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Protein

Olfactory receptor 10T2

Gene

OR10T2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10T2
Alternative name(s):
Olfactory receptor OR1-3
Gene namesi
Name:OR10T2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000186306.1
HGNCiHGNC:14816 OR10T2
neXtProtiNX_Q8NGX3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 100ExtracellularSequence analysisAdd BLAST24
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 237CytoplasmicSequence analysisAdd BLAST19
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi128360
PharmGKBiPA32001

Polymorphism and mutation databases

BioMutaiOR10T2
DMDMi38372780

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507171 – 314Olfactory receptor 10T2Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX3
PeptideAtlasiQ8NGX3
PRIDEiQ8NGX3
ProteomicsDBi73616

PTM databases

iPTMnetiQ8NGX3
PhosphoSitePlusiQ8NGX3

Expressioni

Gene expression databases

CleanExiHS_OR10T2
ExpressionAtlasiQ8NGX3 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334115

Structurei

3D structure databases

ProteinModelPortaliQ8NGX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0G Eukaryota
ENOG41117G5 LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGX3
KOiK04257
OMAiVATNLIC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGX3
TreeFamiTF337249

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGFNKTTVV TQFILVGFSS LGELQLLLFV IFLLLYLTIL VANVTIMAVI
60 70 80 90 100
RFSWTLHTPM YGFLFILSFS ESCYTFVIIP QLLVHLLSDT KTISFMACAT
110 120 130 140 150
QLFFFLGFAC TNCLLIAVMG YDRYVAICHP LRYTLIINKR LGLELISLSG
160 170 180 190 200
ATGFFIALVA TNLICDMRFC GPNRVNHYFC DMAPVIKLAC TDTHVKELAL
210 220 230 240 250
FSLSILVIMV PFLLILISYG FIVNTILKIP SAEGKKAFVT CASHLTVVFV
260 270 280 290 300
HYGCASIIYL RPKSKSASDK DQLVAVTYTV VTPLLNPLVY SLRNKEVKTA
310
LKRVLGMPVA TKMS
Length:314
Mass (Da):35,011
Last modified:October 1, 2002 - v1
Checksum:iABD13B73F6CDD152
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05328416V → A. Corresponds to variant dbSNP:rs6660222Ensembl.1
Natural variantiVAR_05328565F → L. Corresponds to variant dbSNP:rs41488350Ensembl.1
Natural variantiVAR_05328678I → V. Corresponds to variant dbSNP:rs6662597Ensembl.1
Natural variantiVAR_053287137I → M. Corresponds to variant dbSNP:rs6662382Ensembl.1
Natural variantiVAR_053288155F → L. Corresponds to variant dbSNP:rs12062580Ensembl.1
Natural variantiVAR_053289312K → N. Corresponds to variant dbSNP:rs6692949Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065643 Genomic DNA Translation: BAC05869.1
AL121986 Genomic DNA No translation available.
BK004364 Genomic DNA Translation: DAA04762.1
CCDSiCCDS30895.1
RefSeqiNP_001004475.1, NM_001004475.1
UniGeneiHs.553588

Genome annotation databases

EnsembliENST00000334438; ENSP00000334115; ENSG00000186306
GeneIDi128360
KEGGihsa:128360
UCSCiuc010pih.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065643 Genomic DNA Translation: BAC05869.1
AL121986 Genomic DNA No translation available.
BK004364 Genomic DNA Translation: DAA04762.1
CCDSiCCDS30895.1
RefSeqiNP_001004475.1, NM_001004475.1
UniGeneiHs.553588

3D structure databases

ProteinModelPortaliQ8NGX3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334115

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGX3
PhosphoSitePlusiQ8NGX3

Polymorphism and mutation databases

BioMutaiOR10T2
DMDMi38372780

Proteomic databases

PaxDbiQ8NGX3
PeptideAtlasiQ8NGX3
PRIDEiQ8NGX3
ProteomicsDBi73616

Protocols and materials databases

DNASUi128360
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334438; ENSP00000334115; ENSG00000186306
GeneIDi128360
KEGGihsa:128360
UCSCiuc010pih.2 human

Organism-specific databases

CTDi128360
DisGeNETi128360
EuPathDBiHostDB:ENSG00000186306.1
GeneCardsiOR10T2
HGNCiHGNC:14816 OR10T2
neXtProtiNX_Q8NGX3
PharmGKBiPA32001
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0G Eukaryota
ENOG41117G5 LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGX3
KOiK04257
OMAiVATNLIC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGX3
TreeFamiTF337249

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR10T2
GenomeRNAii128360
PROiPR:Q8NGX3

Gene expression databases

CleanExiHS_OR10T2
ExpressionAtlasiQ8NGX3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO10T2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX3
Secondary accession number(s): Q6IF98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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