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Protein

Olfactory receptor 11L1

Gene

OR11L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11L1
Gene namesi
Name:OR11L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197591.3
HGNCiHGNC:14998 OR11L1
neXtProtiNX_Q8NGX0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 322CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32025

Polymorphism and mutation databases

BioMutaiOR11L1
DMDMi38372779

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507271 – 322Olfactory receptor 11L1Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX0
PRIDEiQ8NGX0
ProteomicsDBi73613

Expressioni

Gene expression databases

BgeeiENSG00000197591 Expressed in 4 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_OR11L1

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348033

Structurei

3D structure databases

ProteinModelPortaliQ8NGX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVPB Eukaryota
ENOG410ZE2Y LUCA
GeneTreeiENSGT00800000124041
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGX0
KOiK04257
OMAiYGTMISM
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGX0
TreeFamiTF336512

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPQNTSTVT NFQLLGFQNL LEWQALLFVI FLLIYCLTII GNVVIITVVS
60 70 80 90 100
QGLRLHSPMY MFLQHLSFLE VWYTSTTVPL LLANLLSWGQ AISFSACMAQ
110 120 130 140 150
LYFFVFLGAT ECFLLAFMAY DRYLAICSPL RYPFLMHRGL CARLVVVSWC
160 170 180 190 200
TGVSTGFLPS LMISRLDFCG RNQINHFFCD LPPLMQLSCS RVYITEVTIF
210 220 230 240 250
ILSIAVLCIC FFLTLGPYVF IVSSILRIPS TSGRRKTFST CGSHLAVVTL
260 270 280 290 300
YYGTMISMYV CPSPHLLPEI NKIISVFYTV VTPLLNPVIY SLRNKDFKEA
310 320
VRKVMRRKCG ILWSTSKRKF LY
Length:322
Mass (Da):36,763
Last modified:October 1, 2002 - v1
Checksum:i9BA9A79E14B3685D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053295108G → S2 PublicationsCorresponds to variant dbSNP:rs10888257Ensembl.1
Natural variantiVAR_034305117F → L2 PublicationsCorresponds to variant dbSNP:rs540891010Ensembl.1
Natural variantiVAR_053296142A → T2 PublicationsCorresponds to variant dbSNP:rs10888256Ensembl.1
Natural variantiVAR_053297171R → P. Corresponds to variant dbSNP:rs10888255Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065646 Genomic DNA Translation: BAC05872.1
KP290124 Genomic DNA Translation: ALI87315.1
CH471148 Genomic DNA Translation: EAW77204.1
BC140753 mRNA Translation: AAI40754.1
CCDSiCCDS31098.1
RefSeqiNP_001001959.1, NM_001001959.1
UniGeneiHs.553781

Genome annotation databases

EnsembliENST00000355784; ENSP00000348033; ENSG00000197591
GeneIDi391189
KEGGihsa:391189
UCSCiuc001idn.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065646 Genomic DNA Translation: BAC05872.1
KP290124 Genomic DNA Translation: ALI87315.1
CH471148 Genomic DNA Translation: EAW77204.1
BC140753 mRNA Translation: AAI40754.1
CCDSiCCDS31098.1
RefSeqiNP_001001959.1, NM_001001959.1
UniGeneiHs.553781

3D structure databases

ProteinModelPortaliQ8NGX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348033

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR11L1
DMDMi38372779

Proteomic databases

PaxDbiQ8NGX0
PRIDEiQ8NGX0
ProteomicsDBi73613

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355784; ENSP00000348033; ENSG00000197591
GeneIDi391189
KEGGihsa:391189
UCSCiuc001idn.1 human

Organism-specific databases

CTDi391189
EuPathDBiHostDB:ENSG00000197591.3
GeneCardsiOR11L1
HGNCiHGNC:14998 OR11L1
neXtProtiNX_Q8NGX0
PharmGKBiPA32025
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVPB Eukaryota
ENOG410ZE2Y LUCA
GeneTreeiENSGT00800000124041
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGX0
KOiK04257
OMAiYGTMISM
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGX0
TreeFamiTF336512

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR11L1
GenomeRNAii391189
PROiPR:Q8NGX0

Gene expression databases

BgeeiENSG00000197591 Expressed in 4 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_OR11L1

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO11L1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX0
Secondary accession number(s): B9EIN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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