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Protein

Olfactory receptor 2A1/2A42

Gene

OR2A1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A1/2A42
Alternative name(s):
Olfactory receptor OR7-16
Olfactory receptor OR7-19
Gene namesi
Name:OR2A1
AND
Name:OR2A42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000212807.1
HostDB:ENSG00000221970.1
HGNCiHGNC:8229 OR2A1
HGNC:31230 OR2A42
neXtProtiNX_Q8NGT9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 99ExtracellularSequence analysisAdd BLAST21
Transmembranei100 – 119Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 157Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini158 – 195ExtracellularSequence analysisAdd BLAST38
Transmembranei196 – 218Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 310CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000212807
PharmGKBiPA134971566

Polymorphism and mutation databases

BioMutaiOR2A1
DMDMi38372771

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504591 – 310Olfactory receptor 2A1/2A42Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGT9
PeptideAtlasiQ8NGT9
PRIDEiQ8NGT9
ProteomicsDBi73602

PTM databases

iPTMnetiQ8NGT9
PhosphoSitePlusiQ8NGT9

Expressioni

Gene expression databases

BgeeiENSG00000212807 Expressed in 67 organ(s), highest expression level in thyroid gland
CleanExiHS_OR2A1
HS_OR2A42

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386175

Structurei

3D structure databases

ProteinModelPortaliQ8NGT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHHV Eukaryota
ENOG410Z9E8 LUCA
GeneTreeiENSGT00820000127003
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGT9
KOiK04257
OMAiCGHSECL
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGT9
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGENQTMVTE FLLLGFLLGP RIQMLLFGLF SLFYIFTLLG NGAILGLISL
60 70 80 90 100
DSRLHTPMYF FLSHLAVVDI AYTRNTVPQM LANLLHPAKP ISFAGCMTQT
110 120 130 140 150
FLCLSFGHSE CLLLVLMSYD RYVAICHPLR YSVIMTWRVC ITLAVTSWTC
160 170 180 190 200
GSLLALAHVV LILRLPFSGP HEINHFFCEI LSVLRLACAD TWLNQVVIFA
210 220 230 240 250
ACVFFLVGPP SLVLVSYSHI LAAILRIQSG EGRRKAFSTC SSHLCVVGLF
260 270 280 290 300
FGSAIIMYMA PKSRHPEEQQ KVFFLFYSFF NPTLNPLIYS LRNGEVKGAL
310
RRALGKESHS
Length:310
Mass (Da):34,714
Last modified:October 10, 2003 - v2
Checksum:iCE5E0170B025E871
GO

Sequence cautioni

The sequence BAC05915 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065692 Genomic DNA Translation: BAC05915.1 Different initiation.
AF399597 Genomic DNA Translation: AAK95082.1
BK004217 Genomic DNA Translation: DAA04615.1
BK004418 Genomic DNA Translation: DAA04816.1
CCDSiCCDS43673.1
CCDS56515.1
RefSeqiNP_001001802.2, NM_001001802.2
NP_001005287.1, NM_001005287.1
UniGeneiHs.528398
Hs.591830

Genome annotation databases

EnsembliENST00000391496; ENSP00000375334; ENSG00000212807
ENST00000408951; ENSP00000386175; ENSG00000221970
ENST00000641044; ENSP00000493454; ENSG00000221970
ENST00000641810; ENSP00000493333; ENSG00000212807
GeneIDi346528
402317
KEGGihsa:346528
hsa:402317
UCSCiuc011kub.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)
Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065692 Genomic DNA Translation: BAC05915.1 Different initiation.
AF399597 Genomic DNA Translation: AAK95082.1
BK004217 Genomic DNA Translation: DAA04615.1
BK004418 Genomic DNA Translation: DAA04816.1
CCDSiCCDS43673.1
CCDS56515.1
RefSeqiNP_001001802.2, NM_001001802.2
NP_001005287.1, NM_001005287.1
UniGeneiHs.528398
Hs.591830

3D structure databases

ProteinModelPortaliQ8NGT9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386175

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGT9
PhosphoSitePlusiQ8NGT9

Polymorphism and mutation databases

BioMutaiOR2A1
DMDMi38372771

Proteomic databases

PaxDbiQ8NGT9
PeptideAtlasiQ8NGT9
PRIDEiQ8NGT9
ProteomicsDBi73602

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391496; ENSP00000375334; ENSG00000212807
ENST00000408951; ENSP00000386175; ENSG00000221970
ENST00000641044; ENSP00000493454; ENSG00000221970
ENST00000641810; ENSP00000493333; ENSG00000212807
GeneIDi346528
402317
KEGGihsa:346528
hsa:402317
UCSCiuc011kub.2 human

Organism-specific databases

CTDi346528
402317
EuPathDBiHostDB:ENSG00000212807.1
HostDB:ENSG00000221970.1
GeneCardsiOR2A1
OR2A42
H-InvDBiHIX0033551
HGNCiHGNC:8229 OR2A1
HGNC:31230 OR2A42
neXtProtiNX_Q8NGT9
OpenTargetsiENSG00000212807
PharmGKBiPA134971566
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHHV Eukaryota
ENOG410Z9E8 LUCA
GeneTreeiENSGT00820000127003
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGT9
KOiK04257
OMAiCGHSECL
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGT9
TreeFamiTF337251

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR2A1
PROiPR:Q8NGT9

Gene expression databases

BgeeiENSG00000212807 Expressed in 67 organ(s), highest expression level in thyroid gland
CleanExiHS_OR2A1
HS_OR2A42

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR2A1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT9
Secondary accession number(s): Q6IF44, Q96R46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: September 12, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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