | OR6N2 |
DMDMi | 38372789 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150634 | 1 – 317 | Olfactory receptor 6N2Add BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 189 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGY6 |
PeptideAtlasi | Q8NGY6 |
PRIDEi | Q8NGY6 |
ProteomicsDBi | 73626 |
PTM databases
iPTMneti | Q8NGY6 |
PhosphoSitePlusi | Q8NGY6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188340 Expressed in 1 organ(s), highest expression level in blood |
ExpressionAtlasi | Q8NGY6 baseline and differential |
Organism-specific databases
HPAi | HPA056637 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IHMU Eukaryota ENOG410YFWH LUCA |
GeneTreei | ENSGT00940000158895 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGY6 |
KOi | K04257 |
OMAi | ICGNMLI |
OrthoDBi | 996670at2759 |
PhylomeDBi | Q8NGY6 |
TreeFami | TF337673 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGY6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDQYNHSSLA EFVFLGFASV GYVRGWLFVL LLLAYLFTIC GNMLIFSVIR
60 70 80 90 100
LDAALHTPMY HFVSVLSFLE LWYTATTIPK MLSNILSEKK TISFAGCLLQ
110 120 130 140 150
TYFFHSLGAS ECYLLTAMAY DRYLAICRPL HYPIIMTTTL CAKMAAACWT
160 170 180 190 200
CGFLCPISEV ILASQLPFCA YNEIQHIFCD FPPLLSLACK DTSANILVDF
210 220 230 240 250
AINAFIILIT FFFIMISYAR IIGAVLKIKT ASGRKKAFST CASHLAVVLI
260 270 280 290 300
FFGSIIFMYV RLKKSYSLTL DRTLAIVYSV LTPMVNPIIY SLRNKEIIKA
310
IKRTIFQKGD KASLAHL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053224 | 204 | A → V. Corresponds to variant dbSNP:rs12027473Ensembl. | 1 | |
Natural variantiVAR_062054 | 250 | I → V. Corresponds to variant dbSNP:rs41273541Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065630 Genomic DNA Translation: BAC05856.1 AL513205 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52809.1 BK004200 Genomic DNA Translation: DAA04598.1 |
CCDSi | CCDS30906.1 |
RefSeqi | NP_001005278.1, NM_001005278.1 |
UniGenei | Hs.554487 |
Genome annotation databases
Ensembli | ENST00000339258; ENSP00000344101; ENSG00000188340 ENST00000641131; ENSP00000493148; ENSG00000188340 |
GeneIDi | 81442 |
KEGGi | hsa:81442 |
UCSCi | uc010pir.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065630 Genomic DNA Translation: BAC05856.1 AL513205 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52809.1 BK004200 Genomic DNA Translation: DAA04598.1 |
CCDSi | CCDS30906.1 |
RefSeqi | NP_001005278.1, NM_001005278.1 |
UniGenei | Hs.554487 |
3D structure databases
ProteinModelPortali | Q8NGY6 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000344101 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q8NGY6 |
PhosphoSitePlusi | Q8NGY6 |
Polymorphism and mutation databases
BioMutai | OR6N2 |
DMDMi | 38372789 |
Proteomic databases
PaxDbi | Q8NGY6 |
PeptideAtlasi | Q8NGY6 |
PRIDEi | Q8NGY6 |
ProteomicsDBi | 73626 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000339258; ENSP00000344101; ENSG00000188340 ENST00000641131; ENSP00000493148; ENSG00000188340 |
GeneIDi | 81442 |
KEGGi | hsa:81442 |
UCSCi | uc010pir.2 human |
Organism-specific databases
CTDi | 81442 |
EuPathDBi | HostDB:ENSG00000188340.1 |
GeneCardsi | OR6N2 |
HGNCi | HGNC:15035 OR6N2 |
HPAi | HPA056637 |
neXtProti | NX_Q8NGY6 |
OpenTargetsi | ENSG00000188340 |
PharmGKBi | PA32600 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IHMU Eukaryota ENOG410YFWH LUCA |
GeneTreei | ENSGT00940000158895 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGY6 |
KOi | K04257 |
OMAi | ICGNMLI |
OrthoDBi | 996670at2759 |
PhylomeDBi | Q8NGY6 |
TreeFami | TF337673 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR6N2 |
GenomeRNAii | 81442 |
PROi | PR:Q8NGY6 |
Gene expression databases
Bgeei | ENSG00000188340 Expressed in 1 organ(s), highest expression level in blood |
ExpressionAtlasi | Q8NGY6 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | OR6N2_HUMAN | |
Accessioni | Q8NGY6Primary (citable) accession number: Q8NGY6 Secondary accession number(s): Q6IFR2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 13, 2019 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries