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Protein

Olfactory receptor 13D1

Gene

OR13D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-33 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13D1
Alternative name(s):
Olfactory receptor OR9-15
Gene namesi
Name:OR13D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000179055.6
HGNCiHGNC:14695 OR13D1
neXtProtiNX_Q8NGV5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 78Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini79 – 86CytoplasmicSequence analysis8
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 131ExtracellularSequence analysisAdd BLAST24
Transmembranei132 – 152Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini153 – 171CytoplasmicSequence analysisAdd BLAST19
Transmembranei172 – 192Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini193 – 229ExtracellularSequence analysisAdd BLAST37
Transmembranei230 – 249Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini250 – 269CytoplasmicSequence analysisAdd BLAST20
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 303ExtracellularSequence analysisAdd BLAST13
Transmembranei304 – 324Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini325 – 346CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179055
PharmGKBiPA32040

Polymorphism and mutation databases

BioMutaiOR13D1
DMDMi229462944

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507371 – 346Olfactory receptor 13D1Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi129 ↔ 221PROSITE-ProRule annotation
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGV5
PeptideAtlasiQ8NGV5
PRIDEiQ8NGV5
ProteomicsDBi73608

PTM databases

PhosphoSitePlusiQ8NGV5

Expressioni

Gene expression databases

BgeeiENSG00000179055
CleanExiHS_OR13D1

Organism-specific databases

HPAiHPA055921

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317357

Structurei

3D structure databases

ProteinModelPortaliQ8NGV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITEU Eukaryota
ENOG41113G1 LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGV5
KOiK04257
OMAiLIIFMSE
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGV5
TreeFamiTF352686

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
IPR030787 OR13D1
PANTHERiPTHR26453:SF0 PTHR26453:SF0, 1 hit
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRFTDFDVS NISIYLNHVL FYTTQQAGDL EHMETRNYSA MTEFFLVGLS
60 70 80 90 100
QYPELQLFLF LLCLIMYMII LLGNSLLIII TILDSRLHTP MYFFLGNLSF
110 120 130 140 150
LDICYTSSSI PPMLIIFMSE RKSISFIGCA LQMVVSLGLG STECVLLAVM
160 170 180 190 200
AYDHYVAICN PLRYSIIMNG VLYVQMAAWS WIIGCLTSLL QTVLTMMLPF
210 220 230 240 250
CGNNVIDHIT CEILALLKLV CSDITINVLI MTVTNIVSLV ILLLLIFISY
260 270 280 290 300
VFILSSILRI NCAEGRKKAF STCSAHSIVV ILFYGSALFM YMKPKSKNTN
310 320 330 340
TSDEIIGLSY GVVSPMLNPI IYSLRNKEVK EAVKKVLSRH LHLLKM
Length:346
Mass (Da):39,125
Last modified:May 5, 2009 - v3
Checksum:iD7E7908A875922D8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05507021F → L. Corresponds to variant dbSNP:rs10991359Ensembl.1
Natural variantiVAR_05507164L → V1 PublicationCorresponds to variant dbSNP:rs13294411Ensembl.1
Natural variantiVAR_055072191Q → H1 PublicationCorresponds to variant dbSNP:rs10820709Ensembl.1
Natural variantiVAR_055073277S → L1 PublicationCorresponds to variant dbSNP:rs10761073Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065671 Genomic DNA Translation: BAC05896.1
AL359846 Genomic DNA No translation available.
BC140916 mRNA Translation: AAI40917.1
BK004251 Genomic DNA Translation: DAA04649.1
CCDSiCCDS35094.1
RefSeqiNP_001004484.1, NM_001004484.1
UniGeneiHs.553683

Genome annotation databases

EnsembliENST00000318763; ENSP00000317357; ENSG00000179055
GeneIDi286365
KEGGihsa:286365
UCSCiuc011lvs.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO13D1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGV5
Secondary accession number(s): B9EIS1, Q6IFL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: June 20, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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