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Protein

Olfactory receptor 13C2

Gene

OR13C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C2
Alternative name(s):
Olfactory receptor OR9-12
Gene namesi
Name:OR13C2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000276119.1
HGNCiHGNC:14701 OR13C2
neXtProtiNX_Q8NGS9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 277ExtracellularSequence analysisAdd BLAST19
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 318CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32032

Polymorphism and mutation databases

BioMutaiOR13C2
DMDMi38372766

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507311 – 318Olfactory receptor 13C2Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS9
PRIDEiQ8NGS9
ProteomicsDBi73596

PTM databases

iPTMnetiQ8NGS9
PhosphoSitePlusiQ8NGS9

Expressioni

Gene expression databases

BgeeiENSG00000276119 Expressed in 7 organ(s), highest expression level in adenohypophysis
CleanExiHS_OR13C2
ExpressionAtlasiQ8NGS9 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000438815

Structurei

3D structure databases

ProteinModelPortaliQ8NGS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IENR Eukaryota
ENOG4111CQX LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGS9
KOiK04257
OMAiGVITPMI
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGS9
TreeFamiTF352686

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWENHTILV EFFLKGLSGH PRLELLFFVL IFIMYVVILL GNGTLILISI
60 70 80 90 100
LDPHLHTPMY FFLGNLSFLD ICYTTTSIPS TLVSFLSERK TISLSGCAVQ
110 120 130 140 150
MFLGLAMGTT ECVLLGMMAF DRYVAICNPL RYPIIMSKDA YVPMAAGSWI
160 170 180 190 200
IGAVNSAVQS VFVVQLPFCR NNIINHFTCE ILAVMKLACA DISDNEFIML
210 220 230 240 250
VATTLFILTP LLLIIVSYTL IIVSIFKISS SEGRSKASST CSAHLTVVII
260 270 280 290 300
FYGTILFMYM KPKSKETLNS DDLDATDKII SMFYGVMTPM MNPLIYSLRN
310
KDVKEAVKHL LNRRFFSK
Length:318
Mass (Da):35,694
Last modified:October 1, 2002 - v1
Checksum:iEC9A14508D551C43
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060030160S → T. Corresponds to variant dbSNP:rs1851716Ensembl.1
Natural variantiVAR_060031301K → E. Corresponds to variant dbSNP:rs10156474Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065709 Genomic DNA Translation: BAC05931.1
AL359846 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58987.1
BC136824 mRNA Translation: AAI36825.1
BC136826 mRNA Translation: AAI36827.1
BK004408 Genomic DNA Translation: DAA04806.1
CCDSiCCDS35092.1
RefSeqiNP_001004481.1, NM_001004481.1
UniGeneiHs.553789

Genome annotation databases

EnsembliENST00000542196; ENSP00000438815; ENSG00000276119
GeneIDi392376
KEGGihsa:392376
UCSCiuc011lvq.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065709 Genomic DNA Translation: BAC05931.1
AL359846 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58987.1
BC136824 mRNA Translation: AAI36825.1
BC136826 mRNA Translation: AAI36827.1
BK004408 Genomic DNA Translation: DAA04806.1
CCDSiCCDS35092.1
RefSeqiNP_001004481.1, NM_001004481.1
UniGeneiHs.553789

3D structure databases

ProteinModelPortaliQ8NGS9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000438815

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGS9
PhosphoSitePlusiQ8NGS9

Polymorphism and mutation databases

BioMutaiOR13C2
DMDMi38372766

Proteomic databases

PaxDbiQ8NGS9
PRIDEiQ8NGS9
ProteomicsDBi73596

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000542196; ENSP00000438815; ENSG00000276119
GeneIDi392376
KEGGihsa:392376
UCSCiuc011lvq.2 human

Organism-specific databases

CTDi392376
EuPathDBiHostDB:ENSG00000276119.1
GeneCardsiOR13C2
HGNCiHGNC:14701 OR13C2
neXtProtiNX_Q8NGS9
PharmGKBiPA32032
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IENR Eukaryota
ENOG4111CQX LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGS9
KOiK04257
OMAiGVITPMI
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGS9
TreeFamiTF352686

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR13C2
GenomeRNAii392376
PROiPR:Q8NGS9

Gene expression databases

BgeeiENSG00000276119 Expressed in 7 organ(s), highest expression level in adenohypophysis
CleanExiHS_OR13C2
ExpressionAtlasiQ8NGS9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO13C2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS9
Secondary accession number(s): B9EGV8, Q6IF54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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