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Protein

Olfactory receptor 10K1

Gene

OR10K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10K1
Alternative name(s):
Olfactory receptor OR1-6
Gene namesi
Name:OR10K1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000173285.3
HGNCiHGNC:14693 OR10K1
neXtProtiNX_Q8NGX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi391109
PharmGKBiPA31988

Polymorphism and mutation databases

BioMutaiOR10K1
DMDMi38372781

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507111 – 313Olfactory receptor 10K1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGX5
PeptideAtlasiQ8NGX5
PRIDEiQ8NGX5
ProteomicsDBi73617

PTM databases

iPTMnetiQ8NGX5
PhosphoSitePlusiQ8NGX5

Expressioni

Gene expression databases

CleanExiHS_OR10K1
ExpressionAtlasiQ8NGX5 baseline and differential

Organism-specific databases

HPAiHPA059125

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000289451

Structurei

3D structure databases

ProteinModelPortaliQ8NGX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0G Eukaryota
ENOG41117G5 LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGX5
KOiK04257
OMAiGFSQLVI
OrthoDBiEOG091G0CYL
PhylomeDBiQ8NGX5
TreeFamiTF337249

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQVNKTVVR EFVVLGFSSL ARLQQLLFVI FLLLYLFTLG TNAIIISTIV
60 70 80 90 100
LDRALHTPMY FFLAILSCSE ICYTFVIVPK MLVDLLSQKK TISFLGCAIQ
110 120 130 140 150
MFSFLFFGSS HSFLLAAMGY DRYMAICNPL RYSVLMGHGV CMGLMAAACA
160 170 180 190 200
CGFTVSLVTT SLVFHLPFHS SNQLHHFFCD ISPVLKLASQ HSGFSQLVIF
210 220 230 240 250
MLGVFALVIP LLLILVSYIR IISAILKIPS SVGRYKTFST CASHLIVVTV
260 270 280 290 300
HYSCASFIYL RPKTNYTSSQ DTLISVSYTI LTPLFNPMIY SLRNKEFKSA
310
LRRTIGQTFY PLS
Length:313
Mass (Da):35,079
Last modified:October 1, 2002 - v1
Checksum:i96E546B9EC492965
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065641 Genomic DNA Translation: BAC05867.1
AL365440 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52825.1
BC137323 mRNA Translation: AAI37324.1
BC137324 mRNA Translation: AAI37325.1
BK004190 Genomic DNA Translation: DAA04588.1
CCDSiCCDS30897.1
RefSeqiNP_001004473.1, NM_001004473.1
UniGeneiHs.690410

Genome annotation databases

EnsembliENST00000289451; ENSP00000289451; ENSG00000173285
ENST00000641432; ENSP00000493023; ENSG00000173285
ENST00000641460; ENSP00000493278; ENSG00000173285
ENST00000641535; ENSP00000493025; ENSG00000173285
ENST00000641971; ENSP00000492890; ENSG00000173285
GeneIDi391109
KEGGihsa:391109
UCSCiuc010pij.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065641 Genomic DNA Translation: BAC05867.1
AL365440 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52825.1
BC137323 mRNA Translation: AAI37324.1
BC137324 mRNA Translation: AAI37325.1
BK004190 Genomic DNA Translation: DAA04588.1
CCDSiCCDS30897.1
RefSeqiNP_001004473.1, NM_001004473.1
UniGeneiHs.690410

3D structure databases

ProteinModelPortaliQ8NGX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000289451

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGX5
PhosphoSitePlusiQ8NGX5

Polymorphism and mutation databases

BioMutaiOR10K1
DMDMi38372781

Proteomic databases

PaxDbiQ8NGX5
PeptideAtlasiQ8NGX5
PRIDEiQ8NGX5
ProteomicsDBi73617

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289451; ENSP00000289451; ENSG00000173285
ENST00000641432; ENSP00000493023; ENSG00000173285
ENST00000641460; ENSP00000493278; ENSG00000173285
ENST00000641535; ENSP00000493025; ENSG00000173285
ENST00000641971; ENSP00000492890; ENSG00000173285
GeneIDi391109
KEGGihsa:391109
UCSCiuc010pij.2 human

Organism-specific databases

CTDi391109
DisGeNETi391109
EuPathDBiHostDB:ENSG00000173285.3
GeneCardsiOR10K1
HGNCiHGNC:14693 OR10K1
HPAiHPA059125
neXtProtiNX_Q8NGX5
PharmGKBiPA31988
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0G Eukaryota
ENOG41117G5 LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGX5
KOiK04257
OMAiGFSQLVI
OrthoDBiEOG091G0CYL
PhylomeDBiQ8NGX5
TreeFamiTF337249

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10K1
GenomeRNAii391109
PROiPR:Q8NGX5

Gene expression databases

CleanExiHS_OR10K1
ExpressionAtlasiQ8NGX5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10K1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX5
Secondary accession number(s): Q6IFS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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