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Protein

Olfactory receptor 10X1

Gene

OR10X1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10X1
Alternative name(s):
Olfactory receptor OR1-14
Gene namesi
Name:OR10X1
Synonyms:OR10X1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000186400.3
HostDB:ENSG00000279111.1
HGNCiHGNC:14995 OR10X1
neXtProtiNX_Q8NGY0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 70CytoplasmicSequence analysis8
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 115ExtracellularSequence analysisAdd BLAST24
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 155CytoplasmicSequence analysisAdd BLAST19
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 213ExtracellularSequence analysisAdd BLAST37
Transmembranei214 – 233Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini234 – 253CytoplasmicSequence analysisAdd BLAST20
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini275 – 284ExtracellularSequence analysis10
Transmembranei285 – 305Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini306 – 326CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32007

Polymorphism and mutation databases

BioMutaiOR10X1
DMDMi166214962

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507201 – 326Olfactory receptor 10X1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 205PROSITE-ProRule annotation
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGY0
PeptideAtlasiQ8NGY0
PRIDEiQ8NGY0
ProteomicsDBi73621

PTM databases

iPTMnetiQ8NGY0
PhosphoSitePlusiQ8NGY0

Expressioni

Gene expression databases

CleanExiHS_OR10X1
ExpressionAtlasiQ8NGY0 differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357132

Structurei

3D structure databases

ProteinModelPortaliQ8NGY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKKE Eukaryota
ENOG41115SF LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGY0
KOiK04257
OMAiRRMMGNT
OrthoDBiEOG091G0F6Y
PhylomeDBiQ8NGY0
TreeFamiTF337925

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLNVYCCFF QISDIQTMKI NQTILKEFIL VGFSVYPHVQ TFLFVVFFCL
60 70 80 90 100
YLLTLAGNLI IMGLTWVDRS LHTPMYLFLS ALSFSETCYT LTIVPKMLED
110 120 130 140 150
LLAKDRSISV TGCSLQMCFF LGLGGTNCII LTLMGYDRFL AICNPLRYPL
160 170 180 190 200
LMTNIVCGQL VASACTAGFF ISLTETALIF RDSFCRPNLV KHFFCHMLAV
210 220 230 240 250
IRLSCIDSNH TEFIITLISV SGLLGTLLLI ILTDVFIIST VLRIPSAEGK
260 270 280 290 300
QKAFTTCASH LTVVIIHFGF ASIVYLKPEA SGDDTLIAVP YTVITPFLSP
310 320
IIFSLRNKDM KNAFRRMMGN TVALKK
Length:326
Mass (Da):36,446
Last modified:January 15, 2008 - v2
Checksum:iBFB0BB8E958C15E4
GO

Sequence cautioni

The sequence BAC05862 differs from that shown. Reason: Erroneous initiation.Curated

Polymorphismi

A stop codon at position Trp-66 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05329060I → T. Corresponds to variant dbSNP:rs863363Ensembl.1
Natural variantiVAR_05329181A → S. Corresponds to variant dbSNP:rs950164Ensembl.1
Natural variantiVAR_053292172S → P. Corresponds to variant dbSNP:rs7550131Ensembl.1
Natural variantiVAR_053293180F → L. Corresponds to variant dbSNP:rs16840360Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065636 Genomic DNA Translation: BAC05862.1 Different initiation.
AL160283 Genomic DNA No translation available.
BK004194 Genomic DNA Translation: DAA04592.1
RefSeqiNP_001004477.1, NM_001004477.1
UniGeneiHs.553589

Genome annotation databases

EnsembliENST00000623167; ENSP00000485609; ENSG00000279111
GeneIDi128367
KEGGihsa:128367
UCSCiuc010pin.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065636 Genomic DNA Translation: BAC05862.1 Different initiation.
AL160283 Genomic DNA No translation available.
BK004194 Genomic DNA Translation: DAA04592.1
RefSeqiNP_001004477.1, NM_001004477.1
UniGeneiHs.553589

3D structure databases

ProteinModelPortaliQ8NGY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357132

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGY0
PhosphoSitePlusiQ8NGY0

Polymorphism and mutation databases

BioMutaiOR10X1
DMDMi166214962

Proteomic databases

PaxDbiQ8NGY0
PeptideAtlasiQ8NGY0
PRIDEiQ8NGY0
ProteomicsDBi73621

Protocols and materials databases

DNASUi128367
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000623167; ENSP00000485609; ENSG00000279111
GeneIDi128367
KEGGihsa:128367
UCSCiuc010pin.2 human

Organism-specific databases

CTDi128367
EuPathDBiHostDB:ENSG00000186400.3
HostDB:ENSG00000279111.1
GeneCardsiOR10X1
HGNCiHGNC:14995 OR10X1
neXtProtiNX_Q8NGY0
PharmGKBiPA32007
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKKE Eukaryota
ENOG41115SF LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGY0
KOiK04257
OMAiRRMMGNT
OrthoDBiEOG091G0F6Y
PhylomeDBiQ8NGY0
TreeFamiTF337925

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10X1
GenomeRNAii128367
PROiPR:Q8NGY0

Gene expression databases

CleanExiHS_OR10X1
ExpressionAtlasiQ8NGY0 differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10X1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGY0
Secondary accession number(s): Q6IFR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: September 12, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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