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Protein

Olfactory receptor 10R2

Gene

OR10R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10R2
Alternative name(s):
Olfactory receptor OR1-8
Gene namesi
Name:OR10R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198965.3
HGNCiHGNC:14820 OR10R2
neXtProtiNX_Q8NGX6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini67 – 74CytoplasmicSequence analysis8
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 119ExtracellularSequence analysisAdd BLAST24
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini141 – 159CytoplasmicSequence analysisAdd BLAST19
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 217ExtracellularSequence analysisAdd BLAST37
Transmembranei218 – 237Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini238 – 257CytoplasmicSequence analysisAdd BLAST20
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 291ExtracellularSequence analysisAdd BLAST13
Transmembranei292 – 312Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini313 – 335CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31997

Polymorphism and mutation databases

BioMutaiOR10R2
DMDMi223590254

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507151 – 335Olfactory receptor 10R2Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 209PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX6
PeptideAtlasiQ8NGX6
PRIDEiQ8NGX6
ProteomicsDBi73618

PTM databases

iPTMnetiQ8NGX6
PhosphoSitePlusiQ8NGX6

Expressioni

Gene expression databases

BgeeiENSG00000198965 Expressed in 2 organ(s), highest expression level in anatomical system
CleanExiHS_OR10R2
ExpressionAtlasiQ8NGX6 baseline and differential

Organism-specific databases

HPAiHPA059775
HPA060399

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357134

Structurei

3D structure databases

ProteinModelPortaliQ8NGX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKCP Eukaryota
ENOG4111D9M LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGX6
KOiK04257
OMAiCTNTDVN
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGX6
TreeFamiTF337249

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8NGX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQILIFTYL NMFYFFPPLQ ILAENLTMVT EFLLLGFSSL GEIQLALFVV
60 70 80 90 100
FLFLYLVILS GNVTIISVIH LDKSLHTPMY FFLGILSTSE TFYTFVILPK
110 120 130 140 150
MLINLLSVAR TISFNCCALQ MFFFLGFAIT NCLLLGVMGY DRYAAICHPL
160 170 180 190 200
HYPTLMSWQV CGKLAAACAI GGFLASLTVV NLVFSLPFCS ANKVNHYFCD
210 220 230 240 250
ISAVILLACT NTDVNEFVIF ICGVLVLVVP FLFICVSYLC ILRTILKIPS
260 270 280 290 300
AEGRRKAFST CASHLSVVIV HYGCASFIYL RPTANYVSNK DRLVTVTYTI
310 320 330
VTPLLNPMVY SLRNKDVQLA IRKVLGKKGS LKLYN
Length:335
Mass (Da):37,486
Last modified:February 10, 2009 - v3
Checksum:i9A287B3E86883A8F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A126GVZ9A0A126GVZ9_HUMAN
Olfactory receptor
OR10R2 hCG_39949
324Annotation score:
A0A286YEZ2A0A286YEZ2_HUMAN
Olfactory receptor
OR10R2
324Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054355191A → T. Corresponds to variant dbSNP:rs3820678Ensembl.1
Natural variantiVAR_054356216E → G. Corresponds to variant dbSNP:rs6679056Ensembl.1
Natural variantiVAR_054357239L → F. Corresponds to variant dbSNP:rs1418843Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065640 Genomic DNA Translation: BAC05866.1
AL365440 Genomic DNA No translation available.
AF399582 Genomic DNA Translation: AAK95067.1
BK004191 Genomic DNA Translation: DAA04589.1
CCDSiCCDS30898.1
RefSeqiNP_001004472.1, NM_001004472.1
UniGeneiHs.451913

Genome annotation databases

EnsembliENST00000368152; ENSP00000357134; ENSG00000198965
GeneIDi343406
KEGGihsa:343406
UCSCiuc010pik.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065640 Genomic DNA Translation: BAC05866.1
AL365440 Genomic DNA No translation available.
AF399582 Genomic DNA Translation: AAK95067.1
BK004191 Genomic DNA Translation: DAA04589.1
CCDSiCCDS30898.1
RefSeqiNP_001004472.1, NM_001004472.1
UniGeneiHs.451913

3D structure databases

ProteinModelPortaliQ8NGX6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357134

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGX6
PhosphoSitePlusiQ8NGX6

Polymorphism and mutation databases

BioMutaiOR10R2
DMDMi223590254

Proteomic databases

PaxDbiQ8NGX6
PeptideAtlasiQ8NGX6
PRIDEiQ8NGX6
ProteomicsDBi73618

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368152; ENSP00000357134; ENSG00000198965
GeneIDi343406
KEGGihsa:343406
UCSCiuc010pik.2 human

Organism-specific databases

CTDi343406
EuPathDBiHostDB:ENSG00000198965.3
GeneCardsiOR10R2
HGNCiHGNC:14820 OR10R2
HPAiHPA059775
HPA060399
neXtProtiNX_Q8NGX6
PharmGKBiPA31997
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKCP Eukaryota
ENOG4111D9M LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGX6
KOiK04257
OMAiCTNTDVN
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGX6
TreeFamiTF337249

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10R2
GenomeRNAii343406
PROiPR:Q8NGX6

Gene expression databases

BgeeiENSG00000198965 Expressed in 2 organ(s), highest expression level in anatomical system
CleanExiHS_OR10R2
ExpressionAtlasiQ8NGX6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10R2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX6
Secondary accession number(s): Q5VWM8, Q6IFS1, Q96R61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: November 7, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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