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Protein

Olfactory receptor 10Z1

Gene

OR10Z1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10Z1
Alternative name(s):
Olfactory receptor OR1-15
Gene namesi
Name:OR10Z1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198967.3
HGNCiHGNC:14996 OR10Z1
neXtProtiNX_Q8NGY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi128368
OpenTargetsiENSG00000198967
PharmGKBiPA32009

Polymorphism and mutation databases

BioMutaiOR10Z1
DMDMi38372785

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507211 – 313Olfactory receptor 10Z1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGY1
PeptideAtlasiQ8NGY1
PRIDEiQ8NGY1
ProteomicsDBi73622

PTM databases

iPTMnetiQ8NGY1
PhosphoSitePlusiQ8NGY1

Expressioni

Gene expression databases

BgeeiENSG00000198967 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR10Z1
ExpressionAtlasiQ8NGY1 baseline and differential

Organism-specific databases

HPAiHPA058072

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354707

Structurei

3D structure databases

ProteinModelPortaliQ8NGY1
SMRiQ8NGY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITJ1 Eukaryota
ENOG4111CQ1 LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGY1
KOiK04257
OMAiRNRAVQT
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGY1
TreeFamiTF337249

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQTNVTSWR DFVFLGFSSS GELQLLLFAL FLSLYLVTLT SNVFIIIAIR
60 70 80 90 100
LDSHLHTPMY LFLSFLSFSE TCYTLGIIPR MLSGLAGGDQ AISYVGCAAQ
110 120 130 140 150
MFFSASWACT NCFLLAAMGF DRYVAICAPL HYASHMNPTL CAQLVITSFL
160 170 180 190 200
TGYLFGLGMT LVIFHLSFCS SHEIQHFFCD TPPVLSLACG DTGPSELRIF
210 220 230 240 250
ILSLLVLLVS FFFITISYAY ILAAILRIPS AEGQKKAFST CASHLTVVII
260 270 280 290 300
HYGCASFVYL RPKASYSLER DQLIAMTYTV VTPLLNPIVY SLRNRAIQTA
310
LRNAFRGRLL GKG
Length:313
Mass (Da):34,609
Last modified:October 1, 2002 - v1
Checksum:i5B29E747D07F57FF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034297294N → T1 PublicationCorresponds to variant dbSNP:rs857685Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065635 Genomic DNA Translation: BAC05861.1
AL353894 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52820.1
BK004195 Genomic DNA Translation: DAA04593.1
CCDSiCCDS30901.1
RefSeqiNP_001004478.1, NM_001004478.1
UniGeneiHs.553590

Genome annotation databases

EnsembliENST00000361284; ENSP00000354707; ENSG00000198967
ENST00000641002; ENSP00000493003; ENSG00000198967
GeneIDi128368
KEGGihsa:128368
UCSCiuc010pio.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065635 Genomic DNA Translation: BAC05861.1
AL353894 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52820.1
BK004195 Genomic DNA Translation: DAA04593.1
CCDSiCCDS30901.1
RefSeqiNP_001004478.1, NM_001004478.1
UniGeneiHs.553590

3D structure databases

ProteinModelPortaliQ8NGY1
SMRiQ8NGY1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354707

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGY1
PhosphoSitePlusiQ8NGY1

Polymorphism and mutation databases

BioMutaiOR10Z1
DMDMi38372785

Proteomic databases

PaxDbiQ8NGY1
PeptideAtlasiQ8NGY1
PRIDEiQ8NGY1
ProteomicsDBi73622

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361284; ENSP00000354707; ENSG00000198967
ENST00000641002; ENSP00000493003; ENSG00000198967
GeneIDi128368
KEGGihsa:128368
UCSCiuc010pio.2 human

Organism-specific databases

CTDi128368
DisGeNETi128368
EuPathDBiHostDB:ENSG00000198967.3
GeneCardsiOR10Z1
HGNCiHGNC:14996 OR10Z1
HPAiHPA058072
neXtProtiNX_Q8NGY1
OpenTargetsiENSG00000198967
PharmGKBiPA32009
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITJ1 Eukaryota
ENOG4111CQ1 LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGY1
KOiK04257
OMAiRNRAVQT
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGY1
TreeFamiTF337249

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10Z1
GenomeRNAii128368
PROiPR:Q8NGY1

Gene expression databases

BgeeiENSG00000198967 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR10Z1
ExpressionAtlasiQ8NGY1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10Z1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGY1
Secondary accession number(s): Q5VYL0, Q6IFR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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