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Protein

Olfactory receptor 13C5

Gene

OR13C5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C5
Alternative name(s):
Olfactory receptor OR9-11
Gene namesi
Name:OR13C5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000277556.1
HGNCiHGNC:15100 OR13C5
neXtProtiNX_Q8NGS8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 277ExtracellularSequence analysisAdd BLAST19
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 318CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32035

Polymorphism and mutation databases

BioMutaiOR13C5
DMDMi38372765

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507341 – 318Olfactory receptor 13C5Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS8
PRIDEiQ8NGS8
ProteomicsDBi73595

PTM databases

iPTMnetiQ8NGS8
PhosphoSitePlusiQ8NGS8

Expressioni

Gene expression databases

BgeeiENSG00000277556 Expressed in 5 organ(s), highest expression level in pituitary gland
CleanExiHS_OR13C5

Interactioni

Protein-protein interaction databases

BioGridi126522, 1 interactor
STRINGi9606.ENSP00000363911

Structurei

3D structure databases

ProteinModelPortaliQ8NGS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KD4D Eukaryota
ENOG4110NTD LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGS8
KOiK04257
OMAiIFIFYRV
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGS8
TreeFamiTF352686

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWENHTILV EFFLKGLSGH PRLELLFFVL IFIMYVVILL GNGTLILISI
60 70 80 90 100
LDPHLHTPMY FFLGNLSFLD ICYTTTSIPS TLVSFLSERK TISLSGCAVQ
110 120 130 140 150
MFLSLAMGTT ECVLLGVMAF DRYVAICNPL RYPIIMSKDA YVPMAAGSWI
160 170 180 190 200
IGAVNSAVQT VFVVQLPFCR NNIINHFTCE ILAVMKLACA DISGNEFILL
210 220 230 240 250
VTTTLFLLTP LLLIIVSYTL IILSIFKISS SEGRSKPSST CSARLTVVIT
260 270 280 290 300
FCGTIFLMYM KPKSQETLNS DDLDATDKLI FIFYRVMTPM MNPLIYSLRN
310
KDVKEAVKHL LRRKNFNK
Length:318
Mass (Da):35,796
Last modified:October 1, 2002 - v1
Checksum:i6865DEBF95217C51
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05329918S → F. Corresponds to variant dbSNP:rs1851722Ensembl.1
Natural variantiVAR_03430632F → L. Corresponds to variant dbSNP:rs6479260Ensembl.1
Natural variantiVAR_06003269L → M. Corresponds to variant dbSNP:rs7042502Ensembl.1
Natural variantiVAR_06003386L → V. Corresponds to variant dbSNP:rs4629933Ensembl.1
Natural variantiVAR_060034117V → M. Corresponds to variant dbSNP:rs2417534Ensembl.1
Natural variantiVAR_024132189C → Y. Corresponds to variant dbSNP:rs4117966Ensembl.1
Natural variantiVAR_053300195N → S. Corresponds to variant dbSNP:rs6479259Ensembl.1
Natural variantiVAR_024133258M → T. Corresponds to variant dbSNP:rs1851724Ensembl.1
Natural variantiVAR_024134282I → V. Corresponds to variant dbSNP:rs1523678Ensembl.1
Natural variantiVAR_024135290M → T. Corresponds to variant dbSNP:rs1851725Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065710 Genomic DNA Translation: BAC05932.1
AL450426 Genomic DNA No translation available.
BC136842 mRNA Translation: AAI36843.1
BC136843 mRNA Translation: AAI36844.1
BK004409 Genomic DNA Translation: DAA04807.1
CCDSiCCDS35091.1
RefSeqiNP_001004482.1, NM_001004482.1
UniGeneiHs.553598

Genome annotation databases

EnsembliENST00000374779; ENSP00000363911; ENSG00000277556
GeneIDi138799
KEGGihsa:138799
UCSCiuc011lvp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065710 Genomic DNA Translation: BAC05932.1
AL450426 Genomic DNA No translation available.
BC136842 mRNA Translation: AAI36843.1
BC136843 mRNA Translation: AAI36844.1
BK004409 Genomic DNA Translation: DAA04807.1
CCDSiCCDS35091.1
RefSeqiNP_001004482.1, NM_001004482.1
UniGeneiHs.553598

3D structure databases

ProteinModelPortaliQ8NGS8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126522, 1 interactor
STRINGi9606.ENSP00000363911

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGS8
PhosphoSitePlusiQ8NGS8

Polymorphism and mutation databases

BioMutaiOR13C5
DMDMi38372765

Proteomic databases

PaxDbiQ8NGS8
PRIDEiQ8NGS8
ProteomicsDBi73595

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374779; ENSP00000363911; ENSG00000277556
GeneIDi138799
KEGGihsa:138799
UCSCiuc011lvp.2 human

Organism-specific databases

CTDi138799
EuPathDBiHostDB:ENSG00000277556.1
GeneCardsiOR13C5
HGNCiHGNC:15100 OR13C5
neXtProtiNX_Q8NGS8
PharmGKBiPA32035
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KD4D Eukaryota
ENOG4110NTD LUCA
GeneTreeiENSGT00760000119058
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGS8
KOiK04257
OMAiIFIFYRV
OrthoDBiEOG091G0CU6
PhylomeDBiQ8NGS8
TreeFamiTF352686

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR13C5
GenomeRNAii138799
PROiPR:Q8NGS8

Gene expression databases

BgeeiENSG00000277556 Expressed in 5 organ(s), highest expression level in pituitary gland
CleanExiHS_OR13C5

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO13C5_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS8
Secondary accession number(s): B2RNE5, B9EGW5, Q6IF53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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