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Protein

Olfactory receptor 5H2

Gene

OR5H2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5H2
Alternative name(s):
Olfactory receptor OR3-10
Gene namesi
Name:OR5H2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000197938.4
HGNCiHGNC:14752 OR5H2
neXtProtiNX_Q8NGV7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 61CytoplasmicSequence analysis7
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 102ExtracellularSequence analysisAdd BLAST20
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 148CytoplasmicSequence analysisAdd BLAST25
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 198ExtracellularSequence analysisAdd BLAST29
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 244CytoplasmicSequence analysisAdd BLAST25
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 276ExtracellularSequence analysisAdd BLAST11
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 314CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197938
PharmGKBiPA32533

Polymorphism and mutation databases

BioMutaiOR5H2
DMDMi212276497

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505961 – 314Olfactory receptor 5H2Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi102 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGV7
PRIDEiQ8NGV7
ProteomicsDBi73610

Expressioni

Gene expression databases

BgeeiENSG00000197938
CleanExiHS_OR5H2
ExpressionAtlasiQ8NGV7 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347418

Structurei

3D structure databases

ProteinModelPortaliQ8NGV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J97S Eukaryota
ENOG4111537 LUCA
GeneTreeiENSGT00550000074564
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGV7
KOiK04257
OMAiAKNRMIS
OrthoDBiEOG091G0C7C
PhylomeDBiQ8NGV7
TreeFamiTF352737

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEDMEQDN TTLLTEFVLT GLTYQPEWKM PLFLVFLVIY LITIVWNLGL
60 70 80 90 100
IALIWNDPQL HIPMYFFLGS LAFVDAWISS TVTPKMLVNF LAKNRMISLS
110 120 130 140 150
ECMIQFFSFA FGGTTECFLL ATMAYDRYVA ICKPLLYPVI MNNSLCIRLL
160 170 180 190 200
AFSFLGGFLH ALIHEVLIFR LTFCNSNIIH HFYCDIIPLF MISCTDPSIN
210 220 230 240 250
FLMVFILSGS IQVFTIVTVL NSYTFALFTI LKKKSVRGVR KAFSTCGAHL
260 270 280 290 300
LSVSLYYGPL IFMYLRPASP QADDQDMIDS VFYTIIIPLL NPIIYSLRNK
310
QVIDSFTKMV KRNV
Length:314
Mass (Da):35,974
Last modified:November 4, 2008 - v3
Checksum:iCBAD88D263E03204
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053195230I → V. Corresponds to variant dbSNP:rs16839214Ensembl.1
Natural variantiVAR_053196266R → C. Corresponds to variant dbSNP:rs17787561Ensembl.1
Natural variantiVAR_053197286I → V. Corresponds to variant dbSNP:rs16839611Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065666 Genomic DNA Translation: BAC05892.1
AC117473 Genomic DNA No translation available.
BK004375 Genomic DNA Translation: DAA04773.1
CCDSiCCDS33801.1
RefSeqiNP_001005482.1, NM_001005482.1
UniGeneiHs.554711

Genome annotation databases

EnsembliENST00000355273; ENSP00000347418; ENSG00000197938
GeneIDi79310
KEGGihsa:79310
UCSCiuc003dsj.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR5H2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGV7
Secondary accession number(s): Q6IF87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: June 20, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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