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Protein

Olfactory receptor 2K2

Gene

OR2K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2K2
Alternative name(s):
HTPCRH06
Olfactory receptor OR9-17
Gene namesi
Name:OR2K2
Synonyms:OR2AR1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000171133.2
HGNCiHGNC:8264 OR2K2
neXtProtiNX_Q8NGT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54ExtracellularSequence analysisAdd BLAST54
Transmembranei55 – 78Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini79 – 86CytoplasmicSequence analysis8
Transmembranei87 – 108Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini109 – 129ExtracellularSequence analysisAdd BLAST21
Transmembranei130 – 149Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini150 – 168CytoplasmicSequence analysisAdd BLAST19
Transmembranei169 – 187Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini188 – 223ExtracellularSequence analysisAdd BLAST36
Transmembranei224 – 247Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini248 – 264CytoplasmicSequence analysisAdd BLAST17
Transmembranei265 – 287Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini288 – 300ExtracellularSequence analysisAdd BLAST13
Transmembranei301 – 320Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini321 – 345CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171133
PharmGKBiPA32181

Polymorphism and mutation databases

BioMutaiOR2K2
DMDMi218511729

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504851 – 345Olfactory receptor 2K2Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi126 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGT1
PRIDEiQ8NGT1
ProteomicsDBi73598

PTM databases

iPTMnetiQ8NGT1
PhosphoSitePlusiQ8NGT1

Expressioni

Gene expression databases

BgeeiENSG00000171133 Expressed in 22 organ(s), highest expression level in substantia nigra
CleanExiHS_OR2K2
ExpressionAtlasiQ8NGT1 baseline and differential
GenevisibleiQ8NGT1 HS

Organism-specific databases

HPAiHPA024261

Interactioni

Protein-protein interaction databases

BioGridi117636, 6 interactors
STRINGi9606.ENSP00000305055

Structurei

3D structure databases

ProteinModelPortaliQ8NGT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIC1 Eukaryota
ENOG41114NH LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGT1
KOiK04257
OMAiQIPLCGN
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGT1
TreeFamiTF352686

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NGT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNITLYSFLY VLRLNEGNST GRNIDERKKM QGENFTIWSI FFLEGFSQYP
60 70 80 90 100
GLEVVLFVFS LVMYLTTLLG NSTLILITIL DSRLKTPMYL FLGNLSFMDI
110 120 130 140 150
CYTSASVPTL LVNLLSSQKT IIFSGCAVQM YLSLAMGSTE CVLLAVMAYD
160 170 180 190 200
RYVAICNPLR YSIIMNRCVC ARMATVSWVT GCLTALLETS FALQIPLCGN
210 220 230 240 250
LIDHFTCEIL AVLKLACTSS LLMNTIMLVV SILLLPIPML LVCISYIFIL
260 270 280 290 300
STILRITSAE GRNKAFSTCG AHLTVVILYY GAALSMYLKP SSSNAQKIDK
310 320 330 340
IISLLYGVLT PMLNPIIYSL RNKEVKDAMK KLLGKITLHQ THEHL
Length:345
Mass (Da):38,473
Last modified:December 16, 2008 - v2
Checksum:iDEFA8BE03AF4428D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFP3A0A0C4DFP3_HUMAN
Olfactory receptor
OR2K2 hCG_1790497
316Annotation score:

Sequence cautioni

The sequence BAC05929 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065707 Genomic DNA Translation: BAC05929.1 Different initiation.
AL354661 Genomic DNA No translation available.
BC111086 mRNA Translation: AAI11087.1
BK004277 Genomic DNA Translation: DAA04675.1
RefSeqiNP_995581.1, NM_205859.1
XP_011516822.1, XM_011518520.2
UniGeneiHs.381312

Genome annotation databases

EnsembliENST00000374428; ENSP00000363550; ENSG00000171133
GeneIDi26248
KEGGihsa:26248
UCSCiuc011lwp.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065707 Genomic DNA Translation: BAC05929.1 Different initiation.
AL354661 Genomic DNA No translation available.
BC111086 mRNA Translation: AAI11087.1
BK004277 Genomic DNA Translation: DAA04675.1
RefSeqiNP_995581.1, NM_205859.1
XP_011516822.1, XM_011518520.2
UniGeneiHs.381312

3D structure databases

ProteinModelPortaliQ8NGT1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117636, 6 interactors
STRINGi9606.ENSP00000305055

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGT1
PhosphoSitePlusiQ8NGT1

Polymorphism and mutation databases

BioMutaiOR2K2
DMDMi218511729

Proteomic databases

PaxDbiQ8NGT1
PRIDEiQ8NGT1
ProteomicsDBi73598

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374428; ENSP00000363550; ENSG00000171133
GeneIDi26248
KEGGihsa:26248
UCSCiuc011lwp.2 human

Organism-specific databases

CTDi26248
EuPathDBiHostDB:ENSG00000171133.2
GeneCardsiOR2K2
HGNCiHGNC:8264 OR2K2
HPAiHPA024261
neXtProtiNX_Q8NGT1
OpenTargetsiENSG00000171133
PharmGKBiPA32181
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIC1 Eukaryota
ENOG41114NH LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGT1
KOiK04257
OMAiQIPLCGN
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGT1
TreeFamiTF352686

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR2K2
GenomeRNAii26248
PROiPR:Q8NGT1

Gene expression databases

BgeeiENSG00000171133 Expressed in 22 organ(s), highest expression level in substantia nigra
CleanExiHS_OR2K2
ExpressionAtlasiQ8NGT1 baseline and differential
GenevisibleiQ8NGT1 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR2K2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT1
Secondary accession number(s): Q2TA61, Q5VYK4, Q6IFI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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