UniProtKB - Q8NGU9 (GP150_HUMAN)
Protein
Probable G-protein coupled receptor 150
Gene
GPR150
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- peptide binding Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
- negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q8NGU9 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 150 |
Gene namesi | Name:GPR150 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23628, GPR150 |
neXtProti | NX_Q8NGU9 |
VEuPathDBi | HostDB:ENSG00000178015.4 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | ExtracellularSequence analysis | 3 | |
Transmembranei | 4 – 24 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 25 – 43 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 44 – 64 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 65 – 81 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 82 – 102 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 162 | CytoplasmicSequence analysisAdd BLAST | 60 | |
Transmembranei | 163 – 183 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 184 – 237 | ExtracellularSequence analysisAdd BLAST | 54 | |
Transmembranei | 238 – 258 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 293 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 294 – 314 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 315 – 334 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 335 – 355 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 356 – 434 | CytoplasmicSequence analysisAdd BLAST | 79 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 285601 |
OpenTargetsi | ENSG00000178015 |
PharmGKBi | PA134984082 |
Miscellaneous databases
Pharosi | Q8NGU9, Tdark |
Genetic variation databases
BioMutai | GPR150 |
DMDMi | 54037146 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069630 | 1 – 434 | Probable G-protein coupled receptor 150Add BLAST | 434 |
Proteomic databases
MassIVEi | Q8NGU9 |
PaxDbi | Q8NGU9 |
PeptideAtlasi | Q8NGU9 |
PRIDEi | Q8NGU9 |
ProteomicsDBi | 73606 |
PTM databases
iPTMneti | Q8NGU9 |
PhosphoSitePlusi | Q8NGU9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000178015, Expressed in body of pancreas and 74 other tissues |
Organism-specific databases
HPAi | ENSG00000178015, Tissue enhanced (brain, pancreas) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000369344 |
Miscellaneous databases
RNActi | Q8NGU9, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 188 – 197 | Poly-Pro | 10 | |
Compositional biasi | 418 – 427 | Poly-Pro | 10 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230377 |
HOGENOMi | CLU_009579_15_6_1 |
InParanoidi | Q8NGU9 |
OMAi | WHLQVYA |
OrthoDBi | 1415066at2759 |
PhylomeDBi | Q8NGU9 |
TreeFami | TF106499 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGU9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDLFSPSIL PPAPNISVPI LLGWGLNLTL GQGAPASGPP SRRVRLVFLG
60 70 80 90 100
VILVVAVAGN TTVLCRLCGG GGPWAGPKRR KMDFLLVQLA LADLYACGGT
110 120 130 140 150
ALSQLAWELL GEPRAATGDL ACRFLQLLQA SGRGASAHLV VLIALERRRA
160 170 180 190 200
VRLPHGRPLP ARALAALGWL LALLLALPPA FVVRGDSPSP LPPPPPPTSL
210 220 230 240 250
QPGAPPAARA WPGERRCHGI FAPLPRWHLQ VYAFYEAVAG FVAPVTVLGV
260 270 280 290 300
ACGHLLSVWW RHRPQAPAAA APWSASPGRA PAPSALPRAK VQSLKMSLLL
310 320 330 340 350
ALLFVGCELP YFAARLAAAW SSGPAGDWEG EGLSAALRVV AMANSALNPF
360 370 380 390 400
VYLFFQAGDC RLRRQLRKRL GSLCCAPQGG AEDEEGPRGH QALYRQRWPH
410 420 430
PHYHHARREP LDEGGLRPPP PRPRPLPCSC ESAF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065678 Genomic DNA Translation: BAC05903.1 JF810884 mRNA Translation: AEP43751.1 CH471084 Genomic DNA Translation: EAW96041.1 BC030197 mRNA Translation: AAH30197.1 BK005422 mRNA Translation: DAA64837.1 |
CCDSi | CCDS4074.1 |
RefSeqi | NP_954713.1, NM_199243.1 |
Genome annotation databases
Ensembli | ENST00000380007; ENSP00000369344; ENSG00000178015 |
GeneIDi | 285601 |
KEGGi | hsa:285601 |
UCSCi | uc003kle.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065678 Genomic DNA Translation: BAC05903.1 JF810884 mRNA Translation: AEP43751.1 CH471084 Genomic DNA Translation: EAW96041.1 BC030197 mRNA Translation: AAH30197.1 BK005422 mRNA Translation: DAA64837.1 |
CCDSi | CCDS4074.1 |
RefSeqi | NP_954713.1, NM_199243.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000369344 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q8NGU9 |
PhosphoSitePlusi | Q8NGU9 |
Genetic variation databases
BioMutai | GPR150 |
DMDMi | 54037146 |
Proteomic databases
MassIVEi | Q8NGU9 |
PaxDbi | Q8NGU9 |
PeptideAtlasi | Q8NGU9 |
PRIDEi | Q8NGU9 |
ProteomicsDBi | 73606 |
Protocols and materials databases
Antibodypediai | 13054, 176 antibodies |
Genome annotation databases
Ensembli | ENST00000380007; ENSP00000369344; ENSG00000178015 |
GeneIDi | 285601 |
KEGGi | hsa:285601 |
UCSCi | uc003kle.2, human |
Organism-specific databases
CTDi | 285601 |
DisGeNETi | 285601 |
GeneCardsi | GPR150 |
HGNCi | HGNC:23628, GPR150 |
HPAi | ENSG00000178015, Tissue enhanced (brain, pancreas) |
neXtProti | NX_Q8NGU9 |
OpenTargetsi | ENSG00000178015 |
PharmGKBi | PA134984082 |
VEuPathDBi | HostDB:ENSG00000178015.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230377 |
HOGENOMi | CLU_009579_15_6_1 |
InParanoidi | Q8NGU9 |
OMAi | WHLQVYA |
OrthoDBi | 1415066at2759 |
PhylomeDBi | Q8NGU9 |
TreeFami | TF106499 |
Enzyme and pathway databases
PathwayCommonsi | Q8NGU9 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Miscellaneous databases
BioGRID-ORCSi | 285601, 3 hits in 978 CRISPR screens |
GeneWikii | GPR150 |
GenomeRNAii | 285601 |
Pharosi | Q8NGU9, Tdark |
PROi | PR:Q8NGU9 |
RNActi | Q8NGU9, protein |
Gene expression databases
Bgeei | ENSG00000178015, Expressed in body of pancreas and 74 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP150_HUMAN | |
Accessioni | Q8NGU9Primary (citable) accession number: Q8NGU9 Secondary accession number(s): G4XH61, Q05C22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families