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Protein

Olfactory receptor 9A2

Gene

OR9A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9A2
Alternative name(s):
Olfactory receptor OR7-2
Gene namesi
Name:OR9A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000179468.5
HGNCiHGNC:15093 OR9A2
neXtProtiNX_Q8NGT5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 53CytoplasmicSequence analysis8
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 98ExtracellularSequence analysisAdd BLAST24
Topological domaini117 – 135CytoplasmicSequence analysisAdd BLAST19
Transmembranei136 – 156Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 213Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini214 – 233CytoplasmicSequence analysisAdd BLAST20
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 267ExtracellularSequence analysisAdd BLAST13
Transmembranei268 – 288Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini289 – 310CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179468
PharmGKBiPA32785

Polymorphism and mutation databases

BioMutaiOR9A2
DMDMi38372770

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506761 – 310Olfactory receptor 9A2Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGT5
PRIDEiQ8NGT5
ProteomicsDBi73600

PTM databases

PhosphoSitePlusiQ8NGT5

Expressioni

Gene expression databases

BgeeiENSG00000179468
CleanExiHS_OR9A2

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000316518

Structurei

3D structure databases

ProteinModelPortaliQ8NGT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JB8S Eukaryota
ENOG41114F3 LUCA
GeneTreeiENSGT00760000119169
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGT5
KOiK04257
OMAiMDNHSSA
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGT5
TreeFamiTF336833

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDNHSSATE FHLLGFPGSQ GLHHILFAIF FFFYLVTLMG NTVIIVIVCV
60 70 80 90 100
DKRLQSPMYF FLSHLSTLEI LVTTIIVPMM LWGLLFLGCR QYLSLHVSLN
110 120 130 140 150
FSCGTMEFAL LGVMAVDRYV AVCNPLRYNI IMNSSTCIWV VIVSWVFGFL
160 170 180 190 200
SEIWPIYATF QFTFRKSNSL DHFYCDRGQL LKLSCDNTLL TEFILFLMAV
210 220 230 240 250
FILIGSLIPT IVSYTYIIST ILKIPSASGR RKAFSTFASH FTCVVIGYGS
260 270 280 290 300
CLFLYVKPKQ TQGVEYNKIV SLLVSVLTPF LNPFIFTLRN DKVKEALRDG
310
MKRCCQLLKD
Length:310
Mass (Da):35,330
Last modified:October 1, 2002 - v1
Checksum:i276463E878614FE0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05325353R → H. Corresponds to variant dbSNP:rs9885986Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065696 Genomic DNA Translation: BAC05919.1
AB065874 Genomic DNA Translation: BAC06092.1
CH471198 Genomic DNA Translation: EAW51890.1
BC137048 mRNA Translation: AAI37049.1
BC137049 mRNA Translation: AAI37050.1
BK004391 Genomic DNA Translation: DAA04789.1
CCDSiCCDS34767.1
RefSeqiNP_001001658.1, NM_001001658.1
UniGeneiHs.553594

Genome annotation databases

EnsembliENST00000350513; ENSP00000316518; ENSG00000179468
ENST00000619330; ENSP00000479412; ENSG00000273914
GeneIDi135924
KEGGihsa:135924
UCSCiuc003wcc.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR9A2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT5
Secondary accession number(s): B9EH51, Q6IF71, Q8NGD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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