UniProtKB - Q8NGX9 (OR6P1_HUMAN)
Protein
Olfactory receptor 6P1
Gene
OR6P1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q8NGX9 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 6P1Alternative name(s): Olfactory receptor OR1-12 |
Gene namesi | Name:OR6P1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15036, OR6P1 |
neXtProti | NX_Q8NGX9 |
VEuPathDBi | HostDB:ENSG00000186440.1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 54 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 55 – 75 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 99 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 100 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 139 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 160 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 197 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 198 – 217 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 218 – 237 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 238 – 258 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 271 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 272 – 292 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 293 – 317 | CytoplasmicSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 128366 |
PharmGKBi | PA32601 |
Miscellaneous databases
Pharosi | Q8NGX9, Tdark |
Genetic variation databases
BioMutai | OR6P1 |
DMDMi | 38372784 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150635 | 1 – 317 | Olfactory receptor 6P1Add BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 189 | PROSITE-ProRule annotation | ||
Glycosylationi | 186 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGX9 |
PeptideAtlasi | Q8NGX9 |
PRIDEi | Q8NGX9 |
ProteomicsDBi | 73620 |
PTM databases
GlyGeni | Q8NGX9, 2 sites |
Expressioni
Gene expression databases
ExpressionAtlasi | Q8NGX9, differential |
Organism-specific databases
HPAi | ENSG00000186440, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000334721 |
Miscellaneous databases
RNActi | Q8NGX9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RIR8, Eukaryota |
GeneTreei | ENSGT01010000222267 |
HOGENOMi | CLU_012526_1_0_1 |
InParanoidi | Q8NGX9 |
OMAi | RPRAMYT |
OrthoDBi | 1096554at2759 |
PhylomeDBi | Q8NGX9 |
TreeFami | TF337475 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGX9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRNLSGGHVE EFVLVGFPTT PPLQLLLFVL FFAIYLLTLL ENALIVFTIW
60 70 80 90 100
LAPSLHRPMY FFLGHLSFLE LWYINVTIPR LLAAFLTQDG RVSYVGCMTQ
110 120 130 140 150
LYFFIALACT ECVLLAVMAY DRYLAICGPL LYPSLMPSSL ATRLAAASWG
160 170 180 190 200
SGFFSSMMKL LFISQLSYCG PNIINHFFCD ISPLLNLTCS DKEQAELVDF
210 220 230 240 250
LLALVMILLP LLAVVSSYTA IIAAILRIPT SRGRHKAFST CAAHLAVVVI
260 270 280 290 300
YYSSTLFTYA RPRAMYTFNH NKIISVLYTI IVPFFNPAIY CLRNKEVKEA
310
FRKTVMGRCH YPRDVQD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065637 Genomic DNA Translation: BAC05863.1 AL160283 Genomic DNA No translation available. BK004193 Genomic DNA Translation: DAA04591.1 |
CCDSi | CCDS53391.1 |
RefSeqi | NP_001153797.1, NM_001160325.1 |
Genome annotation databases
Ensembli | ENST00000334632; ENSP00000334721; ENSG00000186440 ENST00000641540; ENSP00000492936; ENSG00000186440 |
GeneIDi | 128366 |
KEGGi | hsa:128366 |
UCSCi | uc010pim.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065637 Genomic DNA Translation: BAC05863.1 AL160283 Genomic DNA No translation available. BK004193 Genomic DNA Translation: DAA04591.1 |
CCDSi | CCDS53391.1 |
RefSeqi | NP_001153797.1, NM_001160325.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000334721 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8NGX9, 2 sites |
Genetic variation databases
BioMutai | OR6P1 |
DMDMi | 38372784 |
Proteomic databases
PaxDbi | Q8NGX9 |
PeptideAtlasi | Q8NGX9 |
PRIDEi | Q8NGX9 |
ProteomicsDBi | 73620 |
Protocols and materials databases
Antibodypediai | 49534, 51 antibodies |
Genome annotation databases
Ensembli | ENST00000334632; ENSP00000334721; ENSG00000186440 ENST00000641540; ENSP00000492936; ENSG00000186440 |
GeneIDi | 128366 |
KEGGi | hsa:128366 |
UCSCi | uc010pim.2, human |
Organism-specific databases
CTDi | 128366 |
DisGeNETi | 128366 |
GeneCardsi | OR6P1 |
HGNCi | HGNC:15036, OR6P1 |
HPAi | ENSG00000186440, Tissue enriched (testis) |
neXtProti | NX_Q8NGX9 |
PharmGKBi | PA32601 |
VEuPathDBi | HostDB:ENSG00000186440.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RIR8, Eukaryota |
GeneTreei | ENSGT01010000222267 |
HOGENOMi | CLU_012526_1_0_1 |
InParanoidi | Q8NGX9 |
OMAi | RPRAMYT |
OrthoDBi | 1096554at2759 |
PhylomeDBi | Q8NGX9 |
TreeFami | TF337475 |
Enzyme and pathway databases
PathwayCommonsi | Q8NGX9 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 128366, 3 hits in 590 CRISPR screens |
GeneWikii | OR6P1 |
Pharosi | Q8NGX9, Tdark |
PROi | PR:Q8NGX9 |
RNActi | Q8NGX9, protein |
Gene expression databases
ExpressionAtlasi | Q8NGX9, differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OR6P1_HUMAN | |
Accessioni | Q8NGX9Primary (citable) accession number: Q8NGX9 Secondary accession number(s): Q6IFR9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families